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Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
(Amer Soc Biochemistry Molecular Biology Inc, Bethesda, 2008)
Unchecked accumulation of reactive oxygen species (ROS) compromises maintenance of hematopoietic stem cells. Regulation of ROS by the tumor suppressor protein ataxia telangiectasia mutated (ATM) is critical for preserving ...
Reversible lymphomagenesis in conditionally c-MYC expressing mice
(Wiley, Hoboken, 2004)
It is well documented that deregulation of MYC leads to tumor development, yet many aspects of this process are only partially understood. We have established a transgenic mouse model in which c-MYC is conditionally expressed ...
CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice
(Wiley-V C H Verlag Gmbh, Weinheim, 2002)
BOB.1/OBF1 (also called OCA-B), a B lymphocyte-specific transcriptional coactivator, is recruited to octamer-containing promoters by interacting with the Oct-1 or Oct-2 proteins. BOB.1/OBF.1-deficient mice show impaired ...
c-MYC activation impairs the NF-kappa B and the interferon response: Implications for the pathogenesis of Burkitt's lymphoma
(Wiley-Liss, Hoboken, 2007)
Deregulation of the proto-oncogene c-myc is a key event in the pathogenesis of many tumors. A paradigm is the activation of the c-myc gene by chromosomal translocations in Burkitt lymphoma (BL). Despite expression of a ...
B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice
(Amer Assoc Immunologists, Bethesda, 2005)
Marginal zone (MZ) B cells and peritoneal B-I cells provide a first defense system of thymus-independent Ab responses against foreign pathogens and therefore share a number of functional properties. Recently, development ...
Identification of novel Myc target genes with a potential role in lymphomagenesis
(Oxford Univ Press, Oxford, 2004)
The c-Myc transcription factor regulates a wide set of genes involved in processes such as proliferation, differentiation and apoptosis. Therefore, altered expression of Myc leads to deregulation of a large number of target ...
Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation
(Amer Assoc Immunologists, Bethesda, 2005)
An as-yet-unidentified mutation, Y-linked autoimmune acceleration (Yaa), is responsible for the accelerated development of lupus-like autoimmune syndrome in mice. In view of a possible role for Yaa as a positive regulator ...
Memory disorder in persons with asperger syndrome
(Elsevier France-Editions Scientifiques Medicales Elsevier, Paris, 2009)
Participation of children and youth with neurodevelopmental disorders in after-school activities
(Taylor and Francis, 2019)
Aim: The aim of this study was to compare the level of participation in social, leisure and recreational activities in a group with intellectual disability, a group with autistic spectrum disorders, and a typically developing ...
Electroencephalography in Assessment of Autism Spectrum Disorders: A Review
(Frontiers Media [Commercial Publisher], 2021)
Electroencephalography (EEG) can further out our understanding of autistic spectrum disorders (ASD) neurophysiology. Epilepsy and ASD comorbidity range between 5 and 46%, but its temporal relationship, causal mechanisms ...