TY  - JOUR
AU  - Šobot, Vesna
AU  - Stamenković, Miroslav
AU  - Simić, Tatjana
AU  - Jerotić, Đurđa
AU  - Đokic, Milica
AU  - Jakšić, Vesna
AU  - Božić, Marija
AU  - Milić, Jovan
AU  - Savić-Radojević, Ana
AU  - Đukić, Tatjana
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/3947
AB  - It is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression
of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms
in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase
(SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single
nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as
GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102
POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both
GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and
SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni
multiple test correction (OR = 6.66, p = 0.005). The present study supports the hypothesis that in combination,
GSTO1/GSTO2, modulate the risk of primary open angle glaucoma.
PB  - Elsevier
PB  - Academic Press
PB  - International Society for Eye Research
T2  - Experimental Eye Research
T1  - Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma
SP  - 108863
VL  - 2014
DO  - 10.1016/j.exer.2021.108863
ER  - 

@article{
author = "Šobot, Vesna and Stamenković, Miroslav and Simić, Tatjana and Jerotić, Đurđa and Đokic, Milica and Jakšić, Vesna and Božić, Marija and Milić, Jovan and Savić-Radojević, Ana and Đukić, Tatjana",
year = "2022",
abstract = "It is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression
of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms
in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase
(SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single
nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as
GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102
POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both
GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and
SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni
multiple test correction (OR = 6.66, p = 0.005). The present study supports the hypothesis that in combination,
GSTO1/GSTO2, modulate the risk of primary open angle glaucoma.",
publisher = "Elsevier, Academic Press, International Society for Eye Research",
journal = "Experimental Eye Research",
title = "Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma",
pages = "108863",
volume = "2014",
doi = "10.1016/j.exer.2021.108863"
}

Šobot, V., Stamenković, M., Simić, T., Jerotić, Đ., Đokic, M., Jakšić, V., Božić, M., Milić, J., Savić-Radojević, A.,& Đukić, T.. (2022). Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. in Experimental Eye Research
Elsevier., 2014, 108863.
https://doi.org/10.1016/j.exer.2021.108863

Šobot V, Stamenković M, Simić T, Jerotić Đ, Đokic M, Jakšić V, Božić M, Milić J, Savić-Radojević A, Đukić T. Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. in Experimental Eye Research. 2022;2014:108863.
doi:10.1016/j.exer.2021.108863 .

Šobot, Vesna, Stamenković, Miroslav, Simić, Tatjana, Jerotić, Đurđa, Đokic, Milica, Jakšić, Vesna, Božić, Marija, Milić, Jovan, Savić-Radojević, Ana, Đukić, Tatjana, "Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma" in Experimental Eye Research, 2014 (2022):108863,
https://doi.org/10.1016/j.exer.2021.108863 . .

TY  - JOUR
AU  - Stamenković, Miroslav
AU  - Lukić, Vesna
AU  - Šuvakov, Sonja
AU  - Simić, Tatjana
AU  - Senćanić, Ivan
AU  - Plješa-Ercegovac, Marija
AU  - Jakšić, Vesna
AU  - Babović, Siniša
AU  - Matić, Marija
AU  - Radosavljević, Aleksandra
AU  - Savić-Radojević, Ana
AU  - Đukić, Tatjana
PY  - 2018
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1157
AB  - AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.
PB  - IJO Press, Xi An
T2  - International Journal of Ophthalmology
T1  - GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers
EP  - 1520
IS  - 9
SP  - 1514
VL  - 11
DO  - 10.18240/ijo.2018.09.14
ER  - 

@article{
author = "Stamenković, Miroslav and Lukić, Vesna and Šuvakov, Sonja and Simić, Tatjana and Senćanić, Ivan and Plješa-Ercegovac, Marija and Jakšić, Vesna and Babović, Siniša and Matić, Marija and Radosavljević, Aleksandra and Savić-Radojević, Ana and Đukić, Tatjana",
year = "2018",
abstract = "AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.",
publisher = "IJO Press, Xi An",
journal = "International Journal of Ophthalmology",
title = "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers",
pages = "1520-1514",
number = "9",
volume = "11",
doi = "10.18240/ijo.2018.09.14"
}

Stamenković, M., Lukić, V., Šuvakov, S., Simić, T., Senćanić, I., Plješa-Ercegovac, M., Jakšić, V., Babović, S., Matić, M., Radosavljević, A., Savić-Radojević, A.,& Đukić, T.. (2018). GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology
IJO Press, Xi An., 11(9), 1514-1520.
https://doi.org/10.18240/ijo.2018.09.14

Stamenković M, Lukić V, Šuvakov S, Simić T, Senćanić I, Plješa-Ercegovac M, Jakšić V, Babović S, Matić M, Radosavljević A, Savić-Radojević A, Đukić T. GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology. 2018;11(9):1514-1520.
doi:10.18240/ijo.2018.09.14 .

Stamenković, Miroslav, Lukić, Vesna, Šuvakov, Sonja, Simić, Tatjana, Senćanić, Ivan, Plješa-Ercegovac, Marija, Jakšić, Vesna, Babović, Siniša, Matić, Marija, Radosavljević, Aleksandra, Savić-Radojević, Ana, Đukić, Tatjana, "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers" in International Journal of Ophthalmology, 11, no. 9 (2018):1514-1520,
https://doi.org/10.18240/ijo.2018.09.14 . .

TY  - CONF
AU  - Đukić, Tatjana
AU  - Šuvakov, Sonja
AU  - Stamenković, Miroslav
AU  - Senćanić, Ivan
AU  - Smiljić, Jelena
AU  - Plješa-Ercegovac, Marija
AU  - Matić, Marija
AU  - Simić, Tatjana
AU  - Savić-Radojević, Ana
PY  - 2016
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1012
PB  - Elsevier Science Inc, New York
C3  - Free Radical Biology and Medicine
T1  - Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma
EP  - S48
SP  - S48
VL  - 96
DO  - 10.1016/j.freeradbiomed.2016.04.101
ER  - 

@conference{
author = "Đukić, Tatjana and Šuvakov, Sonja and Stamenković, Miroslav and Senćanić, Ivan and Smiljić, Jelena and Plješa-Ercegovac, Marija and Matić, Marija and Simić, Tatjana and Savić-Radojević, Ana",
year = "2016",
publisher = "Elsevier Science Inc, New York",
journal = "Free Radical Biology and Medicine",
title = "Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma",
pages = "S48-S48",
volume = "96",
doi = "10.1016/j.freeradbiomed.2016.04.101"
}

Đukić, T., Šuvakov, S., Stamenković, M., Senćanić, I., Smiljić, J., Plješa-Ercegovac, M., Matić, M., Simić, T.,& Savić-Radojević, A.. (2016). Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma. in Free Radical Biology and Medicine
Elsevier Science Inc, New York., 96, S48-S48.
https://doi.org/10.1016/j.freeradbiomed.2016.04.101

Đukić T, Šuvakov S, Stamenković M, Senćanić I, Smiljić J, Plješa-Ercegovac M, Matić M, Simić T, Savić-Radojević A. Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma. in Free Radical Biology and Medicine. 2016;96:S48-S48.
doi:10.1016/j.freeradbiomed.2016.04.101 .

Đukić, Tatjana, Šuvakov, Sonja, Stamenković, Miroslav, Senćanić, Ivan, Smiljić, Jelena, Plješa-Ercegovac, Marija, Matić, Marija, Simić, Tatjana, Savić-Radojević, Ana, "Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma" in Free Radical Biology and Medicine, 96 (2016):S48-S48,
https://doi.org/10.1016/j.freeradbiomed.2016.04.101 . .

TY  - JOUR
AU  - Stamenković, Miroslav
AU  - Radić, Tanja
AU  - Stefanović, Ivan
AU  - Corić, Vesna
AU  - Senćanić, Ivan
AU  - Plješa-Ercegovac, Marija
AU  - Matić, Marija
AU  - Jakšić, Vesna
AU  - Simić, Tatjana
AU  - Savić-Radojević, Ana
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/868
AB  - Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical and Experimental Ophthalmology
T1  - Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation
EP  - 283
IS  - 3
SP  - 277
VL  - 42
DO  - 10.1111/ceo.12180
ER  - 

@article{
author = "Stamenković, Miroslav and Radić, Tanja and Stefanović, Ivan and Corić, Vesna and Senćanić, Ivan and Plješa-Ercegovac, Marija and Matić, Marija and Jakšić, Vesna and Simić, Tatjana and Savić-Radojević, Ana",
year = "2014",
abstract = "Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical and Experimental Ophthalmology",
title = "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation",
pages = "283-277",
number = "3",
volume = "42",
doi = "10.1111/ceo.12180"
}

Stamenković, M., Radić, T., Stefanović, I., Corić, V., Senćanić, I., Plješa-Ercegovac, M., Matić, M., Jakšić, V., Simić, T.,& Savić-Radojević, A.. (2014). Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology
Wiley-Blackwell, Hoboken., 42(3), 277-283.
https://doi.org/10.1111/ceo.12180

Stamenković M, Radić T, Stefanović I, Corić V, Senćanić I, Plješa-Ercegovac M, Matić M, Jakšić V, Simić T, Savić-Radojević A. Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology. 2014;42(3):277-283.
doi:10.1111/ceo.12180 .

Stamenković, Miroslav, Radić, Tanja, Stefanović, Ivan, Corić, Vesna, Senćanić, Ivan, Plješa-Ercegovac, Marija, Matić, Marija, Jakšić, Vesna, Simić, Tatjana, Savić-Radojević, Ana, "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation" in Clinical and Experimental Ophthalmology, 42, no. 3 (2014):277-283,
https://doi.org/10.1111/ceo.12180 . .