TY  - CONF
AU  - Mitrović, Aleksandra
AU  - Stamenković, Dragomir
AU  - Popović, Dejana
AU  - Dragićević, Aleksandra
PY  - 2020
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1296
AB  - Hydrogels have peculiar physical and chemical properties and therefore, are used in a variety of biomedical applications including drug delivery agents, prosthetic devices, the repair and replacement of soft tissues, contact lenses, etc. Consequently, investigation of mechanical, physical and chemical properties is crucial in biomedical application of hydrogels. Poly (2-hydroxyethyl methacrylate) (pHEMA), as a biocompatible hydrogel, was first hydrogel used for making soft contact lenses. Many researches have been modified pHEMA with the aim of improving its properties. Application of nanotechnology is one of the possible solutions for improving the characteristics of this biocompatible hydrogel. In this paper, polyhydroxyethyl methacrylate was used as standard material for soft contact lenses (SL 38). This material was incorporated with fullerene C-60 (SL38-A), fullerol C-60(OH)(24) (SL 38-B) and fullerene metformin hydroxylate C-60(OH)(12)(OC4N5H10)(12) (SL 38-C), respectively. Three new nanophotonic soft contact lenses were made. The main goal of this research was to develop appropriate process parameters for soft contact lens micro-turning. Also, studying the thermal decomposition of standard soft contact lens, pHEMA, as well as three new nanophotonic soft contact lenses was one of the main objectives. Results have shown that manufacturing process of nanofotonic soft contact lens is considered to be a micro-turning process regarding the cutting depth and tool nose ratio. Thermal stability of all three nanofotonic soft contact lenses was significantly improved comparing to the standard soft contact lens. Still, further research needs to be done so these nonophotonic soft contact lenses could find practical application in the field of biomedical engineering.
PB  - Springer International Publishing Ag, Cham
C3  - Computational and Experimental Approaches in Materials Science and Engineering, CNNTECH 2019
T1  - Manufacturing Process and Thermal Stability of Nanophotonic Soft Contact Lenses
EP  - 199
SP  - 184
VL  - 90
DO  - 10.1007/978-3-030-30853-7_11
ER  - 

@conference{
author = "Mitrović, Aleksandra and Stamenković, Dragomir and Popović, Dejana and Dragićević, Aleksandra",
year = "2020",
abstract = "Hydrogels have peculiar physical and chemical properties and therefore, are used in a variety of biomedical applications including drug delivery agents, prosthetic devices, the repair and replacement of soft tissues, contact lenses, etc. Consequently, investigation of mechanical, physical and chemical properties is crucial in biomedical application of hydrogels. Poly (2-hydroxyethyl methacrylate) (pHEMA), as a biocompatible hydrogel, was first hydrogel used for making soft contact lenses. Many researches have been modified pHEMA with the aim of improving its properties. Application of nanotechnology is one of the possible solutions for improving the characteristics of this biocompatible hydrogel. In this paper, polyhydroxyethyl methacrylate was used as standard material for soft contact lenses (SL 38). This material was incorporated with fullerene C-60 (SL38-A), fullerol C-60(OH)(24) (SL 38-B) and fullerene metformin hydroxylate C-60(OH)(12)(OC4N5H10)(12) (SL 38-C), respectively. Three new nanophotonic soft contact lenses were made. The main goal of this research was to develop appropriate process parameters for soft contact lens micro-turning. Also, studying the thermal decomposition of standard soft contact lens, pHEMA, as well as three new nanophotonic soft contact lenses was one of the main objectives. Results have shown that manufacturing process of nanofotonic soft contact lens is considered to be a micro-turning process regarding the cutting depth and tool nose ratio. Thermal stability of all three nanofotonic soft contact lenses was significantly improved comparing to the standard soft contact lens. Still, further research needs to be done so these nonophotonic soft contact lenses could find practical application in the field of biomedical engineering.",
publisher = "Springer International Publishing Ag, Cham",
journal = "Computational and Experimental Approaches in Materials Science and Engineering, CNNTECH 2019",
title = "Manufacturing Process and Thermal Stability of Nanophotonic Soft Contact Lenses",
pages = "199-184",
volume = "90",
doi = "10.1007/978-3-030-30853-7_11"
}

Mitrović, A., Stamenković, D., Popović, D.,& Dragićević, A.. (2020). Manufacturing Process and Thermal Stability of Nanophotonic Soft Contact Lenses. in Computational and Experimental Approaches in Materials Science and Engineering, CNNTECH 2019
Springer International Publishing Ag, Cham., 90, 184-199.
https://doi.org/10.1007/978-3-030-30853-7_11

Mitrović A, Stamenković D, Popović D, Dragićević A. Manufacturing Process and Thermal Stability of Nanophotonic Soft Contact Lenses. in Computational and Experimental Approaches in Materials Science and Engineering, CNNTECH 2019. 2020;90:184-199.
doi:10.1007/978-3-030-30853-7_11 .

Mitrović, Aleksandra, Stamenković, Dragomir, Popović, Dejana, Dragićević, Aleksandra, "Manufacturing Process and Thermal Stability of Nanophotonic Soft Contact Lenses" in Computational and Experimental Approaches in Materials Science and Engineering, CNNTECH 2019, 90 (2020):184-199,
https://doi.org/10.1007/978-3-030-30853-7_11 . .

TY  - JOUR
AU  - Stamenković, Miroslav
AU  - Lukić, Vesna
AU  - Šuvakov, Sonja
AU  - Simić, Tatjana
AU  - Senćanić, Ivan
AU  - Plješa-Ercegovac, Marija
AU  - Jakšić, Vesna
AU  - Babović, Siniša
AU  - Matić, Marija
AU  - Radosavljević, Aleksandra
AU  - Savić-Radojević, Ana
AU  - Đukić, Tatjana
PY  - 2018
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1157
AB  - AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.
PB  - IJO Press, Xi An
T2  - International Journal of Ophthalmology
T1  - GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers
EP  - 1520
IS  - 9
SP  - 1514
VL  - 11
DO  - 10.18240/ijo.2018.09.14
ER  - 

@article{
author = "Stamenković, Miroslav and Lukić, Vesna and Šuvakov, Sonja and Simić, Tatjana and Senćanić, Ivan and Plješa-Ercegovac, Marija and Jakšić, Vesna and Babović, Siniša and Matić, Marija and Radosavljević, Aleksandra and Savić-Radojević, Ana and Đukić, Tatjana",
year = "2018",
abstract = "AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.",
publisher = "IJO Press, Xi An",
journal = "International Journal of Ophthalmology",
title = "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers",
pages = "1520-1514",
number = "9",
volume = "11",
doi = "10.18240/ijo.2018.09.14"
}

Stamenković, M., Lukić, V., Šuvakov, S., Simić, T., Senćanić, I., Plješa-Ercegovac, M., Jakšić, V., Babović, S., Matić, M., Radosavljević, A., Savić-Radojević, A.,& Đukić, T.. (2018). GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology
IJO Press, Xi An., 11(9), 1514-1520.
https://doi.org/10.18240/ijo.2018.09.14

Stamenković M, Lukić V, Šuvakov S, Simić T, Senćanić I, Plješa-Ercegovac M, Jakšić V, Babović S, Matić M, Radosavljević A, Savić-Radojević A, Đukić T. GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology. 2018;11(9):1514-1520.
doi:10.18240/ijo.2018.09.14 .

Stamenković, Miroslav, Lukić, Vesna, Šuvakov, Sonja, Simić, Tatjana, Senćanić, Ivan, Plješa-Ercegovac, Marija, Jakšić, Vesna, Babović, Siniša, Matić, Marija, Radosavljević, Aleksandra, Savić-Radojević, Ana, Đukić, Tatjana, "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers" in International Journal of Ophthalmology, 11, no. 9 (2018):1514-1520,
https://doi.org/10.18240/ijo.2018.09.14 . .

TY  - JOUR
AU  - Stamenković, Miroslav
AU  - Radić, Tanja
AU  - Stefanović, Ivan
AU  - Corić, Vesna
AU  - Senćanić, Ivan
AU  - Plješa-Ercegovac, Marija
AU  - Matić, Marija
AU  - Jakšić, Vesna
AU  - Simić, Tatjana
AU  - Savić-Radojević, Ana
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/868
AB  - Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical and Experimental Ophthalmology
T1  - Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation
EP  - 283
IS  - 3
SP  - 277
VL  - 42
DO  - 10.1111/ceo.12180
ER  - 

@article{
author = "Stamenković, Miroslav and Radić, Tanja and Stefanović, Ivan and Corić, Vesna and Senćanić, Ivan and Plješa-Ercegovac, Marija and Matić, Marija and Jakšić, Vesna and Simić, Tatjana and Savić-Radojević, Ana",
year = "2014",
abstract = "Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical and Experimental Ophthalmology",
title = "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation",
pages = "283-277",
number = "3",
volume = "42",
doi = "10.1111/ceo.12180"
}

Stamenković, M., Radić, T., Stefanović, I., Corić, V., Senćanić, I., Plješa-Ercegovac, M., Matić, M., Jakšić, V., Simić, T.,& Savić-Radojević, A.. (2014). Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology
Wiley-Blackwell, Hoboken., 42(3), 277-283.
https://doi.org/10.1111/ceo.12180

Stamenković M, Radić T, Stefanović I, Corić V, Senćanić I, Plješa-Ercegovac M, Matić M, Jakšić V, Simić T, Savić-Radojević A. Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology. 2014;42(3):277-283.
doi:10.1111/ceo.12180 .

Stamenković, Miroslav, Radić, Tanja, Stefanović, Ivan, Corić, Vesna, Senćanić, Ivan, Plješa-Ercegovac, Marija, Matić, Marija, Jakšić, Vesna, Simić, Tatjana, Savić-Radojević, Ana, "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation" in Clinical and Experimental Ophthalmology, 42, no. 3 (2014):277-283,
https://doi.org/10.1111/ceo.12180 . .

TY  - JOUR
AU  - Tomić, Marija M.
AU  - Conte, Manuel
AU  - Munćan, Jelena S.
AU  - Stamenković, Dragomir
AU  - Koruga, Đuro Lj.
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/855
AB  - Contact lenses represent biomaterials whose main purpose is to correct the specific refractive anomaly of the eye. Since the visible light on its way to the perceptive part of the eye has to pass through the contact lens, the characteristics of the materials can significantly modify it. Biocompatibility of the lens surface is one of the most important issues in achieving contact lens wear without problems. We have developed new nanophotonic contact lens materials by adding nanoparticles of fullerene and their derivatives into standard PMMA RGP material. The aim of our investigation was to compare the influences of these materials on saline which is similar to tear film. We used NIR spectroscopy based on 12 vibration modes, called Aquaphotomics and Opto-magnetic imaging (OMI) spectroscopy as methods for characterizing the samples. The acquired spectrums were commented and compared with the standard contact lens material, which was analyzed by the same method.
AB  - Kontaktna sočiva predstavljaju biomaterijale čija je glavna svrha ispravljanje specifičnih refraktivnih anomalija oka. S obzirom da vidljiva svetlost na svom putu do perceptivnog dela oka mora da prođe kroz kontaktno sočivo, karakteristike materijala mogu značajno da je izmene. Biokompatibilnost površine sočiva je jedno od najvažnijih pitanja u postizanju nošenja kontaktnih sočiva bez problema. Razvijeni su novi nanofotonični materijali za kontaktna sočiva dodavanjem nanočestica fulerena i njihovih derivata u standardni PMMA materijal za tvrda gas propusna kontaktna sočiva. Cilj našeg istraživanja je bilo poređenje uticaja ovih materijala na fiziološki rastvor koji je sličan suznom filmu. Za karakterizaciju uzoraka koristili smo blisku infracrvenu spektroskopiju zasnovanu na 12 vibracionih modova, poznatiju kao Akvafotomika. Dobijeni spektri su komentarisani i upoređeni sa standardnim materijalom za kontaktna sočiva, koji je analiziran istom metodom.
PB  - Univerzitet u Beogradu - Mašinski fakultet, Beograd
T2  - FME Transactions
T1  - Investigation of influence of nanophotonic gas permeable contact lenses on saline by aquaphotomics and OMI spectroscopy
T1  - Ispitivanje uticaja nanofotoničnih tvrdih gaspropusnih kontaktnih sočiva na fiziološki rastvor akvafotomikom i opto-magnetnom imidžing spektroskopijom
EP  - 87
IS  - 1
SP  - 82
VL  - 42
DO  - 10.5937/fmet1401084T
ER  - 

@article{
author = "Tomić, Marija M. and Conte, Manuel and Munćan, Jelena S. and Stamenković, Dragomir and Koruga, Đuro Lj.",
year = "2014",
abstract = "Contact lenses represent biomaterials whose main purpose is to correct the specific refractive anomaly of the eye. Since the visible light on its way to the perceptive part of the eye has to pass through the contact lens, the characteristics of the materials can significantly modify it. Biocompatibility of the lens surface is one of the most important issues in achieving contact lens wear without problems. We have developed new nanophotonic contact lens materials by adding nanoparticles of fullerene and their derivatives into standard PMMA RGP material. The aim of our investigation was to compare the influences of these materials on saline which is similar to tear film. We used NIR spectroscopy based on 12 vibration modes, called Aquaphotomics and Opto-magnetic imaging (OMI) spectroscopy as methods for characterizing the samples. The acquired spectrums were commented and compared with the standard contact lens material, which was analyzed by the same method., Kontaktna sočiva predstavljaju biomaterijale čija je glavna svrha ispravljanje specifičnih refraktivnih anomalija oka. S obzirom da vidljiva svetlost na svom putu do perceptivnog dela oka mora da prođe kroz kontaktno sočivo, karakteristike materijala mogu značajno da je izmene. Biokompatibilnost površine sočiva je jedno od najvažnijih pitanja u postizanju nošenja kontaktnih sočiva bez problema. Razvijeni su novi nanofotonični materijali za kontaktna sočiva dodavanjem nanočestica fulerena i njihovih derivata u standardni PMMA materijal za tvrda gas propusna kontaktna sočiva. Cilj našeg istraživanja je bilo poređenje uticaja ovih materijala na fiziološki rastvor koji je sličan suznom filmu. Za karakterizaciju uzoraka koristili smo blisku infracrvenu spektroskopiju zasnovanu na 12 vibracionih modova, poznatiju kao Akvafotomika. Dobijeni spektri su komentarisani i upoređeni sa standardnim materijalom za kontaktna sočiva, koji je analiziran istom metodom.",
publisher = "Univerzitet u Beogradu - Mašinski fakultet, Beograd",
journal = "FME Transactions",
title = "Investigation of influence of nanophotonic gas permeable contact lenses on saline by aquaphotomics and OMI spectroscopy, Ispitivanje uticaja nanofotoničnih tvrdih gaspropusnih kontaktnih sočiva na fiziološki rastvor akvafotomikom i opto-magnetnom imidžing spektroskopijom",
pages = "87-82",
number = "1",
volume = "42",
doi = "10.5937/fmet1401084T"
}

Tomić, M. M., Conte, M., Munćan, J. S., Stamenković, D.,& Koruga, Đ. Lj.. (2014). Investigation of influence of nanophotonic gas permeable contact lenses on saline by aquaphotomics and OMI spectroscopy. in FME Transactions
Univerzitet u Beogradu - Mašinski fakultet, Beograd., 42(1), 82-87.
https://doi.org/10.5937/fmet1401084T

Tomić MM, Conte M, Munćan JS, Stamenković D, Koruga ĐL. Investigation of influence of nanophotonic gas permeable contact lenses on saline by aquaphotomics and OMI spectroscopy. in FME Transactions. 2014;42(1):82-87.
doi:10.5937/fmet1401084T .

Tomić, Marija M., Conte, Manuel, Munćan, Jelena S., Stamenković, Dragomir, Koruga, Đuro Lj., "Investigation of influence of nanophotonic gas permeable contact lenses on saline by aquaphotomics and OMI spectroscopy" in FME Transactions, 42, no. 1 (2014):82-87,
https://doi.org/10.5937/fmet1401084T . .