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Приказ резултата 11-18 од 18
B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice
(Rockefeller Univ Press, New York, 2003)
Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. ...
The IKK2/NF-kappa B pathway suppresses MYC-induced lymphomagenesis
(Amer Soc Hematology, Washington, 2009)
Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. In many hematologic malignancies, enhanced NF-kappa B exerts prosurvival functions. Here we investigated the role of ...
BOB.1OBF.1 deficiency affects marginal-zone B-cell compartment
(Amer Soc Microbiology, Washington, 2002)
Marginal-zone (MZ) B cells represent a first line of defense against particulate blood-borne antigens. Together with the B1 cells, they are responsible for the early response against type It T-independent antigens. The ...
Detection and prevalence of motor skill disorders
(Pergamon-Elsevier Science Ltd, Oxford, 2009)
The main goal of this research was to establish the prevalence, form of manifestation, level and kind of motor skill disorders in three area of motor development functioning: neuromaturation, coordination and balance. The ...
Analysis of voice impairment in aphasia after stroke-underlying neuroanatomical substrates
(Academic Press Inc Elsevier Science, San Diego, 2012)
Phonation is a fundamental feature of human communication. Control of phonation in the context of speech-language disturbances has traditionally been considered a characteristic of lesions to subcortical structures and ...
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial
(Elsevier Science Inc, New York, 2020)
Background More than a third of patients with epilepsy are treatment resistant, and thus new, more effective therapies to achieve seizure freedom are needed. Cenobamate (YKP3089), an investigational antiepileptic drug, has ...
Foxo3 is required for the regulation of oxidative stress in erythropoiesis
(Amer Soc Clinical Investigation Inc, Ann Arbor, 2007)
Erythroid cells accumulate hemoglobin as they mature and as a result are highly prone to oxidative damage. However, mechanisms of transcriptional control of antioxidant defense in erythroid cells have thus far been poorly ...
ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice
(Wiley, Hoboken, 2010)
Reactive oxygen species (ROS) participate in normal intracellular signalling and in many diseases including cancer and aging, although the associated mechanisms are not fully understood. Forkhead Box O (FoxO) 3 transcription ...