TY  - JOUR
AU  - Pavlović, Dragan
AU  - Đorđević, Jelena
AU  - Pavlović, Aleksandra M.
AU  - Stjepanović, Mirjana
AU  - Baralić, Marko
PY  - 2021
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1330
AB  - Myalgic encephalomyelitis is a complex, multisystem disease with chronic course significantly affecting patients' quality of life. Physical and mental exertion intolerability, muscle pain, and sleep problems are the main features accompanied often with cognitive inefficacy and vegetative symptoms. Prevalence is 7-3000 per 100,000 adults. It is estimated that 90% of the patients are misdiagnosed. Pathogenesis is still only speculative but current research points to disturbances in the immunological system, inflammatory pathways, autonomic and central nervous system, muscle and mitochondria, as well as alterations of gut microbiota and gut permeability. The onset is typically acute, following an infectious disease. Exertional intolerance lasting for more than six months is an important diagnostic factor. The core features must be moderate to severe and present at least 50% of the time. Diagnostic criteria should be fulfilled and differential diagnosis should be made to exclude other potential pathological conditions or to diagnose comorbidities. Brain magnetic resonance imaging morphometry has shown gray matter atrophy in occipital lobes bilaterally, right angular gyrus, and the posterior division of the left parahippocampal gyrus, consistent with memory problems and potentially with impairment of visual processing. Treatment is still symptomatic and of partial benefit. Symptomatic treatment can include medications for controlling pain and sleep problems, graded exercise and cognitive behavioral therapy. Larger controlled trials are needed to shed more light on this challenging condition.
AB  - Mijalgični encefalomijelitis je složeno, multisistemsko oboljenje sa hroničnim tokom koje značajno utiče na kvalitet života bolesnika. Slaba tolerancija na fizički i mentalni napor, bolovi u mišićima i problemi sa spavanjem glavne su odlike i često su praćene kognitivnom neefikasnošću i vegetativnim simptomima. Prevalencija je 7-3000 na 100.000 odraslih. Procenjuje se da je 90% ovih bolesnika pogrešno dijagnostikovano. Patogeneza je i dalje samo spekulativna, ali trenutna istraživanja ukazuju na poremećaje u imunološkom sistemu, inflamatornom odgovoru, autonomnom i centralnom nervnom sistemu, mišićima i mitohondrijama, kao i promene mikrobiote i propustljivosti creva. Početak bolesti je tipično akutan i prati infektivnu bolest. Netolerancija napora koja traje duže od šest meseci važan je dijagnostički kriterijum. Osnovne karakteristike moraju biti umerene do teške i prisutne najmanje 50% vremena. Isključivanje drugih mogućih patoloških stanja ili komorbiditetnih dijagnoza zahteva zadovoljavanje dijagnostičkih kriterijuma i diferencijalno dijagnostičko sagledavanje. Morfometrijska snimanja mozga magnetnom rezonancom pokazala su atrofiju sive mase u okcipitalnim režnjevima bilateralno, desnom angularnom girusu i posteriornom levom parahipokampalnom girusu, što može dovesti do problema sa pamćenjem i oštećenja vizuelne obrade informacija. Lečenje je i dalje simptomatsko i samo delimično uspešno. Simptomatski tretman može da uključuje lekove za kontrolu bola i problema sa spavanjem, doziranu fizičku aktivnost i kognitivno-bihevioralnu terapiju. Potrebne su veće studije da bi se razjasnilo ovo medicinsko stanje.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Myalgic encephalomyelitis: Enigma at the medicine's crossroads
T1  - Mijalgični encefalomijelitis - enigma na raskršću medicine
EP  - 110
IS  - 1-2
SP  - 105
VL  - 149
DO  - 10.2298/SARH200628091P
ER  - 

@article{
author = "Pavlović, Dragan and Đorđević, Jelena and Pavlović, Aleksandra M. and Stjepanović, Mirjana and Baralić, Marko",
year = "2021",
abstract = "Myalgic encephalomyelitis is a complex, multisystem disease with chronic course significantly affecting patients' quality of life. Physical and mental exertion intolerability, muscle pain, and sleep problems are the main features accompanied often with cognitive inefficacy and vegetative symptoms. Prevalence is 7-3000 per 100,000 adults. It is estimated that 90% of the patients are misdiagnosed. Pathogenesis is still only speculative but current research points to disturbances in the immunological system, inflammatory pathways, autonomic and central nervous system, muscle and mitochondria, as well as alterations of gut microbiota and gut permeability. The onset is typically acute, following an infectious disease. Exertional intolerance lasting for more than six months is an important diagnostic factor. The core features must be moderate to severe and present at least 50% of the time. Diagnostic criteria should be fulfilled and differential diagnosis should be made to exclude other potential pathological conditions or to diagnose comorbidities. Brain magnetic resonance imaging morphometry has shown gray matter atrophy in occipital lobes bilaterally, right angular gyrus, and the posterior division of the left parahippocampal gyrus, consistent with memory problems and potentially with impairment of visual processing. Treatment is still symptomatic and of partial benefit. Symptomatic treatment can include medications for controlling pain and sleep problems, graded exercise and cognitive behavioral therapy. Larger controlled trials are needed to shed more light on this challenging condition., Mijalgični encefalomijelitis je složeno, multisistemsko oboljenje sa hroničnim tokom koje značajno utiče na kvalitet života bolesnika. Slaba tolerancija na fizički i mentalni napor, bolovi u mišićima i problemi sa spavanjem glavne su odlike i često su praćene kognitivnom neefikasnošću i vegetativnim simptomima. Prevalencija je 7-3000 na 100.000 odraslih. Procenjuje se da je 90% ovih bolesnika pogrešno dijagnostikovano. Patogeneza je i dalje samo spekulativna, ali trenutna istraživanja ukazuju na poremećaje u imunološkom sistemu, inflamatornom odgovoru, autonomnom i centralnom nervnom sistemu, mišićima i mitohondrijama, kao i promene mikrobiote i propustljivosti creva. Početak bolesti je tipično akutan i prati infektivnu bolest. Netolerancija napora koja traje duže od šest meseci važan je dijagnostički kriterijum. Osnovne karakteristike moraju biti umerene do teške i prisutne najmanje 50% vremena. Isključivanje drugih mogućih patoloških stanja ili komorbiditetnih dijagnoza zahteva zadovoljavanje dijagnostičkih kriterijuma i diferencijalno dijagnostičko sagledavanje. Morfometrijska snimanja mozga magnetnom rezonancom pokazala su atrofiju sive mase u okcipitalnim režnjevima bilateralno, desnom angularnom girusu i posteriornom levom parahipokampalnom girusu, što može dovesti do problema sa pamćenjem i oštećenja vizuelne obrade informacija. Lečenje je i dalje simptomatsko i samo delimično uspešno. Simptomatski tretman može da uključuje lekove za kontrolu bola i problema sa spavanjem, doziranu fizičku aktivnost i kognitivno-bihevioralnu terapiju. Potrebne su veće studije da bi se razjasnilo ovo medicinsko stanje.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Myalgic encephalomyelitis: Enigma at the medicine's crossroads, Mijalgični encefalomijelitis - enigma na raskršću medicine",
pages = "110-105",
number = "1-2",
volume = "149",
doi = "10.2298/SARH200628091P"
}

Pavlović, D., Đorđević, J., Pavlović, A. M., Stjepanović, M.,& Baralić, M.. (2021). Myalgic encephalomyelitis: Enigma at the medicine's crossroads. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 149(1-2), 105-110.
https://doi.org/10.2298/SARH200628091P

Pavlović D, Đorđević J, Pavlović AM, Stjepanović M, Baralić M. Myalgic encephalomyelitis: Enigma at the medicine's crossroads. in Srpski arhiv za celokupno lekarstvo. 2021;149(1-2):105-110.
doi:10.2298/SARH200628091P .

Pavlović, Dragan, Đorđević, Jelena, Pavlović, Aleksandra M., Stjepanović, Mirjana, Baralić, Marko, "Myalgic encephalomyelitis: Enigma at the medicine's crossroads" in Srpski arhiv za celokupno lekarstvo, 149, no. 1-2 (2021):105-110,
https://doi.org/10.2298/SARH200628091P . .

TY  - JOUR
AU  - Stevanović, Aleksandar
AU  - Stefanović, Anja
AU  - Stojanovski, Nataša
AU  - Tomić, Gordana
AU  - Zidverc-Trajković, Jasna
AU  - Pavlović, Aleksandra
PY  - 2019
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5026
AB  - Introduction. Cerebral small vessel disease is a neurological con-
dition characterized by motor, cognitive and affective disorders,

often found on brain magnetic resonance imaging scans in patients
with vascular risk factors. Affective disorders may have a major
impact on patients’ quality of life, although they are often ignored
as an entity in cerebrovascular pathology. Material and Methods.
This prospective study included 80 patients with the diagnosis of
cerebral small vessel disease admitted at the Clinic of Neurology,
Clinical Center of Serbia in the period from January 1, 2017 to
January 1, 2019. Baseline demographic data and brain magnetic

resonance findings were obtained along with the results of cogni-
tive function and affective status tests. Data were analyzed using

standard statistical tests. Results. Standard screening tests revealed
that 51.25% and 33.75% of our patients with cerebral small vessel

disease suffer from apathy and depression, respectively. A sig-
nificant correlation was found between the severity of white mat-
ter changes on magnetic resonance scans and apathy (p = 0.0092).

Additionally, white matter changes were also significantly associ-
ated with depression (p = 0.021). Conclusion. Affective disorders

are not uncommon in cerebral small vessel disease and apathy was

the leading phenomenon among our patients. Since a strong cor-
relation was detected between affective disorders and severity of

vascular changes on magnetic resonance scans, we may conclude
that both apathy and depression are key features of an underlying
brain injury, rather than just comorbidity.
AB  - Uvod. Bolest malih krvnih sudova mozga je neurološko stanje za
koje su karakteristični motorni, kognitivni i afektivni poremećaji i

koje se često dijagnostikuje na snimcima mozga magnetnom rezo-
nancijom kod pacijenata sa vaskularnim faktorima rizika. Promene

u afektivnom statusu imaju veliki uticaj na kvalitet života pacijena-
ta iako su neretko bile zanemaren fenomen u cerebrovaskularnoj

patologiji. Materijal i metode. U prospektivnoj studiji obuhvaćeno
je 80 pacijenata sa dijagnozom bolest malih krvnih sudova mozga

lečenih i ispitivanih na Klinici za neurologiju Kliničkog centra Sr-
bije, u periodu od 1. januara 2017. godine do 1. januara 2019. godine.

Analizirani su osnovni demografski podaci, nalaz na magnetnoj

rezonanciji mozga i rezultati testova kognitivnih funkcija i afektiv-
nog statusa, upotrebom standardnih statističkih metoda. Rezultati.

Rezultati testova za apatiju i depresiju ukazali su da je 51,25% bo-
lesnika sa ovom bolešću pokazivalo prisustvo apatije, a 33,75%

prisustvo depresivnog poremećaja. Dokazana je statistički značajna

povezanost između težine lezija bele mase mozga na magnetnore-
zonantnim snimcima mozga i apatije (p = 0,0092), odnosno težine

lezija bele mase i depresije (p = 0,021). Zaključak. Izmene afektiv-
nog statusa nisu retka manifestacija cerebralne bolesti malih krvnih

sudova mozga, a najčešći fenomen u našoj grupi bolesnika bila je

apatija. Budući da je detektovana značajna povezanost između afek-
tivnih poremaćaja i težine vaskularnih lezija na magnetno-rezonan-
tnim snimcima mozga, smatramo da su apatija i depresivnost najpre

deo kliničke slike ove bolesti a ne jedan od komorbiditeta.
PB  - Society of Physicians of Vojvodina of the Medical Society of Serbia
T2  - Medicinski pregled
T1  - Affective status in cerebral small vessel disease
T1  - Afektivni status kod bolesti malih krvnih sudova mozga
EP  - 285
IS  - 9-10
SP  - 280
VL  - 72
DO  - 10.2298/MPNS1910280S
ER  - 

@article{
author = "Stevanović, Aleksandar and Stefanović, Anja and Stojanovski, Nataša and Tomić, Gordana and Zidverc-Trajković, Jasna and Pavlović, Aleksandra",
year = "2019",
abstract = "Introduction. Cerebral small vessel disease is a neurological con-
dition characterized by motor, cognitive and affective disorders,

often found on brain magnetic resonance imaging scans in patients
with vascular risk factors. Affective disorders may have a major
impact on patients’ quality of life, although they are often ignored
as an entity in cerebrovascular pathology. Material and Methods.
This prospective study included 80 patients with the diagnosis of
cerebral small vessel disease admitted at the Clinic of Neurology,
Clinical Center of Serbia in the period from January 1, 2017 to
January 1, 2019. Baseline demographic data and brain magnetic

resonance findings were obtained along with the results of cogni-
tive function and affective status tests. Data were analyzed using

standard statistical tests. Results. Standard screening tests revealed
that 51.25% and 33.75% of our patients with cerebral small vessel

disease suffer from apathy and depression, respectively. A sig-
nificant correlation was found between the severity of white mat-
ter changes on magnetic resonance scans and apathy (p = 0.0092).

Additionally, white matter changes were also significantly associ-
ated with depression (p = 0.021). Conclusion. Affective disorders

are not uncommon in cerebral small vessel disease and apathy was

the leading phenomenon among our patients. Since a strong cor-
relation was detected between affective disorders and severity of

vascular changes on magnetic resonance scans, we may conclude
that both apathy and depression are key features of an underlying
brain injury, rather than just comorbidity., Uvod. Bolest malih krvnih sudova mozga je neurološko stanje za
koje su karakteristični motorni, kognitivni i afektivni poremećaji i

koje se često dijagnostikuje na snimcima mozga magnetnom rezo-
nancijom kod pacijenata sa vaskularnim faktorima rizika. Promene

u afektivnom statusu imaju veliki uticaj na kvalitet života pacijena-
ta iako su neretko bile zanemaren fenomen u cerebrovaskularnoj

patologiji. Materijal i metode. U prospektivnoj studiji obuhvaćeno
je 80 pacijenata sa dijagnozom bolest malih krvnih sudova mozga

lečenih i ispitivanih na Klinici za neurologiju Kliničkog centra Sr-
bije, u periodu od 1. januara 2017. godine do 1. januara 2019. godine.

Analizirani su osnovni demografski podaci, nalaz na magnetnoj

rezonanciji mozga i rezultati testova kognitivnih funkcija i afektiv-
nog statusa, upotrebom standardnih statističkih metoda. Rezultati.

Rezultati testova za apatiju i depresiju ukazali su da je 51,25% bo-
lesnika sa ovom bolešću pokazivalo prisustvo apatije, a 33,75%

prisustvo depresivnog poremećaja. Dokazana je statistički značajna

povezanost između težine lezija bele mase mozga na magnetnore-
zonantnim snimcima mozga i apatije (p = 0,0092), odnosno težine

lezija bele mase i depresije (p = 0,021). Zaključak. Izmene afektiv-
nog statusa nisu retka manifestacija cerebralne bolesti malih krvnih

sudova mozga, a najčešći fenomen u našoj grupi bolesnika bila je

apatija. Budući da je detektovana značajna povezanost između afek-
tivnih poremaćaja i težine vaskularnih lezija na magnetno-rezonan-
tnim snimcima mozga, smatramo da su apatija i depresivnost najpre

deo kliničke slike ove bolesti a ne jedan od komorbiditeta.",
publisher = "Society of Physicians of Vojvodina of the Medical Society of Serbia",
journal = "Medicinski pregled",
title = "Affective status in cerebral small vessel disease, Afektivni status kod bolesti malih krvnih sudova mozga",
pages = "285-280",
number = "9-10",
volume = "72",
doi = "10.2298/MPNS1910280S"
}

Stevanović, A., Stefanović, A., Stojanovski, N., Tomić, G., Zidverc-Trajković, J.,& Pavlović, A.. (2019). Affective status in cerebral small vessel disease. in Medicinski pregled
Society of Physicians of Vojvodina of the Medical Society of Serbia., 72(9-10), 280-285.
https://doi.org/10.2298/MPNS1910280S

Stevanović A, Stefanović A, Stojanovski N, Tomić G, Zidverc-Trajković J, Pavlović A. Affective status in cerebral small vessel disease. in Medicinski pregled. 2019;72(9-10):280-285.
doi:10.2298/MPNS1910280S .

Stevanović, Aleksandar, Stefanović, Anja, Stojanovski, Nataša, Tomić, Gordana, Zidverc-Trajković, Jasna, Pavlović, Aleksandra, "Affective status in cerebral small vessel disease" in Medicinski pregled, 72, no. 9-10 (2019):280-285,
https://doi.org/10.2298/MPNS1910280S . .

TY  - JOUR
AU  - Pavlović, Aleksandra M.
AU  - Pavlović, Dragan
PY  - 2018
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1166
AB  - Art and creativity originate in the brain and depend on normal brain functioning. Music is a multifacet phenomenon that exists as a universal heritage across all human societies and throughout the entire human history. There are numerous brain-based mechanisms involved in the cognitive processing of music, including music listening, performing, composing, reading, writing, as well as musical aesthetics and musical emotion. Music relates to many brain functions including perception, motor action, cognition, emotion, learning and memory. Various brain regions are associated with music processing and production, including the right anterior and posterior superior temporal lobe, the right inferior frontal cortex, the right prefrontal, bilateral premotor and bilateral parietal areas, the right anterior cerebellar lobe, language areas and limbic structures. In a diseased brain, after acquired brain injury, disorders in music perception or production have been described, although considered rare. Amusia or music-specific agnosia, a defective perception of music or its components is typically associated with temporal lobe lesions, and is more likely to occur with right-sided involvement. Etiology of acquired amusia comprise many diseases and conditions leading to brain injury, including traumatic brain injury, ischemic or hemorrhagic stroke, neoplasma, iatrogenic and epilepsy-related conditions, infections and degenerative diseases. Additionally, there are cases of congenital amusia, attributed to abnormality in neural networks for music, associated with structural variations in the frontal and temporal lobes.
AB  - Umetnost i kreativnost potiču iz mozga i zavise od njegovog normalnog funkcionisanja. Muzika je multifacetni fenomen koji postoji kao univerzalno nasleđe u svim ljudskim društvima i kroz čitavu ljudsku istoriju. Postoje mnogobrojni moždani mehanizmi uključeni u kognitivnu obradu muzike, uključujući slušanje muzike, izvođenje, pisanje, čitanje, kao i muzičku estetiku i muzičke emocije. Muzika se odnosi na mnoge funkcije mozga, uključujući percepciju, motoriku, kogniciju, emocije, učenje i pamćenje. Različiti regioni mozga su povezani sa obradom i proizvodnjom muzike, uključujući prave prednje i zadnje superiorne temporalne režnje, desno inferiorni frontalni korteks, desno prefrontalni, bilateralni premotor i bilateralni parietalni prostori, desni anteriorni cerebelarni režanj, jezičke površine, limbičke strukture. U obolelom mozgu, nakon traume mozga, opisani su poremećaji u percepciji ili produkciji muzike, iako se smatraju retkim. Amuzija ili specifična muzička agnozija, narušena percepcija muzike ili njenih komponenti obično se povezuje sa lezijama temporalnog režnja i pretežno se javlja kod oštećenja desne polovine mozga. Etiologija stečene amusije obuhvata mnoge bolesti i stanja koji dovode do lezija mozga, uključujući traumatske povrede, ishemijski ili hemoragični moždani udar, neoplazme, jatrogena stanja, epilepsije, infekcije i degenerativne bolesti. Postoje i slučajevi kongenitalne amuzije, u vezi poremećaja neuronskih mreža za muziku, povezanih sa strukturnim varijacijama u frontalnom i temporalnom režnju.
PB  - Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd
T2  - Engrami
T1  - Music in healthy and diseased brain
T1  - Muzika kod zdravog i obolelog mozga
EP  - 43
IS  - 1
SP  - 28
VL  - 40
DO  - 10.5937/Engrami1801028P
ER  - 

@article{
author = "Pavlović, Aleksandra M. and Pavlović, Dragan",
year = "2018",
abstract = "Art and creativity originate in the brain and depend on normal brain functioning. Music is a multifacet phenomenon that exists as a universal heritage across all human societies and throughout the entire human history. There are numerous brain-based mechanisms involved in the cognitive processing of music, including music listening, performing, composing, reading, writing, as well as musical aesthetics and musical emotion. Music relates to many brain functions including perception, motor action, cognition, emotion, learning and memory. Various brain regions are associated with music processing and production, including the right anterior and posterior superior temporal lobe, the right inferior frontal cortex, the right prefrontal, bilateral premotor and bilateral parietal areas, the right anterior cerebellar lobe, language areas and limbic structures. In a diseased brain, after acquired brain injury, disorders in music perception or production have been described, although considered rare. Amusia or music-specific agnosia, a defective perception of music or its components is typically associated with temporal lobe lesions, and is more likely to occur with right-sided involvement. Etiology of acquired amusia comprise many diseases and conditions leading to brain injury, including traumatic brain injury, ischemic or hemorrhagic stroke, neoplasma, iatrogenic and epilepsy-related conditions, infections and degenerative diseases. Additionally, there are cases of congenital amusia, attributed to abnormality in neural networks for music, associated with structural variations in the frontal and temporal lobes., Umetnost i kreativnost potiču iz mozga i zavise od njegovog normalnog funkcionisanja. Muzika je multifacetni fenomen koji postoji kao univerzalno nasleđe u svim ljudskim društvima i kroz čitavu ljudsku istoriju. Postoje mnogobrojni moždani mehanizmi uključeni u kognitivnu obradu muzike, uključujući slušanje muzike, izvođenje, pisanje, čitanje, kao i muzičku estetiku i muzičke emocije. Muzika se odnosi na mnoge funkcije mozga, uključujući percepciju, motoriku, kogniciju, emocije, učenje i pamćenje. Različiti regioni mozga su povezani sa obradom i proizvodnjom muzike, uključujući prave prednje i zadnje superiorne temporalne režnje, desno inferiorni frontalni korteks, desno prefrontalni, bilateralni premotor i bilateralni parietalni prostori, desni anteriorni cerebelarni režanj, jezičke površine, limbičke strukture. U obolelom mozgu, nakon traume mozga, opisani su poremećaji u percepciji ili produkciji muzike, iako se smatraju retkim. Amuzija ili specifična muzička agnozija, narušena percepcija muzike ili njenih komponenti obično se povezuje sa lezijama temporalnog režnja i pretežno se javlja kod oštećenja desne polovine mozga. Etiologija stečene amusije obuhvata mnoge bolesti i stanja koji dovode do lezija mozga, uključujući traumatske povrede, ishemijski ili hemoragični moždani udar, neoplazme, jatrogena stanja, epilepsije, infekcije i degenerativne bolesti. Postoje i slučajevi kongenitalne amuzije, u vezi poremećaja neuronskih mreža za muziku, povezanih sa strukturnim varijacijama u frontalnom i temporalnom režnju.",
publisher = "Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd",
journal = "Engrami",
title = "Music in healthy and diseased brain, Muzika kod zdravog i obolelog mozga",
pages = "43-28",
number = "1",
volume = "40",
doi = "10.5937/Engrami1801028P"
}

Pavlović, A. M.,& Pavlović, D.. (2018). Music in healthy and diseased brain. in Engrami
Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd., 40(1), 28-43.
https://doi.org/10.5937/Engrami1801028P

Pavlović AM, Pavlović D. Music in healthy and diseased brain. in Engrami. 2018;40(1):28-43.
doi:10.5937/Engrami1801028P .

Pavlović, Aleksandra M., Pavlović, Dragan, "Music in healthy and diseased brain" in Engrami, 40, no. 1 (2018):28-43,
https://doi.org/10.5937/Engrami1801028P . .

TY  - JOUR
AU  - Markišić, Merdin Š.
AU  - Pavlović, Aleksandra M.
AU  - Pavlović, Dragan
PY  - 2017
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1070
AB  - We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p  lt  0.05), B12 level (r = -0.410, p  lt  0.01), and vitamin D levels (r = -0.465, p  lt  0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.
PB  - Hindawi Ltd, London
T2  - Biomed Research International
T1  - The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke
VL  - 2017
DO  - 10.1155/2017/5489057
ER  - 

@article{
author = "Markišić, Merdin Š. and Pavlović, Aleksandra M. and Pavlović, Dragan",
year = "2017",
abstract = "We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p  lt  0.05), B12 level (r = -0.410, p  lt  0.01), and vitamin D levels (r = -0.465, p  lt  0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.",
publisher = "Hindawi Ltd, London",
journal = "Biomed Research International",
title = "The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke",
volume = "2017",
doi = "10.1155/2017/5489057"
}

Markišić, M. Š., Pavlović, A. M.,& Pavlović, D.. (2017). The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. in Biomed Research International
Hindawi Ltd, London., 2017.
https://doi.org/10.1155/2017/5489057

Markišić MŠ, Pavlović AM, Pavlović D. The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. in Biomed Research International. 2017;2017.
doi:10.1155/2017/5489057 .

Markišić, Merdin Š., Pavlović, Aleksandra M., Pavlović, Dragan, "The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke" in Biomed Research International, 2017 (2017),
https://doi.org/10.1155/2017/5489057 . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Markišić, Merdin Š.
AU  - Pavlović, Aleksandra M.
PY  - 2015
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/912
AB  - Vitamins are necessary factors in human development and normal brain function. Vitamin C is a hydrosoluble compound that humans cannot produce; therefore, we are completely dependent on food intake for vitamin C. Ascorbic acid is an important antioxidative agent and is present in high concentrations in neurons and is also crucial for collagen synthesis throughout the body. Ascorbic acid has a role in modulating many essential neurotransmitters, enables neurogenesis in adult brain and protects cells against infection. While SVCT1 enables the absorption of vitamin C in the intestine, SVCT2 is primarily located in the brain. Ascorbate deficiency is classically expressed as scurvy, which is lethal if not treated. However, subclinical deficiencies are probably much more frequent. Potential fields of vitamin C therapy are in neurodegenerative, cerebrovascular and affective diseases, cancer, brain trauma and others. For example, there is some data on its positive effects in Alzheimer's disease. Various dosing regimes are used, but ascorbate is safe, even in high doses for protracted periods. Better designed studies are needed to elucidate all of the potential therapeutic roles of vitamin C.
AB  - Vitamin su neophodni faktori za razvoj i normalnu funkciju mozga kod ljudi. Vitamin C je hidrosolubilno jedinjenje koje ljudski organizam ne može da sintetiše tako da smo potpuno zavisni od unosa putem hrane. Askorbinska kiselina je važno antioksidativno sredstvo i prisutna je u neuronima u visokim koncentracijama. Takođe je od ključnog značaja za sintezu kolagena u celom organizmu. Askorbinska kiselina ima ulogu u modulaciji mnogih bitnih neurotransmitera, omogućava neurogenezu u mozgu odraslog i štiti ćelije od infekcije. Dok SVCT1 omogućava apsorpciju vitamina C u crevima, SVCT2 se nalazi uglavnom u mozgu. Nedostatak askorbata klasično se ispoljava kao skorbut koji je letalan ako se ne leči, ali je supklinička deficijencija verovatno mnogo češća. Potencijalni terapijski domeni vitamina C terapije su neurodegenerativne, cerebrovaskularne i afektivne bolesti, karcinomi, traume mozga i drugi. Postoje na primer podaci o pozitivnim efektima askorbinske kiseline u Alchajmerovoj bolesti. Koriste se razni režimi doziranja, ali je askorbat pokazao bezbednost čak i u visokim dozama tokom dugih perioda. Potrebne su bolje dizajnirane studije da se razjasne sve potencijalne terapijske uloge vitamina C.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Serbian Journal of Experimental and Clinical Research
T1  - Vitamin C in neuropsychiatry
T1  - Vitamin C u neuropsihijatriji
EP  - 161
IS  - 2
SP  - 157
VL  - 16
DO  - 10.1515/SJECR-2015-0021
ER  - 

@article{
author = "Pavlović, Dragan and Markišić, Merdin Š. and Pavlović, Aleksandra M.",
year = "2015",
abstract = "Vitamins are necessary factors in human development and normal brain function. Vitamin C is a hydrosoluble compound that humans cannot produce; therefore, we are completely dependent on food intake for vitamin C. Ascorbic acid is an important antioxidative agent and is present in high concentrations in neurons and is also crucial for collagen synthesis throughout the body. Ascorbic acid has a role in modulating many essential neurotransmitters, enables neurogenesis in adult brain and protects cells against infection. While SVCT1 enables the absorption of vitamin C in the intestine, SVCT2 is primarily located in the brain. Ascorbate deficiency is classically expressed as scurvy, which is lethal if not treated. However, subclinical deficiencies are probably much more frequent. Potential fields of vitamin C therapy are in neurodegenerative, cerebrovascular and affective diseases, cancer, brain trauma and others. For example, there is some data on its positive effects in Alzheimer's disease. Various dosing regimes are used, but ascorbate is safe, even in high doses for protracted periods. Better designed studies are needed to elucidate all of the potential therapeutic roles of vitamin C., Vitamin su neophodni faktori za razvoj i normalnu funkciju mozga kod ljudi. Vitamin C je hidrosolubilno jedinjenje koje ljudski organizam ne može da sintetiše tako da smo potpuno zavisni od unosa putem hrane. Askorbinska kiselina je važno antioksidativno sredstvo i prisutna je u neuronima u visokim koncentracijama. Takođe je od ključnog značaja za sintezu kolagena u celom organizmu. Askorbinska kiselina ima ulogu u modulaciji mnogih bitnih neurotransmitera, omogućava neurogenezu u mozgu odraslog i štiti ćelije od infekcije. Dok SVCT1 omogućava apsorpciju vitamina C u crevima, SVCT2 se nalazi uglavnom u mozgu. Nedostatak askorbata klasično se ispoljava kao skorbut koji je letalan ako se ne leči, ali je supklinička deficijencija verovatno mnogo češća. Potencijalni terapijski domeni vitamina C terapije su neurodegenerativne, cerebrovaskularne i afektivne bolesti, karcinomi, traume mozga i drugi. Postoje na primer podaci o pozitivnim efektima askorbinske kiseline u Alchajmerovoj bolesti. Koriste se razni režimi doziranja, ali je askorbat pokazao bezbednost čak i u visokim dozama tokom dugih perioda. Potrebne su bolje dizajnirane studije da se razjasne sve potencijalne terapijske uloge vitamina C.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "Vitamin C in neuropsychiatry, Vitamin C u neuropsihijatriji",
pages = "161-157",
number = "2",
volume = "16",
doi = "10.1515/SJECR-2015-0021"
}

Pavlović, D., Markišić, M. Š.,& Pavlović, A. M.. (2015). Vitamin C in neuropsychiatry. in Serbian Journal of Experimental and Clinical Research
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 16(2), 157-161.
https://doi.org/10.1515/SJECR-2015-0021

Pavlović D, Markišić MŠ, Pavlović AM. Vitamin C in neuropsychiatry. in Serbian Journal of Experimental and Clinical Research. 2015;16(2):157-161.
doi:10.1515/SJECR-2015-0021 .

Pavlović, Dragan, Markišić, Merdin Š., Pavlović, Aleksandra M., "Vitamin C in neuropsychiatry" in Serbian Journal of Experimental and Clinical Research, 16, no. 2 (2015):157-161,
https://doi.org/10.1515/SJECR-2015-0021 . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/792
AB  - Vitamin D is a secosteroid hormon with pleiotrophic functions and essential for normal development and health throughout the entire life span. Vitamin D deficiency has epidemic proportions worldwide and interferes with important metabolic processes. Its prevalence is estimated in various populations of different etnicity and age from 50% up to 100% in certain groups. The main source of vitamin D for men is skin production by ultraviolet B radiation acting on 7-dehydrocholesterol. This is cholecalciferol or vitamin D3. Less than 20% is obtained from food. The active form, 1,25-dihydroxy-vitamin D (calcitriol) is synthesized in the kidney. Synthetic capacity declines with ageing. The main function of vitamin D is calcium homeostasis important for musculosceletal health, innate immunity, arterial integrity, endocrine function, antiinflamation, and various local processes (autocrine and epicrine functions) in more than 30 tissues where receptors exist. Vitamin D is also important for cognitive function, mainly executive in the frontal lobe. Normal vitamin D levels are above 75 nmol/L. Vitamin D deficiency is mostly due to the lack of sun exposure but can also be secondary to some individual characteristics. Deficiency during intrauterine development can lead to early and late negative consequences in bone growth, immune system, and cognition. The extreme deficiency causes rikets. In adults vitamin D deficiency has been suggested as a risk factor for infectious and autoimmune diseases, carcinomas (especially of the breast and colon), multiple sclerosis, falls, osteoporosis, bone fractures, cardiovacular and cerebrovascular diseases, diabetes mellitus type I and II, infertility, cognitive decline and dementia. Oral supplementation with serum level normalization can lead to reduction of these risks but even amelioration of some pathological states. Recomendation ranges form 400 IU of vitamin D in infants to 2000 IU in older population, but it should be guided by individual clinical circumstances.
AB  - Vitamin D je sekosteroidni hormon sa pleotropnim funkcijama i presudan za pravilan razvoj i zdravlje kroz ceo životni vek. Nedostatak vitamina D ima razmere epidemije širom sveta i ometa važne metaboličke procese. Procene u različitim populacijama različitog etničkog porekla i starosti su od 50% do 100 % u pojedinim grupama. Glavni izvor vitamina D kod ljudi je sinteza u koži pod dejstvom ultraljubičastog B zračenja na 7- dehidrocholesterol. To je vitamin D3 ili holekalciferol. Manje od 20% se dobija iz hrane. Aktivni oblik, 1,25-dihidroksi- vitamin D (kalcitriol) se sintetiše u bubrezima. Sintetički kapaciteta opada sa starenjem. Glavna funkcija vitamina D je homeostaza kalcijuma, zdravlje muskuloskeletnog sistema, urođeni imunitet, integritet arterija, endokrine funkcije, antiinflamatorno dejstvo i različiti lokalni procesi (autokrine i epikrine funkcije) u više od 30 tkiva gde postoje receptori. Vitamin D je takođe važan za kognitivne funkcije, uglavnom egzekutivne u frontalnom režnju. Normalni nivoi vitamina D su iznad 75 nmol/L. Nedostatak vitamina D je uglavnom uzrokovan nedostatkom sunčeve svetlosti, ali i nekih individualnih karakteristika bolesnika. Nedostatak tokom intrauterinog razvoja može da dovede do ranih i kasnih negativnih posledica na rast kostiju, imuni sistem i kogniciju. Ekstremni nedostatak vitamin D izaziva rahitis. Kod odraslih je nedostatak vitamina D faktor rizika za infektivne i autoimune bolest, karcinome (naročito dojke i debelog creva), multiplu sklerozu, padove, osteoporozu, prelome kostiju, kardiovakularna i cerebrovaskularna oboljenja, dijabetes melitus tip I i II, neplodnost, kognitivni pad i demencije. Oralna suplementacija sa normalizacijom nivoa vitamina u serumu može da dovede do smanjenja ovih rizika ali čak i ublažavanje nekih patoloških stanja. Preporučene doze iznose od 400 IU vitamina D kod odojčadi do 2000 IU u starijoj populaciji, ali bi trebalo da se rukovodi individualnim kliničkim okolnostima.
PB  - Univerzitet u Beogradu - Fakultet za specijalnu edukaciju i rehabilitaciju, Beograd
T2  - Specijalna edukacija i rehabilitacija
T1  - Vitamin D across the life span
T1  - Vitamin D u svim dobima života
EP  - 132
IS  - 1
SP  - 117
VL  - 13
DO  - 10.5937/specedreh13-4631
ER  - 

@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M.",
year = "2014",
abstract = "Vitamin D is a secosteroid hormon with pleiotrophic functions and essential for normal development and health throughout the entire life span. Vitamin D deficiency has epidemic proportions worldwide and interferes with important metabolic processes. Its prevalence is estimated in various populations of different etnicity and age from 50% up to 100% in certain groups. The main source of vitamin D for men is skin production by ultraviolet B radiation acting on 7-dehydrocholesterol. This is cholecalciferol or vitamin D3. Less than 20% is obtained from food. The active form, 1,25-dihydroxy-vitamin D (calcitriol) is synthesized in the kidney. Synthetic capacity declines with ageing. The main function of vitamin D is calcium homeostasis important for musculosceletal health, innate immunity, arterial integrity, endocrine function, antiinflamation, and various local processes (autocrine and epicrine functions) in more than 30 tissues where receptors exist. Vitamin D is also important for cognitive function, mainly executive in the frontal lobe. Normal vitamin D levels are above 75 nmol/L. Vitamin D deficiency is mostly due to the lack of sun exposure but can also be secondary to some individual characteristics. Deficiency during intrauterine development can lead to early and late negative consequences in bone growth, immune system, and cognition. The extreme deficiency causes rikets. In adults vitamin D deficiency has been suggested as a risk factor for infectious and autoimmune diseases, carcinomas (especially of the breast and colon), multiple sclerosis, falls, osteoporosis, bone fractures, cardiovacular and cerebrovascular diseases, diabetes mellitus type I and II, infertility, cognitive decline and dementia. Oral supplementation with serum level normalization can lead to reduction of these risks but even amelioration of some pathological states. Recomendation ranges form 400 IU of vitamin D in infants to 2000 IU in older population, but it should be guided by individual clinical circumstances., Vitamin D je sekosteroidni hormon sa pleotropnim funkcijama i presudan za pravilan razvoj i zdravlje kroz ceo životni vek. Nedostatak vitamina D ima razmere epidemije širom sveta i ometa važne metaboličke procese. Procene u različitim populacijama različitog etničkog porekla i starosti su od 50% do 100 % u pojedinim grupama. Glavni izvor vitamina D kod ljudi je sinteza u koži pod dejstvom ultraljubičastog B zračenja na 7- dehidrocholesterol. To je vitamin D3 ili holekalciferol. Manje od 20% se dobija iz hrane. Aktivni oblik, 1,25-dihidroksi- vitamin D (kalcitriol) se sintetiše u bubrezima. Sintetički kapaciteta opada sa starenjem. Glavna funkcija vitamina D je homeostaza kalcijuma, zdravlje muskuloskeletnog sistema, urođeni imunitet, integritet arterija, endokrine funkcije, antiinflamatorno dejstvo i različiti lokalni procesi (autokrine i epikrine funkcije) u više od 30 tkiva gde postoje receptori. Vitamin D je takođe važan za kognitivne funkcije, uglavnom egzekutivne u frontalnom režnju. Normalni nivoi vitamina D su iznad 75 nmol/L. Nedostatak vitamina D je uglavnom uzrokovan nedostatkom sunčeve svetlosti, ali i nekih individualnih karakteristika bolesnika. Nedostatak tokom intrauterinog razvoja može da dovede do ranih i kasnih negativnih posledica na rast kostiju, imuni sistem i kogniciju. Ekstremni nedostatak vitamin D izaziva rahitis. Kod odraslih je nedostatak vitamina D faktor rizika za infektivne i autoimune bolest, karcinome (naročito dojke i debelog creva), multiplu sklerozu, padove, osteoporozu, prelome kostiju, kardiovakularna i cerebrovaskularna oboljenja, dijabetes melitus tip I i II, neplodnost, kognitivni pad i demencije. Oralna suplementacija sa normalizacijom nivoa vitamina u serumu može da dovede do smanjenja ovih rizika ali čak i ublažavanje nekih patoloških stanja. Preporučene doze iznose od 400 IU vitamina D kod odojčadi do 2000 IU u starijoj populaciji, ali bi trebalo da se rukovodi individualnim kliničkim okolnostima.",
publisher = "Univerzitet u Beogradu - Fakultet za specijalnu edukaciju i rehabilitaciju, Beograd",
journal = "Specijalna edukacija i rehabilitacija",
title = "Vitamin D across the life span, Vitamin D u svim dobima života",
pages = "132-117",
number = "1",
volume = "13",
doi = "10.5937/specedreh13-4631"
}

Pavlović, D.,& Pavlović, A. M.. (2014). Vitamin D across the life span. in Specijalna edukacija i rehabilitacija
Univerzitet u Beogradu - Fakultet za specijalnu edukaciju i rehabilitaciju, Beograd., 13(1), 117-132.
https://doi.org/10.5937/specedreh13-4631

Pavlović D, Pavlović AM. Vitamin D across the life span. in Specijalna edukacija i rehabilitacija. 2014;13(1):117-132.
doi:10.5937/specedreh13-4631 .

Pavlović, Dragan, Pavlović, Aleksandra M., "Vitamin D across the life span" in Specijalna edukacija i rehabilitacija, 13, no. 1 (2014):117-132,
https://doi.org/10.5937/specedreh13-4631 . .

TY  - JOUR
AU  - Veselinović, Nikola
AU  - Pavlović, Aleksandra M.
AU  - Petrović, Boris
AU  - Ristić, Aleksandar
AU  - Novaković, Ivana
AU  - Svabic-Medjedović, Tamara
AU  - Pavlović, Dragan
AU  - Šternić, Nadežda
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/863
AB  - Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Cognitive and Behavioral Neurology
T1  - Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease
EP  - 50
IS  - 1
SP  - 48
VL  - 27
DO  - 10.1097/WNN.0000000000000015
ER  - 

@article{
author = "Veselinović, Nikola and Pavlović, Aleksandra M. and Petrović, Boris and Ristić, Aleksandar and Novaković, Ivana and Svabic-Medjedović, Tamara and Pavlović, Dragan and Šternić, Nadežda",
year = "2014",
abstract = "Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Cognitive and Behavioral Neurology",
title = "Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease",
pages = "50-48",
number = "1",
volume = "27",
doi = "10.1097/WNN.0000000000000015"
}

Veselinović, N., Pavlović, A. M., Petrović, B., Ristić, A., Novaković, I., Svabic-Medjedović, T., Pavlović, D.,& Šternić, N.. (2014). Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease. in Cognitive and Behavioral Neurology
Lippincott Williams & Wilkins, Philadelphia., 27(1), 48-50.
https://doi.org/10.1097/WNN.0000000000000015

Veselinović N, Pavlović AM, Petrović B, Ristić A, Novaković I, Svabic-Medjedović T, Pavlović D, Šternić N. Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease. in Cognitive and Behavioral Neurology. 2014;27(1):48-50.
doi:10.1097/WNN.0000000000000015 .

Veselinović, Nikola, Pavlović, Aleksandra M., Petrović, Boris, Ristić, Aleksandar, Novaković, Ivana, Svabic-Medjedović, Tamara, Pavlović, Dragan, Šternić, Nadežda, "Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease" in Cognitive and Behavioral Neurology, 27, no. 1 (2014):48-50,
https://doi.org/10.1097/WNN.0000000000000015 . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Markišić, Merdin Š.
AU  - Pavlović, Aleksandra M.
AU  - Lačković, Maja
AU  - Božić, Marija M.
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/802
AB  - Vitamin A is essential for the early development and normal functioning of the brain throughout life. A deficiency of vitamin A is one of the leading causes of morbidity and mortality in developing countries, and subclinical deficiency is probably present worldwide. The main active molecule in vitamin A is retinoic acid, which is involved in vision, the immune system, skin health, olfaction and cognition (learning, memory, spatial functions, olfaction, etc.) through processes of neuroplasticity and neurogenesis. Vitamin A is involved in the regulation of about one-sixth of the human genome. It has non-genomic actions in protein translation and paracrine actions. Retinal vitamin A aldehyde is crucial for day and night vision. The best-known manifestation of hypovitaminosis A is night blindness but in more severe cases, it causes blindness. In the hypothalamus, vitamin A, with information from the retina, acts in circadian and seasonal regulation. Increased retinoic acid levels in the blood are associated with increased risk of depression, and lower levels have been connected with Alzheimer's disease, Parkinson's disease, cerebral ischemia, autistic spectrum disorders and schizophrenia. Higher doses and longer periods of treatment pose the threat of hypervitaminosis A. Vitamin A and its analogs are a promising new class of therapeutic agents in a wide spectrum of disorders, albeit with a narrow therapeutic window.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Vitamin a and the nervous system
EP  - 1590
IS  - 4
SP  - 1585
VL  - 66
DO  - 10.2298/ABS1404585P
ER  - 

@article{
author = "Pavlović, Dragan and Markišić, Merdin Š. and Pavlović, Aleksandra M. and Lačković, Maja and Božić, Marija M.",
year = "2014",
abstract = "Vitamin A is essential for the early development and normal functioning of the brain throughout life. A deficiency of vitamin A is one of the leading causes of morbidity and mortality in developing countries, and subclinical deficiency is probably present worldwide. The main active molecule in vitamin A is retinoic acid, which is involved in vision, the immune system, skin health, olfaction and cognition (learning, memory, spatial functions, olfaction, etc.) through processes of neuroplasticity and neurogenesis. Vitamin A is involved in the regulation of about one-sixth of the human genome. It has non-genomic actions in protein translation and paracrine actions. Retinal vitamin A aldehyde is crucial for day and night vision. The best-known manifestation of hypovitaminosis A is night blindness but in more severe cases, it causes blindness. In the hypothalamus, vitamin A, with information from the retina, acts in circadian and seasonal regulation. Increased retinoic acid levels in the blood are associated with increased risk of depression, and lower levels have been connected with Alzheimer's disease, Parkinson's disease, cerebral ischemia, autistic spectrum disorders and schizophrenia. Higher doses and longer periods of treatment pose the threat of hypervitaminosis A. Vitamin A and its analogs are a promising new class of therapeutic agents in a wide spectrum of disorders, albeit with a narrow therapeutic window.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Vitamin a and the nervous system",
pages = "1590-1585",
number = "4",
volume = "66",
doi = "10.2298/ABS1404585P"
}

Pavlović, D., Markišić, M. Š., Pavlović, A. M., Lačković, M.,& Božić, M. M.. (2014). Vitamin a and the nervous system. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 66(4), 1585-1590.
https://doi.org/10.2298/ABS1404585P

Pavlović D, Markišić MŠ, Pavlović AM, Lačković M, Božić MM. Vitamin a and the nervous system. in Archives of Biological Sciences. 2014;66(4):1585-1590.
doi:10.2298/ABS1404585P .

Pavlović, Dragan, Markišić, Merdin Š., Pavlović, Aleksandra M., Lačković, Maja, Božić, Marija M., "Vitamin a and the nervous system" in Archives of Biological Sciences, 66, no. 4 (2014):1585-1590,
https://doi.org/10.2298/ABS1404585P . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
AU  - Totić-Poznanović, Sanja
AU  - Božić, Marija M.
AU  - Đordević, Jelena
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/714
AB  - Vitamin A is a liposoluble vitamin essential for brain function and vision, and is obtained only through food as retinol or as carotenoids. The active metabolite is retinoic acid (RA), which participates in cognitive processes in the hippocampus, particularly in learning and spatial functions as well as in neurogenesis. Retinoic acid is essential for the vision and the maintenance of the cornea, biological rhythms, mucosa defense against infections and regulation of many genes (one sixth of the human genome). In animal models, vitamin A deficiency shows changes that resemble neurodegeneration, and RA levels in the plasma and cerebrospinal fluid of patients with Alzheimer's disease are reduced. There is also a complex relationship between RA and affective disorders, schizophrenia, autism, Parkinson's disease and stroke. In developing countries hypovitaminosis A is one of the leading causes of death and blindness in children, while in developed countries the symptoms are less noticeable. The damage of the cornea and night blindness are the consequences of hypovitaminosis, and there is a possible association of RA and glaucoma, macular degeneration and other eye diseases. A variety of infections can occur and can be deadly. The most efficient use of vitamin A is in the prophylactic purposes in the population at risk, especially pregnant women and infants in developing countries, while the results in the treatment of neurodegenerative and psychiatric diseases are controversial. Excessive doses of vitamin A can lead to hypervitaminosis with bone, gastrointestinal, psychiatric and neurological manifestations. New studies should demonstrate the most appropriate place of vitamin A in the treatment of neuropsychiatric diseases.
AB  - Vitamin A je liposolubilni vitamin neophodan za rad mozga i za vid, a unosi se isključivo putem hrane kao retinol ili u vidu karotenoida. Aktivni metabolit je retinočka kiselina (RA) koja učestvuje u kognitivnim procesima u hipokampusu, naročito u učenju i specijalnim funkcijama i neurogenezi u hipotalamusu. Retiočna kiselina je neophodna za vid, održavanje kornee, za biološke ritmove, odbranu sluznica od infekcija i regulaciju mnogih gena (šestina humanog genoma). U animalnim modelima nedostatak vitamina A daje promene koje liče na neurodegeneraciju, a nivo retinoičke kiseline u plazmi i cerebrospinalnoj tečnosti obolelih od Alchajmerove bolesti je snižen. Takođe postoji složena veza RA i afektivnih poremećaja, shizofrenije, autizma, Parkinsonove bolesti i moždanog udara. U nerazvijenim zemljama je hipovitaminoza A jedan od vodećih uzroka smrtnosti i slepila kod dece, dok su u razvijenijim zemljama simptomi manje uočljivi. Nastaje oštećenje kornee, noćno slepilo, a moguć je udeo RA i u glaukomu, makularnoj degeneraciji kao i drugim očnim bolestima. Nastupaju razne infekcije koje mogu biti i smrtonosne. Najefikasnija primena vitamina A je u profilaktičke svrhe kod stanovništva u riziku, posebno trudnica i odojčadi u nerazvijenim zemljama, dok su rezultati u lečenju neurodegenerativnih i psihijatrijskih bolesti kontroverzni. Preterane doze vitamina A mogu da dovedu do hipervitaminoze sa koštanim, gastrointestinalnim, psihijatrijskim i neurološkim ispoljavanjima. Nove studije treba da pokažu najadekvatnije mesto vitamina A u terapiji neuropsihijatrijskih bolesti.
PB  - Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd
T2  - Engrami
T1  - Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology
T1  - Pogled u mozak - vitamin A u neuropsihijatriji i oftalmologiji
EP  - 89
IS  - 1-2
SP  - 81
VL  - 35
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_714
ER  - 

@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M. and Totić-Poznanović, Sanja and Božić, Marija M. and Đordević, Jelena",
year = "2013",
abstract = "Vitamin A is a liposoluble vitamin essential for brain function and vision, and is obtained only through food as retinol or as carotenoids. The active metabolite is retinoic acid (RA), which participates in cognitive processes in the hippocampus, particularly in learning and spatial functions as well as in neurogenesis. Retinoic acid is essential for the vision and the maintenance of the cornea, biological rhythms, mucosa defense against infections and regulation of many genes (one sixth of the human genome). In animal models, vitamin A deficiency shows changes that resemble neurodegeneration, and RA levels in the plasma and cerebrospinal fluid of patients with Alzheimer's disease are reduced. There is also a complex relationship between RA and affective disorders, schizophrenia, autism, Parkinson's disease and stroke. In developing countries hypovitaminosis A is one of the leading causes of death and blindness in children, while in developed countries the symptoms are less noticeable. The damage of the cornea and night blindness are the consequences of hypovitaminosis, and there is a possible association of RA and glaucoma, macular degeneration and other eye diseases. A variety of infections can occur and can be deadly. The most efficient use of vitamin A is in the prophylactic purposes in the population at risk, especially pregnant women and infants in developing countries, while the results in the treatment of neurodegenerative and psychiatric diseases are controversial. Excessive doses of vitamin A can lead to hypervitaminosis with bone, gastrointestinal, psychiatric and neurological manifestations. New studies should demonstrate the most appropriate place of vitamin A in the treatment of neuropsychiatric diseases., Vitamin A je liposolubilni vitamin neophodan za rad mozga i za vid, a unosi se isključivo putem hrane kao retinol ili u vidu karotenoida. Aktivni metabolit je retinočka kiselina (RA) koja učestvuje u kognitivnim procesima u hipokampusu, naročito u učenju i specijalnim funkcijama i neurogenezi u hipotalamusu. Retiočna kiselina je neophodna za vid, održavanje kornee, za biološke ritmove, odbranu sluznica od infekcija i regulaciju mnogih gena (šestina humanog genoma). U animalnim modelima nedostatak vitamina A daje promene koje liče na neurodegeneraciju, a nivo retinoičke kiseline u plazmi i cerebrospinalnoj tečnosti obolelih od Alchajmerove bolesti je snižen. Takođe postoji složena veza RA i afektivnih poremećaja, shizofrenije, autizma, Parkinsonove bolesti i moždanog udara. U nerazvijenim zemljama je hipovitaminoza A jedan od vodećih uzroka smrtnosti i slepila kod dece, dok su u razvijenijim zemljama simptomi manje uočljivi. Nastaje oštećenje kornee, noćno slepilo, a moguć je udeo RA i u glaukomu, makularnoj degeneraciji kao i drugim očnim bolestima. Nastupaju razne infekcije koje mogu biti i smrtonosne. Najefikasnija primena vitamina A je u profilaktičke svrhe kod stanovništva u riziku, posebno trudnica i odojčadi u nerazvijenim zemljama, dok su rezultati u lečenju neurodegenerativnih i psihijatrijskih bolesti kontroverzni. Preterane doze vitamina A mogu da dovedu do hipervitaminoze sa koštanim, gastrointestinalnim, psihijatrijskim i neurološkim ispoljavanjima. Nove studije treba da pokažu najadekvatnije mesto vitamina A u terapiji neuropsihijatrijskih bolesti.",
publisher = "Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd",
journal = "Engrami",
title = "Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology, Pogled u mozak - vitamin A u neuropsihijatriji i oftalmologiji",
pages = "89-81",
number = "1-2",
volume = "35",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_714"
}

Pavlović, D., Pavlović, A. M., Totić-Poznanović, S., Božić, M. M.,& Đordević, J.. (2013). Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology. in Engrami
Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd., 35(1-2), 81-89.
https://hdl.handle.net/21.15107/rcub_rfasper_714

Pavlović D, Pavlović AM, Totić-Poznanović S, Božić MM, Đordević J. Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology. in Engrami. 2013;35(1-2):81-89.
https://hdl.handle.net/21.15107/rcub_rfasper_714 .

Pavlović, Dragan, Pavlović, Aleksandra M., Totić-Poznanović, Sanja, Božić, Marija M., Đordević, Jelena, "Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology" in Engrami, 35, no. 1-2 (2013):81-89,
https://hdl.handle.net/21.15107/rcub_rfasper_714 .

TY  - JOUR
AU  - Pavlović, Aleksandra M.
AU  - Pavlović, Dragan
AU  - Aleksić, Vuk
AU  - Šternić, Nadežda
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/709
AB  - Vascular dementia (VaD) is the second most frequent dementia after Alzheimer's disease, and is diagnosed during lifetime in 20% of demented patients. Five­year survival rate in VaD is 39%, while it is estimated to be 75% in healthy persons of the same age. It is therefore important to make correct diagnosis of VaD early in the course of the disease. Risk factors for VaD are identical to stroke risk factors, and there are significant possibilities for the prevention of vascular cognitive decline. Cognitive decline develops acutely or step­by­step within three months after stroke, but more gradual progression of intellectual decline is also possible. Neurological examination can reveal pyramidal and extrapyramidal signs, pseudobulbar palsy, gait disturbance and urinary incontinence. Neuropsychological profile comprises the loss of cognitive set shifting, decline in word fluency, verbal learning difficulties, perseverations, difficulties in complex figure copying, and in patients with cortically located lesions also problems with speech and praxia. The basis of the diagnosis is, besides history, neurological examination and neuropsychological assessment, computed tomography and/ or magnetic resonance brain imaging. Vascular risk factors control is the most important measure in VaD prevention. Modern guidelines for the treatment of cognitive decline in VaD emphasize that donepezil can be useful in the improvement of cognitive status at the level of Class IIa recommendation at the level of evidence A, while memantine may be useful in patients with mixed VaD and Alzheimer's disease dementia.
AB  - Vaskularna demencija (VaD) je posle Alchajmerove bolesti druga po učestalosti demencija, koja se zaživotno dijagnostikuje kod oko 20% svih dementnih bolesnika. Petogodišnje preživljavanje obolelih od VaD je 39%, u odnosu na 75% zdravih osoba istog životnog doba. Zbog toga je veoma važno pravovremeno i tačno postaviti dijagnozu VaD. Faktori rizika za nastanak VaD su istovetni onima za moždani udar, te postoje značajne mogućnosti za prevenciju vaskularnog kognitivnog pada. Kognitivni pad se ispoljava naglo ili postepeno tokom tri meseca od moždanog udara, ali je moguće i tzv. šunjajuće napredovanje intelektualnog propadanja. U neurološkom nalazu se mogu naći piramidalni i ekstrapiramidalni znaci, pseudobulbarna paraliza, poremećaji hodanja i inkontinencija urina. Neuropsihološki profil obuhvata teškoće promene kognitivnog seta, pogoršanje fonemske fluentnosti, oštećenje verbalnog učenja, perseverativnost, teškoće kopiranja složenog crteža, a kod kortikalno lociranih lezija i smetnje govora i praksije. Osnova dijagnoze je, pored anamneze, neurološkog pregleda i neuropsihološkog ispitivanja, nalaz na snimcima mozga skenerom i/ili magnetnom rezonancijom. Kontrola vaskularnih faktora rizika je najznačajnija mera u prevenciji VaD. Savremene preporuke za lečenje bolesnika sa VaD ističu da donepezil može biti koristan za poboljšanje kognitivnog stanja bolesnika sa VaD na nivou klase IIa preporuka, nivoa dokaza A, dok memantin može biti koristan kod bolesnika s mešovitom VaD, s elementima Alchajmerove bolesti.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Vascular dementia: Facts and controversies
T1  - Vaskularna demencija - istine i kontroverze
EP  - 255
IS  - 3-4
SP  - 247
VL  - 141
DO  - 10.2298/SARH1304247P
ER  - 

@article{
author = "Pavlović, Aleksandra M. and Pavlović, Dragan and Aleksić, Vuk and Šternić, Nadežda",
year = "2013",
abstract = "Vascular dementia (VaD) is the second most frequent dementia after Alzheimer's disease, and is diagnosed during lifetime in 20% of demented patients. Five­year survival rate in VaD is 39%, while it is estimated to be 75% in healthy persons of the same age. It is therefore important to make correct diagnosis of VaD early in the course of the disease. Risk factors for VaD are identical to stroke risk factors, and there are significant possibilities for the prevention of vascular cognitive decline. Cognitive decline develops acutely or step­by­step within three months after stroke, but more gradual progression of intellectual decline is also possible. Neurological examination can reveal pyramidal and extrapyramidal signs, pseudobulbar palsy, gait disturbance and urinary incontinence. Neuropsychological profile comprises the loss of cognitive set shifting, decline in word fluency, verbal learning difficulties, perseverations, difficulties in complex figure copying, and in patients with cortically located lesions also problems with speech and praxia. The basis of the diagnosis is, besides history, neurological examination and neuropsychological assessment, computed tomography and/ or magnetic resonance brain imaging. Vascular risk factors control is the most important measure in VaD prevention. Modern guidelines for the treatment of cognitive decline in VaD emphasize that donepezil can be useful in the improvement of cognitive status at the level of Class IIa recommendation at the level of evidence A, while memantine may be useful in patients with mixed VaD and Alzheimer's disease dementia., Vaskularna demencija (VaD) je posle Alchajmerove bolesti druga po učestalosti demencija, koja se zaživotno dijagnostikuje kod oko 20% svih dementnih bolesnika. Petogodišnje preživljavanje obolelih od VaD je 39%, u odnosu na 75% zdravih osoba istog životnog doba. Zbog toga je veoma važno pravovremeno i tačno postaviti dijagnozu VaD. Faktori rizika za nastanak VaD su istovetni onima za moždani udar, te postoje značajne mogućnosti za prevenciju vaskularnog kognitivnog pada. Kognitivni pad se ispoljava naglo ili postepeno tokom tri meseca od moždanog udara, ali je moguće i tzv. šunjajuće napredovanje intelektualnog propadanja. U neurološkom nalazu se mogu naći piramidalni i ekstrapiramidalni znaci, pseudobulbarna paraliza, poremećaji hodanja i inkontinencija urina. Neuropsihološki profil obuhvata teškoće promene kognitivnog seta, pogoršanje fonemske fluentnosti, oštećenje verbalnog učenja, perseverativnost, teškoće kopiranja složenog crteža, a kod kortikalno lociranih lezija i smetnje govora i praksije. Osnova dijagnoze je, pored anamneze, neurološkog pregleda i neuropsihološkog ispitivanja, nalaz na snimcima mozga skenerom i/ili magnetnom rezonancijom. Kontrola vaskularnih faktora rizika je najznačajnija mera u prevenciji VaD. Savremene preporuke za lečenje bolesnika sa VaD ističu da donepezil može biti koristan za poboljšanje kognitivnog stanja bolesnika sa VaD na nivou klase IIa preporuka, nivoa dokaza A, dok memantin može biti koristan kod bolesnika s mešovitom VaD, s elementima Alchajmerove bolesti.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Vascular dementia: Facts and controversies, Vaskularna demencija - istine i kontroverze",
pages = "255-247",
number = "3-4",
volume = "141",
doi = "10.2298/SARH1304247P"
}

Pavlović, A. M., Pavlović, D., Aleksić, V.,& Šternić, N.. (2013). Vascular dementia: Facts and controversies. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 141(3-4), 247-255.
https://doi.org/10.2298/SARH1304247P

Pavlović AM, Pavlović D, Aleksić V, Šternić N. Vascular dementia: Facts and controversies. in Srpski arhiv za celokupno lekarstvo. 2013;141(3-4):247-255.
doi:10.2298/SARH1304247P .

Pavlović, Aleksandra M., Pavlović, Dragan, Aleksić, Vuk, Šternić, Nadežda, "Vascular dementia: Facts and controversies" in Srpski arhiv za celokupno lekarstvo, 141, no. 3-4 (2013):247-255,
https://doi.org/10.2298/SARH1304247P . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
AU  - Lačković, Maja
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/695
AB  - Omega-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs) are thought to be important for normal dopaminergic, glutamatergic and serotonergic neurotransmission. Depression is less prevalent in societies with high fish consumption, and depressed patients have significantly lower red blood cell ω-3 levels. Studies with ω-3 supplementation have led to controversial results. A significantly longer remission of bipolar symptomatology has been confirmed from a high-dose DHA and EPA mixture. Greater seafood consumption per capita has been connected with a lower prevalence of bipolar spectrum disorders. Reduced levels of ω-6 and ω-3 PUFAs were found in patients with schizophrenia.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Omega 3 fatty acids in psychiatry
EP  - 46
IS  - 1
SP  - 43
VL  - 65
DO  - 10.2298/ABS1301043P
ER  - 

@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M. and Lačković, Maja",
year = "2013",
abstract = "Omega-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs) are thought to be important for normal dopaminergic, glutamatergic and serotonergic neurotransmission. Depression is less prevalent in societies with high fish consumption, and depressed patients have significantly lower red blood cell ω-3 levels. Studies with ω-3 supplementation have led to controversial results. A significantly longer remission of bipolar symptomatology has been confirmed from a high-dose DHA and EPA mixture. Greater seafood consumption per capita has been connected with a lower prevalence of bipolar spectrum disorders. Reduced levels of ω-6 and ω-3 PUFAs were found in patients with schizophrenia.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Omega 3 fatty acids in psychiatry",
pages = "46-43",
number = "1",
volume = "65",
doi = "10.2298/ABS1301043P"
}

Pavlović, D., Pavlović, A. M.,& Lačković, M.. (2013). Omega 3 fatty acids in psychiatry. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 65(1), 43-46.
https://doi.org/10.2298/ABS1301043P

Pavlović D, Pavlović AM, Lačković M. Omega 3 fatty acids in psychiatry. in Archives of Biological Sciences. 2013;65(1):43-46.
doi:10.2298/ABS1301043P .

Pavlović, Dragan, Pavlović, Aleksandra M., Lačković, Maja, "Omega 3 fatty acids in psychiatry" in Archives of Biological Sciences, 65, no. 1 (2013):43-46,
https://doi.org/10.2298/ABS1301043P . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
AU  - Lačković, Maja
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/692
AB  - Alzheimer's disease (AD), the most prevalent dementia, is characterized not only by cognitive but also behavior- al changes that pose the heaviest burden to caregivers. Differences in the clinical picture depending on the time of disease onset have been observed. We correlated cognitive and behavioral deficits in patients with presenile- and senile-onset AD to explore the differences. We tested 60 AD patients, 19 male and 41 female, mean age 65.2 years with the Dementia Behavior Disturbance Scale (DBD) and a standard neuropsychological battery. The patients were divided according to their DBD score into two groups: group I - score 0-2 (n=24; 40%), group II - score 3≥ (n=36; 60%), comparable in disease duration and neurological findings. The cognitive scores were significantly higher in the group with less behavioral changes than in the group with more behavioral changes: Mini Mental State Examination score (p=0.0015), serial subtraction (p=0.0009), block design (p=0.0049), copy of complex figure (p=0.0125), complex visual organization (p=0.0099), divided attention, visual memory and speech comprehension. A significantly higher frequency of behavioral disturbances was registered in patients with senile onset than in the presenile-onset group (p lt 0.005). There were no sex differences. Our data show a correlation between cognitive decline and behavioral changes in late onset AD patients, indicating that more behavioral disturbances were associated with a more severe degree of cognitive decline, especially in non-verbal functions and attention deficits, compared to early onset patients.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease
EP  - 1147
IS  - 3
SP  - 1141
VL  - 65
DO  - 10.2298/ABS1303141P
ER  - 

@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M. and Lačković, Maja",
year = "2013",
abstract = "Alzheimer's disease (AD), the most prevalent dementia, is characterized not only by cognitive but also behavior- al changes that pose the heaviest burden to caregivers. Differences in the clinical picture depending on the time of disease onset have been observed. We correlated cognitive and behavioral deficits in patients with presenile- and senile-onset AD to explore the differences. We tested 60 AD patients, 19 male and 41 female, mean age 65.2 years with the Dementia Behavior Disturbance Scale (DBD) and a standard neuropsychological battery. The patients were divided according to their DBD score into two groups: group I - score 0-2 (n=24; 40%), group II - score 3≥ (n=36; 60%), comparable in disease duration and neurological findings. The cognitive scores were significantly higher in the group with less behavioral changes than in the group with more behavioral changes: Mini Mental State Examination score (p=0.0015), serial subtraction (p=0.0009), block design (p=0.0049), copy of complex figure (p=0.0125), complex visual organization (p=0.0099), divided attention, visual memory and speech comprehension. A significantly higher frequency of behavioral disturbances was registered in patients with senile onset than in the presenile-onset group (p lt 0.005). There were no sex differences. Our data show a correlation between cognitive decline and behavioral changes in late onset AD patients, indicating that more behavioral disturbances were associated with a more severe degree of cognitive decline, especially in non-verbal functions and attention deficits, compared to early onset patients.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease",
pages = "1147-1141",
number = "3",
volume = "65",
doi = "10.2298/ABS1303141P"
}

Pavlović, D., Pavlović, A. M.,& Lačković, M.. (2013). Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 65(3), 1141-1147.
https://doi.org/10.2298/ABS1303141P

Pavlović D, Pavlović AM, Lačković M. Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease. in Archives of Biological Sciences. 2013;65(3):1141-1147.
doi:10.2298/ABS1303141P .

Pavlović, Dragan, Pavlović, Aleksandra M., Lačković, Maja, "Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease" in Archives of Biological Sciences, 65, no. 3 (2013):1141-1147,
https://doi.org/10.2298/ABS1303141P . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
PY  - 2012
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/609
AB  - Attention deficit hyperactivity disorder (ADHD) is a group of disorders whose characteristics are excessive and disorganized activity and impersistence, starting in early childhood, usually up to 5-years of age. Hyperactive disorder affects approximately 5-10% of children all around the world, 4 times more oft en in boys than in girls, and in some individuals persist into adulthood. It is characterized by a lack of persistence in activities that require cognitive involvement, and tendency to go from one activity to another without finishing last with disorganized and poorly regulated excessive activity. Oft en there are associated disorders. Conduct disorders can isolate these children from other children. Common disorders of cognitive functions are specific delay in motor and language development. Secondary they show dissocial behavior and low self-esteem. Disturbed regulation of noradrenergic system in ADHD leads to inefficient functioning of the posterior cortex of attention, and dopaminergic dysregulation leads to the frontal executive function disorder. With neuropsychological perspective, ADHD consists of impulsiveness, planning problems, inattention, hyperactivity, problems of modulating gratification and emotional regulation. In the acting on dopaminergic and noradrenergic system: methylphenidate, dextroamphetamine, pimolin, and recently atomoxetin, clonidine, guanfacine, and sometimes antidepressants and antipsychotics treatment of ADHD is used combined therapy including medication, behavior modification techniques, and environment modification. Pharmacotherapy consists of applied psychostimulants.
AB  - Hiperkinetki poremećaji (engl. attention deficit hyperactivity disorder, ADHD) su grupa poremećaja čije su karakteristike: preterana i dezorganizovana aktivnost i neistrajnost, a počinju u ranom detinjstvu, obično do pete godine života. Hiperaktivni poremećaj zahvata oko 5-10% dece u svim zemljama sveta, četiri puta češće kod dečaka nego kod devojčica, a kod izvesnog broja osoba perzistira i u zrelom dobu. Karakteriše se odsustvom upornosti u aktivnostima koje zahtevaju kognitivnu angažovanost i sklonost da se ide iz jedne u drugu aktivnost bez završavanja prethodne, zajedno sa dezorganizovanom i slabo regulisanom preteranom aktivnošću. Često postoje i udruženi poremećaji. Poremećaji ponašanja mogu da ih izoluju od druge dece. Uobičajeni su poremećaji kognitivnih funkcija sa specifičnim kašnjenjem razvoja motorike i govora. Sekundarno se javlja nisko samopouzdanje i disocijalno ponašanje. Poremećaj regulacije noradrenergičkog sistema u ADHD dovodi do neefikasnog funkcionisanja sistema pažnje posteriorne kore, dok dopaminergička disregulacija dovodi do poremećaja funkcije prednjeg egzekutivnog sistema. Sa neuropsihološkog aspekta, ADHD se sastoji od impulsivnosti, problema planiranja, nepažnje, hiperaktivnosti, problema modulacije gratifikacije i emocionalne regulacije. U terapiji ADHD se primenjuje kombinovana terapija koja obuhvata lekove, bihevioralne tehnike i modifikaciju okoline. U farmakoterapiji se primenjuju psihostimulansi koji deluju na dopaminergički i noradrenergički sistem: metilfenidat, dekstroamfetamin, pimolin, a u novije vreme i atomoksetin, klonidin, guanfacin, nekad i antipsihotici i antidepresivi.
PB  - Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd
T2  - Aktuelnosti iz neurologije, psihijatrije i graničnih područja
T1  - Attention deficit hyperactivity disorder
T1  - Hiperkinetski poremećaji
EP  - 52
IS  - 3-4
SP  - 44
VL  - 20
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_609
ER  - 

@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M.",
year = "2012",
abstract = "Attention deficit hyperactivity disorder (ADHD) is a group of disorders whose characteristics are excessive and disorganized activity and impersistence, starting in early childhood, usually up to 5-years of age. Hyperactive disorder affects approximately 5-10% of children all around the world, 4 times more oft en in boys than in girls, and in some individuals persist into adulthood. It is characterized by a lack of persistence in activities that require cognitive involvement, and tendency to go from one activity to another without finishing last with disorganized and poorly regulated excessive activity. Oft en there are associated disorders. Conduct disorders can isolate these children from other children. Common disorders of cognitive functions are specific delay in motor and language development. Secondary they show dissocial behavior and low self-esteem. Disturbed regulation of noradrenergic system in ADHD leads to inefficient functioning of the posterior cortex of attention, and dopaminergic dysregulation leads to the frontal executive function disorder. With neuropsychological perspective, ADHD consists of impulsiveness, planning problems, inattention, hyperactivity, problems of modulating gratification and emotional regulation. In the acting on dopaminergic and noradrenergic system: methylphenidate, dextroamphetamine, pimolin, and recently atomoxetin, clonidine, guanfacine, and sometimes antidepressants and antipsychotics treatment of ADHD is used combined therapy including medication, behavior modification techniques, and environment modification. Pharmacotherapy consists of applied psychostimulants., Hiperkinetki poremećaji (engl. attention deficit hyperactivity disorder, ADHD) su grupa poremećaja čije su karakteristike: preterana i dezorganizovana aktivnost i neistrajnost, a počinju u ranom detinjstvu, obično do pete godine života. Hiperaktivni poremećaj zahvata oko 5-10% dece u svim zemljama sveta, četiri puta češće kod dečaka nego kod devojčica, a kod izvesnog broja osoba perzistira i u zrelom dobu. Karakteriše se odsustvom upornosti u aktivnostima koje zahtevaju kognitivnu angažovanost i sklonost da se ide iz jedne u drugu aktivnost bez završavanja prethodne, zajedno sa dezorganizovanom i slabo regulisanom preteranom aktivnošću. Često postoje i udruženi poremećaji. Poremećaji ponašanja mogu da ih izoluju od druge dece. Uobičajeni su poremećaji kognitivnih funkcija sa specifičnim kašnjenjem razvoja motorike i govora. Sekundarno se javlja nisko samopouzdanje i disocijalno ponašanje. Poremećaj regulacije noradrenergičkog sistema u ADHD dovodi do neefikasnog funkcionisanja sistema pažnje posteriorne kore, dok dopaminergička disregulacija dovodi do poremećaja funkcije prednjeg egzekutivnog sistema. Sa neuropsihološkog aspekta, ADHD se sastoji od impulsivnosti, problema planiranja, nepažnje, hiperaktivnosti, problema modulacije gratifikacije i emocionalne regulacije. U terapiji ADHD se primenjuje kombinovana terapija koja obuhvata lekove, bihevioralne tehnike i modifikaciju okoline. U farmakoterapiji se primenjuju psihostimulansi koji deluju na dopaminergički i noradrenergički sistem: metilfenidat, dekstroamfetamin, pimolin, a u novije vreme i atomoksetin, klonidin, guanfacin, nekad i antipsihotici i antidepresivi.",
publisher = "Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd",
journal = "Aktuelnosti iz neurologije, psihijatrije i graničnih područja",
title = "Attention deficit hyperactivity disorder, Hiperkinetski poremećaji",
pages = "52-44",
number = "3-4",
volume = "20",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_609"
}

Pavlović, D.,& Pavlović, A. M.. (2012). Attention deficit hyperactivity disorder. in Aktuelnosti iz neurologije, psihijatrije i graničnih područja
Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd., 20(3-4), 44-52.
https://hdl.handle.net/21.15107/rcub_rfasper_609

Pavlović D, Pavlović AM. Attention deficit hyperactivity disorder. in Aktuelnosti iz neurologije, psihijatrije i graničnih područja. 2012;20(3-4):44-52.
https://hdl.handle.net/21.15107/rcub_rfasper_609 .

Pavlović, Dragan, Pavlović, Aleksandra M., "Attention deficit hyperactivity disorder" in Aktuelnosti iz neurologije, psihijatrije i graničnih područja, 20, no. 3-4 (2012):44-52,
https://hdl.handle.net/21.15107/rcub_rfasper_609 .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
PY  - 2012
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/608
AB  - Psychological resilience is a positive adaptation, or the ability to maintain or restore mental health despite experiencing hardship. Relevant to the resilience are personality factors, biological factors, systemic factors, and there interaction. Indicators of resilience in children are school performance, symptoms of depression and anxiety, social skills, substance abuse and delinquency and indicators in adults are: employment, homelessness, substance abuse and crime. Factors of increased resilience can be divided into: public health measures, the government measures, child development, mental health in the workplace and improving cognitive reserve in the elderly. Developmental cascades try to explain how to maintain positive changes, enhancing, expanding and moving between system levels or generations. Interventions to increase the resilience are foster care, adoption, and parent training. Understanding the factors of resilience is of great importance for preventive work with children and implementation of interventions to enhance the mental resilience in children. It is particularly important to strengthen the resilience before children and adults experience a crisis.
AB  - Psihološka rezilijentnost je pozitivna adaptacija ili sposobnost da se održi ili povrati mentalno zdravlje uprkos doživljavanja nevolja. Od značaja za rezilijentnost su faktori ličnosti, biološki faktori, sistemski faktori, kao i interakcija ovih faktora. Indikatori rezilijentnosti kod dece su: uspeh u školi, simptomi depresije i anksioznosti, socijalne veštine, zloupotreba supstanci i delikvencija, a indikatori kod odraslih su: zaposlenost, beskućništvo, zloupotreba supstanci i kriminal. Faktori povećanja rezilijentnosti mogu da se podele na: mere javnog zdravlja, vladine mere, razvoj dece, mentalno zdravlje na radnom mestu i unapređenje kognitivnih rezervi kod starijih. Razvojne kaskade pokušavaju da objasne kako se pozitivne promene održavaju, pojačavaju, šire i pomeraju između sistemskih nivoa ili generacija. Intervencije za povećanje rezilijence su hraniteljstvo, usvojenje i obuka roditelja. Poznavanje faktora rezilijentnosti je od velikog značaja za preventivni rad sa decom i primenu intervencija za jačanje mentalne otpornosti kod dece. Posebno je važno jačanje rezilijentnosti pre nego što deca ali i odrasli dožive krizne situacije.
PB  - Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd
T2  - Aktuelnosti iz neurologije, psihijatrije i graničnih područja
T1  - Resilience
T1  - Rezilijentnost
EP  - 43
IS  - 3-4
SP  - 39
VL  - 20
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_608
ER  - 

@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M.",
year = "2012",
abstract = "Psychological resilience is a positive adaptation, or the ability to maintain or restore mental health despite experiencing hardship. Relevant to the resilience are personality factors, biological factors, systemic factors, and there interaction. Indicators of resilience in children are school performance, symptoms of depression and anxiety, social skills, substance abuse and delinquency and indicators in adults are: employment, homelessness, substance abuse and crime. Factors of increased resilience can be divided into: public health measures, the government measures, child development, mental health in the workplace and improving cognitive reserve in the elderly. Developmental cascades try to explain how to maintain positive changes, enhancing, expanding and moving between system levels or generations. Interventions to increase the resilience are foster care, adoption, and parent training. Understanding the factors of resilience is of great importance for preventive work with children and implementation of interventions to enhance the mental resilience in children. It is particularly important to strengthen the resilience before children and adults experience a crisis., Psihološka rezilijentnost je pozitivna adaptacija ili sposobnost da se održi ili povrati mentalno zdravlje uprkos doživljavanja nevolja. Od značaja za rezilijentnost su faktori ličnosti, biološki faktori, sistemski faktori, kao i interakcija ovih faktora. Indikatori rezilijentnosti kod dece su: uspeh u školi, simptomi depresije i anksioznosti, socijalne veštine, zloupotreba supstanci i delikvencija, a indikatori kod odraslih su: zaposlenost, beskućništvo, zloupotreba supstanci i kriminal. Faktori povećanja rezilijentnosti mogu da se podele na: mere javnog zdravlja, vladine mere, razvoj dece, mentalno zdravlje na radnom mestu i unapređenje kognitivnih rezervi kod starijih. Razvojne kaskade pokušavaju da objasne kako se pozitivne promene održavaju, pojačavaju, šire i pomeraju između sistemskih nivoa ili generacija. Intervencije za povećanje rezilijence su hraniteljstvo, usvojenje i obuka roditelja. Poznavanje faktora rezilijentnosti je od velikog značaja za preventivni rad sa decom i primenu intervencija za jačanje mentalne otpornosti kod dece. Posebno je važno jačanje rezilijentnosti pre nego što deca ali i odrasli dožive krizne situacije.",
publisher = "Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd",
journal = "Aktuelnosti iz neurologije, psihijatrije i graničnih područja",
title = "Resilience, Rezilijentnost",
pages = "43-39",
number = "3-4",
volume = "20",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_608"
}

Pavlović, D.,& Pavlović, A. M.. (2012). Resilience. in Aktuelnosti iz neurologije, psihijatrije i graničnih područja
Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd., 20(3-4), 39-43.
https://hdl.handle.net/21.15107/rcub_rfasper_608

Pavlović D, Pavlović AM. Resilience. in Aktuelnosti iz neurologije, psihijatrije i graničnih područja. 2012;20(3-4):39-43.
https://hdl.handle.net/21.15107/rcub_rfasper_608 .

Pavlović, Dragan, Pavlović, Aleksandra M., "Resilience" in Aktuelnosti iz neurologije, psihijatrije i graničnih područja, 20, no. 3-4 (2012):39-43,
https://hdl.handle.net/21.15107/rcub_rfasper_608 .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
PY  - 2012
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/580
AB  - Mixed dementia (MD) is co-existance of both Alzheimer's disease (AD) and vacular dementia (VD) in the same patient. With aging of popularion, this diagnostic cathegory will continue to be problem in clinical practice. Neuropathological studies indicate that MD represents a very common pathology, especially in the elderly. The differentiation between AD and VD is complex since their clinical presentations may overlap and diagnostic criteria do not provide adequate differentiation. There are also overlapping pathological processes in AD and VD, and both conditions share vascular risk factors. Treatment of MD patients is challenging, and there is a potential for use of cholinestherase inhibitors, risk factor management and also for use of other medications. MD remains challenging clinical diagnosis.
AB  - Mešovita demencija (MD) je zajedničko postojanje Alchajmerove bolesti (AB) i vaskulne demencije (VaD) kod istog bolesnika. Sa starenjem populacije, ovaj dijagnostički entitet će se sve više postavljati kao problem u praksi. Neuropatološke studije ukazuju da je MD veoma čest patološki nalaz, posebno kod starijih. Razlikovanje AB i VaD je složeno budući da njihove kliničke prezentacije mogu da se preklapaju, a da dijagnostički kriterijumi ne omogućavaju afekvatnu diferencijaciju. Patološki procesi u AB i VaD se takodje preklapaju i obe bolesti dele vaskulne faktore rizika. Poseban izazov je problem lečenja bolesnika sa MD, gde svoje mesto imaju inhibitori holinesteraze, tretiranje faktora rizika, a moguće je i neki drugi lekovi. Postavljanje dijagnoze MD i dalje je izazov za lekara praktičara.
PB  - Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd
T2  - Engrami
T1  - Mixed dementia
T1  - Mešovita demencija
EP  - 47
IS  - 3
SP  - 39
VL  - 34
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_580
ER  - 

@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M.",
year = "2012",
abstract = "Mixed dementia (MD) is co-existance of both Alzheimer's disease (AD) and vacular dementia (VD) in the same patient. With aging of popularion, this diagnostic cathegory will continue to be problem in clinical practice. Neuropathological studies indicate that MD represents a very common pathology, especially in the elderly. The differentiation between AD and VD is complex since their clinical presentations may overlap and diagnostic criteria do not provide adequate differentiation. There are also overlapping pathological processes in AD and VD, and both conditions share vascular risk factors. Treatment of MD patients is challenging, and there is a potential for use of cholinestherase inhibitors, risk factor management and also for use of other medications. MD remains challenging clinical diagnosis., Mešovita demencija (MD) je zajedničko postojanje Alchajmerove bolesti (AB) i vaskulne demencije (VaD) kod istog bolesnika. Sa starenjem populacije, ovaj dijagnostički entitet će se sve više postavljati kao problem u praksi. Neuropatološke studije ukazuju da je MD veoma čest patološki nalaz, posebno kod starijih. Razlikovanje AB i VaD je složeno budući da njihove kliničke prezentacije mogu da se preklapaju, a da dijagnostički kriterijumi ne omogućavaju afekvatnu diferencijaciju. Patološki procesi u AB i VaD se takodje preklapaju i obe bolesti dele vaskulne faktore rizika. Poseban izazov je problem lečenja bolesnika sa MD, gde svoje mesto imaju inhibitori holinesteraze, tretiranje faktora rizika, a moguće je i neki drugi lekovi. Postavljanje dijagnoze MD i dalje je izazov za lekara praktičara.",
publisher = "Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd",
journal = "Engrami",
title = "Mixed dementia, Mešovita demencija",
pages = "47-39",
number = "3",
volume = "34",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_580"
}

Pavlović, D.,& Pavlović, A. M.. (2012). Mixed dementia. in Engrami
Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd., 34(3), 39-47.
https://hdl.handle.net/21.15107/rcub_rfasper_580

Pavlović D, Pavlović AM. Mixed dementia. in Engrami. 2012;34(3):39-47.
https://hdl.handle.net/21.15107/rcub_rfasper_580 .

Pavlović, Dragan, Pavlović, Aleksandra M., "Mixed dementia" in Engrami, 34, no. 3 (2012):39-47,
https://hdl.handle.net/21.15107/rcub_rfasper_580 .