Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease
Апстракт
Alzheimer's disease (AD), the most prevalent dementia, is characterized not only by cognitive but also behavior- al changes that pose the heaviest burden to caregivers. Differences in the clinical picture depending on the time of disease onset have been observed. We correlated cognitive and behavioral deficits in patients with presenile- and senile-onset AD to explore the differences. We tested 60 AD patients, 19 male and 41 female, mean age 65.2 years with the Dementia Behavior Disturbance Scale (DBD) and a standard neuropsychological battery. The patients were divided according to their DBD score into two groups: group I - score 0-2 (n=24; 40%), group II - score 3≥ (n=36; 60%), comparable in disease duration and neurological findings. The cognitive scores were significantly higher in the group with less behavioral changes than in the group with more behavioral changes: Mini Mental State Examination score (p=0.0015), serial subtraction (p=0.0009), block design (p=0.0049), copy of comp...lex figure (p=0.0125), complex visual organization (p=0.0099), divided attention, visual memory and speech comprehension. A significantly higher frequency of behavioral disturbances was registered in patients with senile onset than in the presenile-onset group (p lt 0.005). There were no sex differences. Our data show a correlation between cognitive decline and behavioral changes in late onset AD patients, indicating that more behavioral disturbances were associated with a more severe degree of cognitive decline, especially in non-verbal functions and attention deficits, compared to early onset patients.
Кључне речи:
Alzheimer's disease / senile onset / behavior / cognitionИзвор:
Archives of Biological Sciences, 2013, 65, 3, 1141-1147Издавач:
- Srpsko biološko društvo, Beograd, i dr.
Финансирање / пројекти:
- Неуроендокрина контрола секреције хормона раста код човека - нови изазови. Контрола енергетске хомеостазе код човека у различитим патолошким стањима. Клиничко-патолошка корелација и генетска основа тумора хипофизе и неуроендокриних тумора (RS-MESTD-Basic Research (BR or ON)-175033)
- Депресија изазвана васкуларним болестима мозга: примена неуровизуализационих метода у превенцији, раном откривању и лечењу (RS-MESTD-Basic Research (BR or ON)-175022)
DOI: 10.2298/ABS1303141P
ISSN: 0354-4664
WoS: 000322348800039
Scopus: 2-s2.0-84882609186
Институција/група
rFASPERTY - JOUR AU - Pavlović, Dragan AU - Pavlović, Aleksandra M. AU - Lačković, Maja PY - 2013 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/692 AB - Alzheimer's disease (AD), the most prevalent dementia, is characterized not only by cognitive but also behavior- al changes that pose the heaviest burden to caregivers. Differences in the clinical picture depending on the time of disease onset have been observed. We correlated cognitive and behavioral deficits in patients with presenile- and senile-onset AD to explore the differences. We tested 60 AD patients, 19 male and 41 female, mean age 65.2 years with the Dementia Behavior Disturbance Scale (DBD) and a standard neuropsychological battery. The patients were divided according to their DBD score into two groups: group I - score 0-2 (n=24; 40%), group II - score 3≥ (n=36; 60%), comparable in disease duration and neurological findings. The cognitive scores were significantly higher in the group with less behavioral changes than in the group with more behavioral changes: Mini Mental State Examination score (p=0.0015), serial subtraction (p=0.0009), block design (p=0.0049), copy of complex figure (p=0.0125), complex visual organization (p=0.0099), divided attention, visual memory and speech comprehension. A significantly higher frequency of behavioral disturbances was registered in patients with senile onset than in the presenile-onset group (p lt 0.005). There were no sex differences. Our data show a correlation between cognitive decline and behavioral changes in late onset AD patients, indicating that more behavioral disturbances were associated with a more severe degree of cognitive decline, especially in non-verbal functions and attention deficits, compared to early onset patients. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease EP - 1147 IS - 3 SP - 1141 VL - 65 DO - 10.2298/ABS1303141P ER -
@article{ author = "Pavlović, Dragan and Pavlović, Aleksandra M. and Lačković, Maja", year = "2013", abstract = "Alzheimer's disease (AD), the most prevalent dementia, is characterized not only by cognitive but also behavior- al changes that pose the heaviest burden to caregivers. Differences in the clinical picture depending on the time of disease onset have been observed. We correlated cognitive and behavioral deficits in patients with presenile- and senile-onset AD to explore the differences. We tested 60 AD patients, 19 male and 41 female, mean age 65.2 years with the Dementia Behavior Disturbance Scale (DBD) and a standard neuropsychological battery. The patients were divided according to their DBD score into two groups: group I - score 0-2 (n=24; 40%), group II - score 3≥ (n=36; 60%), comparable in disease duration and neurological findings. The cognitive scores were significantly higher in the group with less behavioral changes than in the group with more behavioral changes: Mini Mental State Examination score (p=0.0015), serial subtraction (p=0.0009), block design (p=0.0049), copy of complex figure (p=0.0125), complex visual organization (p=0.0099), divided attention, visual memory and speech comprehension. A significantly higher frequency of behavioral disturbances was registered in patients with senile onset than in the presenile-onset group (p lt 0.005). There were no sex differences. Our data show a correlation between cognitive decline and behavioral changes in late onset AD patients, indicating that more behavioral disturbances were associated with a more severe degree of cognitive decline, especially in non-verbal functions and attention deficits, compared to early onset patients.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease", pages = "1147-1141", number = "3", volume = "65", doi = "10.2298/ABS1303141P" }
Pavlović, D., Pavlović, A. M.,& Lačković, M.. (2013). Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 65(3), 1141-1147. https://doi.org/10.2298/ABS1303141P
Pavlović D, Pavlović AM, Lačković M. Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease. in Archives of Biological Sciences. 2013;65(3):1141-1147. doi:10.2298/ABS1303141P .
Pavlović, Dragan, Pavlović, Aleksandra M., Lačković, Maja, "Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease" in Archives of Biological Sciences, 65, no. 3 (2013):1141-1147, https://doi.org/10.2298/ABS1303141P . .