TY  - JOUR
AU  - Đorđević, Jelena
AU  - Pavlović, Aleksandra
AU  - Mihajlović, Goran
AU  - Hinić, Darko
AU  - Vojvodić, Jovana
AU  - Živanović, Marko
AU  - Pavlović, Dragan
PY  - 2024
UR  - https://doiserbia.nb.rs/Article.aspx?ID=0048-57052400006D
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5410
AB  - Theory of Mind (ToM) is a social-cognitive ability to understand the mental states of others. ToM functions are compromised in the case of mental disorders characterized by cognitive impairments. The Faux Pas Recognition test (FPRT) is considered a good measure of verbal aspects of ToM as it measures social adaptation through the adequate interpretation of potentially sensitive and awkward social situations. However, data on FPRT psychometric properties is somewhat limited. The aim of the present study is the psychometric evaluation of the FPRT in Serbian population. The adapted version in Serbian has been administered to 268 healthy participants, 30 patients with schizophrenia and 31 with bipolar affective disorder. The results show a high internal consistencies of Faux Pas stories (α = .954), Control stories (α = .929) and overall test (α = .936). Both Horn’s parallel analysis and confirmatory factor analysis indicated that a single-factor solution is optimal, supporting the premise of a general ToM ability underlying performance across test. The Faux Pas test showed good discriminative power in differentiation between individuals from healthy and clinical populations making it a useful clinical instrument.
PB  - Serbian Psychological Society
T2  - Psihologija
T2  - Psihologija
T1  - Assessing theory of mind abilities in schizophrenia and bipolar disorder: A psychometric study of the Faux Pas Recognition test in Serbian
EP  - 6
IS  - 00
SP  - 6
DO  - https://doi.org/10.2298/PSI220824006D
DO  - https://doi.org/10.2298/PSI220824006D
ER  - 

@article{
author = "Đorđević, Jelena and Pavlović, Aleksandra and Mihajlović, Goran and Hinić, Darko and Vojvodić, Jovana and Živanović, Marko and Pavlović, Dragan",
year = "2024",
abstract = "Theory of Mind (ToM) is a social-cognitive ability to understand the mental states of others. ToM functions are compromised in the case of mental disorders characterized by cognitive impairments. The Faux Pas Recognition test (FPRT) is considered a good measure of verbal aspects of ToM as it measures social adaptation through the adequate interpretation of potentially sensitive and awkward social situations. However, data on FPRT psychometric properties is somewhat limited. The aim of the present study is the psychometric evaluation of the FPRT in Serbian population. The adapted version in Serbian has been administered to 268 healthy participants, 30 patients with schizophrenia and 31 with bipolar affective disorder. The results show a high internal consistencies of Faux Pas stories (α = .954), Control stories (α = .929) and overall test (α = .936). Both Horn’s parallel analysis and confirmatory factor analysis indicated that a single-factor solution is optimal, supporting the premise of a general ToM ability underlying performance across test. The Faux Pas test showed good discriminative power in differentiation between individuals from healthy and clinical populations making it a useful clinical instrument.",
publisher = "Serbian Psychological Society",
journal = "Psihologija, Psihologija",
title = "Assessing theory of mind abilities in schizophrenia and bipolar disorder: A psychometric study of the Faux Pas Recognition test in Serbian",
pages = "6-6",
number = "00",
doi = "https://doi.org/10.2298/PSI220824006D, https://doi.org/10.2298/PSI220824006D"
}

Đorđević, J., Pavlović, A., Mihajlović, G., Hinić, D., Vojvodić, J., Živanović, M.,& Pavlović, D.. (2024). Assessing theory of mind abilities in schizophrenia and bipolar disorder: A psychometric study of the Faux Pas Recognition test in Serbian. in Psihologija
Serbian Psychological Society.(00), 6-6.
https://doi.org/https://doi.org/10.2298/PSI220824006D

Đorđević J, Pavlović A, Mihajlović G, Hinić D, Vojvodić J, Živanović M, Pavlović D. Assessing theory of mind abilities in schizophrenia and bipolar disorder: A psychometric study of the Faux Pas Recognition test in Serbian. in Psihologija. 2024;(00):6-6.
doi:https://doi.org/10.2298/PSI220824006D .

Đorđević, Jelena, Pavlović, Aleksandra, Mihajlović, Goran, Hinić, Darko, Vojvodić, Jovana, Živanović, Marko, Pavlović, Dragan, "Assessing theory of mind abilities in schizophrenia and bipolar disorder: A psychometric study of the Faux Pas Recognition test in Serbian" in Psihologija, no. 00 (2024):6-6,
https://doi.org/https://doi.org/10.2298/PSI220824006D . .

TY  - JOUR
AU  - Mijajlovic, Milija
AU  - Bozovic, Ivo
AU  - Pavlović, Aleksandra
AU  - Rakocevic-Stojanovic, Vidosava
AU  - Gluscevic, Sanja
AU  - Stojanovic, Amalija
AU  - Basta, Ivana
AU  - Meola, Giovanni
AU  - Peric, Stojan
PY  - 2024
UR  - https://www.sciencedirect.com/science/article/pii/S2405844024028871
UR  - internal-pdf://2340/S2405844024028871.html
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5409
AB  - IntroductionMyotonic dystrophy type 1 (DM1) and 2 (DM2) are genetically determined progressive muscular disorders with multisystemic affection, including brain involvement. Transcranial sonography (TCS) is a reliable diagnostic tool for the investigation of deep brain structures. We sought to evaluate TCS findings in genetically confirmed DM1 and DM2 patients, and further correlate these results with patients’ clinical features.MethodsThis cross-sectional study included 163 patients (102 DM1, 61 DM2). Echogenicity of the brainstem raphe (BR) and substantia nigra (SN) as well as the diameter of the third ventricle (DTV) were assessed by TCS. Patients were evaluated using the Hamilton Depression Rating Scale, Fatigue Severity Scale and Daytime Sleepiness Scale.ResultsSN hyperechogenicity was observed in 40% of DM1 and 34% of DM2 patients. SN hypoechogenicity was detected in 17% of DM1 and 7% of DM2 patients. BR hypoechogenicity was found in 36% of DM1 and 47% of DM2 subjects. Enlarged DTV was noted in 19% of DM1 and 15% of DM2 patients. Older, weaker, depressive, and fatigued DM1 patients were more likely to have BR hypoechogenicity (p < 0.05). DTV correlated with age and disease duration in DM1 (p < 0.01). In DM2 patients SN hyperechogenicity correlated with fatigue. Excessive daytime sleepiness was associated with hypoechogenic BR (p < 0.05) and enlarged DVT (p < 0.01) in DM2 patients.ConclusionsTCS is an easy applicable and sensitive neuroimaging technique that could offer new information regarding several brainstem structures in DM1 and DM2. This may lead to better understanding of the pathogenesis of the brain involvement in DM with possible clinical implications.
PB  - Elsevier
T2  - Heliyon
T2  - HeliyonHeliyon
T1  - Transcranial brain parenchyma sonographic findings in patients with myotonic dystrophy type 1 and 2
IS  - 5
SP  - e26856
VL  - 10
DO  - 10.1016/j.heliyon.2024.e26856
ER  - 

@article{
author = "Mijajlovic, Milija and Bozovic, Ivo and Pavlović, Aleksandra and Rakocevic-Stojanovic, Vidosava and Gluscevic, Sanja and Stojanovic, Amalija and Basta, Ivana and Meola, Giovanni and Peric, Stojan",
year = "2024",
abstract = "IntroductionMyotonic dystrophy type 1 (DM1) and 2 (DM2) are genetically determined progressive muscular disorders with multisystemic affection, including brain involvement. Transcranial sonography (TCS) is a reliable diagnostic tool for the investigation of deep brain structures. We sought to evaluate TCS findings in genetically confirmed DM1 and DM2 patients, and further correlate these results with patients’ clinical features.MethodsThis cross-sectional study included 163 patients (102 DM1, 61 DM2). Echogenicity of the brainstem raphe (BR) and substantia nigra (SN) as well as the diameter of the third ventricle (DTV) were assessed by TCS. Patients were evaluated using the Hamilton Depression Rating Scale, Fatigue Severity Scale and Daytime Sleepiness Scale.ResultsSN hyperechogenicity was observed in 40% of DM1 and 34% of DM2 patients. SN hypoechogenicity was detected in 17% of DM1 and 7% of DM2 patients. BR hypoechogenicity was found in 36% of DM1 and 47% of DM2 subjects. Enlarged DTV was noted in 19% of DM1 and 15% of DM2 patients. Older, weaker, depressive, and fatigued DM1 patients were more likely to have BR hypoechogenicity (p < 0.05). DTV correlated with age and disease duration in DM1 (p < 0.01). In DM2 patients SN hyperechogenicity correlated with fatigue. Excessive daytime sleepiness was associated with hypoechogenic BR (p < 0.05) and enlarged DVT (p < 0.01) in DM2 patients.ConclusionsTCS is an easy applicable and sensitive neuroimaging technique that could offer new information regarding several brainstem structures in DM1 and DM2. This may lead to better understanding of the pathogenesis of the brain involvement in DM with possible clinical implications.",
publisher = "Elsevier",
journal = "Heliyon, HeliyonHeliyon",
title = "Transcranial brain parenchyma sonographic findings in patients with myotonic dystrophy type 1 and 2",
number = "5",
pages = "e26856",
volume = "10",
doi = "10.1016/j.heliyon.2024.e26856"
}

Mijajlovic, M., Bozovic, I., Pavlović, A., Rakocevic-Stojanovic, V., Gluscevic, S., Stojanovic, A., Basta, I., Meola, G.,& Peric, S.. (2024). Transcranial brain parenchyma sonographic findings in patients with myotonic dystrophy type 1 and 2. in Heliyon
Elsevier., 10(5), e26856.
https://doi.org/10.1016/j.heliyon.2024.e26856

Mijajlovic M, Bozovic I, Pavlović A, Rakocevic-Stojanovic V, Gluscevic S, Stojanovic A, Basta I, Meola G, Peric S. Transcranial brain parenchyma sonographic findings in patients with myotonic dystrophy type 1 and 2. in Heliyon. 2024;10(5):e26856.
doi:10.1016/j.heliyon.2024.e26856 .

Mijajlovic, Milija, Bozovic, Ivo, Pavlović, Aleksandra, Rakocevic-Stojanovic, Vidosava, Gluscevic, Sanja, Stojanovic, Amalija, Basta, Ivana, Meola, Giovanni, Peric, Stojan, "Transcranial brain parenchyma sonographic findings in patients with myotonic dystrophy type 1 and 2" in Heliyon, 10, no. 5 (2024):e26856,
https://doi.org/10.1016/j.heliyon.2024.e26856 . .

TY  - JOUR
AU  - Wardlaw, Joanna M
AU  - Chabriat, Hugues
AU  - de Leeuw, Frank-Erik
AU  - Debette, Stéphanie
AU  - Dichgans, Martin
AU  - Doubal, Fergus
AU  - Jokinen, Hanna
AU  - Katsanos, Aristeidis H
AU  - Ornello, Raffaele
AU  - Pantoni, Leonardo
AU  - Pasi, Marco
AU  - Pavlović, Aleksandra
AU  - Rudilosso, Salvatore
AU  - Schmidt, Reinhold
AU  - Staals, Julie
AU  - Taylor-Rowan, Martin
AU  - Hussain, Salman
AU  - Lindgren, Arne G
PY  - 2024
UR  - https://doi.org/10.1177/23969873231219416
UR  - internal-pdf://2338/Wardlaw et al. - 2024 - European stroke organisation (ESO) guideline on ce.pdf
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5408
AB  - A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome rates differing from other stroke subtypes. This European Stroke Organisation (ESO) guideline provides evidence-based recommendations to assist with clinical decisions about management of lacunar ischaemic stroke to prevent adverse clinical outcomes. The guideline was developed according to ESO standard operating procedures and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. We addressed acute treatment (including progressive lacunar stroke) and secondary prevention in lacunar ischaemic stroke, and prioritised the interventions of thrombolysis, antiplatelet drugs, blood pressure lowering, lipid lowering, lifestyle, and other interventions and their potential effects on the clinical outcomes recurrent stroke, dependency, major adverse cardiovascular events, death, cognitive decline, mobility, gait, or mood disorders. We systematically reviewed the literature, assessed the evidence and where feasible formulated evidence-based recommendations, and expert concensus statements. We found little direct evidence, mostly of low quality. We recommend that patients with suspected acute lacunar ischaemic stroke receive intravenous alteplase, antiplatelet drugs and avoid blood pressure lowering according to current acute ischaemic stroke guidelines. For secondary prevention, we recommend single antiplatelet treatment long-term, blood pressure control, and lipid lowering according to current guidelines. We recommend smoking cessation, regular exercise, other healthy lifestyle modifications, and avoid obesity for general health benefits. We cannot make any recommendation concerning progressive stroke or other drugs. Large randomised controlled trials with clinically important endpoints, including cognitive endpoints, are a priority for lacunar ischaemic stroke.
PB  - Sage
T2  - European Stroke Journal
T2  - European Stroke Journal
T1  - European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke
SP  - 23969873231219416
DO  - 10.1177/23969873231219416
ER  - 

@article{
author = "Wardlaw, Joanna M and Chabriat, Hugues and de Leeuw, Frank-Erik and Debette, Stéphanie and Dichgans, Martin and Doubal, Fergus and Jokinen, Hanna and Katsanos, Aristeidis H and Ornello, Raffaele and Pantoni, Leonardo and Pasi, Marco and Pavlović, Aleksandra and Rudilosso, Salvatore and Schmidt, Reinhold and Staals, Julie and Taylor-Rowan, Martin and Hussain, Salman and Lindgren, Arne G",
year = "2024",
abstract = "A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome rates differing from other stroke subtypes. This European Stroke Organisation (ESO) guideline provides evidence-based recommendations to assist with clinical decisions about management of lacunar ischaemic stroke to prevent adverse clinical outcomes. The guideline was developed according to ESO standard operating procedures and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. We addressed acute treatment (including progressive lacunar stroke) and secondary prevention in lacunar ischaemic stroke, and prioritised the interventions of thrombolysis, antiplatelet drugs, blood pressure lowering, lipid lowering, lifestyle, and other interventions and their potential effects on the clinical outcomes recurrent stroke, dependency, major adverse cardiovascular events, death, cognitive decline, mobility, gait, or mood disorders. We systematically reviewed the literature, assessed the evidence and where feasible formulated evidence-based recommendations, and expert concensus statements. We found little direct evidence, mostly of low quality. We recommend that patients with suspected acute lacunar ischaemic stroke receive intravenous alteplase, antiplatelet drugs and avoid blood pressure lowering according to current acute ischaemic stroke guidelines. For secondary prevention, we recommend single antiplatelet treatment long-term, blood pressure control, and lipid lowering according to current guidelines. We recommend smoking cessation, regular exercise, other healthy lifestyle modifications, and avoid obesity for general health benefits. We cannot make any recommendation concerning progressive stroke or other drugs. Large randomised controlled trials with clinically important endpoints, including cognitive endpoints, are a priority for lacunar ischaemic stroke.",
publisher = "Sage",
journal = "European Stroke Journal, European Stroke Journal",
title = "European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke",
pages = "23969873231219416",
doi = "10.1177/23969873231219416"
}

Wardlaw, J. M., Chabriat, H., de Leeuw, F., Debette, S., Dichgans, M., Doubal, F., Jokinen, H., Katsanos, A. H., Ornello, R., Pantoni, L., Pasi, M., Pavlović, A., Rudilosso, S., Schmidt, R., Staals, J., Taylor-Rowan, M., Hussain, S.,& Lindgren, A. G.. (2024). European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke. in European Stroke Journal
Sage., 23969873231219416.
https://doi.org/10.1177/23969873231219416

Wardlaw JM, Chabriat H, de Leeuw F, Debette S, Dichgans M, Doubal F, Jokinen H, Katsanos AH, Ornello R, Pantoni L, Pasi M, Pavlović A, Rudilosso S, Schmidt R, Staals J, Taylor-Rowan M, Hussain S, Lindgren AG. European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke. in European Stroke Journal. 2024;:23969873231219416.
doi:10.1177/23969873231219416 .

Wardlaw, Joanna M, Chabriat, Hugues, de Leeuw, Frank-Erik, Debette, Stéphanie, Dichgans, Martin, Doubal, Fergus, Jokinen, Hanna, Katsanos, Aristeidis H, Ornello, Raffaele, Pantoni, Leonardo, Pasi, Marco, Pavlović, Aleksandra, Rudilosso, Salvatore, Schmidt, Reinhold, Staals, Julie, Taylor-Rowan, Martin, Hussain, Salman, Lindgren, Arne G, "European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke" in European Stroke Journal (2024):23969873231219416,
https://doi.org/10.1177/23969873231219416 . .

TY  - CONF
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra
PY  - 2023
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5387
AB  - Uvod: Vitamin B12 ili kobalamin je hidrosolubilni vitamin koji učestvuje u
stvaranju kateholamina, dezoksiribonukleinske kiseline, mijelina i u hematopoezi.

On je esencijalan faktor u intrauterinom razvoju mozga i mijelinizaciji
sve do puberteta, pa i kasnije. Ljudski organizam nema sposobnost sinteze
kobalamina, pa je zavistan od unosa ishranom ili supstitucijom.
Cilj: Pregled savremene literature o deficijenciji vitamina B12 kod dece i adolescenata,
prikaz
tipične
kliničke
slike i
diskusija
terapijskih
pristupa.
Metode:
Pretraga
elektronskih
baza
podataka
u
sklopu
servisa
Konzorcijuma
biblioteka
Srbije
za
objedinjenu
nabavku
(KOBSON)
sa
ključnim
rečima:
vitamin

B12,
kobalamin,
deficijencija,
deca,
adolescenti.
Rezultati:
Deficit
vitamina
B12
je
čest
među
decom
i
omladinom
u
zemlјama

u
razvoju,
ali
sve
češće
i
u
razvijenim
zemljama.
Kod
dece
postoje
tri
osnovna
uzroka
deficijencije:
1.
smanjen
unos,
2.
poremećaj
resorpcije,

3. urođeni
poremećaji transporta i metabolizma. Snižen nivo vitamina B12 u krvi
povezan je sa negativnim ishodom trudnoće po majku i dete, podižući rizik
za
razvojne
anomalije,
spontani
pobačaj,
preeklampsiju
i
nisku
težinu
deteta
na
rođenju.
Neuropsihološke
posledice
kod
dece
su
kognitivni
poremećaji

(smetnje
pažnje,
pamćenja
i
sniženje
akademskog
postignuća),
izmene
afekta

i
ponašanja.
Nekoliko
kohortnih
studija
pokazalo
je
povezanost
nivoa
vitamina

B12 u krvi ili zastupljenost u ishrani majke sa kognitivnim ishodima kod
dece. Međutim, najveći broj do sada objavljenih studija o negativnom uticaju
sniženog nivoa vitamina B12 na kognitivni status dece je opservacionog tipa,
te ne mogu potvrditi kauzalnu povezanost. Dijagnoza deficita vitamina B12
zasniva se na kliničkoj slici, neurološkom i psihijatrijskom nalazu, ispitivanju
kognicije i laboratorijskoj dijagnostici, koja obuhvata cirkulatorne i funkcionalne
biomarkere.
Nadoknada
deficita
kobalamina
je
podjednako
efikasna
i

parenteralno i
oralno,
ukoliko se
daju
adekvatne
doze.
Zaključak:
Nedostatak
vitamina
B12
je
relativno
čest
među
decom
i
omladinom
i
dovodi
do
neuroloških
i
psihijatrijskih
smetnji
koje,
ako
se
ne
leče,
mogu

dovesti
do
ireverzibilnih
promena.
AB  - Introduction: Vitamin B12, also known as cobalamin, is a water- soluble vitamin
that participates in the synthesis of catecholamines, deoxyribonucleic acid, myelin, and
hematopoiesis. It is an essential factor in the intrauterine development of the brain and
myelination, extending through puberty, and later on in life. The human body lacks the
ability to synthesize cobalamin, thus depending on dietary intake or supplementation.
Aim: Review of current literature on vitamin B12 deficiency in children and adolescents,
typical presentation and therapeutic approach.
Methods: Literature search via electronic database within the Serbian Library
Consortium for Coordinated Acquisition (KOBSON) with keywords: vitamin B12, cobalamin,
deficiency, children, adolescents.
Results: Vitamin B12 deficiency is common among children and adolescents in
developing countries, but it is becoming increasingly prevalent in developed countries as well. In children, there are three main causes of deficiency: 1. Reduced intake, 2. Impaired
absorption, 3. Inherited transport and metabolism disorders. Decreased levels of vitamin B12
in the blood are associated with adverse outcomes for both the mother and child during
pregnancy, increasing the risk of developmental abnormalities, spontaneous abortion,
preeclampsia, and low birth weight. Neuropsychological consequences in children include
cognitive disorders (attention deficits, memory impairments, and decreased academic
achievement), changes in mood, and behavior. Several cohort studies have shown an
association between vitamin B12 levels in the blood or maternal dietary intake and cognitive
outcomes in children. However, the majority of published studies on the negative impact of
low vitamin B12 levels on the cognitive status of children are observational in nature and
cannot confirm a causal relationship. The diagnosis of vitamin B12 deficiency is based on
clinical presentation, neurological and psychiatric findings, cognitive testing, and laboratory
diagnostics, which include circulating and functional biomarkers. Replenishment of
cobalamin deficiency is equally effective via parenteral and oral routes if adequate doses are
administered.
Conclusion: Vitamin B12 deficiency is relatively common among children and adolescents,
and it leads to neurological and psychiatric impairments that, if left untreated, can result in
irreversible changes.
PB  - Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju University of Belgrade – Faculty of Special Education and Rehabilitation
C3  - Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine
T1  - Status vitamina b12 i razvoj dece
T1  - Vitamin b12 status and development in children and adolescents
EP  - 587
SP  - 581
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_5387
ER  - 

@conference{
author = "Pavlović, Dragan and Pavlović, Aleksandra",
year = "2023",
abstract = "Uvod: Vitamin B12 ili kobalamin je hidrosolubilni vitamin koji učestvuje u
stvaranju kateholamina, dezoksiribonukleinske kiseline, mijelina i u hematopoezi.

On je esencijalan faktor u intrauterinom razvoju mozga i mijelinizaciji
sve do puberteta, pa i kasnije. Ljudski organizam nema sposobnost sinteze
kobalamina, pa je zavistan od unosa ishranom ili supstitucijom.
Cilj: Pregled savremene literature o deficijenciji vitamina B12 kod dece i adolescenata,
prikaz
tipične
kliničke
slike i
diskusija
terapijskih
pristupa.
Metode:
Pretraga
elektronskih
baza
podataka
u
sklopu
servisa
Konzorcijuma
biblioteka
Srbije
za
objedinjenu
nabavku
(KOBSON)
sa
ključnim
rečima:
vitamin

B12,
kobalamin,
deficijencija,
deca,
adolescenti.
Rezultati:
Deficit
vitamina
B12
je
čest
među
decom
i
omladinom
u
zemlјama

u
razvoju,
ali
sve
češće
i
u
razvijenim
zemljama.
Kod
dece
postoje
tri
osnovna
uzroka
deficijencije:
1.
smanjen
unos,
2.
poremećaj
resorpcije,

3. urođeni
poremećaji transporta i metabolizma. Snižen nivo vitamina B12 u krvi
povezan je sa negativnim ishodom trudnoće po majku i dete, podižući rizik
za
razvojne
anomalije,
spontani
pobačaj,
preeklampsiju
i
nisku
težinu
deteta
na
rođenju.
Neuropsihološke
posledice
kod
dece
su
kognitivni
poremećaji

(smetnje
pažnje,
pamćenja
i
sniženje
akademskog
postignuća),
izmene
afekta

i
ponašanja.
Nekoliko
kohortnih
studija
pokazalo
je
povezanost
nivoa
vitamina

B12 u krvi ili zastupljenost u ishrani majke sa kognitivnim ishodima kod
dece. Međutim, najveći broj do sada objavljenih studija o negativnom uticaju
sniženog nivoa vitamina B12 na kognitivni status dece je opservacionog tipa,
te ne mogu potvrditi kauzalnu povezanost. Dijagnoza deficita vitamina B12
zasniva se na kliničkoj slici, neurološkom i psihijatrijskom nalazu, ispitivanju
kognicije i laboratorijskoj dijagnostici, koja obuhvata cirkulatorne i funkcionalne
biomarkere.
Nadoknada
deficita
kobalamina
je
podjednako
efikasna
i

parenteralno i
oralno,
ukoliko se
daju
adekvatne
doze.
Zaključak:
Nedostatak
vitamina
B12
je
relativno
čest
među
decom
i
omladinom
i
dovodi
do
neuroloških
i
psihijatrijskih
smetnji
koje,
ako
se
ne
leče,
mogu

dovesti
do
ireverzibilnih
promena., Introduction: Vitamin B12, also known as cobalamin, is a water- soluble vitamin
that participates in the synthesis of catecholamines, deoxyribonucleic acid, myelin, and
hematopoiesis. It is an essential factor in the intrauterine development of the brain and
myelination, extending through puberty, and later on in life. The human body lacks the
ability to synthesize cobalamin, thus depending on dietary intake or supplementation.
Aim: Review of current literature on vitamin B12 deficiency in children and adolescents,
typical presentation and therapeutic approach.
Methods: Literature search via electronic database within the Serbian Library
Consortium for Coordinated Acquisition (KOBSON) with keywords: vitamin B12, cobalamin,
deficiency, children, adolescents.
Results: Vitamin B12 deficiency is common among children and adolescents in
developing countries, but it is becoming increasingly prevalent in developed countries as well. In children, there are three main causes of deficiency: 1. Reduced intake, 2. Impaired
absorption, 3. Inherited transport and metabolism disorders. Decreased levels of vitamin B12
in the blood are associated with adverse outcomes for both the mother and child during
pregnancy, increasing the risk of developmental abnormalities, spontaneous abortion,
preeclampsia, and low birth weight. Neuropsychological consequences in children include
cognitive disorders (attention deficits, memory impairments, and decreased academic
achievement), changes in mood, and behavior. Several cohort studies have shown an
association between vitamin B12 levels in the blood or maternal dietary intake and cognitive
outcomes in children. However, the majority of published studies on the negative impact of
low vitamin B12 levels on the cognitive status of children are observational in nature and
cannot confirm a causal relationship. The diagnosis of vitamin B12 deficiency is based on
clinical presentation, neurological and psychiatric findings, cognitive testing, and laboratory
diagnostics, which include circulating and functional biomarkers. Replenishment of
cobalamin deficiency is equally effective via parenteral and oral routes if adequate doses are
administered.
Conclusion: Vitamin B12 deficiency is relatively common among children and adolescents,
and it leads to neurological and psychiatric impairments that, if left untreated, can result in
irreversible changes.",
publisher = "Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju University of Belgrade – Faculty of Special Education and Rehabilitation",
journal = "Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine",
title = "Status vitamina b12 i razvoj dece, Vitamin b12 status and development in children and adolescents",
pages = "587-581",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_5387"
}

Pavlović, D.,& Pavlović, A.. (2023). Status vitamina b12 i razvoj dece. in Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine
Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju University of Belgrade – Faculty of Special Education and Rehabilitation., 581-587.
https://hdl.handle.net/21.15107/rcub_rfasper_5387

Pavlović D, Pavlović A. Status vitamina b12 i razvoj dece. in Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine. 2023;:581-587.
https://hdl.handle.net/21.15107/rcub_rfasper_5387 .

Pavlović, Dragan, Pavlović, Aleksandra, "Status vitamina b12 i razvoj dece" in Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine (2023):581-587,
https://hdl.handle.net/21.15107/rcub_rfasper_5387 .

TY  - CONF
AU  - Pavlović, Aleksandra
AU  - Đurić Zdravković, Aleksandra
AU  - Gligorović, Milica
PY  - 2023
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5332
AB  - Uvod: Kritičnim fazama neuroplastičnosti smatraju se periodi u kojima je
razvoj funkcionalnih svojstava mozga izrazito modulisan iskustvom, a razdoblje
ranog detinjstva se naglašava kao jedan od krucijalnih činilaca razlika
u njenim mehanizmima, koji mogu da utiču na pojavu nekih neurorazvojnih
poremećaja.
Cilj: Cilj rada je analiza podataka o ustrojstvu neuroplastičnosti kod pojedinih
neurorazvojnih poremećaja (intelektualna ometenost, poremećaj iz spektra
autizma i poremećaj pažnje s hiperaktivnošću), kao i mogućoj stimulaciji u
ovom domenu.
Metode: U svrhu ostvarivanja cilja izvršen je pregled literature objavljene u
recenziranim akademskim publikacijama.
Rezultati: Rezultati niza studija ukazuju na to da se izmenjena neuroplastičnost
može smatrati osnovom nekih od ovih poremećaja. Rana intervencija
usmerena na facilitaciju mehanizama neuroplastičnosti poboljšava razvojne
ishode kod dece s neurorazvojnim poremećajima.
Zaključak: Potvrđena je efikasnost više različitih oblika tretmana u ovom domenu,
koji podrazumevaju obogaćivanje životne sredine, primenu neinvazivnih
stimulativnih protokola i kognitivni trening.
AB  - Introduction: Critical phases of neuroplasticity are considered to be periods in which
the development of the brain’s functional properties is strongly modulated by experience,
and the period of early childhood is emphasized as one of the crucial factors of differences in
its mechanisms, which can influence the appearance of some neurodevelopmental disorders.
Aim: The aim of the paper is to analyze data on the structure of neuroplasticity in
persons with certain neurodevelopmental disorders (intellectual disability, autism spectrum
disorder, and attention deficit hyperactivity disorder), as well as on possible stimulation in
this domain.
Methods: To achieve this goal, a review of the literature published in peer-reviewed
academic publications was carried out.
Results: Results from a number of studies indicate that altered neuroplasticity may
underlie some of these disorders. Early intervention aimed at facilitating neuroplasticity
mechanisms improves developmental outcomes in children with neurodevelopmental
disorders.
Conclusion: Several effective treatments have been confirmed in this domain, including
environmental enrichment, application of noninvasive stimulation protocols, and cognitive
training.
PB  - Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju/ University of Belgrade – Faculty of Special Education and Rehabilitation
C3  - Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine
T1  - Neuroplastičnost kod osoba s neurorazvojnim Poremećajima
T1  - Neuroplasticity in persons with neurodevelopmental Disorders
EP  - 204
SP  - 199
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_5332
ER  - 

@conference{
author = "Pavlović, Aleksandra and Đurić Zdravković, Aleksandra and Gligorović, Milica",
year = "2023",
abstract = "Uvod: Kritičnim fazama neuroplastičnosti smatraju se periodi u kojima je
razvoj funkcionalnih svojstava mozga izrazito modulisan iskustvom, a razdoblje
ranog detinjstva se naglašava kao jedan od krucijalnih činilaca razlika
u njenim mehanizmima, koji mogu da utiču na pojavu nekih neurorazvojnih
poremećaja.
Cilj: Cilj rada je analiza podataka o ustrojstvu neuroplastičnosti kod pojedinih
neurorazvojnih poremećaja (intelektualna ometenost, poremećaj iz spektra
autizma i poremećaj pažnje s hiperaktivnošću), kao i mogućoj stimulaciji u
ovom domenu.
Metode: U svrhu ostvarivanja cilja izvršen je pregled literature objavljene u
recenziranim akademskim publikacijama.
Rezultati: Rezultati niza studija ukazuju na to da se izmenjena neuroplastičnost
može smatrati osnovom nekih od ovih poremećaja. Rana intervencija
usmerena na facilitaciju mehanizama neuroplastičnosti poboljšava razvojne
ishode kod dece s neurorazvojnim poremećajima.
Zaključak: Potvrđena je efikasnost više različitih oblika tretmana u ovom domenu,
koji podrazumevaju obogaćivanje životne sredine, primenu neinvazivnih
stimulativnih protokola i kognitivni trening., Introduction: Critical phases of neuroplasticity are considered to be periods in which
the development of the brain’s functional properties is strongly modulated by experience,
and the period of early childhood is emphasized as one of the crucial factors of differences in
its mechanisms, which can influence the appearance of some neurodevelopmental disorders.
Aim: The aim of the paper is to analyze data on the structure of neuroplasticity in
persons with certain neurodevelopmental disorders (intellectual disability, autism spectrum
disorder, and attention deficit hyperactivity disorder), as well as on possible stimulation in
this domain.
Methods: To achieve this goal, a review of the literature published in peer-reviewed
academic publications was carried out.
Results: Results from a number of studies indicate that altered neuroplasticity may
underlie some of these disorders. Early intervention aimed at facilitating neuroplasticity
mechanisms improves developmental outcomes in children with neurodevelopmental
disorders.
Conclusion: Several effective treatments have been confirmed in this domain, including
environmental enrichment, application of noninvasive stimulation protocols, and cognitive
training.",
publisher = "Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju/ University of Belgrade – Faculty of Special Education and Rehabilitation",
journal = "Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine",
title = "Neuroplastičnost kod osoba s neurorazvojnim Poremećajima, Neuroplasticity in persons with neurodevelopmental Disorders",
pages = "204-199",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_5332"
}

Pavlović, A., Đurić Zdravković, A.,& Gligorović, M.. (2023). Neuroplastičnost kod osoba s neurorazvojnim Poremećajima. in Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine
Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju/ University of Belgrade – Faculty of Special Education and Rehabilitation., 199-204.
https://hdl.handle.net/21.15107/rcub_rfasper_5332

Pavlović A, Đurić Zdravković A, Gligorović M. Neuroplastičnost kod osoba s neurorazvojnim Poremećajima. in Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine. 2023;:199-204.
https://hdl.handle.net/21.15107/rcub_rfasper_5332 .

Pavlović, Aleksandra, Đurić Zdravković, Aleksandra, Gligorović, Milica, "Neuroplastičnost kod osoba s neurorazvojnim Poremećajima" in Zbornik radova - 12. Međunarodni naučni skup Specijalna edukacija i rehabilitacija danas Beograd, 27–28. oktobar 2023. Godine (2023):199-204,
https://hdl.handle.net/21.15107/rcub_rfasper_5332 .

TY  - JOUR
AU  - Bozovic, Ivo
AU  - Jeremic, Marta
AU  - Pavlović, Aleksandra
AU  - Jovanovic, Carna
AU  - Kresojevic, Nikola
AU  - Vojvodic, Nikola
AU  - Jovanovic, Dejana
AU  - Sokic, Dragoslav
AU  - Mijajlovic, Milija
PY  - 2023
UR  - https://www.mdpi.com/2076-3425/13/5/747
UR  - C:\Users\FASPER\Zotero\storage\KN238T94\Bozovic et al. - 2023 - Cerebral Amyloid Angiopathy-Related Inflammation (.pdf
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5292
AB  - Cerebral amyloid angiopathy-related inflammation (CAA-rI) is a largely reversible, subacute encephalopathy, which is considered as a rare variant of cerebral amyloid angiopathy (CAA). Although the diagnosis of this inflammatory vasculopathy is generally clinico-pathologic, a probable or possible diagnosis can often be established based on current clinico-radiological diagnostic criteria. This is important since CAA-rI is considered as a treatable disorder, which most commonly occurs in the elderly population. Behavioral changes and cognitive deterioration are highlighted as the most common clinical signs of CAA-rI, followed by a heterogeneous spectrum of typical and atypical clinical presentations. However, despite the well-established clinical and radiological features incorporated in the current diagnostic criteria for this CAA variant, this rare disorder is still insufficiently recognized and treated. Here, we have shown three patients diagnosed with probable CAA-rI, with significant heterogeneity in the clinical and neuroradiological presentations, followed by different disease courses and outcomes after the introduction of immunosuppressive treatment. Moreover, we have also summarized up-to-date literature data about this rare, yet underdiagnosed, immune-mediated vasculopathy.
PB  - MDPI [Commercial Publisher]
T2  - Brain Sciences
T1  - Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review
IS  - 5
SP  - 747
VL  - 13
DO  - 10.3390/brainsci13050747
ER  - 

@article{
author = "Bozovic, Ivo and Jeremic, Marta and Pavlović, Aleksandra and Jovanovic, Carna and Kresojevic, Nikola and Vojvodic, Nikola and Jovanovic, Dejana and Sokic, Dragoslav and Mijajlovic, Milija",
year = "2023",
abstract = "Cerebral amyloid angiopathy-related inflammation (CAA-rI) is a largely reversible, subacute encephalopathy, which is considered as a rare variant of cerebral amyloid angiopathy (CAA). Although the diagnosis of this inflammatory vasculopathy is generally clinico-pathologic, a probable or possible diagnosis can often be established based on current clinico-radiological diagnostic criteria. This is important since CAA-rI is considered as a treatable disorder, which most commonly occurs in the elderly population. Behavioral changes and cognitive deterioration are highlighted as the most common clinical signs of CAA-rI, followed by a heterogeneous spectrum of typical and atypical clinical presentations. However, despite the well-established clinical and radiological features incorporated in the current diagnostic criteria for this CAA variant, this rare disorder is still insufficiently recognized and treated. Here, we have shown three patients diagnosed with probable CAA-rI, with significant heterogeneity in the clinical and neuroradiological presentations, followed by different disease courses and outcomes after the introduction of immunosuppressive treatment. Moreover, we have also summarized up-to-date literature data about this rare, yet underdiagnosed, immune-mediated vasculopathy.",
publisher = "MDPI [Commercial Publisher]",
journal = "Brain Sciences",
title = "Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review",
number = "5",
pages = "747",
volume = "13",
doi = "10.3390/brainsci13050747"
}

Bozovic, I., Jeremic, M., Pavlović, A., Jovanovic, C., Kresojevic, N., Vojvodic, N., Jovanovic, D., Sokic, D.,& Mijajlovic, M.. (2023). Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review. in Brain Sciences
MDPI [Commercial Publisher]., 13(5), 747.
https://doi.org/10.3390/brainsci13050747

Bozovic I, Jeremic M, Pavlović A, Jovanovic C, Kresojevic N, Vojvodic N, Jovanovic D, Sokic D, Mijajlovic M. Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review. in Brain Sciences. 2023;13(5):747.
doi:10.3390/brainsci13050747 .

Bozovic, Ivo, Jeremic, Marta, Pavlović, Aleksandra, Jovanovic, Carna, Kresojevic, Nikola, Vojvodic, Nikola, Jovanovic, Dejana, Sokic, Dragoslav, Mijajlovic, Milija, "Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review" in Brain Sciences, 13, no. 5 (2023):747,
https://doi.org/10.3390/brainsci13050747 . .

TY  - JOUR
AU  - Pavlović, Aleksandra
PY  - 2023
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5032
AB  - Stroke associated with pregnancy and the postpartum period (SiPP) is not common but its consequences can
be devastating both for the mother and the child. Pregnancy confers a substantially increased risk of stroke, especially
during the third trimester and until 6 weeks postpartum. SiPP is heterogeneous both in aetiology and presentation as it
includes both ischemic and haemorrhagic events as well as cerebral venous thrombosis. Specific risk factors for SiPP have
been identified and well described, such as hypertensive disorders of pregnancy and a prothrombotic state. However, it
is still a controversial issue if pregnancy should be considered a risk factor for stroke, although pregnancy and postpartum period clearly increase the stroke risk compared to non-pregnant time. Recent European Stroke Organization [ESO]
guidelines addressed the management of acute SiPP while other issues, particularly primary and secondary prevention
are still under investigated. There is also a lack of research and knowledge regarding long-term mother and foetus/child
outcomes post-SiPP. This paper addresses current knowledge on SiPP management and prognosis and discusses new
challenging clinical scenarios including the relationship between COVID-19 infection and SiPP.
PB  - Klinički bolnički centar Sestre milosrdnice [University Publisher] Department of Psychiatry [Imprint]
T2  - Archives of Psychiatry Research
T1  - Stroke in Pregnancy and Puerperium – Current Knowledge, Questions and Controversies
EP  - 100
IS  - 1
SP  - 95
VL  - 59
DO  - 10.20471/may.2023.59.01.12
ER  - 

@article{
author = "Pavlović, Aleksandra",
year = "2023",
abstract = "Stroke associated with pregnancy and the postpartum period (SiPP) is not common but its consequences can
be devastating both for the mother and the child. Pregnancy confers a substantially increased risk of stroke, especially
during the third trimester and until 6 weeks postpartum. SiPP is heterogeneous both in aetiology and presentation as it
includes both ischemic and haemorrhagic events as well as cerebral venous thrombosis. Specific risk factors for SiPP have
been identified and well described, such as hypertensive disorders of pregnancy and a prothrombotic state. However, it
is still a controversial issue if pregnancy should be considered a risk factor for stroke, although pregnancy and postpartum period clearly increase the stroke risk compared to non-pregnant time. Recent European Stroke Organization [ESO]
guidelines addressed the management of acute SiPP while other issues, particularly primary and secondary prevention
are still under investigated. There is also a lack of research and knowledge regarding long-term mother and foetus/child
outcomes post-SiPP. This paper addresses current knowledge on SiPP management and prognosis and discusses new
challenging clinical scenarios including the relationship between COVID-19 infection and SiPP.",
publisher = "Klinički bolnički centar Sestre milosrdnice [University Publisher] Department of Psychiatry [Imprint]",
journal = "Archives of Psychiatry Research",
title = "Stroke in Pregnancy and Puerperium – Current Knowledge, Questions and Controversies",
pages = "100-95",
number = "1",
volume = "59",
doi = "10.20471/may.2023.59.01.12"
}

Pavlović, A.. (2023). Stroke in Pregnancy and Puerperium – Current Knowledge, Questions and Controversies. in Archives of Psychiatry Research
Klinički bolnički centar Sestre milosrdnice [University Publisher] Department of Psychiatry [Imprint]., 59(1), 95-100.
https://doi.org/10.20471/may.2023.59.01.12

Pavlović A. Stroke in Pregnancy and Puerperium – Current Knowledge, Questions and Controversies. in Archives of Psychiatry Research. 2023;59(1):95-100.
doi:10.20471/may.2023.59.01.12 .

Pavlović, Aleksandra, "Stroke in Pregnancy and Puerperium – Current Knowledge, Questions and Controversies" in Archives of Psychiatry Research, 59, no. 1 (2023):95-100,
https://doi.org/10.20471/may.2023.59.01.12 . .

TY  - JOUR
AU  - Foddis, Marco
AU  - Blumenau, Sonja
AU  - Holtgrewe, Manuel
AU  - Paquette, Kimberly
AU  - Westra, Kaitlyn
AU  - Alonso, Isabel
AU  - Macario, Maria do Carmo
AU  - Morgadinho, Ana Sofia
AU  - Velon, Ana Graça
AU  - Santo, Gustavo
AU  - Santana, Isabel
AU  - Mönkäre, Saana
AU  - Kuuluvainen, Liina
AU  - Schleutker, Johanna
AU  - Pöyhönen, Minna
AU  - Myllykangas, Liisa
AU  - Pavlović, Aleksandra
AU  - Kostic, Vladimir
AU  - Dobricic, Valerija
AU  - Lohmann, Ebba
AU  - Hanagasi, Hasmet
AU  - Santos, Mariana
AU  - Guven, Gamze
AU  - Bilgic, Basar
AU  - Bras, Jose
AU  - Beule, Dieter
AU  - Dirnagl, Ulrich
AU  - Guerreiro, Rita
AU  - Sassi, Celeste
PY  - 2023
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0197458022002433
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5020
AB  - Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and retinal vasculopathy with cerebral leukodystrophy and systemic manifestations (RVCL-S) are the most common forms of rare monogenic early-onset cerebral small vessel disease and share clinical, and, to different extents, neuroradiological and neuropathological features. However, whether CADASIL and RVCL-S overlapping phenotype may be explained by shared genetic risk or causative factors such as TREX1 coding variants remains poorly understood. To investigate this intriguing hypothesis, we used exome sequencing to screen TREX1 protein-coding variability in a large multi-ethnic cohort of 180 early-onset independent familial and apparently sporadic CADASIL-like Caucasian patients from the USA, Portugal, Finland, Serbia and Turkey. We report 2 very rare and likely pathogenic TREX1 mutations: a loss of function mutation (p.Ala129fs) clustering in the catalytic domain, in an apparently sporadic 46-year-old patient from the USA and a missense mutation (p.Tyr305Cys) in the well conserved C-terminal region, in a 57-year-old patient with positive family history from Serbia. In concert with recent findings, our study expands the clinical spectrum of diseases associated with TREX1 mutations.
PB  - Elsevier
T2  - Neurobiology of Aging
T1  - TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients
EP  - 215
SP  - 208
VL  - 123
DO  - 10.1016/j.neurobiolaging.2022.11.013
ER  - 

@article{
author = "Foddis, Marco and Blumenau, Sonja and Holtgrewe, Manuel and Paquette, Kimberly and Westra, Kaitlyn and Alonso, Isabel and Macario, Maria do Carmo and Morgadinho, Ana Sofia and Velon, Ana Graça and Santo, Gustavo and Santana, Isabel and Mönkäre, Saana and Kuuluvainen, Liina and Schleutker, Johanna and Pöyhönen, Minna and Myllykangas, Liisa and Pavlović, Aleksandra and Kostic, Vladimir and Dobricic, Valerija and Lohmann, Ebba and Hanagasi, Hasmet and Santos, Mariana and Guven, Gamze and Bilgic, Basar and Bras, Jose and Beule, Dieter and Dirnagl, Ulrich and Guerreiro, Rita and Sassi, Celeste",
year = "2023, 2023",
abstract = "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and retinal vasculopathy with cerebral leukodystrophy and systemic manifestations (RVCL-S) are the most common forms of rare monogenic early-onset cerebral small vessel disease and share clinical, and, to different extents, neuroradiological and neuropathological features. However, whether CADASIL and RVCL-S overlapping phenotype may be explained by shared genetic risk or causative factors such as TREX1 coding variants remains poorly understood. To investigate this intriguing hypothesis, we used exome sequencing to screen TREX1 protein-coding variability in a large multi-ethnic cohort of 180 early-onset independent familial and apparently sporadic CADASIL-like Caucasian patients from the USA, Portugal, Finland, Serbia and Turkey. We report 2 very rare and likely pathogenic TREX1 mutations: a loss of function mutation (p.Ala129fs) clustering in the catalytic domain, in an apparently sporadic 46-year-old patient from the USA and a missense mutation (p.Tyr305Cys) in the well conserved C-terminal region, in a 57-year-old patient with positive family history from Serbia. In concert with recent findings, our study expands the clinical spectrum of diseases associated with TREX1 mutations.",
publisher = "Elsevier",
journal = "Neurobiology of Aging",
title = "TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients",
pages = "215-208",
volume = "123",
doi = "10.1016/j.neurobiolaging.2022.11.013"
}

Foddis, M., Blumenau, S., Holtgrewe, M., Paquette, K., Westra, K., Alonso, I., Macario, M. d. C., Morgadinho, A. S., Velon, A. G., Santo, G., Santana, I., Mönkäre, S., Kuuluvainen, L., Schleutker, J., Pöyhönen, M., Myllykangas, L., Pavlović, A., Kostic, V., Dobricic, V., Lohmann, E., Hanagasi, H., Santos, M., Guven, G., Bilgic, B., Bras, J., Beule, D., Dirnagl, U., Guerreiro, R.,& Sassi, C.. (2023). TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients. in Neurobiology of Aging
Elsevier., 123, 208-215.
https://doi.org/10.1016/j.neurobiolaging.2022.11.013

Foddis M, Blumenau S, Holtgrewe M, Paquette K, Westra K, Alonso I, Macario MDC, Morgadinho AS, Velon AG, Santo G, Santana I, Mönkäre S, Kuuluvainen L, Schleutker J, Pöyhönen M, Myllykangas L, Pavlović A, Kostic V, Dobricic V, Lohmann E, Hanagasi H, Santos M, Guven G, Bilgic B, Bras J, Beule D, Dirnagl U, Guerreiro R, Sassi C. TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients. in Neurobiology of Aging. 2023;123:208-215.
doi:10.1016/j.neurobiolaging.2022.11.013 .

Foddis, Marco, Blumenau, Sonja, Holtgrewe, Manuel, Paquette, Kimberly, Westra, Kaitlyn, Alonso, Isabel, Macario, Maria do Carmo, Morgadinho, Ana Sofia, Velon, Ana Graça, Santo, Gustavo, Santana, Isabel, Mönkäre, Saana, Kuuluvainen, Liina, Schleutker, Johanna, Pöyhönen, Minna, Myllykangas, Liisa, Pavlović, Aleksandra, Kostic, Vladimir, Dobricic, Valerija, Lohmann, Ebba, Hanagasi, Hasmet, Santos, Mariana, Guven, Gamze, Bilgic, Basar, Bras, Jose, Beule, Dieter, Dirnagl, Ulrich, Guerreiro, Rita, Sassi, Celeste, "TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients" in Neurobiology of Aging, 123 (2023):208-215,
https://doi.org/10.1016/j.neurobiolaging.2022.11.013 . .

TY  - JOUR
AU  - Pavlović, Aleksandra
AU  - Pekmezović, Tatjana
AU  - Mijajlović, Milija
AU  - Tomić, Gordana
AU  - Zidverc Trajković, Jasna
PY  - 2023
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5018
AB  - Background: Sex is a significant determinant of survival and functional outcome after stroke. Long-term cognitive outcome after acute lacunar stroke in the context of sex differences has been rarely reported. Methods: A cohort of small vessel disease (SVD) patients presenting with first-ever acute lacunar stroke and normal cognitive status has been evaluated 4 years after the qualifying event for the presence of cognitive impairment (CI) with a comprehensive neuropsychological battery. Differences in baseline clinical and neuroimaging characteristics were compared between sexes in relation to cognitive status. Results: A total of 124 female and 150 male patients were analyzed. No difference was detected between the groups regarding age (p = 0.932) or frequency of common vascular risk factors (p > 0.1 for all). At the baseline assessment, women had more disabilities compared to men with a mean modified Rankin scale (mRS) score of 2.5 (1.5 in men, p < 0.0001). Scores of white matter hyperintensities (WMH) of presumed vascular origin and a total number of lacunes of presumed vascular origin on brain MRI were higher in women compared to men (p < 0.0001 for all). As many as 64.6% of patients had CI of any severity on follow-up, women more frequently (77.4%) than men (54.0%; p < 0.0001). Univariate logistic regression analysis showed that female sex, higher NIHSS and mRS scores, presence of depression, and increasing WMH severity were associated with an increased risk for CI. Multivariate regression analysis indicated that only depression (OR 1.74, 95%CI 1.25–2.44; p = 0.001) and WMH severity (OR 1.10, 95%CI 1.03–1.17; p = 0.004) were independently associated with the CI. Conclusion: At the long-term follow-up, women lacunar stroke survivors, compared to men, more frequently had CI in the presence of more severe vascular brain lesions, but this association was dependent on the occurrence of depression and severity of WMH, and could not be explained by differences in common vascular risk factors. Copyright © 2023 Pavlovic, Pekmezovic, Mijajlovic, Tomic and Zidverc Trajkovic
PB  - Frontiers Media
T2  - Frontiers in Neurology
T1  - Is the female sex associated with an increased risk for long-term cognitive decline after the first-ever lacunar stroke? Prospective study on small vessel disease cohort
VL  - 13
DO  - 10.3389/fneur.2022.1052401
ER  - 

@article{
author = "Pavlović, Aleksandra and Pekmezović, Tatjana and Mijajlović, Milija and Tomić, Gordana and Zidverc Trajković, Jasna",
year = "2023",
abstract = "Background: Sex is a significant determinant of survival and functional outcome after stroke. Long-term cognitive outcome after acute lacunar stroke in the context of sex differences has been rarely reported. Methods: A cohort of small vessel disease (SVD) patients presenting with first-ever acute lacunar stroke and normal cognitive status has been evaluated 4 years after the qualifying event for the presence of cognitive impairment (CI) with a comprehensive neuropsychological battery. Differences in baseline clinical and neuroimaging characteristics were compared between sexes in relation to cognitive status. Results: A total of 124 female and 150 male patients were analyzed. No difference was detected between the groups regarding age (p = 0.932) or frequency of common vascular risk factors (p > 0.1 for all). At the baseline assessment, women had more disabilities compared to men with a mean modified Rankin scale (mRS) score of 2.5 (1.5 in men, p < 0.0001). Scores of white matter hyperintensities (WMH) of presumed vascular origin and a total number of lacunes of presumed vascular origin on brain MRI were higher in women compared to men (p < 0.0001 for all). As many as 64.6% of patients had CI of any severity on follow-up, women more frequently (77.4%) than men (54.0%; p < 0.0001). Univariate logistic regression analysis showed that female sex, higher NIHSS and mRS scores, presence of depression, and increasing WMH severity were associated with an increased risk for CI. Multivariate regression analysis indicated that only depression (OR 1.74, 95%CI 1.25–2.44; p = 0.001) and WMH severity (OR 1.10, 95%CI 1.03–1.17; p = 0.004) were independently associated with the CI. Conclusion: At the long-term follow-up, women lacunar stroke survivors, compared to men, more frequently had CI in the presence of more severe vascular brain lesions, but this association was dependent on the occurrence of depression and severity of WMH, and could not be explained by differences in common vascular risk factors. Copyright © 2023 Pavlovic, Pekmezovic, Mijajlovic, Tomic and Zidverc Trajkovic",
publisher = "Frontiers Media",
journal = "Frontiers in Neurology",
title = "Is the female sex associated with an increased risk for long-term cognitive decline after the first-ever lacunar stroke? Prospective study on small vessel disease cohort",
volume = "13",
doi = "10.3389/fneur.2022.1052401"
}

Pavlović, A., Pekmezović, T., Mijajlović, M., Tomić, G.,& Zidverc Trajković, J.. (2023). Is the female sex associated with an increased risk for long-term cognitive decline after the first-ever lacunar stroke? Prospective study on small vessel disease cohort. in Frontiers in Neurology
Frontiers Media., 13.
https://doi.org/10.3389/fneur.2022.1052401

Pavlović A, Pekmezović T, Mijajlović M, Tomić G, Zidverc Trajković J. Is the female sex associated with an increased risk for long-term cognitive decline after the first-ever lacunar stroke? Prospective study on small vessel disease cohort. in Frontiers in Neurology. 2023;13.
doi:10.3389/fneur.2022.1052401 .

Pavlović, Aleksandra, Pekmezović, Tatjana, Mijajlović, Milija, Tomić, Gordana, Zidverc Trajković, Jasna, "Is the female sex associated with an increased risk for long-term cognitive decline after the first-ever lacunar stroke? Prospective study on small vessel disease cohort" in Frontiers in Neurology, 13 (2023),
https://doi.org/10.3389/fneur.2022.1052401 . .

TY  - CONF
AU  - Đurić-Zdravković, Aleksandra
AU  - Pavlović, Aleksandra
AU  - Milanović-Dobrota, Biljana
AU  - Vidojković, Sara
PY  - 2023
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5172
AB  - Rani intervencijski programi protežiraju funkcionalne ishode. Rana intervencija zasnovana na
rutinama za decu sa razvojnim kašnjenjima podstiče saradnju između terapeuta i porodice, u cilju
poboljšanja učešća dece u porodičnim rutinama sa ciljevima koje porodica protežira, a koji su u
najboljem razvojnom interesu deteta. Kada su razvojne intervencije ugrađene u redovne rutine i
aktivnosti deteta, naučene veštine su funkcionalnije. Intervencije se mogu integrisati u igru, u
vreme obroka, vreme kupanja, ili kroz bilo koju drugu dnevnu rutinu. Aktivnosti koje čine opštu
strukturu detetovog dana smatraju se rutinama. Unutar svake rutine postoji skup aktivnosti ili
ponašanja koja se nazivaju rituali. Intervencija zasnovana na rutinama protežira rutine koje se
dešavaju u prirodnom okruženju deteta, pri čemu terapeuti mogu da se fokusiraju na plasiranje
novih veština, zasnovanih na svakodnevnim iskustvima. Pri prikupljanju jedinstvenog skupa
obrazaca i rituala u svakodnevnom životu terapeut može da koristi polustrukturisani format
intervjua. Svaki ritual u okviru rutine treba proceniti prema tome da li je neophodan za rutinu
koja se dešava, da li olakšava dnevno funkcionisanje i na koji način promoviše nezavisnost deteta.
Zadatak terapeuta koji se bave i sprovode ranu intervenciju je da usklade mogućnosti učenja u
kontekstu dnevnih rutina sa željenim razvojnim i bihevioralnim ishodima za dete. Sprovođenjem
ovakvog programa deca će imati najviše mogućnosti da nauče ciljane veštine, a roditelji će biti
opremljeni informacijama koje su im potrebne za unapređenje razvoja deteta.
AB  - Early intervention programs endorse functional outcomes. Early intervention based on routines
for children with developmental delays, encourages collaboration between therapist and family,
aiming to improve children's participation in family routines with family-promoted goals that are
in the child's best developmental interests. When developmental interventions are incorporated
into a child's regular routines and activities, the skills learned are more functional. Interventions
can be integrated into playtime, mealtime, bath time, or any other daily routine. Activities that
make up general structure of a child's day are considered routines. Within each routine is a set of
activities or behaviors called rituals. Routine-based intervention endorse routines that occur in
the child's natural environment, whereby therapists can focus on the placement of new skills,
based on everyday experiences. In collecting a unique set of patterns and rituals in everyday life,
the therapist can use a semi-structured interview format. Each ritual within the routine should be
evaluated according to whether it is necessary for the routine that takes place, whether it facilitates
daily functioning and how it promotes the child's independence. The task of early intervention
therapist is to align learning opportunities in the context of daily routines with the desired
developmental and behavioral outcomes for the child. By implementing this kind of a program,
children will have the most opportunities to learn targeted skills, and parents will be equipped
with information they need to improve their child's development.
PB  - Udruženje za podršku i kreativni razvoj djece i mladih i Edukacijsko-rehabilitacijski fakultet, Univerzitet u Tuzli
C3  - Unapređenje kvalitete života djece i mladih
T1  - Rutine i rituali u ranoj intervenciji
T1  - Routines and rituals in early intervention
EP  - 50
SP  - 43
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_5172
ER  - 

@conference{
author = "Đurić-Zdravković, Aleksandra and Pavlović, Aleksandra and Milanović-Dobrota, Biljana and Vidojković, Sara",
year = "2023",
abstract = "Rani intervencijski programi protežiraju funkcionalne ishode. Rana intervencija zasnovana na
rutinama za decu sa razvojnim kašnjenjima podstiče saradnju između terapeuta i porodice, u cilju
poboljšanja učešća dece u porodičnim rutinama sa ciljevima koje porodica protežira, a koji su u
najboljem razvojnom interesu deteta. Kada su razvojne intervencije ugrađene u redovne rutine i
aktivnosti deteta, naučene veštine su funkcionalnije. Intervencije se mogu integrisati u igru, u
vreme obroka, vreme kupanja, ili kroz bilo koju drugu dnevnu rutinu. Aktivnosti koje čine opštu
strukturu detetovog dana smatraju se rutinama. Unutar svake rutine postoji skup aktivnosti ili
ponašanja koja se nazivaju rituali. Intervencija zasnovana na rutinama protežira rutine koje se
dešavaju u prirodnom okruženju deteta, pri čemu terapeuti mogu da se fokusiraju na plasiranje
novih veština, zasnovanih na svakodnevnim iskustvima. Pri prikupljanju jedinstvenog skupa
obrazaca i rituala u svakodnevnom životu terapeut može da koristi polustrukturisani format
intervjua. Svaki ritual u okviru rutine treba proceniti prema tome da li je neophodan za rutinu
koja se dešava, da li olakšava dnevno funkcionisanje i na koji način promoviše nezavisnost deteta.
Zadatak terapeuta koji se bave i sprovode ranu intervenciju je da usklade mogućnosti učenja u
kontekstu dnevnih rutina sa željenim razvojnim i bihevioralnim ishodima za dete. Sprovođenjem
ovakvog programa deca će imati najviše mogućnosti da nauče ciljane veštine, a roditelji će biti
opremljeni informacijama koje su im potrebne za unapređenje razvoja deteta., Early intervention programs endorse functional outcomes. Early intervention based on routines
for children with developmental delays, encourages collaboration between therapist and family,
aiming to improve children's participation in family routines with family-promoted goals that are
in the child's best developmental interests. When developmental interventions are incorporated
into a child's regular routines and activities, the skills learned are more functional. Interventions
can be integrated into playtime, mealtime, bath time, or any other daily routine. Activities that
make up general structure of a child's day are considered routines. Within each routine is a set of
activities or behaviors called rituals. Routine-based intervention endorse routines that occur in
the child's natural environment, whereby therapists can focus on the placement of new skills,
based on everyday experiences. In collecting a unique set of patterns and rituals in everyday life,
the therapist can use a semi-structured interview format. Each ritual within the routine should be
evaluated according to whether it is necessary for the routine that takes place, whether it facilitates
daily functioning and how it promotes the child's independence. The task of early intervention
therapist is to align learning opportunities in the context of daily routines with the desired
developmental and behavioral outcomes for the child. By implementing this kind of a program,
children will have the most opportunities to learn targeted skills, and parents will be equipped
with information they need to improve their child's development.",
publisher = "Udruženje za podršku i kreativni razvoj djece i mladih i Edukacijsko-rehabilitacijski fakultet, Univerzitet u Tuzli",
journal = "Unapređenje kvalitete života djece i mladih",
title = "Rutine i rituali u ranoj intervenciji, Routines and rituals in early intervention",
pages = "50-43",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_5172"
}

Đurić-Zdravković, A., Pavlović, A., Milanović-Dobrota, B.,& Vidojković, S.. (2023). Rutine i rituali u ranoj intervenciji. in Unapređenje kvalitete života djece i mladih
Udruženje za podršku i kreativni razvoj djece i mladih i Edukacijsko-rehabilitacijski fakultet, Univerzitet u Tuzli., 43-50.
https://hdl.handle.net/21.15107/rcub_rfasper_5172

Đurić-Zdravković A, Pavlović A, Milanović-Dobrota B, Vidojković S. Rutine i rituali u ranoj intervenciji. in Unapređenje kvalitete života djece i mladih. 2023;:43-50.
https://hdl.handle.net/21.15107/rcub_rfasper_5172 .

Đurić-Zdravković, Aleksandra, Pavlović, Aleksandra, Milanović-Dobrota, Biljana, Vidojković, Sara, "Rutine i rituali u ranoj intervenciji" in Unapređenje kvalitete života djece i mladih (2023):43-50,
https://hdl.handle.net/21.15107/rcub_rfasper_5172 .

TY  - JOUR
AU  - Djordjevic, Jelena
AU  - Arsić, Slađana
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5021
AB  - Cognitive dysfunction has been recognized as a key aspect
of schizophrenia evident even during remission of symptoms.
During the previous decade, interest in cognitive deficits has
increased due to the recognition of their key importance for
the functional outcome and degree of social adaptation. Prominent cognitive deficits are disorders of memory, attention and
executive functions that manifest themselves as a disorder
of verbal fluency, problems with serial learning, difficulty in
problem solving, and disturbance of executive functions. The
observed cognitive deficit is attributed to the dysfunction of
cortical-cerebellar-thalamic circuits. Social cognition is the
ability to construct an image of relationships between oneself
and others and the ability to use flexible mental constructs as
a guide to social interactions. The data from previous studies
strongly support the association of neurocognitive and sociocognitive deficits with the performance of independent functioning and quality of life, emphasizing the need for prevention and treatment of cognitive deficits.
AB  - Kognitivna disfunkcija je prepoznata kao ključni aspekt šizofrenije, očigledan čak i tokom remisije simptoma.
Tokom prethodne decenije povećano je interesovanje za
kognitivne deficite zbog prepoznavanja njihovog ključnog
značaja za funkcionalni ishod i stepen socijalne adaptacije.
Izraženi kognitivni deficiti su poremećaji pamćenja, pažnje
i izvršnih funkcija koji se manifestuju kao poremećaj verbalne fluentnosti, problemi sa serijskim učenjem, teškoće
u rešavanju problema i poremećaj izvršnih funkcija.
Uočeni kognitivni deficit se pripisuje disfunkciji kortikalno
– cerebelarno - talamičkih kortikalnih kola. Socijalna kognicija je sposobnost da se konstruiše slika odnosa između
sebe i drugih i sposobnost korišćenja fleksibilnih mentalnih konstrukata kao vodiča za društvene interakcije. Podaci iz prethodnih studija snažno podržavaju povezanost
neurokognitivnih i sociokognitivnih deficita sa performansama samostalnog funkcionisanja i kvalitetom života,
naglašavajući potrebu za prevencijom i lečenjem kognitivnih deficita.
PB  - Akademija vaspitačko-medicinskih strukovnih studija,Kruševac; Zavod za javno zdravlje Ćuprija „Pomoravlje“ Ćuprija; Srpsko lekarsko društvo Podružnica Ćuprija; Društvo za neuronauke „Sozercanje iz Šumadije“, Kragujevac
T2  - PONS Medicinskog časopis
T1  - Cognitive aspects of schizophrenia / a narrative review
T1  - Kognitivni aspekti šizofrenije - narativni pregled
EP  - 25
IS  - 1
SP  - 19
VL  - 19
DO  - 10.5937/pomc19-37359
ER  - 

@article{
author = "Djordjevic, Jelena and Arsić, Slađana and Pavlović, Dragan and Pavlović, Aleksandra",
year = "2022",
abstract = "Cognitive dysfunction has been recognized as a key aspect
of schizophrenia evident even during remission of symptoms.
During the previous decade, interest in cognitive deficits has
increased due to the recognition of their key importance for
the functional outcome and degree of social adaptation. Prominent cognitive deficits are disorders of memory, attention and
executive functions that manifest themselves as a disorder
of verbal fluency, problems with serial learning, difficulty in
problem solving, and disturbance of executive functions. The
observed cognitive deficit is attributed to the dysfunction of
cortical-cerebellar-thalamic circuits. Social cognition is the
ability to construct an image of relationships between oneself
and others and the ability to use flexible mental constructs as
a guide to social interactions. The data from previous studies
strongly support the association of neurocognitive and sociocognitive deficits with the performance of independent functioning and quality of life, emphasizing the need for prevention and treatment of cognitive deficits., Kognitivna disfunkcija je prepoznata kao ključni aspekt šizofrenije, očigledan čak i tokom remisije simptoma.
Tokom prethodne decenije povećano je interesovanje za
kognitivne deficite zbog prepoznavanja njihovog ključnog
značaja za funkcionalni ishod i stepen socijalne adaptacije.
Izraženi kognitivni deficiti su poremećaji pamćenja, pažnje
i izvršnih funkcija koji se manifestuju kao poremećaj verbalne fluentnosti, problemi sa serijskim učenjem, teškoće
u rešavanju problema i poremećaj izvršnih funkcija.
Uočeni kognitivni deficit se pripisuje disfunkciji kortikalno
– cerebelarno - talamičkih kortikalnih kola. Socijalna kognicija je sposobnost da se konstruiše slika odnosa između
sebe i drugih i sposobnost korišćenja fleksibilnih mentalnih konstrukata kao vodiča za društvene interakcije. Podaci iz prethodnih studija snažno podržavaju povezanost
neurokognitivnih i sociokognitivnih deficita sa performansama samostalnog funkcionisanja i kvalitetom života,
naglašavajući potrebu za prevencijom i lečenjem kognitivnih deficita.",
publisher = "Akademija vaspitačko-medicinskih strukovnih studija,Kruševac; Zavod za javno zdravlje Ćuprija „Pomoravlje“ Ćuprija; Srpsko lekarsko društvo Podružnica Ćuprija; Društvo za neuronauke „Sozercanje iz Šumadije“, Kragujevac",
journal = "PONS Medicinskog časopis",
title = "Cognitive aspects of schizophrenia / a narrative review, Kognitivni aspekti šizofrenije - narativni pregled",
pages = "25-19",
number = "1",
volume = "19",
doi = "10.5937/pomc19-37359"
}

Djordjevic, J., Arsić, S., Pavlović, D.,& Pavlović, A.. (2022). Cognitive aspects of schizophrenia / a narrative review. in PONS Medicinskog časopis
Akademija vaspitačko-medicinskih strukovnih studija,Kruševac; Zavod za javno zdravlje Ćuprija „Pomoravlje“ Ćuprija; Srpsko lekarsko društvo Podružnica Ćuprija; Društvo za neuronauke „Sozercanje iz Šumadije“, Kragujevac., 19(1), 19-25.
https://doi.org/10.5937/pomc19-37359

Djordjevic J, Arsić S, Pavlović D, Pavlović A. Cognitive aspects of schizophrenia / a narrative review. in PONS Medicinskog časopis. 2022;19(1):19-25.
doi:10.5937/pomc19-37359 .

Djordjevic, Jelena, Arsić, Slađana, Pavlović, Dragan, Pavlović, Aleksandra, "Cognitive aspects of schizophrenia / a narrative review" in PONS Medicinskog časopis, 19, no. 1 (2022):19-25,
https://doi.org/10.5937/pomc19-37359 . .

TY  - JOUR
AU  - Jovanović, Stevan
AU  - Stojanović-Jovanović, Biljana
AU  - Pavlović, Aleksandra
AU  - Milošević, Radovan
AU  - Pavlović, Dragan
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5023
AB  - Background/Aim. Aging entails a wide range of cognitive
processes that are not independent of one another. It leads
to changes in physical-motor characteristics and sometimes

to disability. The aim of this study was to examine the asso-
ciation between multiple cognitive performances in elderly

subjects and their physical-motor abilities. Method. The
study included 98 elderly participants (60+) (16 males and

82 females). Cognitive abilities were assessed by the Mon-
treal Cognitive Assessment (MoCA)/Serbian version, and

physical measures were assessed by the Senior Fitness Test
with its five subtests, supplemented by the Walking Speed
Test. Results. Several MoCA items demonstrated relatively
low variability, i.e., they proved to be too easy for most of

the participants. The participants exhibited the lowest per-
formance on the memory relating to other domains, fol-
lowed by executive functions, visuospatial skills, attention,

concentration, and working memory domains, with the

highest performance on temporal and spatial orientation re-
lating to other domains. Executive functions and language

correlated most significantly with physical strength. Agility
and dynamic balance, lower- and upper-body strength, and
aerobic endurance correlated moderately and positively.
Conclusion. This study underlines the positive correlation
between physical fitness and cognitive level in the elderly

and emphasizes the importance of physical fitness for cog-
nitive functions, especially those of executive type in elderly

subjects. Clinicians should consider the association between
cognitive function and physical-motor performances when
dealing with functioning improvement in the elderly. The

importance of designing the most efficient exercise pro-
grams to achieve maximal somatic and cognitive effects is

emphasized.
AB  - Uvod/Cilj. Proces starenja podrazumeva promene na širo-
kom spektru kognitivnih procesa koji nisu nezavisni jedni od

drugih. On, takođe, dovodi do promena u fizičko-motoričkim
karakteristikama, a ponekad i do invaliditeta. Cilj istraživanja

bio je da se ispita povezanost između više kognitivnih per-
formansi kod starijih ispitanika i njihovih fizičko-motoričkih

sposobnosti. Metode. U istraživanju je učestvovalo ukupno
98 starijih ispitanika (60+) (16 muškog i 82 ženskog pola).
Kognitivne sposobnosti procenjene su Montrealskom skalom

kognicije (Montreal Cognitive Assessment – MoCA)/srpska verzi-
ja, a mere fizičkih sposobnosti su procenjene Senior Fitness tes-
tom koji se sastoji od pet subtestova, dopunjenih testom

brzine hoda. Rezultati. Na nekoliko subtestova MoCA re-
zultati su ukazali na relativno malu varijabilnost, tj. pokazalo

se da su previše jednostavni za većinu ispitanika. Ispitanici su

pokazali najslabije rezultate u funkcionisanju memorije u od-
nosu na druge domene, a zatim slede izvršne funkcije, vizue-
lno prostorne veštine, pažnja, koncentracija i radna memorija,

sa najvišim performansama na vremenskoj i prostornoj ori-
jentaciji u odnosu na druge domene. Izvršne funkcije i jezik

su najznačajnije korelirali sa fizičkom snagom. Spretnost i
dinamična ravnoteža, snaga donjih i gornjih ekstremiteta i
aerobna izdržljivost su korelirali umereno i pozitivno.
Zaključak. Studija ukazuje na pozitivne korelacije između

fizičko-motoričkih sposobnosti i kognitivnog nivoa kod stari-
jih osoba i naglašava značaj fizičke spremnosti za kognitivno

funkcionisanje, a naročito u domenu izvršnih funkcija kod
njih. Kliničari bi trebalo da imaju u vidu povezanost između
kognitivnih funkcija i fizičko-motoričkih performansi, kada se
bave poboljšanjem funkcionisanja starijih osoba. Ukazuje se
na važnost dizajniranja najefikasnijih programa vežbanja za
postizanje maksimalnih somatskih i kognitivnih efekata.
PB  - Vojnomedicinska akademija
T2  - Vojnosanitetski pregled
T1  - Cognitive ability and motor performances in the elderly
T1  - Kognitivne sposobnosti i motoričke performanse starijih osoba
EP  - 474
IS  - 5
SP  - 465
VL  - 79
DO  - 10.2298/VSP200812143J
ER  - 

@article{
author = "Jovanović, Stevan and Stojanović-Jovanović, Biljana and Pavlović, Aleksandra and Milošević, Radovan and Pavlović, Dragan",
year = "2022",
abstract = "Background/Aim. Aging entails a wide range of cognitive
processes that are not independent of one another. It leads
to changes in physical-motor characteristics and sometimes

to disability. The aim of this study was to examine the asso-
ciation between multiple cognitive performances in elderly

subjects and their physical-motor abilities. Method. The
study included 98 elderly participants (60+) (16 males and

82 females). Cognitive abilities were assessed by the Mon-
treal Cognitive Assessment (MoCA)/Serbian version, and

physical measures were assessed by the Senior Fitness Test
with its five subtests, supplemented by the Walking Speed
Test. Results. Several MoCA items demonstrated relatively
low variability, i.e., they proved to be too easy for most of

the participants. The participants exhibited the lowest per-
formance on the memory relating to other domains, fol-
lowed by executive functions, visuospatial skills, attention,

concentration, and working memory domains, with the

highest performance on temporal and spatial orientation re-
lating to other domains. Executive functions and language

correlated most significantly with physical strength. Agility
and dynamic balance, lower- and upper-body strength, and
aerobic endurance correlated moderately and positively.
Conclusion. This study underlines the positive correlation
between physical fitness and cognitive level in the elderly

and emphasizes the importance of physical fitness for cog-
nitive functions, especially those of executive type in elderly

subjects. Clinicians should consider the association between
cognitive function and physical-motor performances when
dealing with functioning improvement in the elderly. The

importance of designing the most efficient exercise pro-
grams to achieve maximal somatic and cognitive effects is

emphasized., Uvod/Cilj. Proces starenja podrazumeva promene na širo-
kom spektru kognitivnih procesa koji nisu nezavisni jedni od

drugih. On, takođe, dovodi do promena u fizičko-motoričkim
karakteristikama, a ponekad i do invaliditeta. Cilj istraživanja

bio je da se ispita povezanost između više kognitivnih per-
formansi kod starijih ispitanika i njihovih fizičko-motoričkih

sposobnosti. Metode. U istraživanju je učestvovalo ukupno
98 starijih ispitanika (60+) (16 muškog i 82 ženskog pola).
Kognitivne sposobnosti procenjene su Montrealskom skalom

kognicije (Montreal Cognitive Assessment – MoCA)/srpska verzi-
ja, a mere fizičkih sposobnosti su procenjene Senior Fitness tes-
tom koji se sastoji od pet subtestova, dopunjenih testom

brzine hoda. Rezultati. Na nekoliko subtestova MoCA re-
zultati su ukazali na relativno malu varijabilnost, tj. pokazalo

se da su previše jednostavni za većinu ispitanika. Ispitanici su

pokazali najslabije rezultate u funkcionisanju memorije u od-
nosu na druge domene, a zatim slede izvršne funkcije, vizue-
lno prostorne veštine, pažnja, koncentracija i radna memorija,

sa najvišim performansama na vremenskoj i prostornoj ori-
jentaciji u odnosu na druge domene. Izvršne funkcije i jezik

su najznačajnije korelirali sa fizičkom snagom. Spretnost i
dinamična ravnoteža, snaga donjih i gornjih ekstremiteta i
aerobna izdržljivost su korelirali umereno i pozitivno.
Zaključak. Studija ukazuje na pozitivne korelacije između

fizičko-motoričkih sposobnosti i kognitivnog nivoa kod stari-
jih osoba i naglašava značaj fizičke spremnosti za kognitivno

funkcionisanje, a naročito u domenu izvršnih funkcija kod
njih. Kliničari bi trebalo da imaju u vidu povezanost između
kognitivnih funkcija i fizičko-motoričkih performansi, kada se
bave poboljšanjem funkcionisanja starijih osoba. Ukazuje se
na važnost dizajniranja najefikasnijih programa vežbanja za
postizanje maksimalnih somatskih i kognitivnih efekata.",
publisher = "Vojnomedicinska akademija",
journal = "Vojnosanitetski pregled",
title = "Cognitive ability and motor performances in the elderly, Kognitivne sposobnosti i motoričke performanse starijih osoba",
pages = "474-465",
number = "5",
volume = "79",
doi = "10.2298/VSP200812143J"
}

Jovanović, S., Stojanović-Jovanović, B., Pavlović, A., Milošević, R.,& Pavlović, D.. (2022). Cognitive ability and motor performances in the elderly. in Vojnosanitetski pregled
Vojnomedicinska akademija., 79(5), 465-474.
https://doi.org/10.2298/VSP200812143J

Jovanović S, Stojanović-Jovanović B, Pavlović A, Milošević R, Pavlović D. Cognitive ability and motor performances in the elderly. in Vojnosanitetski pregled. 2022;79(5):465-474.
doi:10.2298/VSP200812143J .

Jovanović, Stevan, Stojanović-Jovanović, Biljana, Pavlović, Aleksandra, Milošević, Radovan, Pavlović, Dragan, "Cognitive ability and motor performances in the elderly" in Vojnosanitetski pregled, 79, no. 5 (2022):465-474,
https://doi.org/10.2298/VSP200812143J . .

TY  - JOUR
AU  - Božić, Marija
AU  - Milenković, Marija
AU  - Pavlović, Dragan
AU  - Stamenković, Miroslav
AU  - Pavlović, Aleksandra
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/4569
AB  - Vitamin B1 (aneurin, thiamine) is a water-soluble vitamin necessary for the normal function of the nervous
system, visual system and heart and is part of important enzymes in the body. Thiamine enables the normal
use of glucose, other carbohydrates and proteins, and enables the supply of energy to the organism.
The main sources of thiamine are exogenous and small amounts are synthesized by microorganisms of
the human intestinal microbiome.
Vitamin B1 cannot accumulate in the body, so signs of deficiency are quickly manifested. Hypovitaminosis
B1 is seen in chronic ethyl abuse, persistent vomiting (as in some pregnant women) or after bariatric
surgical procedures, but in a mild form it is present in the general population.
Normal daily needs for vitamin B1 depend on calorie intake, and 0.4 mg should be ingested for every
1000 kcal.
AB  - Vitamin B1 (aneurin, tiamin) rastvorljiv je u vodi, neopho-
dan je za normalno funkcionisanje nervnog sistema, organa
vida i srca i deo je važnih enzima u telu. Tiamin omogućava
normalnu upotrebu glukoze, drugih ugljenih hidrata i pro-
teina i snabdevanje organizma energijom.
Glavni izvori tiamina su egzogeni i male količine sinte-
tišu mikroorganizmi ljudskog crevnog mikrobioma.
Vitamin B1 se ne može nakupljati u telu, pa se znakovi ne-
dostatka brzo manifestuju. Hipovitaminoza B1 se opaža
kod hronične zloupotrebe alkohola, upornog povraćanja
(kao kod nekih trudnica) ili posle barijatrijskih hirur-
ških procedura, ali u blagom obliku je prisutna i u opštoj
populaciji.
Normalne dnevne potrebe za vitaminom B1 zavise od unosa
kalorija, pa na svakih 1000 kcal treba unetiti 0,4 mg ovog
vitamina.
PB  - Serbian Medical Society
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Vitamin B1, eye and brain
T1  - Vitamin B1, oko i mozak
IS  - 3-4
SP  - 233
VL  - 150
VL  - 237
DO  - 10.2298/SARH210929019B
ER  - 

@article{
author = "Božić, Marija and Milenković, Marija and Pavlović, Dragan and Stamenković, Miroslav and Pavlović, Aleksandra",
year = "2022",
abstract = "Vitamin B1 (aneurin, thiamine) is a water-soluble vitamin necessary for the normal function of the nervous
system, visual system and heart and is part of important enzymes in the body. Thiamine enables the normal
use of glucose, other carbohydrates and proteins, and enables the supply of energy to the organism.
The main sources of thiamine are exogenous and small amounts are synthesized by microorganisms of
the human intestinal microbiome.
Vitamin B1 cannot accumulate in the body, so signs of deficiency are quickly manifested. Hypovitaminosis
B1 is seen in chronic ethyl abuse, persistent vomiting (as in some pregnant women) or after bariatric
surgical procedures, but in a mild form it is present in the general population.
Normal daily needs for vitamin B1 depend on calorie intake, and 0.4 mg should be ingested for every
1000 kcal., Vitamin B1 (aneurin, tiamin) rastvorljiv je u vodi, neopho-
dan je za normalno funkcionisanje nervnog sistema, organa
vida i srca i deo je važnih enzima u telu. Tiamin omogućava
normalnu upotrebu glukoze, drugih ugljenih hidrata i pro-
teina i snabdevanje organizma energijom.
Glavni izvori tiamina su egzogeni i male količine sinte-
tišu mikroorganizmi ljudskog crevnog mikrobioma.
Vitamin B1 se ne može nakupljati u telu, pa se znakovi ne-
dostatka brzo manifestuju. Hipovitaminoza B1 se opaža
kod hronične zloupotrebe alkohola, upornog povraćanja
(kao kod nekih trudnica) ili posle barijatrijskih hirur-
ških procedura, ali u blagom obliku je prisutna i u opštoj
populaciji.
Normalne dnevne potrebe za vitaminom B1 zavise od unosa
kalorija, pa na svakih 1000 kcal treba unetiti 0,4 mg ovog
vitamina.",
publisher = "Serbian Medical Society",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Vitamin B1, eye and brain, Vitamin B1, oko i mozak",
number = "3-4",
pages = "233",
volume = "150, 237",
doi = "10.2298/SARH210929019B"
}

Božić, M., Milenković, M., Pavlović, D., Stamenković, M.,& Pavlović, A.. (2022). Vitamin B1, eye and brain. in Srpski arhiv za celokupno lekarstvo
Serbian Medical Society., 150(3-4), 233.
https://doi.org/10.2298/SARH210929019B

Božić M, Milenković M, Pavlović D, Stamenković M, Pavlović A. Vitamin B1, eye and brain. in Srpski arhiv za celokupno lekarstvo. 2022;150(3-4):233.
doi:10.2298/SARH210929019B .

Božić, Marija, Milenković, Marija, Pavlović, Dragan, Stamenković, Miroslav, Pavlović, Aleksandra, "Vitamin B1, eye and brain" in Srpski arhiv za celokupno lekarstvo, 150, no. 3-4 (2022):233,
https://doi.org/10.2298/SARH210929019B . .

TY  - JOUR
AU  - Pavlović, Viktor
AU  - Parojčić, Aleksandra
AU  - Pavlović, Aleksandra
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5022
AB  - Fenomen približavanja modelu odnosi se na tendenciju da se zadati model kopira njemu
veoma blizu ili preko njega. Ovaj fenomen klasično se shvata kao vid konstrukcione apraksije
koji se javlja pri zadacima grafomotornog kopiranja ili pri gestualnim imitacijama. Njegovo
ispoljavanje na neuropsihološkim testovima uzima se kao neurokognitivni indikator
demencija, a najčešće kao indikator Alchajmerove demencije. Međutim, iako visoko specifičan
znak za ovu vrstu demencije, savremena literatura upućuje na zaključak da ovaj fenomen
svakako nije patognomoničan za Alchajmerovu bolest, već da se javlja u širokom spektru
neurokognitivnih poremećaja sa ili bez demencije. Iako je naša stručna javnost upoznata sa
fenomenom približavanja modelu, do sada se o njemu nije na sistematičan način izlagalo. Iz
tog razloga, osim diskusije o značaju približavanja modelu u kliničkoj praksi, rad objedinjuje
i kritički analizira dosadašnja saznanja u vezi sa fenomenom. U radu autori diskutuju: (1)
Istorijski razvoj i konceptualizacija fenomena; (2) Neuroanatomski korelati fenomena; (3)
Hipoteza o kompenzaciji; (4) Hipoteza o atrakciji.
AB  - The closing-in phenomenon occurs when a drawing is reproduced close to or
superimposed on the original model. This phenomenon is classically understood as a
type of constructional apraxia that occurs during graphomotor copying tasks or
gestural imitations. Its manifestation on neuropsychological tests is taken as a
neurocognitive indicator of dementia, most often as an indicator of Alzheimer's
disease. Although a highly specific sign for this dementia type, current literature
suggests that it is certainly not pathognomonic for Alzheimer's dementia, but occurs
in a wide range of neurocognitive disorders with or without dementia. Although the
Serbian academic circles are familiar with this phenomenon, thus far it hasn’t been
sistematically explored. For this reason, in addition to discussing the significance of
this phenomenon in clinical practice, in this paper we also summarize and critically
analyze current knowledge regarding closing-in phenomenon. In this paper we
discuss: (1) Historical development and conceptualization; (2) Neuroanatomical
correlates of the phenomenon; (3) Compensation hypothesis; (4) Attraction
hypothesis.
PB  - Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd
T2  - Engrami
T1  - Fenomen približavanja modelu: intrigantni oblik konstrukcione apraksije
T1  - The Closing-in phenomenon: intricate aspect of constructional apraxia
EP  - 17
IS  - 2
SP  - 1
VL  - 44
DO  - 10.5937/engrami44-37649
ER  - 

@article{
author = "Pavlović, Viktor and Parojčić, Aleksandra and Pavlović, Aleksandra",
year = "2022",
abstract = "Fenomen približavanja modelu odnosi se na tendenciju da se zadati model kopira njemu
veoma blizu ili preko njega. Ovaj fenomen klasično se shvata kao vid konstrukcione apraksije
koji se javlja pri zadacima grafomotornog kopiranja ili pri gestualnim imitacijama. Njegovo
ispoljavanje na neuropsihološkim testovima uzima se kao neurokognitivni indikator
demencija, a najčešće kao indikator Alchajmerove demencije. Međutim, iako visoko specifičan
znak za ovu vrstu demencije, savremena literatura upućuje na zaključak da ovaj fenomen
svakako nije patognomoničan za Alchajmerovu bolest, već da se javlja u širokom spektru
neurokognitivnih poremećaja sa ili bez demencije. Iako je naša stručna javnost upoznata sa
fenomenom približavanja modelu, do sada se o njemu nije na sistematičan način izlagalo. Iz
tog razloga, osim diskusije o značaju približavanja modelu u kliničkoj praksi, rad objedinjuje
i kritički analizira dosadašnja saznanja u vezi sa fenomenom. U radu autori diskutuju: (1)
Istorijski razvoj i konceptualizacija fenomena; (2) Neuroanatomski korelati fenomena; (3)
Hipoteza o kompenzaciji; (4) Hipoteza o atrakciji., The closing-in phenomenon occurs when a drawing is reproduced close to or
superimposed on the original model. This phenomenon is classically understood as a
type of constructional apraxia that occurs during graphomotor copying tasks or
gestural imitations. Its manifestation on neuropsychological tests is taken as a
neurocognitive indicator of dementia, most often as an indicator of Alzheimer's
disease. Although a highly specific sign for this dementia type, current literature
suggests that it is certainly not pathognomonic for Alzheimer's dementia, but occurs
in a wide range of neurocognitive disorders with or without dementia. Although the
Serbian academic circles are familiar with this phenomenon, thus far it hasn’t been
sistematically explored. For this reason, in addition to discussing the significance of
this phenomenon in clinical practice, in this paper we also summarize and critically
analyze current knowledge regarding closing-in phenomenon. In this paper we
discuss: (1) Historical development and conceptualization; (2) Neuroanatomical
correlates of the phenomenon; (3) Compensation hypothesis; (4) Attraction
hypothesis.",
publisher = "Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd",
journal = "Engrami",
title = "Fenomen približavanja modelu: intrigantni oblik konstrukcione apraksije, The Closing-in phenomenon: intricate aspect of constructional apraxia",
pages = "17-1",
number = "2",
volume = "44",
doi = "10.5937/engrami44-37649"
}

Pavlović, V., Parojčić, A.,& Pavlović, A.. (2022). Fenomen približavanja modelu: intrigantni oblik konstrukcione apraksije. in Engrami
Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd., 44(2), 1-17.
https://doi.org/10.5937/engrami44-37649

Pavlović V, Parojčić A, Pavlović A. Fenomen približavanja modelu: intrigantni oblik konstrukcione apraksije. in Engrami. 2022;44(2):1-17.
doi:10.5937/engrami44-37649 .

Pavlović, Viktor, Parojčić, Aleksandra, Pavlović, Aleksandra, "Fenomen približavanja modelu: intrigantni oblik konstrukcione apraksije" in Engrami, 44, no. 2 (2022):1-17,
https://doi.org/10.5937/engrami44-37649 . .

TY  - CONF
AU  - Pavlović, Aleksandra
AU  - Stevanović, Aleksandar
AU  - Vujičić, Danilo
AU  - Pavlović, Viktor
AU  - Tomić, Gordana
AU  - Mijajlović, Milija
AU  - Radojičić, Aleksandra
AU  - Zidverc Trajković, Jasna
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/4964
AB  - Bolest malih krvnih sudova mozga (BMKS) je odgovorna za najveći broj možda- nih udara i vaskularno kognitivno oštećenje i obično je posledica klasičnih vaskularnih faktora rizika. Cilj našeg rada je da se u kohorti bolesnika sa BMKS ispita povezanost stepena obrazovanja i kliničke i radiološke sli- ke BMKS. U studiji je analizirano 424 ispitanika, srednje životne dobi od 62 godine, 53% muškog pola, različitog stepena obrazovanja u trajanju od 8 do 20 godina. Pokazana je statistički značajna povezanost stepena obrazovanja sa postojanjem simptoma depresije (p=0,050), ukupnom težinom lezija na MR moz- ga (p=0,029), kao i ukupnim brojem izolovanih lakunarnih ishemija (p=0,032).
Zabeležena je povezanost pola (p=0,055) i lezija u periventrikularnoj regiji (p=0,062) sa stepenom obrazovanja na nivou statističkog trenda. Mehanizmi kojima stepen obrazovanja može uticati na rizik za nastanak vaskular- nih lezija mozga nisu u potpunosti razjašnjenji. Deo ove povezanost se može objasniti nižim socijalno-ekonomskim statusom, povećanom učestalošću vaskularnih bolesti (hipertenzija, dijabetes) i nezdravim navikama (pušenje, visokokalorijska ishrana, sedentarni način života), ali postoje dokazi da je ova korelacija nezavisna od klasičnih vaskularnih faktora rizika. Otkrivanje i rano korigovanje preventibilnih faktora za nastanak vaskularnih lezija mozga od velikog je društvenog značaja, uz potencijal da rane socijalne i eduka- tivne intervencije pozitivno utiču na status cerebralne cirkulacije kasnije u životu.
AB  - Cerebral small vessel disease (CSVD), the most frequent cause of stroke and vascular cognitive impairment, is typically associated with common vascular risk factors. Our paper aims to analyze the correlation between the level of education and clinical and radiological presentation in a cohort of patients with CSVD. A total of 424 patients have been recruited, with a mean age of 62 years, 53% males, with years of education ranging from 8 to 20. We found a statistically
significant correlation between depressive symptoms (p=0.050), total severity of cerebral lesions on MR scans (p=0.029), and the total number of lacunar ischemic lesions (p=0.032). The correlation between sex (p=0.055) and periventricular lesions (p=0.062) with educational status was at the level of the statistical trend. The putative mechanisms of the association between education and the risk for vascular brain lesions were not fully elucidated. Partially, this association can be explained by lower socioeconomic status, increased incidence of vascular diseases (hypertension, diabetes), and unhealthy lifestyle (smoking, poor diet, sedentary lifestyle), however, this association might also be independent of common vascular risk factors. Identification and early management of preventable risk factors for cerebral vascular lesions are of most importance to society, with the potential of early social and educational intervention to positively affect cerebral circulation status later in life.
PB  - Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju (ICF)
C3  - Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine
T1  - Povezanost stepena obrazovanja i bolesti malih krvnih sudova mozga
T1  - Level of education and cerebral small vessel disease
EP  - 192
SP  - 185
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_4964
ER  - 

@conference{
author = "Pavlović, Aleksandra and Stevanović, Aleksandar and Vujičić, Danilo and Pavlović, Viktor and Tomić, Gordana and Mijajlović, Milija and Radojičić, Aleksandra and Zidverc Trajković, Jasna",
year = "2022",
abstract = "Bolest malih krvnih sudova mozga (BMKS) je odgovorna za najveći broj možda- nih udara i vaskularno kognitivno oštećenje i obično je posledica klasičnih vaskularnih faktora rizika. Cilj našeg rada je da se u kohorti bolesnika sa BMKS ispita povezanost stepena obrazovanja i kliničke i radiološke sli- ke BMKS. U studiji je analizirano 424 ispitanika, srednje životne dobi od 62 godine, 53% muškog pola, različitog stepena obrazovanja u trajanju od 8 do 20 godina. Pokazana je statistički značajna povezanost stepena obrazovanja sa postojanjem simptoma depresije (p=0,050), ukupnom težinom lezija na MR moz- ga (p=0,029), kao i ukupnim brojem izolovanih lakunarnih ishemija (p=0,032).
Zabeležena je povezanost pola (p=0,055) i lezija u periventrikularnoj regiji (p=0,062) sa stepenom obrazovanja na nivou statističkog trenda. Mehanizmi kojima stepen obrazovanja može uticati na rizik za nastanak vaskular- nih lezija mozga nisu u potpunosti razjašnjenji. Deo ove povezanost se može objasniti nižim socijalno-ekonomskim statusom, povećanom učestalošću vaskularnih bolesti (hipertenzija, dijabetes) i nezdravim navikama (pušenje, visokokalorijska ishrana, sedentarni način života), ali postoje dokazi da je ova korelacija nezavisna od klasičnih vaskularnih faktora rizika. Otkrivanje i rano korigovanje preventibilnih faktora za nastanak vaskularnih lezija mozga od velikog je društvenog značaja, uz potencijal da rane socijalne i eduka- tivne intervencije pozitivno utiču na status cerebralne cirkulacije kasnije u životu., Cerebral small vessel disease (CSVD), the most frequent cause of stroke and vascular cognitive impairment, is typically associated with common vascular risk factors. Our paper aims to analyze the correlation between the level of education and clinical and radiological presentation in a cohort of patients with CSVD. A total of 424 patients have been recruited, with a mean age of 62 years, 53% males, with years of education ranging from 8 to 20. We found a statistically
significant correlation between depressive symptoms (p=0.050), total severity of cerebral lesions on MR scans (p=0.029), and the total number of lacunar ischemic lesions (p=0.032). The correlation between sex (p=0.055) and periventricular lesions (p=0.062) with educational status was at the level of the statistical trend. The putative mechanisms of the association between education and the risk for vascular brain lesions were not fully elucidated. Partially, this association can be explained by lower socioeconomic status, increased incidence of vascular diseases (hypertension, diabetes), and unhealthy lifestyle (smoking, poor diet, sedentary lifestyle), however, this association might also be independent of common vascular risk factors. Identification and early management of preventable risk factors for cerebral vascular lesions are of most importance to society, with the potential of early social and educational intervention to positively affect cerebral circulation status later in life.",
publisher = "Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju (ICF)",
journal = "Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine",
title = "Povezanost stepena obrazovanja i bolesti malih krvnih sudova mozga, Level of education and cerebral small vessel disease",
pages = "192-185",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_4964"
}

Pavlović, A., Stevanović, A., Vujičić, D., Pavlović, V., Tomić, G., Mijajlović, M., Radojičić, A.,& Zidverc Trajković, J.. (2022). Povezanost stepena obrazovanja i bolesti malih krvnih sudova mozga. in Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine
Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju (ICF)., 185-192.
https://hdl.handle.net/21.15107/rcub_rfasper_4964

Pavlović A, Stevanović A, Vujičić D, Pavlović V, Tomić G, Mijajlović M, Radojičić A, Zidverc Trajković J. Povezanost stepena obrazovanja i bolesti malih krvnih sudova mozga. in Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine. 2022;:185-192.
https://hdl.handle.net/21.15107/rcub_rfasper_4964 .

Pavlović, Aleksandra, Stevanović, Aleksandar, Vujičić, Danilo, Pavlović, Viktor, Tomić, Gordana, Mijajlović, Milija, Radojičić, Aleksandra, Zidverc Trajković, Jasna, "Povezanost stepena obrazovanja i bolesti malih krvnih sudova mozga" in Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine (2022):185-192,
https://hdl.handle.net/21.15107/rcub_rfasper_4964 .

TY  - CONF
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/4966
AB  - Poremećaj pažnje sa hiperaktivnošću (eng. attention deficit/hyperactivity disorder ADHD) je multifaktorski poremećaj čija učestalost iznosi 5–7% kod dece i oko 2,5% kod odraslih. Smatra se da je moguće postojanje tri slična ali po- sebna tipa poremećaja. Posebno se izdvaja ADHD sa početkom u odraslom dobu.
Procenjuje se da su nasledni faktori prisutni kod otprilike 77% slučajeva ADHD-a, pri čemu je identifikovano 18 različitih gena, međutim, spoljašni faktori igraju značajnu ulogu u ekspresiji simptoma. Postoji više modela moždane disfunkcije u ADHD kao što su prefrontalno-egzekutivni model, model pažnje, model nagrade, poremećaj neuronske mreže mirovanja, model kognicije i energije i neurorazvojni model. Biohemijske promene su višestruke i uključuju dopaminergički, adrenergički, serotonergički i holinergički si- stem. Ispitivanja strukture mozga su pokazala smanjenu zapreminu mozga kod dece sa ADHD, a posebno prefrontalne kore, prednje cingularne kore, bazalnih ganglija i malog mozga, a donekle i temporalnog i parijetalnog režnja. Postoje individualne varijacije u međusobnom odnosu kortikalne i supkortikalne disfunkcije što dovodi do heterogenog kliničkog ispoljavanja. S obzirom na nedovoljnu efikasnost i značajne neželjene efekte upotrebe psihostimulan- sa u lečenju ADHD, primena mikronutrijenata je moguća terapija bez značajnih neželjenih pojava i to pre svega cinka, omega-3 masnih kiselina i vitamina D, kao i multivitamina-multiminerala.
AB  - Attention deficit/hyperactivity disorder (ADHD) is a multifactorial disorder diagnosed in 5-7% children and 2,5% of adults in general population. Three similar but distinct subtypes of ADHD has been identified. A separate form is ADHD with adult onset. Hereditary factors are explaining 77% of cases with at least 18 different susceptibility genes identified, each one with small effect size. However, the inlfuence of several envorinmental factors have been recognized. There are several models of brain dysfunction in ADHD, comprising prefrontal-executive model, attention model, reward model, disruption of neuronal default-mode network, cognition and energy model and neurodevelopmental model.
There are multiple biochemical alterations in ADHD, including dopaminergic, adrenergic, serotonergic and cholinergic system.
Current research indicate reduced brain volume in children with ADHD, particularly in prefrontal cortex, anterior cingulate cortex, basal ganglia and cerebellum, but also in temporal and parietal lobe to a certain extent. The extent of cortical and subcortical brain involvement varies between individuals which leads to wide variety of clinical presentation. Considering reduced efficacy and significant side effects of psychostimulants in ADHD treatment, the use of micronutrients is a potential therapeutical approach without significant side effects. Most o evidence is available to the use of zinc, omega-3 fat acids and vitamin D, as well as for multivitamins and minerals.
PB  - Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju (ICF)
C3  - Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine
T1  - Poremećaj pažnje sa hiperaktivnošću – savremeni pregled neurobioloških osnova
T1  - An update on neurobiology of attention deficit hyperactivity disorder
EP  - 209
SP  - 201
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_4966
ER  - 

@conference{
author = "Pavlović, Dragan and Pavlović, Aleksandra",
year = "2022",
abstract = "Poremećaj pažnje sa hiperaktivnošću (eng. attention deficit/hyperactivity disorder ADHD) je multifaktorski poremećaj čija učestalost iznosi 5–7% kod dece i oko 2,5% kod odraslih. Smatra se da je moguće postojanje tri slična ali po- sebna tipa poremećaja. Posebno se izdvaja ADHD sa početkom u odraslom dobu.
Procenjuje se da su nasledni faktori prisutni kod otprilike 77% slučajeva ADHD-a, pri čemu je identifikovano 18 različitih gena, međutim, spoljašni faktori igraju značajnu ulogu u ekspresiji simptoma. Postoji više modela moždane disfunkcije u ADHD kao što su prefrontalno-egzekutivni model, model pažnje, model nagrade, poremećaj neuronske mreže mirovanja, model kognicije i energije i neurorazvojni model. Biohemijske promene su višestruke i uključuju dopaminergički, adrenergički, serotonergički i holinergički si- stem. Ispitivanja strukture mozga su pokazala smanjenu zapreminu mozga kod dece sa ADHD, a posebno prefrontalne kore, prednje cingularne kore, bazalnih ganglija i malog mozga, a donekle i temporalnog i parijetalnog režnja. Postoje individualne varijacije u međusobnom odnosu kortikalne i supkortikalne disfunkcije što dovodi do heterogenog kliničkog ispoljavanja. S obzirom na nedovoljnu efikasnost i značajne neželjene efekte upotrebe psihostimulan- sa u lečenju ADHD, primena mikronutrijenata je moguća terapija bez značajnih neželjenih pojava i to pre svega cinka, omega-3 masnih kiselina i vitamina D, kao i multivitamina-multiminerala., Attention deficit/hyperactivity disorder (ADHD) is a multifactorial disorder diagnosed in 5-7% children and 2,5% of adults in general population. Three similar but distinct subtypes of ADHD has been identified. A separate form is ADHD with adult onset. Hereditary factors are explaining 77% of cases with at least 18 different susceptibility genes identified, each one with small effect size. However, the inlfuence of several envorinmental factors have been recognized. There are several models of brain dysfunction in ADHD, comprising prefrontal-executive model, attention model, reward model, disruption of neuronal default-mode network, cognition and energy model and neurodevelopmental model.
There are multiple biochemical alterations in ADHD, including dopaminergic, adrenergic, serotonergic and cholinergic system.
Current research indicate reduced brain volume in children with ADHD, particularly in prefrontal cortex, anterior cingulate cortex, basal ganglia and cerebellum, but also in temporal and parietal lobe to a certain extent. The extent of cortical and subcortical brain involvement varies between individuals which leads to wide variety of clinical presentation. Considering reduced efficacy and significant side effects of psychostimulants in ADHD treatment, the use of micronutrients is a potential therapeutical approach without significant side effects. Most o evidence is available to the use of zinc, omega-3 fat acids and vitamin D, as well as for multivitamins and minerals.",
publisher = "Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju (ICF)",
journal = "Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine",
title = "Poremećaj pažnje sa hiperaktivnošću – savremeni pregled neurobioloških osnova, An update on neurobiology of attention deficit hyperactivity disorder",
pages = "209-201",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_4966"
}

Pavlović, D.,& Pavlović, A.. (2022). Poremećaj pažnje sa hiperaktivnošću – savremeni pregled neurobioloških osnova. in Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine
Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju (ICF)., 201-209.
https://hdl.handle.net/21.15107/rcub_rfasper_4966

Pavlović D, Pavlović A. Poremećaj pažnje sa hiperaktivnošću – savremeni pregled neurobioloških osnova. in Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine. 2022;:201-209.
https://hdl.handle.net/21.15107/rcub_rfasper_4966 .

Pavlović, Dragan, Pavlović, Aleksandra, "Poremećaj pažnje sa hiperaktivnošću – savremeni pregled neurobioloških osnova" in Zbornik radova - Nacionalni naučni skup " obrazovanje i rehabilitacija odraslih osoba sa smetnjama u razvoju i problemima u ponašanju ", Beograd, Srbija, 21. decembar 2022. godine (2022):201-209,
https://hdl.handle.net/21.15107/rcub_rfasper_4966 .

TY  - JOUR
AU  - Lačković, Maja
AU  - Ivković, Maja
AU  - Vićentić, Sreten
AU  - Jerotić, Stefan
AU  - Nestorović, Milica
AU  - Stojković, Tihomir
AU  - Pavlović, Aleksandra
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/4844
AB  - The blood-brain barrier (BBB) is formed by continuous, closely connected endothelial cells, enveloped in the basal lamina, pericytes, and foot extensions of astrocytes. BBB has a vital role in brain metabolism and protects the brain parenchyma from harmful agents present in the systemic circulation. Damage to the BBB and an increase in its permeability have an important role in many neurodegenerative diseases.
This paper aims to review the literature on the impact of the BBB damage on psychiatric illness, a largely neglected and under researched area. Links between BBB impairment and specific neuropsychiatric disorders are described including schizophrenia, affective disorders, dementias with behavioral disorders, and alcohol use disorder, with comparison to typical hereditary small vessel diseases affecting the BBB such as cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL) and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). The authors critically summarize possible pathogenic mechanisms linking BBB damage and these common disorders.
AB  - Крвно-мождана баријера (КМБ) се састоји од континураних, тесно спојених ендотелних ћелија омотаних базалном ламином, перицитима и сто-паластим продужецима астроцита. КМБ има виталну функцију и можданом метаболизму и штити мождани паренхим од штетних фактора присутних у системској циркулацији. Показано је да оштећење КМБ и повећање њене пропустљи-вости има значајну улогу у многим неуродегене-ративним обољењима.
Циљ овога рада је преглед литературе о значају оштећења КМБ код психијатријских обољења, до сада занемареној и недовољно истраженој облас-ти. Повезаност измедју поремећаја КМБ и неуро-психијатријских поремећаја је посебно анализи-рана за схизофренију, афективне поремећаје, де-менције са бихевиоралним изменама, поремећај употребе алкохола, са посебним освртом на на-следне болести малих крвних судова мозга са оштећењем КМБ као што су церебрална аутозо-мално доминантна артериопатија са супкортика-ним инфарктима и леукоенцефалопатијом (CADASIL) и митохондријска енцефаломиопатија са лактатном ацидозом и епизодама налик можда-ном удару (MELAS). Аутори критички сумирају могуће патогенетске механизме који повезују оштећења КМБ са овим честим обољењима.
PB  - Srpsko lekarsko društvo
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The role of the blood-brain barrier in psychiatric disorders
T1  - Uloga krvno-moždane barijere u psihijatrijskim oboljenjima
DO  - 10.2298/SARH220417081L
ER  - 

@article{
author = "Lačković, Maja and Ivković, Maja and Vićentić, Sreten and Jerotić, Stefan and Nestorović, Milica and Stojković, Tihomir and Pavlović, Aleksandra",
year = "2022",
abstract = "The blood-brain barrier (BBB) is formed by continuous, closely connected endothelial cells, enveloped in the basal lamina, pericytes, and foot extensions of astrocytes. BBB has a vital role in brain metabolism and protects the brain parenchyma from harmful agents present in the systemic circulation. Damage to the BBB and an increase in its permeability have an important role in many neurodegenerative diseases.
This paper aims to review the literature on the impact of the BBB damage on psychiatric illness, a largely neglected and under researched area. Links between BBB impairment and specific neuropsychiatric disorders are described including schizophrenia, affective disorders, dementias with behavioral disorders, and alcohol use disorder, with comparison to typical hereditary small vessel diseases affecting the BBB such as cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL) and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). The authors critically summarize possible pathogenic mechanisms linking BBB damage and these common disorders., Крвно-мождана баријера (КМБ) се састоји од континураних, тесно спојених ендотелних ћелија омотаних базалном ламином, перицитима и сто-паластим продужецима астроцита. КМБ има виталну функцију и можданом метаболизму и штити мождани паренхим од штетних фактора присутних у системској циркулацији. Показано је да оштећење КМБ и повећање њене пропустљи-вости има значајну улогу у многим неуродегене-ративним обољењима.
Циљ овога рада је преглед литературе о значају оштећења КМБ код психијатријских обољења, до сада занемареној и недовољно истраженој облас-ти. Повезаност измедју поремећаја КМБ и неуро-психијатријских поремећаја је посебно анализи-рана за схизофренију, афективне поремећаје, де-менције са бихевиоралним изменама, поремећај употребе алкохола, са посебним освртом на на-следне болести малих крвних судова мозга са оштећењем КМБ као што су церебрална аутозо-мално доминантна артериопатија са супкортика-ним инфарктима и леукоенцефалопатијом (CADASIL) и митохондријска енцефаломиопатија са лактатном ацидозом и епизодама налик можда-ном удару (MELAS). Аутори критички сумирају могуће патогенетске механизме који повезују оштећења КМБ са овим честим обољењима.",
publisher = "Srpsko lekarsko društvo",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The role of the blood-brain barrier in psychiatric disorders, Uloga krvno-moždane barijere u psihijatrijskim oboljenjima",
doi = "10.2298/SARH220417081L"
}

Lačković, M., Ivković, M., Vićentić, S., Jerotić, S., Nestorović, M., Stojković, T.,& Pavlović, A.. (2022). The role of the blood-brain barrier in psychiatric disorders. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo..
https://doi.org/10.2298/SARH220417081L

Lačković M, Ivković M, Vićentić S, Jerotić S, Nestorović M, Stojković T, Pavlović A. The role of the blood-brain barrier in psychiatric disorders. in Srpski arhiv za celokupno lekarstvo. 2022;.
doi:10.2298/SARH220417081L .

Lačković, Maja, Ivković, Maja, Vićentić, Sreten, Jerotić, Stefan, Nestorović, Milica, Stojković, Tihomir, Pavlović, Aleksandra, "The role of the blood-brain barrier in psychiatric disorders" in Srpski arhiv za celokupno lekarstvo (2022),
https://doi.org/10.2298/SARH220417081L . .

TY  - CONF
AU  - Pavlović, Aleksandra
AU  - Milenković, Marija
AU  - Stevanović, Aleksandar
AU  - Pavlović, Dragan
PY  - 2021
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/3689
AB  - Uvod: Iako je SARS-CoV-2 respiratorna infekcija, virus je neurotropan i 40% bolesnika ima neurološke manifestacije. Česta pojava slučajeva sa produženim smetnjama posle COVID-19 nametnula je uvođenje sindroma „dugog COVID-a”, koji označava set različitih simptoma koji perzistiraju minimum četiri nedelje nakon akutne infekcije. Jedna od vodećih manifestacija je kognitivni pad.
Cilj: Analiza učestalosti i neuropsihološkog profila kognitivnog pada u „dugom COVID-u”.
Metod: Pregled literature.
Rezultati: Među CNS posledicama „dugog COVID-a” najčešće se registruju kognitivni pad, glavobolja, izmene sna i vrtoglavica. Kognitivne izmene bolesnici opisuju kao doživljaj postojanja „magle u glavi”, a podrazumeva pad koncentracije ili smetnje kratkoročnog pamćenja, koji može da utiče na povratak uobičajenom socijalnom i profesionalnom funkcionisanju. Neurokognitivne komplikacije akutne SARS-CoV-2 infekcije se opisuju naročito kod kritično obolelih i respiratorno ugroženih bolesnika i porede sa sličnim sindromima posle sepse ili boravka u jedinicama intenzivnog lečenja („post-ICU syndrome“). Međutim, bar 20% bolesnika sa blagim formama COVID-19 koje nisu zahtevale hospitalizaciju takođe ima produžene kognitivne smetnje. Fenomeni u sklopu „brain fog“ slični su onima kod osoba sa sindromom hroničnog umora. Infekcija SARS-Cov-2 virusom bilo kog stepena težine povećava rizik za nastanak kognitivnog pada. Do sada nije istražen uticaj kognitivnog pada nakon COVID-19 na kvalitet života i aktivnosti svakodnevnog življenja, kao i uticaj psiholoških i socijalnih aspekata pandemije na kogniciju. Mogući mehanizmi kognitivne disfukcije su: direktna infekcija CNS-a, udaljeni efekti sistemske infekcije („citokinska oluja” i dr.), vaskularno oštećenje mozga, neuroinflamacija, autoimuni odgovor protiv CNS-a, hipometabolizam limbičkog sistema i orbitofrontalnog korteksa, kao i neurodegeneracija slična onoj u Alchajmerovoj bolesti, pri čemu je moguće da se neki od ovih mehanizama prepliću.
Zaključak: Kognitive manifestacije „dugog COVID-a” nisu retke i značajno utiču na povratak u uobičajeni lični i profesionalni milje preživelih. Neophodno je dugoročno praćenje ovih bolesnika i sagledavanje različitih etioloških i terapijskih aspekata kognitivnih izmena u okviru „dugog COVID-a”.
AB  - Introduction: Although SARS-CoV-2 is a respiratory infection, the virus is neurotropic and neurological manifestations are seen in 40% patients. Recognition of prolonged post-COVID symptoms led to the introduction of the term “long COVID syndrome”, referring to a set of various symptoms persisting for a minimum of four weeks after acute infection. One of the main manifestations is cognitive decline.
Aim: Analysis of incidence and neuropsychological profile of cognitive decline in “long COVID” syndrome.
Method: Literature review.
Results: Most frequent CNS manifestations of “long COVID” include cognitive decline, headache, sleep disturbance, and dizziness. Cognitive changes are reported as “brain fog” and correspond to a decline in attention and short-term memory, impacting return to premorbid social and professional activities. Acute SARS-CoV-2 neurocognitive complications are seen particularly in critically ill and respiratory insufficient patients, comparable to the similar phenomenon of post-sepsis and intensive care unit treatment (“post-ICU syndrome”). However, 20% of patients with mild COVID-19, not requiring hospitalization, also reported prolonged cognitive complaints, resembling those in patients with chronic fatigue syndrome. SARS-Cov-2 infection of any severity increases the risk for cognitive decline. The impact of post-COVID cognitive decline on the quality of life and activities of daily living as well as the influence of psychological and social aspects of the pandemic on cognition remain to be investigated. Potential mechanisms of cognitive dysfunction are direct CNS infection, remote effects of systemic infection (“cytokine storm” etc.), vascular brain damage, neuroinflammation, autoimmune response directed to the CNS components, hypometabolism in the limbic and orbitofrontal cortex, as well as neurodegeneration comparable to those in Alzheimer’s disease. Several different mechanisms may also be intertwined.
Conclusion: Cognitive manifestations of “long COVID” are not rare and have a significant influence on personal and professional activities of the survivors. Long-term follow-up and analysis of various etiological and therapeutic aspects of cognitive changes within “long-COVID” are needed.
PB  - Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation
C3  - Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021
T1  - Neurokognitivni sindrom „dugog covid-a”: pregled literature
T1  - Neurocognitive syndrome of “long covid”: literature review
EP  - 90
SP  - 89
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_3689
ER  - 

@conference{
author = "Pavlović, Aleksandra and Milenković, Marija and Stevanović, Aleksandar and Pavlović, Dragan",
year = "2021",
abstract = "Uvod: Iako je SARS-CoV-2 respiratorna infekcija, virus je neurotropan i 40% bolesnika ima neurološke manifestacije. Česta pojava slučajeva sa produženim smetnjama posle COVID-19 nametnula je uvođenje sindroma „dugog COVID-a”, koji označava set različitih simptoma koji perzistiraju minimum četiri nedelje nakon akutne infekcije. Jedna od vodećih manifestacija je kognitivni pad.
Cilj: Analiza učestalosti i neuropsihološkog profila kognitivnog pada u „dugom COVID-u”.
Metod: Pregled literature.
Rezultati: Među CNS posledicama „dugog COVID-a” najčešće se registruju kognitivni pad, glavobolja, izmene sna i vrtoglavica. Kognitivne izmene bolesnici opisuju kao doživljaj postojanja „magle u glavi”, a podrazumeva pad koncentracije ili smetnje kratkoročnog pamćenja, koji može da utiče na povratak uobičajenom socijalnom i profesionalnom funkcionisanju. Neurokognitivne komplikacije akutne SARS-CoV-2 infekcije se opisuju naročito kod kritično obolelih i respiratorno ugroženih bolesnika i porede sa sličnim sindromima posle sepse ili boravka u jedinicama intenzivnog lečenja („post-ICU syndrome“). Međutim, bar 20% bolesnika sa blagim formama COVID-19 koje nisu zahtevale hospitalizaciju takođe ima produžene kognitivne smetnje. Fenomeni u sklopu „brain fog“ slični su onima kod osoba sa sindromom hroničnog umora. Infekcija SARS-Cov-2 virusom bilo kog stepena težine povećava rizik za nastanak kognitivnog pada. Do sada nije istražen uticaj kognitivnog pada nakon COVID-19 na kvalitet života i aktivnosti svakodnevnog življenja, kao i uticaj psiholoških i socijalnih aspekata pandemije na kogniciju. Mogući mehanizmi kognitivne disfukcije su: direktna infekcija CNS-a, udaljeni efekti sistemske infekcije („citokinska oluja” i dr.), vaskularno oštećenje mozga, neuroinflamacija, autoimuni odgovor protiv CNS-a, hipometabolizam limbičkog sistema i orbitofrontalnog korteksa, kao i neurodegeneracija slična onoj u Alchajmerovoj bolesti, pri čemu je moguće da se neki od ovih mehanizama prepliću.
Zaključak: Kognitive manifestacije „dugog COVID-a” nisu retke i značajno utiču na povratak u uobičajeni lični i profesionalni milje preživelih. Neophodno je dugoročno praćenje ovih bolesnika i sagledavanje različitih etioloških i terapijskih aspekata kognitivnih izmena u okviru „dugog COVID-a”., Introduction: Although SARS-CoV-2 is a respiratory infection, the virus is neurotropic and neurological manifestations are seen in 40% patients. Recognition of prolonged post-COVID symptoms led to the introduction of the term “long COVID syndrome”, referring to a set of various symptoms persisting for a minimum of four weeks after acute infection. One of the main manifestations is cognitive decline.
Aim: Analysis of incidence and neuropsychological profile of cognitive decline in “long COVID” syndrome.
Method: Literature review.
Results: Most frequent CNS manifestations of “long COVID” include cognitive decline, headache, sleep disturbance, and dizziness. Cognitive changes are reported as “brain fog” and correspond to a decline in attention and short-term memory, impacting return to premorbid social and professional activities. Acute SARS-CoV-2 neurocognitive complications are seen particularly in critically ill and respiratory insufficient patients, comparable to the similar phenomenon of post-sepsis and intensive care unit treatment (“post-ICU syndrome”). However, 20% of patients with mild COVID-19, not requiring hospitalization, also reported prolonged cognitive complaints, resembling those in patients with chronic fatigue syndrome. SARS-Cov-2 infection of any severity increases the risk for cognitive decline. The impact of post-COVID cognitive decline on the quality of life and activities of daily living as well as the influence of psychological and social aspects of the pandemic on cognition remain to be investigated. Potential mechanisms of cognitive dysfunction are direct CNS infection, remote effects of systemic infection (“cytokine storm” etc.), vascular brain damage, neuroinflammation, autoimmune response directed to the CNS components, hypometabolism in the limbic and orbitofrontal cortex, as well as neurodegeneration comparable to those in Alzheimer’s disease. Several different mechanisms may also be intertwined.
Conclusion: Cognitive manifestations of “long COVID” are not rare and have a significant influence on personal and professional activities of the survivors. Long-term follow-up and analysis of various etiological and therapeutic aspects of cognitive changes within “long-COVID” are needed.",
publisher = "Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation",
journal = "Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021",
title = "Neurokognitivni sindrom „dugog covid-a”: pregled literature, Neurocognitive syndrome of “long covid”: literature review",
pages = "90-89",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_3689"
}

Pavlović, A., Milenković, M., Stevanović, A.,& Pavlović, D.. (2021). Neurokognitivni sindrom „dugog covid-a”: pregled literature. in Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021
Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation., 89-90.
https://hdl.handle.net/21.15107/rcub_rfasper_3689

Pavlović A, Milenković M, Stevanović A, Pavlović D. Neurokognitivni sindrom „dugog covid-a”: pregled literature. in Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021. 2021;:89-90.
https://hdl.handle.net/21.15107/rcub_rfasper_3689 .

Pavlović, Aleksandra, Milenković, Marija, Stevanović, Aleksandar, Pavlović, Dragan, "Neurokognitivni sindrom „dugog covid-a”: pregled literature" in Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021 (2021):89-90,
https://hdl.handle.net/21.15107/rcub_rfasper_3689 .

TY  - JOUR
AU  - Messerschmidt, Clemens
AU  - Foddis, Marco
AU  - Blumenau, Sonja
AU  - Müller, Susanne
AU  - Bentele, Kajetan
AU  - Holtgrewe, Manuel
AU  - Kun-Rodrigues, Celia
AU  - Alonso, Isabel
AU  - do Carmo Macario, Maria
AU  - Morgadinho, Ana Sofia
AU  - Velon, Ana Graça
AU  - Santo, Gustavo
AU  - Santana, Isabel
AU  - Mönkäre, Saana
AU  - Kuuluvainen, Liina
AU  - Schleutker, Johanna
AU  - Pöyhönen, Minna
AU  - Myllykangas, Liisa
AU  - Senatore, Assunta
AU  - Berchtold, Daniel
AU  - Winek, Katarzyna
AU  - Meisel, Andreas
AU  - Pavlović, Aleksandra
AU  - Kostić, Vladimir
AU  - Dobricic, Valerija
AU  - Lohmann, Ebba
AU  - Hanagasi, Hasmet
AU  - Guven, Gamze
AU  - Bilgic, Basar
AU  - Bras, Jose
AU  - Guerreiro, Rita
AU  - Beule, Dieter
AU  - Dirnagl, Ulrich
AU  - Sassi, Celeste
PY  - 2021
PY  - 2021
UR  - https://www.nature.com/articles/s41598-021-84919-x
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5024
AB  - Recently, several genome-wide association studies identified PHACTR1 as key locus for five diverse vascular disorders: coronary artery disease, migraine, fibromuscular dysplasia, cervical artery dissection and hypertension. Although these represent significant risk factors or comorbidities for ischemic stroke, PHACTR1 role in brain small vessel ischemic disease and ischemic stroke most important survival mechanism, such as the recruitment of brain collateral arteries like posterior communicating arteries (PcomAs), remains unknown. Therefore, we applied exome and genome sequencing in a multi-ethnic cohort of 180 early-onset independent familial and apparently sporadic brain small vessel ischemic disease and CADASIL-like Caucasian patients from US, Portugal, Finland, Serbia and Turkey and in 2 C57BL/6J stroke mouse models (bilateral common carotid artery stenosis [BCCAS] and middle cerebral artery occlusion [MCAO]), characterized by different degrees of PcomAs patency. We report 3 very rare coding variants in the small vessel ischemic disease-CADASIL-like cohort (p.Glu198Gln, p.Arg204Gly, p.Val251Leu) and a stop-gain mutation (p.Gln273*) in one MCAO mouse. These coding variants do not cluster in PHACTR1 known pathogenic domains and are not likely to play a critical role in small vessel ischemic disease or brain collateral circulation. We also exclude the possibility that copy number variants (CNVs) or a variant enrichment in Phactr1 may be associated with PcomA recruitment in BCCAS mice or linked to diverse vascular traits (cerebral blood flow pre-surgery, PcomA size, leptomeningeal microcollateral length and junction density during brain hypoperfusion) in C57BL/6J mice, respectively. Genetic variability in PHACTR1 is not likely to be a common susceptibility factor influencing small vessel ischemic disease in patients and PcomA recruitment in C57BL/6J mice. Nonetheless, rare variants in PHACTR1 RPEL domains may influence the stroke outcome and are worth investigating in a larger cohort of small vessel ischemic disease patients, different ischemic stroke subtypes and with functional studies.
PB  - Nature Research
T2  - Scientific Reports
T1  - PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice
IS  - 1
SP  - 6072
VL  - 11
DO  - 10.1038/s41598-021-84919-x
ER  - 

@article{
author = "Messerschmidt, Clemens and Foddis, Marco and Blumenau, Sonja and Müller, Susanne and Bentele, Kajetan and Holtgrewe, Manuel and Kun-Rodrigues, Celia and Alonso, Isabel and do Carmo Macario, Maria and Morgadinho, Ana Sofia and Velon, Ana Graça and Santo, Gustavo and Santana, Isabel and Mönkäre, Saana and Kuuluvainen, Liina and Schleutker, Johanna and Pöyhönen, Minna and Myllykangas, Liisa and Senatore, Assunta and Berchtold, Daniel and Winek, Katarzyna and Meisel, Andreas and Pavlović, Aleksandra and Kostić, Vladimir and Dobricic, Valerija and Lohmann, Ebba and Hanagasi, Hasmet and Guven, Gamze and Bilgic, Basar and Bras, Jose and Guerreiro, Rita and Beule, Dieter and Dirnagl, Ulrich and Sassi, Celeste",
year = "2021, 2021",
abstract = "Recently, several genome-wide association studies identified PHACTR1 as key locus for five diverse vascular disorders: coronary artery disease, migraine, fibromuscular dysplasia, cervical artery dissection and hypertension. Although these represent significant risk factors or comorbidities for ischemic stroke, PHACTR1 role in brain small vessel ischemic disease and ischemic stroke most important survival mechanism, such as the recruitment of brain collateral arteries like posterior communicating arteries (PcomAs), remains unknown. Therefore, we applied exome and genome sequencing in a multi-ethnic cohort of 180 early-onset independent familial and apparently sporadic brain small vessel ischemic disease and CADASIL-like Caucasian patients from US, Portugal, Finland, Serbia and Turkey and in 2 C57BL/6J stroke mouse models (bilateral common carotid artery stenosis [BCCAS] and middle cerebral artery occlusion [MCAO]), characterized by different degrees of PcomAs patency. We report 3 very rare coding variants in the small vessel ischemic disease-CADASIL-like cohort (p.Glu198Gln, p.Arg204Gly, p.Val251Leu) and a stop-gain mutation (p.Gln273*) in one MCAO mouse. These coding variants do not cluster in PHACTR1 known pathogenic domains and are not likely to play a critical role in small vessel ischemic disease or brain collateral circulation. We also exclude the possibility that copy number variants (CNVs) or a variant enrichment in Phactr1 may be associated with PcomA recruitment in BCCAS mice or linked to diverse vascular traits (cerebral blood flow pre-surgery, PcomA size, leptomeningeal microcollateral length and junction density during brain hypoperfusion) in C57BL/6J mice, respectively. Genetic variability in PHACTR1 is not likely to be a common susceptibility factor influencing small vessel ischemic disease in patients and PcomA recruitment in C57BL/6J mice. Nonetheless, rare variants in PHACTR1 RPEL domains may influence the stroke outcome and are worth investigating in a larger cohort of small vessel ischemic disease patients, different ischemic stroke subtypes and with functional studies.",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice",
number = "1",
pages = "6072",
volume = "11",
doi = "10.1038/s41598-021-84919-x"
}

Messerschmidt, C., Foddis, M., Blumenau, S., Müller, S., Bentele, K., Holtgrewe, M., Kun-Rodrigues, C., Alonso, I., do Carmo Macario, M., Morgadinho, A. S., Velon, A. G., Santo, G., Santana, I., Mönkäre, S., Kuuluvainen, L., Schleutker, J., Pöyhönen, M., Myllykangas, L., Senatore, A., Berchtold, D., Winek, K., Meisel, A., Pavlović, A., Kostić, V., Dobricic, V., Lohmann, E., Hanagasi, H., Guven, G., Bilgic, B., Bras, J., Guerreiro, R., Beule, D., Dirnagl, U.,& Sassi, C.. (2021). PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice. in Scientific Reports
Nature Research., 11(1), 6072.
https://doi.org/10.1038/s41598-021-84919-x

Messerschmidt C, Foddis M, Blumenau S, Müller S, Bentele K, Holtgrewe M, Kun-Rodrigues C, Alonso I, do Carmo Macario M, Morgadinho AS, Velon AG, Santo G, Santana I, Mönkäre S, Kuuluvainen L, Schleutker J, Pöyhönen M, Myllykangas L, Senatore A, Berchtold D, Winek K, Meisel A, Pavlović A, Kostić V, Dobricic V, Lohmann E, Hanagasi H, Guven G, Bilgic B, Bras J, Guerreiro R, Beule D, Dirnagl U, Sassi C. PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice. in Scientific Reports. 2021;11(1):6072.
doi:10.1038/s41598-021-84919-x .

Messerschmidt, Clemens, Foddis, Marco, Blumenau, Sonja, Müller, Susanne, Bentele, Kajetan, Holtgrewe, Manuel, Kun-Rodrigues, Celia, Alonso, Isabel, do Carmo Macario, Maria, Morgadinho, Ana Sofia, Velon, Ana Graça, Santo, Gustavo, Santana, Isabel, Mönkäre, Saana, Kuuluvainen, Liina, Schleutker, Johanna, Pöyhönen, Minna, Myllykangas, Liisa, Senatore, Assunta, Berchtold, Daniel, Winek, Katarzyna, Meisel, Andreas, Pavlović, Aleksandra, Kostić, Vladimir, Dobricic, Valerija, Lohmann, Ebba, Hanagasi, Hasmet, Guven, Gamze, Bilgic, Basar, Bras, Jose, Guerreiro, Rita, Beule, Dieter, Dirnagl, Ulrich, Sassi, Celeste, "PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice" in Scientific Reports, 11, no. 1 (2021):6072,
https://doi.org/10.1038/s41598-021-84919-x . .

TY  - CONF
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra
AU  - Milenković, Marija
PY  - 2021
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/3784
AB  - Uvod: Cink je drugi najzastuplјeniji esencijalni metal u organizmu i jedini koji je prisutan u svim klasama enzima. Cink se resorbuje u tankom crevu. Nema depoa cinka u organizmu. On se izlučuje putem bubrega, kože i creva. Hrana životinjsкog porekla ima manje cinka ali nema fitata pa je dobar izvor cinka.
Cilј: Cilј rada je da se pregledom relevantne literature izdvoje istraživanja koja potvrđuju značaj cinka u radu mozga i razvoju dece.
Metod: Izvršeno je pretraživanje baze podataka Pub Med korišćenjem klјučnih reči cink, mozak, kognicija, deca.
Rezultati: Cink je neophodan za funkcionisanje centralnog nervnog sistema, učestvuje u neurotransmisiji, posebno u hipokampusu gde reguliše glutamate i gamaaminobuternu kiselinu koji su najzastuplјeniji neurotransmiteri u moz- gu. Ovim se omogućuju normalne kognitivne funkcije. Osim u prenosu infor- macija, cink u mozgu omogućava i metabolizam DNK, rast moždanog tubulina i fosforilaciju. Cink stabilizuje ćelijske membrane i druge ćelijske komponente i bitan je za transkripciju polinukleotida u procesu genetske ekspresije. Cink omogućava deobu, rast i diferencijaciju ćelija, što je bitno za intrauterini ra- zvoj ploda, stimuliše rast i razvoj organizma, a važan je i za čulo ukusa i mi- risa. Cink je kritičan za rast i razvoj mozga, u sintezi DNK, RNK i proteina, pa nedostatak cinka u intrauterinom periodu može da dovede do malformacija mozga, a kod dece do sporijeg i slabijeg razvoja. Smatra se da kao posledi- ca nedostatka cinka u svetu godišnje umre oko 800.000 dece. Manjak cinka dovodi do usporenja rasta i razvoja kod dece, usporenja seksualnog razvoja, gubitka apetita, poremećaja imuniteta, dijareje, muškog hipogonadizma, in- fertiliteta i oštećenja oka.
Zaklјučak: Cink je klјučan mikronutrijent za rad neurona i veoma je bitan u normalnom razvoju dece. Balans cinka je neophodno postići tokom celog živo- ta čoveka kako bi se omogućio normalan razvoj i kognicija.
AB  - Introduction: Zinc is the second most abundant essential metal in the body and the only one present in all classes of enzymes. Zinc is absorbed in the small intestine. There is no zinc depot in the body. It is excreted through the kidneys, skin and intestines. Foods of animal origin have less zinc but no phytate so they are a good source of zinc. 
Aim: The aim of this paper is to examine the importance of zinc in brain function and child development.
Method: The Pub Med database was searched using the keywords zinc, brain, cognition, children.
Results: Zinc is necessary for the functioning of the central nervous system, it participates in neurotransmission, especially in the hippocampus, where it regulates glutamate and gamma-aminobutyric acid, which are the most common neurotransmitters in the brain. This allows for normal cognitive functions. In addition to transmitting information, zinc in the brain also enables DNA metabolism, brain tubulin growth and phosphorylation.
Zinc stabilizes cell membranes and other cell components and is essential for the transcription of polynucleotides in the process of genetic expression. Zinc balance disorder occurs in Alzheimer’s disease, depression, etc. Zinc enables cell division, growth and differentiation, which is important for the intrauterine development of the fetus, stimulates the growth and development of the organism, and is also important for the sense of taste and smell. Zinc is critical for the growth and development of the brain, in the synthesis of DNA, RNA and proteins, so the lack of zinc in the intrauterine period can lead to brain malformations, and in children to slower and weaker development. It is estimated that around 800,000 children die each year as a result of zinc deficiency in the world. Zinc deficiency leads to growth retardation and development in children, slowing of sexual development, loss of appetite, immune disorders, diarrhea, male hypogonadism, infertility and eye damage.
Conclusion: Zinc is a key micronutrient for the work of neurons and is very important in the normal development of children. Zinc balance is necessary to be achieved throughout a person’s life in order to enable normal development and cognition.
PB  - Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation
C3  - Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.
T1  - Značaj cinka u radu mozga i razvoju dece – narativni prikaz
T1  - The importance of zinc in brain function and child development – a narrative review
EP  - 267
SP  - 259
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_3784
ER  - 

@conference{
author = "Pavlović, Dragan and Pavlović, Aleksandra and Milenković, Marija",
year = "2021",
abstract = "Uvod: Cink je drugi najzastuplјeniji esencijalni metal u organizmu i jedini koji je prisutan u svim klasama enzima. Cink se resorbuje u tankom crevu. Nema depoa cinka u organizmu. On se izlučuje putem bubrega, kože i creva. Hrana životinjsкog porekla ima manje cinka ali nema fitata pa je dobar izvor cinka.
Cilј: Cilј rada je da se pregledom relevantne literature izdvoje istraživanja koja potvrđuju značaj cinka u radu mozga i razvoju dece.
Metod: Izvršeno je pretraživanje baze podataka Pub Med korišćenjem klјučnih reči cink, mozak, kognicija, deca.
Rezultati: Cink je neophodan za funkcionisanje centralnog nervnog sistema, učestvuje u neurotransmisiji, posebno u hipokampusu gde reguliše glutamate i gamaaminobuternu kiselinu koji su najzastuplјeniji neurotransmiteri u moz- gu. Ovim se omogućuju normalne kognitivne funkcije. Osim u prenosu infor- macija, cink u mozgu omogućava i metabolizam DNK, rast moždanog tubulina i fosforilaciju. Cink stabilizuje ćelijske membrane i druge ćelijske komponente i bitan je za transkripciju polinukleotida u procesu genetske ekspresije. Cink omogućava deobu, rast i diferencijaciju ćelija, što je bitno za intrauterini ra- zvoj ploda, stimuliše rast i razvoj organizma, a važan je i za čulo ukusa i mi- risa. Cink je kritičan za rast i razvoj mozga, u sintezi DNK, RNK i proteina, pa nedostatak cinka u intrauterinom periodu može da dovede do malformacija mozga, a kod dece do sporijeg i slabijeg razvoja. Smatra se da kao posledi- ca nedostatka cinka u svetu godišnje umre oko 800.000 dece. Manjak cinka dovodi do usporenja rasta i razvoja kod dece, usporenja seksualnog razvoja, gubitka apetita, poremećaja imuniteta, dijareje, muškog hipogonadizma, in- fertiliteta i oštećenja oka.
Zaklјučak: Cink je klјučan mikronutrijent za rad neurona i veoma je bitan u normalnom razvoju dece. Balans cinka je neophodno postići tokom celog živo- ta čoveka kako bi se omogućio normalan razvoj i kognicija., Introduction: Zinc is the second most abundant essential metal in the body and the only one present in all classes of enzymes. Zinc is absorbed in the small intestine. There is no zinc depot in the body. It is excreted through the kidneys, skin and intestines. Foods of animal origin have less zinc but no phytate so they are a good source of zinc. 
Aim: The aim of this paper is to examine the importance of zinc in brain function and child development.
Method: The Pub Med database was searched using the keywords zinc, brain, cognition, children.
Results: Zinc is necessary for the functioning of the central nervous system, it participates in neurotransmission, especially in the hippocampus, where it regulates glutamate and gamma-aminobutyric acid, which are the most common neurotransmitters in the brain. This allows for normal cognitive functions. In addition to transmitting information, zinc in the brain also enables DNA metabolism, brain tubulin growth and phosphorylation.
Zinc stabilizes cell membranes and other cell components and is essential for the transcription of polynucleotides in the process of genetic expression. Zinc balance disorder occurs in Alzheimer’s disease, depression, etc. Zinc enables cell division, growth and differentiation, which is important for the intrauterine development of the fetus, stimulates the growth and development of the organism, and is also important for the sense of taste and smell. Zinc is critical for the growth and development of the brain, in the synthesis of DNA, RNA and proteins, so the lack of zinc in the intrauterine period can lead to brain malformations, and in children to slower and weaker development. It is estimated that around 800,000 children die each year as a result of zinc deficiency in the world. Zinc deficiency leads to growth retardation and development in children, slowing of sexual development, loss of appetite, immune disorders, diarrhea, male hypogonadism, infertility and eye damage.
Conclusion: Zinc is a key micronutrient for the work of neurons and is very important in the normal development of children. Zinc balance is necessary to be achieved throughout a person’s life in order to enable normal development and cognition.",
publisher = "Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation",
journal = "Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.",
title = "Značaj cinka u radu mozga i razvoju dece – narativni prikaz, The importance of zinc in brain function and child development – a narrative review",
pages = "267-259",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_3784"
}

Pavlović, D., Pavlović, A.,& Milenković, M.. (2021). Značaj cinka u radu mozga i razvoju dece – narativni prikaz. in Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.
Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation., 259-267.
https://hdl.handle.net/21.15107/rcub_rfasper_3784

Pavlović D, Pavlović A, Milenković M. Značaj cinka u radu mozga i razvoju dece – narativni prikaz. in Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.. 2021;:259-267.
https://hdl.handle.net/21.15107/rcub_rfasper_3784 .

Pavlović, Dragan, Pavlović, Aleksandra, Milenković, Marija, "Značaj cinka u radu mozga i razvoju dece – narativni prikaz" in Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021. (2021):259-267,
https://hdl.handle.net/21.15107/rcub_rfasper_3784 .

TY  - CONF
AU  - Pavlović, Aleksandra
AU  - Milenković, Marija
AU  - Stevanović, Aleksandar
AU  - Pavlović, Dragan
PY  - 2021
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/3776
AB  - Uvod: Iako je SARS-CoV-2 respiratorna infekcija, virus je neurotropan i 40% bolesnika ima neurološke manifestacije. Česta pojava slučajeva sa produženim smetnjama posle COVID-19 nametnula je uvođenje sindroma „dugog COVID-a“, koji označava set različitih simptoma koji perzistiraju minimum četiri nedelje nakon akutne infekcije. Jedna od vodećih manifestacija je kognitivni pad.
Cilj: Analiza učestalosti i neuropsihološkog profila kognitivnog pada u „dugom COVID-u“.
Metod: Pregled literature.
Rezultati: Među CNS posledicama „dugog COVID-a“ najčešće se registruju ko- gnitivni pad, glavobolja, izmene sna i vrtoglavica. Kognitivne izmene bolesnici opisuju kao doživljaj postojanja „magle u glavi“, a podrazumeva pad koncen- tracije ili smetnje kratkoročnog pamćenja, koji može da utiče na povratak uo- bičajenom socijalnom i profesionalnom funkcionisanju. Neurokognitivne kom- plikacije akutne SARS-CoV-2 infekcije se opisuju naročito kod kritično obolelih i respiratorno ugroženih bolesnika i porede sa sličnim sindromima posle sepse ili boravka u jedinicama intenzivnog lečenja (“post-ICU syndrome“). Međutim, bar 20% bolesnika sa blagim formama COVID-19 koje nisu zahtevale hospita- lizaciju takođe ima produžene kognitivne smetnje. Fenomeni u sklopu „bra- in fog“ slični su onima kod osoba sa sindromom hroničnog umora. Infekcija SARS-Cov-2 virusom bilo kog stepena težine povećava rizik za nastanak kogni- tivnog pada. Do sada nije istražen uticaj kognitivnog pada nakon COVID-19 na kvalitet života i aktivnosti svakodnevnog življenja, kao i uticaj psiholoških i so- cijalnih aspekata pandemije na kogniciju. Mogući mehanizmi kognitivne dis- fukcije su: direktna infekcija CNS-a, udaljeni efekti sistemske infekcije („cito- kinska oluja“ i dr.), vaskularno oštećenje mozga, neuroinflamacija, autoimuni odgovor protiv CNS-a, hipometabolizam limbičkog sistema i orbitofrontalnog korteksa, kao i neurodegeneracija slična onoj u Alchajmerovoj bolesti, pri čemu je moguće da se neki od ovih mehanizama prepliću.
Zaključak: Kognitive manifestacije „dugog COVID-a“ nisu retke i značajno uti- ču na povratak u uobičajeni lični i profesionalni milje preživelih. Neophodno je dugoročno praćenje ovih bolesnika i sagledavanje različitih etioloških i terapij- skih aspekata kognitivnih izmena u okviru „dugog COVID-a”.
AB  - Introduction: Although SARS-CoV-2 is a respiratory infection, the virus is neurotropic and neurological manifestations are seen in 40% patients. Recognition of prolonged post- COVID symptoms led to the introduction of the term “long COVID syndrome”, referring to a set of various symptoms persisting for a minimum of four weeks after acute infection. One of the main manifestations is cognitive decline.
Aim: Analysis of incidence and neuropsychological profile of cognitive decline in “long COVID” syndrome.
Method: Literature review.
Results: Most frequent CNS manifestations of “long COVID” include cognitive decline, headache, sleep disturbance, and dizziness. Cognitive changes are reported as “brain fog” and correspond to a decline in attention and short-term memory, impacting return to premorbid social and professional activities. Acute SARS-CoV-2 neurocognitive complications are seen particularly in critically ill and respiratory insufficient patients, comparable to the similar phenomenon of post-sepsis and intensive care unit treatment (“post-ICU syndrome”).
However, 20% of patients with mild COVID-19, not requiring hospitalization, also reported prolonged cognitive complaints, resembling those in patients with chronic fatigue syndrome.
SARS-Cov-2 infection of any severity increases the risk for cognitive decline. The impact of post-COVID cognitive decline on the quality of life and activities of daily living as well as the influence of psychological and social aspects of the pandemic on cognition remain to be investigated. Potential mechanisms of cognitive dysfunction are direct CNS infection, remote effects of systemic infection (“cytokine storm” etc.), vascular brain damage, neuroinflammation, autoimmune response directed to the CNS components, hypometabolism in the limbic and orbitofrontal cortex, as well as neurodegeneration comparable to those in Alzheimer’s disease. Several different mechanisms may also be intertwined.
Conclusion: Cognitive manifestations of “long COVID” are not rare and have a significant influence on personal and professional activities of the survivors. Long-term follow-up and analysis of various etiological and therapeutic aspects of cognitive changes within “long-COVID” are needed.
PB  - Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation
C3  - Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.
T1  - Neurokognitivni sindrom „dugog covid-a”: pregled literature
T1  - Neurocognitive syndrome of “long covid”: literature review
EP  - 239
SP  - 231
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_3776
ER  - 

@conference{
author = "Pavlović, Aleksandra and Milenković, Marija and Stevanović, Aleksandar and Pavlović, Dragan",
year = "2021",
abstract = "Uvod: Iako je SARS-CoV-2 respiratorna infekcija, virus je neurotropan i 40% bolesnika ima neurološke manifestacije. Česta pojava slučajeva sa produženim smetnjama posle COVID-19 nametnula je uvođenje sindroma „dugog COVID-a“, koji označava set različitih simptoma koji perzistiraju minimum četiri nedelje nakon akutne infekcije. Jedna od vodećih manifestacija je kognitivni pad.
Cilj: Analiza učestalosti i neuropsihološkog profila kognitivnog pada u „dugom COVID-u“.
Metod: Pregled literature.
Rezultati: Među CNS posledicama „dugog COVID-a“ najčešće se registruju ko- gnitivni pad, glavobolja, izmene sna i vrtoglavica. Kognitivne izmene bolesnici opisuju kao doživljaj postojanja „magle u glavi“, a podrazumeva pad koncen- tracije ili smetnje kratkoročnog pamćenja, koji može da utiče na povratak uo- bičajenom socijalnom i profesionalnom funkcionisanju. Neurokognitivne kom- plikacije akutne SARS-CoV-2 infekcije se opisuju naročito kod kritično obolelih i respiratorno ugroženih bolesnika i porede sa sličnim sindromima posle sepse ili boravka u jedinicama intenzivnog lečenja (“post-ICU syndrome“). Međutim, bar 20% bolesnika sa blagim formama COVID-19 koje nisu zahtevale hospita- lizaciju takođe ima produžene kognitivne smetnje. Fenomeni u sklopu „bra- in fog“ slični su onima kod osoba sa sindromom hroničnog umora. Infekcija SARS-Cov-2 virusom bilo kog stepena težine povećava rizik za nastanak kogni- tivnog pada. Do sada nije istražen uticaj kognitivnog pada nakon COVID-19 na kvalitet života i aktivnosti svakodnevnog življenja, kao i uticaj psiholoških i so- cijalnih aspekata pandemije na kogniciju. Mogući mehanizmi kognitivne dis- fukcije su: direktna infekcija CNS-a, udaljeni efekti sistemske infekcije („cito- kinska oluja“ i dr.), vaskularno oštećenje mozga, neuroinflamacija, autoimuni odgovor protiv CNS-a, hipometabolizam limbičkog sistema i orbitofrontalnog korteksa, kao i neurodegeneracija slična onoj u Alchajmerovoj bolesti, pri čemu je moguće da se neki od ovih mehanizama prepliću.
Zaključak: Kognitive manifestacije „dugog COVID-a“ nisu retke i značajno uti- ču na povratak u uobičajeni lični i profesionalni milje preživelih. Neophodno je dugoročno praćenje ovih bolesnika i sagledavanje različitih etioloških i terapij- skih aspekata kognitivnih izmena u okviru „dugog COVID-a”., Introduction: Although SARS-CoV-2 is a respiratory infection, the virus is neurotropic and neurological manifestations are seen in 40% patients. Recognition of prolonged post- COVID symptoms led to the introduction of the term “long COVID syndrome”, referring to a set of various symptoms persisting for a minimum of four weeks after acute infection. One of the main manifestations is cognitive decline.
Aim: Analysis of incidence and neuropsychological profile of cognitive decline in “long COVID” syndrome.
Method: Literature review.
Results: Most frequent CNS manifestations of “long COVID” include cognitive decline, headache, sleep disturbance, and dizziness. Cognitive changes are reported as “brain fog” and correspond to a decline in attention and short-term memory, impacting return to premorbid social and professional activities. Acute SARS-CoV-2 neurocognitive complications are seen particularly in critically ill and respiratory insufficient patients, comparable to the similar phenomenon of post-sepsis and intensive care unit treatment (“post-ICU syndrome”).
However, 20% of patients with mild COVID-19, not requiring hospitalization, also reported prolonged cognitive complaints, resembling those in patients with chronic fatigue syndrome.
SARS-Cov-2 infection of any severity increases the risk for cognitive decline. The impact of post-COVID cognitive decline on the quality of life and activities of daily living as well as the influence of psychological and social aspects of the pandemic on cognition remain to be investigated. Potential mechanisms of cognitive dysfunction are direct CNS infection, remote effects of systemic infection (“cytokine storm” etc.), vascular brain damage, neuroinflammation, autoimmune response directed to the CNS components, hypometabolism in the limbic and orbitofrontal cortex, as well as neurodegeneration comparable to those in Alzheimer’s disease. Several different mechanisms may also be intertwined.
Conclusion: Cognitive manifestations of “long COVID” are not rare and have a significant influence on personal and professional activities of the survivors. Long-term follow-up and analysis of various etiological and therapeutic aspects of cognitive changes within “long-COVID” are needed.",
publisher = "Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation",
journal = "Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.",
title = "Neurokognitivni sindrom „dugog covid-a”: pregled literature, Neurocognitive syndrome of “long covid”: literature review",
pages = "239-231",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_3776"
}

Pavlović, A., Milenković, M., Stevanović, A.,& Pavlović, D.. (2021). Neurokognitivni sindrom „dugog covid-a”: pregled literature. in Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.
Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation., 231-239.
https://hdl.handle.net/21.15107/rcub_rfasper_3776

Pavlović A, Milenković M, Stevanović A, Pavlović D. Neurokognitivni sindrom „dugog covid-a”: pregled literature. in Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.. 2021;:231-239.
https://hdl.handle.net/21.15107/rcub_rfasper_3776 .

Pavlović, Aleksandra, Milenković, Marija, Stevanović, Aleksandar, Pavlović, Dragan, "Neurokognitivni sindrom „dugog covid-a”: pregled literature" in Zbornik radova - 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021. (2021):231-239,
https://hdl.handle.net/21.15107/rcub_rfasper_3776 .

TY  - CONF
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra
AU  - Milenković, Marija
PY  - 2021
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/3695
AB  - Uvod: Cink je drugi najzastupljeniji esencijalni metal u organizmu i jedini koji je prisutan u svim klasama enzima. Cink se resorbuje u tankom crevu. Nema depoa cinka u organizmu. On se izlučuje putem bubrega, kože i creva. Hrana životinjskog porekla ima manje cinka ali nema fitata pa je dobar izvor cinka.
Cilj: Cilj rada je da se pregledom relevantne literature izdvoje istraživanja koja potvrđuju značaj cinka u radu mozga i razvoju dece.
Metod: Izvršeno je pretraživanje baze podataka Pub Med korišćenjem ključnih reči cink, mozak, kognicija, deca.
Rezultati: Cink je neophodan za funkcionisanje centralnog nervnog sistema, učestvuje u neurotransmisiji, posebno u hipokampusu gde reguliše glutamate i gamaaminobuternu kiselinu koji su najzastupljeniji neurotransmiteri u mozgu. Ovim se omogućuju normalne kognitivne funkcije. Osim u prenosu informacija, cink u mozgu omogućava i metabolizam DNK, rast moždanog tubulina i fosforilaciju. Cink stabilizuje ćelijske membrane i druge ćelijske komponente i bitan je za transkripciju polinukleotida u procesu genetske ekspresije. Cink omogućava deobu, rast i diferencijaciju ćelija, što je bitno za intrauterini razvoj ploda, stimuliše rast i razvoj organizma, a važan je i za čulo ukusa i mirisa. Cink je kritičan za rast i razvoj mozga, u sintezi DNK, RNK i proteina, pa nedostatak cinka u intrauterinom period može da dovede do malformacija mozga, a kod dece do sporijeg i slabijeg razvoja. Smatra se da kao posledica nedostatka cinka u svetu godišnje umre oko 800,000 dece. Manjak cinka dovodi do usporenja rasta i razvoja kod dece, usporenja seksualnog razvoja, gubitka apetita, poremećaja imuniteta, dijareje, muškog hipogonadizma, infertiliteta i oštećenja oka.
Zaključak: Cink je ključan mikronutrijent za rad neurona i veoma je bitan u normalnom razvoju dece. Balans cinka je neophodno postići tokom celog života čoveka kako bi se omogućio normalan razvoj i kognicija.
AB  - Introduction: Zinc is the second most abundant essential metal in the body and the only one present in all classes of enzymes. Zinc is absorbed in the small intestine. There is no zinc depot in the body. It is excreted through the kidneys, skin and intestines. Foods of animal origin have less zinc but no phytate so they are a good source of zinc.
Aim: The aim of this paper is to examine the importance of zinc in brain function and child development.
Method: The Pub Med database was searched using the keywords zinc, brain, cognition, children.
Results: Zinc is necessary for the functioning of the central nervous system, it participates in neurotransmission, especially in the hippocampus, where it regulates glutamate and gamma-aminobutyric acid, which are the most common neurotransmitters in the brain. This allows for normal cognitive functions. In addition to transmitting information, zinc in the brain also enables DNA metabolism, brain tubulin growth and phosphorylation. Zinc stabilizes cell membranes and other cell components and is essential for the transcription of polynucleotides in the process of genetic expression. Zinc balance disorder occurs in Alzheimer’s disease, depression, etc. Zinc enables cell division, growth and differentiation, which is important for the intrauterine development of the fetus, stimulates the growth and development of the organism, and is also important for the sense of taste and smell. Zinc is critical for the growth and development of the brain, in the synthesis of DNA, RNA and proteins, so the lack of zinc in the intrauterine period can lead to brain malformations, and in children to slower and weaker development. It is estimated that around 800,000 children die each year as a result of zinc deficiency in the world. Zinc deficiency leads to growth retardation and development in children, slowing of sexual development, loss of appetite, immune disorders, diarrhea, male hypogonadism, infertility and eye damage.
Conclusion: Zinc is a key micronutrient for the work of neurons and is very important in the normal development of children. Zinc balance is necessary to be achieved throughout a person’s life in order to enable normal development and cognition.
PB  - Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation
C3  - Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.
T1  - Značaj cinka u radu mozga i razvoju dece – narativni prikaz
T1  - The importance of zinc in brain function and child development – a narrative review
EP  - 102
SP  - 101
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_3695
ER  - 

@conference{
author = "Pavlović, Dragan and Pavlović, Aleksandra and Milenković, Marija",
year = "2021",
abstract = "Uvod: Cink je drugi najzastupljeniji esencijalni metal u organizmu i jedini koji je prisutan u svim klasama enzima. Cink se resorbuje u tankom crevu. Nema depoa cinka u organizmu. On se izlučuje putem bubrega, kože i creva. Hrana životinjskog porekla ima manje cinka ali nema fitata pa je dobar izvor cinka.
Cilj: Cilj rada je da se pregledom relevantne literature izdvoje istraživanja koja potvrđuju značaj cinka u radu mozga i razvoju dece.
Metod: Izvršeno je pretraživanje baze podataka Pub Med korišćenjem ključnih reči cink, mozak, kognicija, deca.
Rezultati: Cink je neophodan za funkcionisanje centralnog nervnog sistema, učestvuje u neurotransmisiji, posebno u hipokampusu gde reguliše glutamate i gamaaminobuternu kiselinu koji su najzastupljeniji neurotransmiteri u mozgu. Ovim se omogućuju normalne kognitivne funkcije. Osim u prenosu informacija, cink u mozgu omogućava i metabolizam DNK, rast moždanog tubulina i fosforilaciju. Cink stabilizuje ćelijske membrane i druge ćelijske komponente i bitan je za transkripciju polinukleotida u procesu genetske ekspresije. Cink omogućava deobu, rast i diferencijaciju ćelija, što je bitno za intrauterini razvoj ploda, stimuliše rast i razvoj organizma, a važan je i za čulo ukusa i mirisa. Cink je kritičan za rast i razvoj mozga, u sintezi DNK, RNK i proteina, pa nedostatak cinka u intrauterinom period može da dovede do malformacija mozga, a kod dece do sporijeg i slabijeg razvoja. Smatra se da kao posledica nedostatka cinka u svetu godišnje umre oko 800,000 dece. Manjak cinka dovodi do usporenja rasta i razvoja kod dece, usporenja seksualnog razvoja, gubitka apetita, poremećaja imuniteta, dijareje, muškog hipogonadizma, infertiliteta i oštećenja oka.
Zaključak: Cink je ključan mikronutrijent za rad neurona i veoma je bitan u normalnom razvoju dece. Balans cinka je neophodno postići tokom celog života čoveka kako bi se omogućio normalan razvoj i kognicija., Introduction: Zinc is the second most abundant essential metal in the body and the only one present in all classes of enzymes. Zinc is absorbed in the small intestine. There is no zinc depot in the body. It is excreted through the kidneys, skin and intestines. Foods of animal origin have less zinc but no phytate so they are a good source of zinc.
Aim: The aim of this paper is to examine the importance of zinc in brain function and child development.
Method: The Pub Med database was searched using the keywords zinc, brain, cognition, children.
Results: Zinc is necessary for the functioning of the central nervous system, it participates in neurotransmission, especially in the hippocampus, where it regulates glutamate and gamma-aminobutyric acid, which are the most common neurotransmitters in the brain. This allows for normal cognitive functions. In addition to transmitting information, zinc in the brain also enables DNA metabolism, brain tubulin growth and phosphorylation. Zinc stabilizes cell membranes and other cell components and is essential for the transcription of polynucleotides in the process of genetic expression. Zinc balance disorder occurs in Alzheimer’s disease, depression, etc. Zinc enables cell division, growth and differentiation, which is important for the intrauterine development of the fetus, stimulates the growth and development of the organism, and is also important for the sense of taste and smell. Zinc is critical for the growth and development of the brain, in the synthesis of DNA, RNA and proteins, so the lack of zinc in the intrauterine period can lead to brain malformations, and in children to slower and weaker development. It is estimated that around 800,000 children die each year as a result of zinc deficiency in the world. Zinc deficiency leads to growth retardation and development in children, slowing of sexual development, loss of appetite, immune disorders, diarrhea, male hypogonadism, infertility and eye damage.
Conclusion: Zinc is a key micronutrient for the work of neurons and is very important in the normal development of children. Zinc balance is necessary to be achieved throughout a person’s life in order to enable normal development and cognition.",
publisher = "Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation",
journal = "Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.",
title = "Značaj cinka u radu mozga i razvoju dece – narativni prikaz, The importance of zinc in brain function and child development – a narrative review",
pages = "102-101",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_3695"
}

Pavlović, D., Pavlović, A.,& Milenković, M.. (2021). Značaj cinka u radu mozga i razvoju dece – narativni prikaz. in Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.
Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju / University of Belgrade – Faculty of Special Education and Rehabilitation., 101-102.
https://hdl.handle.net/21.15107/rcub_rfasper_3695

Pavlović D, Pavlović A, Milenković M. Značaj cinka u radu mozga i razvoju dece – narativni prikaz. in Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021.. 2021;:101-102.
https://hdl.handle.net/21.15107/rcub_rfasper_3695 .

Pavlović, Dragan, Pavlović, Aleksandra, Milenković, Marija, "Značaj cinka u radu mozga i razvoju dece – narativni prikaz" in Zbornik rezimea – 11. Međunarodni naučni skup „Specijalna edukacija i rehabilitacija danas“, Beograd, Srbija, 29–30.10.2021. (2021):101-102,
https://hdl.handle.net/21.15107/rcub_rfasper_3695 .

TY  - JOUR
AU  - Verdelho, Ana
AU  - Biessels, Geert Jan
AU  - Chabriat, Hugues
AU  - Charidimou, Andreas
AU  - Duering, Marco
AU  - Godefroy, Olivier
AU  - Pantoni, Leonardo
AU  - Pavlović, Aleksandra
AU  - Wardlaw, Joanna
PY  - 2021
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1326
AB  - Purpose: Practical suggestions on clinical decisions about vascular disease management in patients with cognitive impairment are proposed. Methods: The document was produced by the Dementia Committee of the European Stroke Organisation (ESO) based on the evidence from the literature where available and on the clinical experience of the Committee members. This paper was endorsed by the ESO. Findings: Vascular risk factors and cerebrovascular disease are frequent in patients with cognitive impairment. While acute stroke treatment has evolved substantially in last decades, evidence of management of cerebrovascular pathology beyond stroke in patients with cognitive impairment and dementia is quite limited. Additionally, trials to test some daily-life clinical decisions are likely to be complex, difficult to undertake and take many years to provide sufficient evidence to produce recommendations. This document was conceived to provide some suggestions until data from field trials are available. It was conceived for the use of clinicians from memory clinics or involved specifically in cognitive disorders, addressing practical aspects on diagnostic tools, vascular risk management and suggestions on some therapeutic options. Discussion and conclusions: The authors did not aim to do an exhaustive or systematic review or to cover all current evidence. The document approach in a very practical way frequent issues concerning cerebrovascular disease in patients with known cognitive impairment.
PB  - Sage Publications Ltd, London
T2  - European Stroke Journal
T1  - Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee - A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinics
EP  - 119
IS  - 2
SP  - 111
VL  - 6
DO  - 10.1177/2396987321994294
ER  - 

@article{
author = "Verdelho, Ana and Biessels, Geert Jan and Chabriat, Hugues and Charidimou, Andreas and Duering, Marco and Godefroy, Olivier and Pantoni, Leonardo and Pavlović, Aleksandra and Wardlaw, Joanna",
year = "2021",
abstract = "Purpose: Practical suggestions on clinical decisions about vascular disease management in patients with cognitive impairment are proposed. Methods: The document was produced by the Dementia Committee of the European Stroke Organisation (ESO) based on the evidence from the literature where available and on the clinical experience of the Committee members. This paper was endorsed by the ESO. Findings: Vascular risk factors and cerebrovascular disease are frequent in patients with cognitive impairment. While acute stroke treatment has evolved substantially in last decades, evidence of management of cerebrovascular pathology beyond stroke in patients with cognitive impairment and dementia is quite limited. Additionally, trials to test some daily-life clinical decisions are likely to be complex, difficult to undertake and take many years to provide sufficient evidence to produce recommendations. This document was conceived to provide some suggestions until data from field trials are available. It was conceived for the use of clinicians from memory clinics or involved specifically in cognitive disorders, addressing practical aspects on diagnostic tools, vascular risk management and suggestions on some therapeutic options. Discussion and conclusions: The authors did not aim to do an exhaustive or systematic review or to cover all current evidence. The document approach in a very practical way frequent issues concerning cerebrovascular disease in patients with known cognitive impairment.",
publisher = "Sage Publications Ltd, London",
journal = "European Stroke Journal",
title = "Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee - A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinics",
pages = "119-111",
number = "2",
volume = "6",
doi = "10.1177/2396987321994294"
}

Verdelho, A., Biessels, G. J., Chabriat, H., Charidimou, A., Duering, M., Godefroy, O., Pantoni, L., Pavlović, A.,& Wardlaw, J.. (2021). Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee - A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinics. in European Stroke Journal
Sage Publications Ltd, London., 6(2), 111-119.
https://doi.org/10.1177/2396987321994294

Verdelho A, Biessels GJ, Chabriat H, Charidimou A, Duering M, Godefroy O, Pantoni L, Pavlović A, Wardlaw J. Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee - A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinics. in European Stroke Journal. 2021;6(2):111-119.
doi:10.1177/2396987321994294 .

Verdelho, Ana, Biessels, Geert Jan, Chabriat, Hugues, Charidimou, Andreas, Duering, Marco, Godefroy, Olivier, Pantoni, Leonardo, Pavlović, Aleksandra, Wardlaw, Joanna, "Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee - A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinics" in European Stroke Journal, 6, no. 2 (2021):111-119,
https://doi.org/10.1177/2396987321994294 . .

TY  - JOUR
AU  - Verdelho, Ana
AU  - Wardlaw, Joanna
AU  - Pavlović, Aleksandra
AU  - Pantoni, Leonardo
AU  - Godefroy, Olivier
AU  - Duering, Marco
AU  - Charidimou, Andreas
AU  - Chabriat, Hugues
AU  - Biessels, Geert Jan
PY  - 2021
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1324
AB  - Purpose Many daily-life clinical decisions in patients with cerebrovascular disease and cognitive impairment are complex. Evidence-based information sustaining these decisions is frequently lacking. The aim of this paper is to propose a practical clinical approach to cognitive impairments in patients with known cerebrovascular disease. Methods The document was produced by the Dementia Committee of the European Stroke Organisation (ESO), based on evidence from the literature where available and on the clinical experience of the Committee members. This paper was endorsed by the ESO. Findings Many patients with stroke or other cerebrovascular disease have cognitive impairment, but this is often not recognized. With improvement in acute stroke care, and with the ageing of populations, it is expected that more stroke survivors and more patients with cerebrovascular disease will need adequate management of cognitive impairment of vascular etiology. This document was conceived for the use of strokologists and for those clinicians involved in cerebrovascular disease, with specific and practical hints concerning diagnostic tools, cognitive impairment management and decision on some therapeutic options. Discussion and conclusions: It is essential to consider a possible cognitive deterioration in every patient who experiences a stroke. Neuropsychological evaluation should be adapted to the clinical status. Brain imaging is the most informative biomarker concerning prognosis. Treatment should always include adequate secondary prevention.
PB  - Sage Publications Ltd, London
T2  - European Stroke Journal
T1  - Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee
EP  - 17
IS  - 1
SP  - 5
VL  - 6
DO  - 10.1177/23969873211000258
ER  - 

@article{
author = "Verdelho, Ana and Wardlaw, Joanna and Pavlović, Aleksandra and Pantoni, Leonardo and Godefroy, Olivier and Duering, Marco and Charidimou, Andreas and Chabriat, Hugues and Biessels, Geert Jan",
year = "2021",
abstract = "Purpose Many daily-life clinical decisions in patients with cerebrovascular disease and cognitive impairment are complex. Evidence-based information sustaining these decisions is frequently lacking. The aim of this paper is to propose a practical clinical approach to cognitive impairments in patients with known cerebrovascular disease. Methods The document was produced by the Dementia Committee of the European Stroke Organisation (ESO), based on evidence from the literature where available and on the clinical experience of the Committee members. This paper was endorsed by the ESO. Findings Many patients with stroke or other cerebrovascular disease have cognitive impairment, but this is often not recognized. With improvement in acute stroke care, and with the ageing of populations, it is expected that more stroke survivors and more patients with cerebrovascular disease will need adequate management of cognitive impairment of vascular etiology. This document was conceived for the use of strokologists and for those clinicians involved in cerebrovascular disease, with specific and practical hints concerning diagnostic tools, cognitive impairment management and decision on some therapeutic options. Discussion and conclusions: It is essential to consider a possible cognitive deterioration in every patient who experiences a stroke. Neuropsychological evaluation should be adapted to the clinical status. Brain imaging is the most informative biomarker concerning prognosis. Treatment should always include adequate secondary prevention.",
publisher = "Sage Publications Ltd, London",
journal = "European Stroke Journal",
title = "Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee",
pages = "17-5",
number = "1",
volume = "6",
doi = "10.1177/23969873211000258"
}

Verdelho, A., Wardlaw, J., Pavlović, A., Pantoni, L., Godefroy, O., Duering, M., Charidimou, A., Chabriat, H.,& Biessels, G. J.. (2021). Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee. in European Stroke Journal
Sage Publications Ltd, London., 6(1), 5-17.
https://doi.org/10.1177/23969873211000258

Verdelho A, Wardlaw J, Pavlović A, Pantoni L, Godefroy O, Duering M, Charidimou A, Chabriat H, Biessels GJ. Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee. in European Stroke Journal. 2021;6(1):5-17.
doi:10.1177/23969873211000258 .

Verdelho, Ana, Wardlaw, Joanna, Pavlović, Aleksandra, Pantoni, Leonardo, Godefroy, Olivier, Duering, Marco, Charidimou, Andreas, Chabriat, Hugues, Biessels, Geert Jan, "Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee" in European Stroke Journal, 6, no. 1 (2021):5-17,
https://doi.org/10.1177/23969873211000258 . .

TY  - CONF
AU  - Pavlović, Aleksandra
AU  - Pavlović, Dragan
PY  - 2020
UR  - http://www.icf.fasper.bg.ac.rs/zbornici/20201221_1-ZBORNIK-RADOVA-SKUP-NAC_2020.pdf
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/3467
AB  - Adults with Down syndrome are at an
increased risk of developing early onset
Alzheimer’s diseasе. Dementia is typically
preceded by prodromal pre-clinical phase.
Pathohistological characteristics of Alzheimer’s diseasе are universally present
by the fifth decade in Down syndrome
patients. Trajectories of cognitive decline
associated with dementia in Down syndrome
population are not fully described. Having
in mind pre-existing cognitive difficulties, early dementia signs may be overlooked or misdiagnosed, missing the opportunity
for the early use of pharmacological and
psychosocial interventions. Down syndrome
population could be a target for investigation
of preventive and therapeutic measures in
management of Alzheimer’s diseasе. World
Heаlth Organisation called for inclusion of
intellectual disability in national dementia
plans.
AB  - Odrasle osobe sa Daunovim sindromom su u velikom riziku za razvoj Alchajmerove bolesti ranog početka. Demenciji prethodi period prodromalne, pre-kliničke faze. Histopatološki nalazi karakteristični za Alchajmerovu bolest su gotovo pravilo kod osoba sa Daunovim sindromom u petoj deceniji života. Trajektorije kognitivnog propadanja kod populacije sa Daunovim sindromom nisu u potpunosti definisane. Budući da kod ovih osoba već postoji intelektu- alna ometenost, suptilni rani znaci kognitivnog pada se mogu prevideti ili pogrešno dijagnostikovati čime se propušta prilika za pravovremenu pri- menu farmakoloških i psihosocijalnih intervencija. Populacija sa Daunovim sindromom bi mogla biti ciljna za ispitivanje preventivnih i terapijski mera za nastanak Alchajmerove bolesti. Iz ovih razloga, Svetska zdravstvena organizacija je pozvala na uključivanje intelektualne ometenosti u nacional- ne planove za demenciju.
PB  - Univerzitet u Beogradu - Fakultet za specijalnu edukaciju i rehabilitaciju
C3  - Nacionalni naučni skup „Evaluacija efekata inkluzivnog obrazovanja u republici Srbiji” - Zbornik radova
T1  - intelektualna ometenost i razvoj demencije: demencija kod osoba sa daunovim sindromom
T1  - Intellectual disability and development of dementia: dementia in persons with down syndrome
EP  - 223
SP  - 217
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_3467
ER  - 

@conference{
author = "Pavlović, Aleksandra and Pavlović, Dragan",
year = "2020",
abstract = "Adults with Down syndrome are at an
increased risk of developing early onset
Alzheimer’s diseasе. Dementia is typically
preceded by prodromal pre-clinical phase.
Pathohistological characteristics of Alzheimer’s diseasе are universally present
by the fifth decade in Down syndrome
patients. Trajectories of cognitive decline
associated with dementia in Down syndrome
population are not fully described. Having
in mind pre-existing cognitive difficulties, early dementia signs may be overlooked or misdiagnosed, missing the opportunity
for the early use of pharmacological and
psychosocial interventions. Down syndrome
population could be a target for investigation
of preventive and therapeutic measures in
management of Alzheimer’s diseasе. World
Heаlth Organisation called for inclusion of
intellectual disability in national dementia
plans., Odrasle osobe sa Daunovim sindromom su u velikom riziku za razvoj Alchajmerove bolesti ranog početka. Demenciji prethodi period prodromalne, pre-kliničke faze. Histopatološki nalazi karakteristični za Alchajmerovu bolest su gotovo pravilo kod osoba sa Daunovim sindromom u petoj deceniji života. Trajektorije kognitivnog propadanja kod populacije sa Daunovim sindromom nisu u potpunosti definisane. Budući da kod ovih osoba već postoji intelektu- alna ometenost, suptilni rani znaci kognitivnog pada se mogu prevideti ili pogrešno dijagnostikovati čime se propušta prilika za pravovremenu pri- menu farmakoloških i psihosocijalnih intervencija. Populacija sa Daunovim sindromom bi mogla biti ciljna za ispitivanje preventivnih i terapijski mera za nastanak Alchajmerove bolesti. Iz ovih razloga, Svetska zdravstvena organizacija je pozvala na uključivanje intelektualne ometenosti u nacional- ne planove za demenciju.",
publisher = "Univerzitet u Beogradu - Fakultet za specijalnu edukaciju i rehabilitaciju",
journal = "Nacionalni naučni skup „Evaluacija efekata inkluzivnog obrazovanja u republici Srbiji” - Zbornik radova",
title = "intelektualna ometenost i razvoj demencije: demencija kod osoba sa daunovim sindromom, Intellectual disability and development of dementia: dementia in persons with down syndrome",
pages = "223-217",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_3467"
}

Pavlović, A.,& Pavlović, D.. (2020). intelektualna ometenost i razvoj demencije: demencija kod osoba sa daunovim sindromom. in Nacionalni naučni skup „Evaluacija efekata inkluzivnog obrazovanja u republici Srbiji” - Zbornik radova
Univerzitet u Beogradu - Fakultet za specijalnu edukaciju i rehabilitaciju., 217-223.
https://hdl.handle.net/21.15107/rcub_rfasper_3467

Pavlović A, Pavlović D. intelektualna ometenost i razvoj demencije: demencija kod osoba sa daunovim sindromom. in Nacionalni naučni skup „Evaluacija efekata inkluzivnog obrazovanja u republici Srbiji” - Zbornik radova. 2020;:217-223.
https://hdl.handle.net/21.15107/rcub_rfasper_3467 .

Pavlović, Aleksandra, Pavlović, Dragan, "intelektualna ometenost i razvoj demencije: demencija kod osoba sa daunovim sindromom" in Nacionalni naučni skup „Evaluacija efekata inkluzivnog obrazovanja u republici Srbiji” - Zbornik radova (2020):217-223,
https://hdl.handle.net/21.15107/rcub_rfasper_3467 .