Đordević, Jelena

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  • Đordević, Jelena (5)
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Omega 3 masne kiseline u psihijatriji - mit i stvarnost

Pavlović, Dragan; Pavlović, Aleksandra M.; Đordević, Jelena

(Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd, 2020)

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
AU  - Đordević, Jelena
PY  - 2020
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1302
AB  - Omega 3 fatty acids are long-chain polyunsaturated fatty acids (LC-PUFAs). The basic molecule is the Alpha-linolenic acid (ALA) from which LC-PUFAs are formed: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). DHA is the predominant fatty acid in the brain especially in synaptic membranes, astrocytes, myelin and organelle membranes. LC-PUFAs lead to increased membrane fluidity and permeability, and most of the positive effects depend on immunomodulatory activities, via mechanisms of gene expression, cell signaling, and membrane organization. Previous studies in animal models have shown that LC-PUFAs are essential for normal dopaminergic, glutamatergic and serotonergic neurotransmission. Preclinical and clinical studies have demonstrated the role of PUFAs as an effective adjuvant therapy for unipolar and bipolar depression. Lack of omega 3 fatty acids plays a role in the onset of anxiety and aggression. Low omega 3 fatty acids in the prefrontal cortex of people with schizophrenia reduce dopaminergic neurotransmission, contributing to negative and neurocognitive symptoms, while subsequent disinhibition in the limbic system causes positive symptoms. Some evidence suggests that LC-PUFA may delay or even prevent the progression of particular psychotic disorders in high-risk children and adolescents. Epidemiological studies have shown a positive correlation between the relatively high intake of DHA and EPA and the lower relative risk of mild cognitive impairment and dementia or their progression. The recommended daily intake of EPA and DHA varies significantly: 300-500 mg/day as recommended by the World Health Organization (WHO), up to 1-2 grams/day in Norway. Daily intakes of EPA and DHA up to 3 grams are generally recognized as safe. EPA and DHA at doses greater than 3 grams per day can have side effects: an increase in bleeding frequency, oxidation of n-3PUFAs with the formation of biologically active oxidation products, and more.
AB  - Omega 3 masne kiseline su polinezasićene masne kiseline dugih lanaca (LC-PUFAs). Osnovni molekul je alfa-linolenska kiselina (ALA) od koje nastaju LC-PUFA: eikosapentaenoična kiselina (EPA) i dokosaheksaenoička kiselina (DHA). DHA je dominantna masna kiselina u mozgu naročito u sinaptičkim membranama, astrocitima, mijelinu i membranama organela. LC-PUFAs dovode do povećane fluidnosti i permeabilnosti membrana, a većina pozitivnih efekata zavisi od imunomodulacionih aktivnosti, preko mehanizama ekspresije gena, ćelijske signalizacije i organizacije membrane. Dosadašnjim istrazivanjima na animalnim modelima pokazano je da su LC-PUFAs neophodne za normalnu dopaminergičku, glutamatergičku i serotonergičku neurotransmisiju. Prekliničke i kliničke studije su pokazale ulogu PUFAs kao efikasne adjuvantne terapije unipolarne i bipolarne depresije. Nedostatak omega 3 masnih kiselina ima ulogu u nastanku anksioznosti i agresivnosti. Niske omega 3 masne kiseline u prefrontalnoj kori mozga u osoba sa shizofrenijom smanjuju dopaminergičku neurotransmisiju, doprinoseći negativnim i neurokognitivnim simptomima dok posledična dezinhibicija u limbičkom sistemu izaziva pozitivne simptome. Neki dokazi ukazuju da LC-PUFA može da odloži ili čak spreči napredovanje pojedinih psihotičnih poremećaja u visoko rizične dece i adolescenata. Epidemiološke studije su pokazale pozitivnu korelaciju između relativno visokog unosa DHA i EPA i nižeg relativnog rizika od pojave blagog kognitivnog poremećaja i demencije ili njihovog napredovanja. Preporučeni dnevni unos EPA i DHA značajno varira: 300-500 mg/dan kako Svetska zdravstvena organizacija (SZO) preporučuje, pa sve do 1-2 grama/dan u Norveškoj. Dnevni unos EPA i DHA do 3 grama je generalno priznat kao siguran. EPA i DHA u dozama većim od 3 grama dnevno može da da neželjene efekte: povećanje učestalosti krvarenja, oksidaciju n-3PUFAs sa nastankom biološki aktivnih oksidacionih produkata i drugo.
PB  - Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd
T2  - Engrami
T1  - Omega 3 masne kiseline u psihijatriji - mit i stvarnost
T1  - Omega 3 fatty acids in psychiatry: Myth and reality
EP  - 57
IS  - 1
SP  - 44
VL  - 42
DO  - 10.5937/engrami2001044P
ER  - 
@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M. and Đordević, Jelena",
year = "2020",
abstract = "Omega 3 fatty acids are long-chain polyunsaturated fatty acids (LC-PUFAs). The basic molecule is the Alpha-linolenic acid (ALA) from which LC-PUFAs are formed: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). DHA is the predominant fatty acid in the brain especially in synaptic membranes, astrocytes, myelin and organelle membranes. LC-PUFAs lead to increased membrane fluidity and permeability, and most of the positive effects depend on immunomodulatory activities, via mechanisms of gene expression, cell signaling, and membrane organization. Previous studies in animal models have shown that LC-PUFAs are essential for normal dopaminergic, glutamatergic and serotonergic neurotransmission. Preclinical and clinical studies have demonstrated the role of PUFAs as an effective adjuvant therapy for unipolar and bipolar depression. Lack of omega 3 fatty acids plays a role in the onset of anxiety and aggression. Low omega 3 fatty acids in the prefrontal cortex of people with schizophrenia reduce dopaminergic neurotransmission, contributing to negative and neurocognitive symptoms, while subsequent disinhibition in the limbic system causes positive symptoms. Some evidence suggests that LC-PUFA may delay or even prevent the progression of particular psychotic disorders in high-risk children and adolescents. Epidemiological studies have shown a positive correlation between the relatively high intake of DHA and EPA and the lower relative risk of mild cognitive impairment and dementia or their progression. The recommended daily intake of EPA and DHA varies significantly: 300-500 mg/day as recommended by the World Health Organization (WHO), up to 1-2 grams/day in Norway. Daily intakes of EPA and DHA up to 3 grams are generally recognized as safe. EPA and DHA at doses greater than 3 grams per day can have side effects: an increase in bleeding frequency, oxidation of n-3PUFAs with the formation of biologically active oxidation products, and more., Omega 3 masne kiseline su polinezasićene masne kiseline dugih lanaca (LC-PUFAs). Osnovni molekul je alfa-linolenska kiselina (ALA) od koje nastaju LC-PUFA: eikosapentaenoična kiselina (EPA) i dokosaheksaenoička kiselina (DHA). DHA je dominantna masna kiselina u mozgu naročito u sinaptičkim membranama, astrocitima, mijelinu i membranama organela. LC-PUFAs dovode do povećane fluidnosti i permeabilnosti membrana, a većina pozitivnih efekata zavisi od imunomodulacionih aktivnosti, preko mehanizama ekspresije gena, ćelijske signalizacije i organizacije membrane. Dosadašnjim istrazivanjima na animalnim modelima pokazano je da su LC-PUFAs neophodne za normalnu dopaminergičku, glutamatergičku i serotonergičku neurotransmisiju. Prekliničke i kliničke studije su pokazale ulogu PUFAs kao efikasne adjuvantne terapije unipolarne i bipolarne depresije. Nedostatak omega 3 masnih kiselina ima ulogu u nastanku anksioznosti i agresivnosti. Niske omega 3 masne kiseline u prefrontalnoj kori mozga u osoba sa shizofrenijom smanjuju dopaminergičku neurotransmisiju, doprinoseći negativnim i neurokognitivnim simptomima dok posledična dezinhibicija u limbičkom sistemu izaziva pozitivne simptome. Neki dokazi ukazuju da LC-PUFA može da odloži ili čak spreči napredovanje pojedinih psihotičnih poremećaja u visoko rizične dece i adolescenata. Epidemiološke studije su pokazale pozitivnu korelaciju između relativno visokog unosa DHA i EPA i nižeg relativnog rizika od pojave blagog kognitivnog poremećaja i demencije ili njihovog napredovanja. Preporučeni dnevni unos EPA i DHA značajno varira: 300-500 mg/dan kako Svetska zdravstvena organizacija (SZO) preporučuje, pa sve do 1-2 grama/dan u Norveškoj. Dnevni unos EPA i DHA do 3 grama je generalno priznat kao siguran. EPA i DHA u dozama većim od 3 grama dnevno može da da neželjene efekte: povećanje učestalosti krvarenja, oksidaciju n-3PUFAs sa nastankom biološki aktivnih oksidacionih produkata i drugo.",
publisher = "Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd",
journal = "Engrami",
title = "Omega 3 masne kiseline u psihijatriji - mit i stvarnost, Omega 3 fatty acids in psychiatry: Myth and reality",
pages = "57-44",
number = "1",
volume = "42",
doi = "10.5937/engrami2001044P"
}
Pavlović, D., Pavlović, A. M.,& Đordević, J.. (2020). Omega 3 masne kiseline u psihijatriji - mit i stvarnost. in Engrami
Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd., 42(1), 44-57.
https://doi.org/10.5937/engrami2001044P
Pavlović D, Pavlović AM, Đordević J. Omega 3 masne kiseline u psihijatriji - mit i stvarnost. in Engrami. 2020;42(1):44-57.
doi:10.5937/engrami2001044P .
Pavlović, Dragan, Pavlović, Aleksandra M., Đordević, Jelena, "Omega 3 masne kiseline u psihijatriji - mit i stvarnost" in Engrami, 42, no. 1 (2020):44-57,
https://doi.org/10.5937/engrami2001044P . .
1

Comparison of neurocognition and social cognition between schizophrenia and bipolar disorder

Mihajlović, Goran; Pavlović, Dragan; Živanović, Marko; Đordević, Jelena

(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2018)

TY  - CONF
AU  - Mihajlović, Goran
AU  - Pavlović, Dragan
AU  - Živanović, Marko
AU  - Đordević, Jelena
PY  - 2018
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1152
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
C3  - European Psychiatry
T1  - Comparison of neurocognition and social cognition between schizophrenia and bipolar disorder
EP  - S348
SP  - S348
VL  - 48
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_1152
ER  - 
@conference{
author = "Mihajlović, Goran and Pavlović, Dragan and Živanović, Marko and Đordević, Jelena",
year = "2018",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Psychiatry",
title = "Comparison of neurocognition and social cognition between schizophrenia and bipolar disorder",
pages = "S348-S348",
volume = "48",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_1152"
}
Mihajlović, G., Pavlović, D., Živanović, M.,& Đordević, J.. (2018). Comparison of neurocognition and social cognition between schizophrenia and bipolar disorder. in European Psychiatry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 48, S348-S348.
https://hdl.handle.net/21.15107/rcub_rfasper_1152
Mihajlović G, Pavlović D, Živanović M, Đordević J. Comparison of neurocognition and social cognition between schizophrenia and bipolar disorder. in European Psychiatry. 2018;48:S348-S348.
https://hdl.handle.net/21.15107/rcub_rfasper_1152 .
Mihajlović, Goran, Pavlović, Dragan, Živanović, Marko, Đordević, Jelena, "Comparison of neurocognition and social cognition between schizophrenia and bipolar disorder" in European Psychiatry, 48 (2018):S348-S348,
https://hdl.handle.net/21.15107/rcub_rfasper_1152 .

Psychometric evaluation and validation of the Serbian version of "Reading the Mind in the Eyes" test

Đordević, Jelena; Živanović, Marko; Pavlović, Aleksandra M.; Mihajlović, Goran; Stasević-Karličić, Ivana; Pavlović, Dragan

(Društvo psihologa Srbije, Beograd, 2017)

TY  - JOUR
AU  - Đordević, Jelena
AU  - Živanović, Marko
AU  - Pavlović, Aleksandra M.
AU  - Mihajlović, Goran
AU  - Stasević-Karličić, Ivana
AU  - Pavlović, Dragan
PY  - 2017
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1075
AB  - "Reading the Mind in the Eyes" test (RMET) is one of the most popular and widely used measures of individual differences in Theory of Mind (ToM) capabilities. Despite demonstrating good validity in differentiating various clinical groups exhibiting ToM deficits from unimpaired controls, previous studies raised the question of the RMET's homogeneity, latent structure, and reliability. The aim of this study is to provide evidence on psychometric properties, latent structure, and validity of the newly adapted Serbian version of the RMET. In total, 260 participants (61.9% females) took part in the study. The sample consisted of both unimpaired controls (76.5%), and a clinical group of participants that are believed to demonstrate ToM deficits (23.5%), namely, persons diagnosed with schizophrenia and bipolar disorder (54.1% females). RMET has demonstrated fair psychometric properties (KMO=.723; alpha=.747; H1=.076; H5=.465), successfully differentiating between clinical group and control [F (1,254)=26.175, p  lt . 001, eta(2)(p) =.093], while typical gender differences in performance were found only in control group. Tests of several models based on the previous literature revealed that the affect-specific factors underlying performance on RMET demonstrate poor fit. The best fitting model obtained included reduced scale with a single-factor underlying the test's performance (TLI=.953, CFI=.958, RMSEA=.020). Based on the fit parameters we propose 18-item short-form of the Serbian version of RMET (KMO=.797; alpha=.728; H1=.129; H5=.677) for economic, reliable and valid measurement of ToM abilities.
PB  - Društvo psihologa Srbije, Beograd
T2  - Psihologija
T1  - Psychometric evaluation and validation of the Serbian version of "Reading the Mind in the Eyes" test
EP  - 502
IS  - 4
SP  - 483
VL  - 50
DO  - 10.2298/PSI170504010D
ER  - 
@article{
author = "Đordević, Jelena and Živanović, Marko and Pavlović, Aleksandra M. and Mihajlović, Goran and Stasević-Karličić, Ivana and Pavlović, Dragan",
year = "2017",
abstract = ""Reading the Mind in the Eyes" test (RMET) is one of the most popular and widely used measures of individual differences in Theory of Mind (ToM) capabilities. Despite demonstrating good validity in differentiating various clinical groups exhibiting ToM deficits from unimpaired controls, previous studies raised the question of the RMET's homogeneity, latent structure, and reliability. The aim of this study is to provide evidence on psychometric properties, latent structure, and validity of the newly adapted Serbian version of the RMET. In total, 260 participants (61.9% females) took part in the study. The sample consisted of both unimpaired controls (76.5%), and a clinical group of participants that are believed to demonstrate ToM deficits (23.5%), namely, persons diagnosed with schizophrenia and bipolar disorder (54.1% females). RMET has demonstrated fair psychometric properties (KMO=.723; alpha=.747; H1=.076; H5=.465), successfully differentiating between clinical group and control [F (1,254)=26.175, p  lt . 001, eta(2)(p) =.093], while typical gender differences in performance were found only in control group. Tests of several models based on the previous literature revealed that the affect-specific factors underlying performance on RMET demonstrate poor fit. The best fitting model obtained included reduced scale with a single-factor underlying the test's performance (TLI=.953, CFI=.958, RMSEA=.020). Based on the fit parameters we propose 18-item short-form of the Serbian version of RMET (KMO=.797; alpha=.728; H1=.129; H5=.677) for economic, reliable and valid measurement of ToM abilities.",
publisher = "Društvo psihologa Srbije, Beograd",
journal = "Psihologija",
title = "Psychometric evaluation and validation of the Serbian version of "Reading the Mind in the Eyes" test",
pages = "502-483",
number = "4",
volume = "50",
doi = "10.2298/PSI170504010D"
}
Đordević, J., Živanović, M., Pavlović, A. M., Mihajlović, G., Stasević-Karličić, I.,& Pavlović, D.. (2017). Psychometric evaluation and validation of the Serbian version of "Reading the Mind in the Eyes" test. in Psihologija
Društvo psihologa Srbije, Beograd., 50(4), 483-502.
https://doi.org/10.2298/PSI170504010D
Đordević J, Živanović M, Pavlović AM, Mihajlović G, Stasević-Karličić I, Pavlović D. Psychometric evaluation and validation of the Serbian version of "Reading the Mind in the Eyes" test. in Psihologija. 2017;50(4):483-502.
doi:10.2298/PSI170504010D .
Đordević, Jelena, Živanović, Marko, Pavlović, Aleksandra M., Mihajlović, Goran, Stasević-Karličić, Ivana, Pavlović, Dragan, "Psychometric evaluation and validation of the Serbian version of "Reading the Mind in the Eyes" test" in Psihologija, 50, no. 4 (2017):483-502,
https://doi.org/10.2298/PSI170504010D . .
8
2
7

Specialization of cerebral hemispheres in humans

Đordević, Jelena; Pavlović, Dragan; Mihajlović, Goran; Pavlović, Aleksandra M.

(Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd, 2013)

TY  - JOUR
AU  - Đordević, Jelena
AU  - Pavlović, Dragan
AU  - Mihajlović, Goran
AU  - Pavlović, Aleksandra M.
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/758
AB  - Greek physicians of the Classical Era, considered that right brain hemisphere is specialized in perception, and left for understanding and comprehension. The raise of modern neuroscience intensified studies in differences between hemispheres. The present findings highlight the fact that there is asymmetry of the hemispheres at almost all levels, as well as numerous interhemispheric differences in neuropsychological function. Differences exist in the size and weight of the hemispheres, in the size and shape of the defined areas of the brain, in the in the number and the size of the neurons, in relation to the extent of branching of dendrites within the area and in the structure of the gray and white matter .There are also considerable differences in relation to the dopaminergic and noradrenergic transmission. All these differences, mostly on histological and physiological level are prerogative for hemispheric functional specialization i.e. assymetry. The left hemisphere is specialized for verbal functions, calculia and skillful learned movements (praxis). The right hemisphere is specialized for processing visual information, such as the perception of complex geometric shapes, facial recognition, observation of non-verbal sounds, performing various spatial functions, tactile perception of complex structures, musical ability, prosody, non-verbal thinking and memory. The left hemisphere is analytical, sequential, and the right is synthetic, holistic. The left hemisphere has more capacity for abstract or impersonal, while the right hemisphere is less prone to abstraction and prioritize the individual. Interhemispheric interaction is a very important function. Corpus callosum allows functional independence of the hemispheres, but also the integration, contributing to the wholeness of our perception of the world and our adaptive behaviors.
AB  - Grčki lekari antičkog doba smatrali su da je desna hemisfera mozga specijalizovana za percepciju, a leva za shvatanje i razumevanje. Tokom razvoja moderne neuronauke povećan je broj studija o razlikama između hemisfera. Sadašnji nalazi ističu činjenicu da postoji asimetrija hemisfera na gotovo svim nivoima, kao i brojne interhemisfene razlike u neuropsihološkim funkcijama. Razlike postoje u veličini i težini hemisfera, veličini i obliku definisanih area mozga, u broju i veličini neurona, u odnosu na opseg grananja dendrita unutar područja i u strukturi sive i bele mase. Postoje, takođe, značajne razlike u dopaminergičkoj i noradrenergičkoj transmisiji. Sve ove razlike, uglavnom na histološkom i fiziološkom nivou su neophodne za funkcionalnu specijalizaciju menisfera, tj asimetriju. Leva hemisfera je specijalizovana za verbalne funkcije, računanje i vešte naučene pokrete (praksija). Desna hemisfera je specijalizovana za obradu vizuelnih informacija, kao što su percepcije složenih geometrijskih oblika, prepoznavanje lica, percepciju neverbalnih zvukova, različite spacijalne funkcije, taktilnu percepciju složenih struktura, muzičke sposobnosti, prozodiju, neverbalno razmišljanje i memoriju. Leva hemisfera je analitička, sekvencijalna, dok je desna sintetička, holistička. Leva hemisfera ima više kapaciteta za apstraktno ili bezlično, a desna hemisfera je manje sklona apstrakciji i prioritet daje ličnom. Interhemisferična interakcija je veoma važna. Korpus kalozum omogucćava funkcionalnu nezavisnost hemisfera, ali i integraciju, doprinoseći celovitosti naše percepcije sveta i adaptivnom ponašanju.
PB  - Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd
T2  - Engrami
T1  - Specialization of cerebral hemispheres in humans
T1  - Specijalizacija moždanih hemisfera
EP  - 70
IS  - 3-4
SP  - 63
VL  - 35
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_758
ER  - 
@article{
author = "Đordević, Jelena and Pavlović, Dragan and Mihajlović, Goran and Pavlović, Aleksandra M.",
year = "2013",
abstract = "Greek physicians of the Classical Era, considered that right brain hemisphere is specialized in perception, and left for understanding and comprehension. The raise of modern neuroscience intensified studies in differences between hemispheres. The present findings highlight the fact that there is asymmetry of the hemispheres at almost all levels, as well as numerous interhemispheric differences in neuropsychological function. Differences exist in the size and weight of the hemispheres, in the size and shape of the defined areas of the brain, in the in the number and the size of the neurons, in relation to the extent of branching of dendrites within the area and in the structure of the gray and white matter .There are also considerable differences in relation to the dopaminergic and noradrenergic transmission. All these differences, mostly on histological and physiological level are prerogative for hemispheric functional specialization i.e. assymetry. The left hemisphere is specialized for verbal functions, calculia and skillful learned movements (praxis). The right hemisphere is specialized for processing visual information, such as the perception of complex geometric shapes, facial recognition, observation of non-verbal sounds, performing various spatial functions, tactile perception of complex structures, musical ability, prosody, non-verbal thinking and memory. The left hemisphere is analytical, sequential, and the right is synthetic, holistic. The left hemisphere has more capacity for abstract or impersonal, while the right hemisphere is less prone to abstraction and prioritize the individual. Interhemispheric interaction is a very important function. Corpus callosum allows functional independence of the hemispheres, but also the integration, contributing to the wholeness of our perception of the world and our adaptive behaviors., Grčki lekari antičkog doba smatrali su da je desna hemisfera mozga specijalizovana za percepciju, a leva za shvatanje i razumevanje. Tokom razvoja moderne neuronauke povećan je broj studija o razlikama između hemisfera. Sadašnji nalazi ističu činjenicu da postoji asimetrija hemisfera na gotovo svim nivoima, kao i brojne interhemisfene razlike u neuropsihološkim funkcijama. Razlike postoje u veličini i težini hemisfera, veličini i obliku definisanih area mozga, u broju i veličini neurona, u odnosu na opseg grananja dendrita unutar područja i u strukturi sive i bele mase. Postoje, takođe, značajne razlike u dopaminergičkoj i noradrenergičkoj transmisiji. Sve ove razlike, uglavnom na histološkom i fiziološkom nivou su neophodne za funkcionalnu specijalizaciju menisfera, tj asimetriju. Leva hemisfera je specijalizovana za verbalne funkcije, računanje i vešte naučene pokrete (praksija). Desna hemisfera je specijalizovana za obradu vizuelnih informacija, kao što su percepcije složenih geometrijskih oblika, prepoznavanje lica, percepciju neverbalnih zvukova, različite spacijalne funkcije, taktilnu percepciju složenih struktura, muzičke sposobnosti, prozodiju, neverbalno razmišljanje i memoriju. Leva hemisfera je analitička, sekvencijalna, dok je desna sintetička, holistička. Leva hemisfera ima više kapaciteta za apstraktno ili bezlično, a desna hemisfera je manje sklona apstrakciji i prioritet daje ličnom. Interhemisferična interakcija je veoma važna. Korpus kalozum omogucćava funkcionalnu nezavisnost hemisfera, ali i integraciju, doprinoseći celovitosti naše percepcije sveta i adaptivnom ponašanju.",
publisher = "Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd",
journal = "Engrami",
title = "Specialization of cerebral hemispheres in humans, Specijalizacija moždanih hemisfera",
pages = "70-63",
number = "3-4",
volume = "35",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_758"
}
Đordević, J., Pavlović, D., Mihajlović, G.,& Pavlović, A. M.. (2013). Specialization of cerebral hemispheres in humans. in Engrami
Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd., 35(3-4), 63-70.
https://hdl.handle.net/21.15107/rcub_rfasper_758
Đordević J, Pavlović D, Mihajlović G, Pavlović AM. Specialization of cerebral hemispheres in humans. in Engrami. 2013;35(3-4):63-70.
https://hdl.handle.net/21.15107/rcub_rfasper_758 .
Đordević, Jelena, Pavlović, Dragan, Mihajlović, Goran, Pavlović, Aleksandra M., "Specialization of cerebral hemispheres in humans" in Engrami, 35, no. 3-4 (2013):63-70,
https://hdl.handle.net/21.15107/rcub_rfasper_758 .

Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology

Pavlović, Dragan; Pavlović, Aleksandra M.; Totić-Poznanović, Sanja; Božić, Marija M.; Đordević, Jelena

(Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd, 2013)

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
AU  - Totić-Poznanović, Sanja
AU  - Božić, Marija M.
AU  - Đordević, Jelena
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/714
AB  - Vitamin A is a liposoluble vitamin essential for brain function and vision, and is obtained only through food as retinol or as carotenoids. The active metabolite is retinoic acid (RA), which participates in cognitive processes in the hippocampus, particularly in learning and spatial functions as well as in neurogenesis. Retinoic acid is essential for the vision and the maintenance of the cornea, biological rhythms, mucosa defense against infections and regulation of many genes (one sixth of the human genome). In animal models, vitamin A deficiency shows changes that resemble neurodegeneration, and RA levels in the plasma and cerebrospinal fluid of patients with Alzheimer's disease are reduced. There is also a complex relationship between RA and affective disorders, schizophrenia, autism, Parkinson's disease and stroke. In developing countries hypovitaminosis A is one of the leading causes of death and blindness in children, while in developed countries the symptoms are less noticeable. The damage of the cornea and night blindness are the consequences of hypovitaminosis, and there is a possible association of RA and glaucoma, macular degeneration and other eye diseases. A variety of infections can occur and can be deadly. The most efficient use of vitamin A is in the prophylactic purposes in the population at risk, especially pregnant women and infants in developing countries, while the results in the treatment of neurodegenerative and psychiatric diseases are controversial. Excessive doses of vitamin A can lead to hypervitaminosis with bone, gastrointestinal, psychiatric and neurological manifestations. New studies should demonstrate the most appropriate place of vitamin A in the treatment of neuropsychiatric diseases.
AB  - Vitamin A je liposolubilni vitamin neophodan za rad mozga i za vid, a unosi se isključivo putem hrane kao retinol ili u vidu karotenoida. Aktivni metabolit je retinočka kiselina (RA) koja učestvuje u kognitivnim procesima u hipokampusu, naročito u učenju i specijalnim funkcijama i neurogenezi u hipotalamusu. Retiočna kiselina je neophodna za vid, održavanje kornee, za biološke ritmove, odbranu sluznica od infekcija i regulaciju mnogih gena (šestina humanog genoma). U animalnim modelima nedostatak vitamina A daje promene koje liče na neurodegeneraciju, a nivo retinoičke kiseline u plazmi i cerebrospinalnoj tečnosti obolelih od Alchajmerove bolesti je snižen. Takođe postoji složena veza RA i afektivnih poremećaja, shizofrenije, autizma, Parkinsonove bolesti i moždanog udara. U nerazvijenim zemljama je hipovitaminoza A jedan od vodećih uzroka smrtnosti i slepila kod dece, dok su u razvijenijim zemljama simptomi manje uočljivi. Nastaje oštećenje kornee, noćno slepilo, a moguć je udeo RA i u glaukomu, makularnoj degeneraciji kao i drugim očnim bolestima. Nastupaju razne infekcije koje mogu biti i smrtonosne. Najefikasnija primena vitamina A je u profilaktičke svrhe kod stanovništva u riziku, posebno trudnica i odojčadi u nerazvijenim zemljama, dok su rezultati u lečenju neurodegenerativnih i psihijatrijskih bolesti kontroverzni. Preterane doze vitamina A mogu da dovedu do hipervitaminoze sa koštanim, gastrointestinalnim, psihijatrijskim i neurološkim ispoljavanjima. Nove studije treba da pokažu najadekvatnije mesto vitamina A u terapiji neuropsihijatrijskih bolesti.
PB  - Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd
T2  - Engrami
T1  - Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology
T1  - Pogled u mozak - vitamin A u neuropsihijatriji i oftalmologiji
EP  - 89
IS  - 1-2
SP  - 81
VL  - 35
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_714
ER  - 
@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M. and Totić-Poznanović, Sanja and Božić, Marija M. and Đordević, Jelena",
year = "2013",
abstract = "Vitamin A is a liposoluble vitamin essential for brain function and vision, and is obtained only through food as retinol or as carotenoids. The active metabolite is retinoic acid (RA), which participates in cognitive processes in the hippocampus, particularly in learning and spatial functions as well as in neurogenesis. Retinoic acid is essential for the vision and the maintenance of the cornea, biological rhythms, mucosa defense against infections and regulation of many genes (one sixth of the human genome). In animal models, vitamin A deficiency shows changes that resemble neurodegeneration, and RA levels in the plasma and cerebrospinal fluid of patients with Alzheimer's disease are reduced. There is also a complex relationship between RA and affective disorders, schizophrenia, autism, Parkinson's disease and stroke. In developing countries hypovitaminosis A is one of the leading causes of death and blindness in children, while in developed countries the symptoms are less noticeable. The damage of the cornea and night blindness are the consequences of hypovitaminosis, and there is a possible association of RA and glaucoma, macular degeneration and other eye diseases. A variety of infections can occur and can be deadly. The most efficient use of vitamin A is in the prophylactic purposes in the population at risk, especially pregnant women and infants in developing countries, while the results in the treatment of neurodegenerative and psychiatric diseases are controversial. Excessive doses of vitamin A can lead to hypervitaminosis with bone, gastrointestinal, psychiatric and neurological manifestations. New studies should demonstrate the most appropriate place of vitamin A in the treatment of neuropsychiatric diseases., Vitamin A je liposolubilni vitamin neophodan za rad mozga i za vid, a unosi se isključivo putem hrane kao retinol ili u vidu karotenoida. Aktivni metabolit je retinočka kiselina (RA) koja učestvuje u kognitivnim procesima u hipokampusu, naročito u učenju i specijalnim funkcijama i neurogenezi u hipotalamusu. Retiočna kiselina je neophodna za vid, održavanje kornee, za biološke ritmove, odbranu sluznica od infekcija i regulaciju mnogih gena (šestina humanog genoma). U animalnim modelima nedostatak vitamina A daje promene koje liče na neurodegeneraciju, a nivo retinoičke kiseline u plazmi i cerebrospinalnoj tečnosti obolelih od Alchajmerove bolesti je snižen. Takođe postoji složena veza RA i afektivnih poremećaja, shizofrenije, autizma, Parkinsonove bolesti i moždanog udara. U nerazvijenim zemljama je hipovitaminoza A jedan od vodećih uzroka smrtnosti i slepila kod dece, dok su u razvijenijim zemljama simptomi manje uočljivi. Nastaje oštećenje kornee, noćno slepilo, a moguć je udeo RA i u glaukomu, makularnoj degeneraciji kao i drugim očnim bolestima. Nastupaju razne infekcije koje mogu biti i smrtonosne. Najefikasnija primena vitamina A je u profilaktičke svrhe kod stanovništva u riziku, posebno trudnica i odojčadi u nerazvijenim zemljama, dok su rezultati u lečenju neurodegenerativnih i psihijatrijskih bolesti kontroverzni. Preterane doze vitamina A mogu da dovedu do hipervitaminoze sa koštanim, gastrointestinalnim, psihijatrijskim i neurološkim ispoljavanjima. Nove studije treba da pokažu najadekvatnije mesto vitamina A u terapiji neuropsihijatrijskih bolesti.",
publisher = "Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd",
journal = "Engrami",
title = "Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology, Pogled u mozak - vitamin A u neuropsihijatriji i oftalmologiji",
pages = "89-81",
number = "1-2",
volume = "35",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_714"
}
Pavlović, D., Pavlović, A. M., Totić-Poznanović, S., Božić, M. M.,& Đordević, J.. (2013). Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology. in Engrami
Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd., 35(1-2), 81-89.
https://hdl.handle.net/21.15107/rcub_rfasper_714
Pavlović D, Pavlović AM, Totić-Poznanović S, Božić MM, Đordević J. Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology. in Engrami. 2013;35(1-2):81-89.
https://hdl.handle.net/21.15107/rcub_rfasper_714 .
Pavlović, Dragan, Pavlović, Aleksandra M., Totić-Poznanović, Sanja, Božić, Marija M., Đordević, Jelena, "Insights into human brain: Vitamin A in neuropsychiatry and ophtalmology" in Engrami, 35, no. 1-2 (2013):81-89,
https://hdl.handle.net/21.15107/rcub_rfasper_714 .