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Reduction of marginal zone B cells in CD22-deficient mice
(Wiley-V C H Verlag Gmbh, Weinheim, 2002)
CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed ...
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
(Amer Soc Biochemistry Molecular Biology Inc, Bethesda, 2008)
Unchecked accumulation of reactive oxygen species (ROS) compromises maintenance of hematopoietic stem cells. Regulation of ROS by the tumor suppressor protein ataxia telangiectasia mutated (ATM) is critical for preserving ...
Reversible lymphomagenesis in conditionally c-MYC expressing mice
(Wiley, Hoboken, 2004)
It is well documented that deregulation of MYC leads to tumor development, yet many aspects of this process are only partially understood. We have established a transgenic mouse model in which c-MYC is conditionally expressed ...
CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice
(Wiley-V C H Verlag Gmbh, Weinheim, 2002)
BOB.1/OBF1 (also called OCA-B), a B lymphocyte-specific transcriptional coactivator, is recruited to octamer-containing promoters by interacting with the Oct-1 or Oct-2 proteins. BOB.1/OBF.1-deficient mice show impaired ...
c-MYC activation impairs the NF-kappa B and the interferon response: Implications for the pathogenesis of Burkitt's lymphoma
(Wiley-Liss, Hoboken, 2007)
Deregulation of the proto-oncogene c-myc is a key event in the pathogenesis of many tumors. A paradigm is the activation of the c-myc gene by chromosomal translocations in Burkitt lymphoma (BL). Despite expression of a ...
B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice
(Amer Assoc Immunologists, Bethesda, 2005)
Marginal zone (MZ) B cells and peritoneal B-I cells provide a first defense system of thymus-independent Ab responses against foreign pathogens and therefore share a number of functional properties. Recently, development ...
Identification of novel Myc target genes with a potential role in lymphomagenesis
(Oxford Univ Press, Oxford, 2004)
The c-Myc transcription factor regulates a wide set of genes involved in processes such as proliferation, differentiation and apoptosis. Therefore, altered expression of Myc leads to deregulation of a large number of target ...
Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation
(Amer Assoc Immunologists, Bethesda, 2005)
An as-yet-unidentified mutation, Y-linked autoimmune acceleration (Yaa), is responsible for the accelerated development of lupus-like autoimmune syndrome in mice. In view of a possible role for Yaa as a positive regulator ...
Memory disorder in persons with asperger syndrome
(Elsevier France-Editions Scientifiques Medicales Elsevier, Paris, 2009)