@article{
author = "Stevanović, Aleksandar and Stefanović, Anja and Stojanovski, Nataša and Tomić, Gordana and Zidverc-Trajković, Jasna and Pavlović, Aleksandra",
year = "2019",
abstract = "Introduction. Cerebral small vessel disease is a neurological con-
dition characterized by motor, cognitive and affective disorders,
often found on brain magnetic resonance imaging scans in patients
with vascular risk factors. Affective disorders may have a major
impact on patients’ quality of life, although they are often ignored
as an entity in cerebrovascular pathology. Material and Methods.
This prospective study included 80 patients with the diagnosis of
cerebral small vessel disease admitted at the Clinic of Neurology,
Clinical Center of Serbia in the period from January 1, 2017 to
January 1, 2019. Baseline demographic data and brain magnetic
resonance findings were obtained along with the results of cogni-
tive function and affective status tests. Data were analyzed using
standard statistical tests. Results. Standard screening tests revealed
that 51.25% and 33.75% of our patients with cerebral small vessel
disease suffer from apathy and depression, respectively. A sig-
nificant correlation was found between the severity of white mat-
ter changes on magnetic resonance scans and apathy (p = 0.0092).
Additionally, white matter changes were also significantly associ-
ated with depression (p = 0.021). Conclusion. Affective disorders
are not uncommon in cerebral small vessel disease and apathy was
the leading phenomenon among our patients. Since a strong cor-
relation was detected between affective disorders and severity of
vascular changes on magnetic resonance scans, we may conclude
that both apathy and depression are key features of an underlying
brain injury, rather than just comorbidity., Uvod. Bolest malih krvnih sudova mozga je neurološko stanje za
koje su karakteristični motorni, kognitivni i afektivni poremećaji i
koje se često dijagnostikuje na snimcima mozga magnetnom rezo-
nancijom kod pacijenata sa vaskularnim faktorima rizika. Promene
u afektivnom statusu imaju veliki uticaj na kvalitet života pacijena-
ta iako su neretko bile zanemaren fenomen u cerebrovaskularnoj
patologiji. Materijal i metode. U prospektivnoj studiji obuhvaćeno
je 80 pacijenata sa dijagnozom bolest malih krvnih sudova mozga
lečenih i ispitivanih na Klinici za neurologiju Kliničkog centra Sr-
bije, u periodu od 1. januara 2017. godine do 1. januara 2019. godine.
Analizirani su osnovni demografski podaci, nalaz na magnetnoj
rezonanciji mozga i rezultati testova kognitivnih funkcija i afektiv-
nog statusa, upotrebom standardnih statističkih metoda. Rezultati.
Rezultati testova za apatiju i depresiju ukazali su da je 51,25% bo-
lesnika sa ovom bolešću pokazivalo prisustvo apatije, a 33,75%
prisustvo depresivnog poremećaja. Dokazana je statistički značajna
povezanost između težine lezija bele mase mozga na magnetnore-
zonantnim snimcima mozga i apatije (p = 0,0092), odnosno težine
lezija bele mase i depresije (p = 0,021). Zaključak. Izmene afektiv-
nog statusa nisu retka manifestacija cerebralne bolesti malih krvnih
sudova mozga, a najčešći fenomen u našoj grupi bolesnika bila je
apatija. Budući da je detektovana značajna povezanost između afek-
tivnih poremaćaja i težine vaskularnih lezija na magnetno-rezonan-
tnim snimcima mozga, smatramo da su apatija i depresivnost najpre
deo kliničke slike ove bolesti a ne jedan od komorbiditeta.",
publisher = "Society of Physicians of Vojvodina of the Medical Society of Serbia",
journal = "Medicinski pregled",
title = "Affective status in cerebral small vessel disease, Afektivni status kod bolesti malih krvnih sudova mozga",
pages = "285-280",
number = "9-10",
volume = "72",
doi = "10.2298/MPNS1910280S"
}
