TY  - JOUR
AU  - Stamenković, Miroslav
AU  - Lukić, Vesna
AU  - Šuvakov, Sonja
AU  - Simić, Tatjana
AU  - Senćanić, Ivan
AU  - Plješa-Ercegovac, Marija
AU  - Jakšić, Vesna
AU  - Babović, Siniša
AU  - Matić, Marija
AU  - Radosavljević, Aleksandra
AU  - Savić-Radojević, Ana
AU  - Đukić, Tatjana
PY  - 2018
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1157
AB  - AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.
PB  - IJO Press, Xi An
T2  - International Journal of Ophthalmology
T1  - GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers
EP  - 1520
IS  - 9
SP  - 1514
VL  - 11
DO  - 10.18240/ijo.2018.09.14
ER  - 

@article{
author = "Stamenković, Miroslav and Lukić, Vesna and Šuvakov, Sonja and Simić, Tatjana and Senćanić, Ivan and Plješa-Ercegovac, Marija and Jakšić, Vesna and Babović, Siniša and Matić, Marija and Radosavljević, Aleksandra and Savić-Radojević, Ana and Đukić, Tatjana",
year = "2018",
abstract = "AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.",
publisher = "IJO Press, Xi An",
journal = "International Journal of Ophthalmology",
title = "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers",
pages = "1520-1514",
number = "9",
volume = "11",
doi = "10.18240/ijo.2018.09.14"
}

Stamenković, M., Lukić, V., Šuvakov, S., Simić, T., Senćanić, I., Plješa-Ercegovac, M., Jakšić, V., Babović, S., Matić, M., Radosavljević, A., Savić-Radojević, A.,& Đukić, T.. (2018). GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology
IJO Press, Xi An., 11(9), 1514-1520.
https://doi.org/10.18240/ijo.2018.09.14

Stamenković M, Lukić V, Šuvakov S, Simić T, Senćanić I, Plješa-Ercegovac M, Jakšić V, Babović S, Matić M, Radosavljević A, Savić-Radojević A, Đukić T. GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology. 2018;11(9):1514-1520.
doi:10.18240/ijo.2018.09.14 .

Stamenković, Miroslav, Lukić, Vesna, Šuvakov, Sonja, Simić, Tatjana, Senćanić, Ivan, Plješa-Ercegovac, Marija, Jakšić, Vesna, Babović, Siniša, Matić, Marija, Radosavljević, Aleksandra, Savić-Radojević, Ana, Đukić, Tatjana, "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers" in International Journal of Ophthalmology, 11, no. 9 (2018):1514-1520,
https://doi.org/10.18240/ijo.2018.09.14 . .

TY  - CONF
AU  - Đukić, Tatjana
AU  - Šuvakov, Sonja
AU  - Stamenković, Miroslav
AU  - Senćanić, Ivan
AU  - Smiljić, Jelena
AU  - Plješa-Ercegovac, Marija
AU  - Matić, Marija
AU  - Simić, Tatjana
AU  - Savić-Radojević, Ana
PY  - 2016
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1012
PB  - Elsevier Science Inc, New York
C3  - Free Radical Biology and Medicine
T1  - Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma
EP  - S48
SP  - S48
VL  - 96
DO  - 10.1016/j.freeradbiomed.2016.04.101
ER  - 

@conference{
author = "Đukić, Tatjana and Šuvakov, Sonja and Stamenković, Miroslav and Senćanić, Ivan and Smiljić, Jelena and Plješa-Ercegovac, Marija and Matić, Marija and Simić, Tatjana and Savić-Radojević, Ana",
year = "2016",
publisher = "Elsevier Science Inc, New York",
journal = "Free Radical Biology and Medicine",
title = "Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma",
pages = "S48-S48",
volume = "96",
doi = "10.1016/j.freeradbiomed.2016.04.101"
}

Đukić, T., Šuvakov, S., Stamenković, M., Senćanić, I., Smiljić, J., Plješa-Ercegovac, M., Matić, M., Simić, T.,& Savić-Radojević, A.. (2016). Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma. in Free Radical Biology and Medicine
Elsevier Science Inc, New York., 96, S48-S48.
https://doi.org/10.1016/j.freeradbiomed.2016.04.101

Đukić T, Šuvakov S, Stamenković M, Senćanić I, Smiljić J, Plješa-Ercegovac M, Matić M, Simić T, Savić-Radojević A. Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma. in Free Radical Biology and Medicine. 2016;96:S48-S48.
doi:10.1016/j.freeradbiomed.2016.04.101 .

Đukić, Tatjana, Šuvakov, Sonja, Stamenković, Miroslav, Senćanić, Ivan, Smiljić, Jelena, Plješa-Ercegovac, Marija, Matić, Marija, Simić, Tatjana, Savić-Radojević, Ana, "Association of glutathione S-transferases M1 and T1 polymorphisms with glaucoma" in Free Radical Biology and Medicine, 96 (2016):S48-S48,
https://doi.org/10.1016/j.freeradbiomed.2016.04.101 . .

TY  - JOUR
AU  - Stamenković, Miroslav
AU  - Radić, Tanja
AU  - Stefanović, Ivan
AU  - Corić, Vesna
AU  - Senćanić, Ivan
AU  - Plješa-Ercegovac, Marija
AU  - Matić, Marija
AU  - Jakšić, Vesna
AU  - Simić, Tatjana
AU  - Savić-Radojević, Ana
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/868
AB  - Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical and Experimental Ophthalmology
T1  - Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation
EP  - 283
IS  - 3
SP  - 277
VL  - 42
DO  - 10.1111/ceo.12180
ER  - 

@article{
author = "Stamenković, Miroslav and Radić, Tanja and Stefanović, Ivan and Corić, Vesna and Senćanić, Ivan and Plješa-Ercegovac, Marija and Matić, Marija and Jakšić, Vesna and Simić, Tatjana and Savić-Radojević, Ana",
year = "2014",
abstract = "Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical and Experimental Ophthalmology",
title = "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation",
pages = "283-277",
number = "3",
volume = "42",
doi = "10.1111/ceo.12180"
}

Stamenković, M., Radić, T., Stefanović, I., Corić, V., Senćanić, I., Plješa-Ercegovac, M., Matić, M., Jakšić, V., Simić, T.,& Savić-Radojević, A.. (2014). Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology
Wiley-Blackwell, Hoboken., 42(3), 277-283.
https://doi.org/10.1111/ceo.12180

Stamenković M, Radić T, Stefanović I, Corić V, Senćanić I, Plješa-Ercegovac M, Matić M, Jakšić V, Simić T, Savić-Radojević A. Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology. 2014;42(3):277-283.
doi:10.1111/ceo.12180 .

Stamenković, Miroslav, Radić, Tanja, Stefanović, Ivan, Corić, Vesna, Senćanić, Ivan, Plješa-Ercegovac, Marija, Matić, Marija, Jakšić, Vesna, Simić, Tatjana, Savić-Radojević, Ana, "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation" in Clinical and Experimental Ophthalmology, 42, no. 3 (2014):277-283,
https://doi.org/10.1111/ceo.12180 . .