Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review
Аутори
Bozovic, IvoJeremic, Marta
Pavlović, Aleksandra
Jovanovic, Carna
Kresojevic, Nikola
Vojvodic, Nikola
Jovanovic, Dejana
Sokic, Dragoslav
Mijajlovic, Milija
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Cerebral amyloid angiopathy-related inflammation (CAA-rI) is a largely reversible, subacute encephalopathy, which is considered as a rare variant of cerebral amyloid angiopathy (CAA). Although the diagnosis of this inflammatory vasculopathy is generally clinico-pathologic, a probable or possible diagnosis can often be established based on current clinico-radiological diagnostic criteria. This is important since CAA-rI is considered as a treatable disorder, which most commonly occurs in the elderly population. Behavioral changes and cognitive deterioration are highlighted as the most common clinical signs of CAA-rI, followed by a heterogeneous spectrum of typical and atypical clinical presentations. However, despite the well-established clinical and radiological features incorporated in the current diagnostic criteria for this CAA variant, this rare disorder is still insufficiently recognized and treated. Here, we have shown three patients diagnosed with probable CAA-rI, with significan...t heterogeneity in the clinical and neuroradiological presentations, followed by different disease courses and outcomes after the introduction of immunosuppressive treatment. Moreover, we have also summarized up-to-date literature data about this rare, yet underdiagnosed, immune-mediated vasculopathy.
Кључне речи:
cerebral amyloid angiopathy / cerebral amyloid angiopathy-related inflammation / diagnostics / heterogeneous clinico-radiological presentations / patients / review / treatmentИзвор:
Brain Sciences, 2023, 13, 5, 747-Издавач:
- MDPI [Commercial Publisher]
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200110 (Универзитет у Београду, Медицински факултет) (RS-MESTD-inst-2020-200110)
URI
https://www.mdpi.com/2076-3425/13/5/747C:\Users\FASPER\Zotero\storage\KN238T94\Bozovic et al. - 2023 - Cerebral Amyloid Angiopathy-Related Inflammation (.pdf
http://rfasper.fasper.bg.ac.rs/handle/123456789/5292
Институција/група
rFASPERTY - JOUR AU - Bozovic, Ivo AU - Jeremic, Marta AU - Pavlović, Aleksandra AU - Jovanovic, Carna AU - Kresojevic, Nikola AU - Vojvodic, Nikola AU - Jovanovic, Dejana AU - Sokic, Dragoslav AU - Mijajlovic, Milija PY - 2023 UR - https://www.mdpi.com/2076-3425/13/5/747 UR - C:\Users\FASPER\Zotero\storage\KN238T94\Bozovic et al. - 2023 - Cerebral Amyloid Angiopathy-Related Inflammation (.pdf UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/5292 AB - Cerebral amyloid angiopathy-related inflammation (CAA-rI) is a largely reversible, subacute encephalopathy, which is considered as a rare variant of cerebral amyloid angiopathy (CAA). Although the diagnosis of this inflammatory vasculopathy is generally clinico-pathologic, a probable or possible diagnosis can often be established based on current clinico-radiological diagnostic criteria. This is important since CAA-rI is considered as a treatable disorder, which most commonly occurs in the elderly population. Behavioral changes and cognitive deterioration are highlighted as the most common clinical signs of CAA-rI, followed by a heterogeneous spectrum of typical and atypical clinical presentations. However, despite the well-established clinical and radiological features incorporated in the current diagnostic criteria for this CAA variant, this rare disorder is still insufficiently recognized and treated. Here, we have shown three patients diagnosed with probable CAA-rI, with significant heterogeneity in the clinical and neuroradiological presentations, followed by different disease courses and outcomes after the introduction of immunosuppressive treatment. Moreover, we have also summarized up-to-date literature data about this rare, yet underdiagnosed, immune-mediated vasculopathy. PB - MDPI [Commercial Publisher] T2 - Brain Sciences T1 - Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review IS - 5 SP - 747 VL - 13 DO - 10.3390/brainsci13050747 ER -
@article{ author = "Bozovic, Ivo and Jeremic, Marta and Pavlović, Aleksandra and Jovanovic, Carna and Kresojevic, Nikola and Vojvodic, Nikola and Jovanovic, Dejana and Sokic, Dragoslav and Mijajlovic, Milija", year = "2023", abstract = "Cerebral amyloid angiopathy-related inflammation (CAA-rI) is a largely reversible, subacute encephalopathy, which is considered as a rare variant of cerebral amyloid angiopathy (CAA). Although the diagnosis of this inflammatory vasculopathy is generally clinico-pathologic, a probable or possible diagnosis can often be established based on current clinico-radiological diagnostic criteria. This is important since CAA-rI is considered as a treatable disorder, which most commonly occurs in the elderly population. Behavioral changes and cognitive deterioration are highlighted as the most common clinical signs of CAA-rI, followed by a heterogeneous spectrum of typical and atypical clinical presentations. However, despite the well-established clinical and radiological features incorporated in the current diagnostic criteria for this CAA variant, this rare disorder is still insufficiently recognized and treated. Here, we have shown three patients diagnosed with probable CAA-rI, with significant heterogeneity in the clinical and neuroradiological presentations, followed by different disease courses and outcomes after the introduction of immunosuppressive treatment. Moreover, we have also summarized up-to-date literature data about this rare, yet underdiagnosed, immune-mediated vasculopathy.", publisher = "MDPI [Commercial Publisher]", journal = "Brain Sciences", title = "Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review", number = "5", pages = "747", volume = "13", doi = "10.3390/brainsci13050747" }
Bozovic, I., Jeremic, M., Pavlović, A., Jovanovic, C., Kresojevic, N., Vojvodic, N., Jovanovic, D., Sokic, D.,& Mijajlovic, M.. (2023). Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review. in Brain Sciences MDPI [Commercial Publisher]., 13(5), 747. https://doi.org/10.3390/brainsci13050747
Bozovic I, Jeremic M, Pavlović A, Jovanovic C, Kresojevic N, Vojvodic N, Jovanovic D, Sokic D, Mijajlovic M. Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review. in Brain Sciences. 2023;13(5):747. doi:10.3390/brainsci13050747 .
Bozovic, Ivo, Jeremic, Marta, Pavlović, Aleksandra, Jovanovic, Carna, Kresojevic, Nikola, Vojvodic, Nikola, Jovanovic, Dejana, Sokic, Dragoslav, Mijajlovic, Milija, "Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review" in Brain Sciences, 13, no. 5 (2023):747, https://doi.org/10.3390/brainsci13050747 . .