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AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation
(Amer Soc Hematology, Washington, 2006)
AKT serine threonine kinase of the protein kinase B (PKB) family plays essential roles in cell survival, growth, metabolism, and differentiation. In the erythroid system, AKT is known to be rapidly phosphorylated and ...
Myc Regulates Embryonic Vascular Permeability and Remodeling
(Lippincott Williams & Wilkins, Philadelphia, 2009)
Previous work has shown that c-Myc is required for adequate vasculogenesis and angiogenesis. To further investigate the contribution of Myc to these processes, we conditionally expressed c-Myc in embryonic endothelial cells ...
The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells
(Amer Assoc Immunologists, Bethesda, 2003)
The accelerated development of systemic lupus erythematosus (SLE) in BXSB male mice is associated with the presence of an as yet unidentified mutant gene, Yaa (Y-linked autoimmune acceleration). In view of a possible role ...
B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice
(Rockefeller Univ Press, New York, 2003)
Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. ...
The IKK2/NF-kappa B pathway suppresses MYC-induced lymphomagenesis
(Amer Soc Hematology, Washington, 2009)
Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. In many hematologic malignancies, enhanced NF-kappa B exerts prosurvival functions. Here we investigated the role of ...
BOB.1OBF.1 deficiency affects marginal-zone B-cell compartment
(Amer Soc Microbiology, Washington, 2002)
Marginal-zone (MZ) B cells represent a first line of defense against particulate blood-borne antigens. Together with the B1 cells, they are responsible for the early response against type It T-independent antigens. The ...
Detection and prevalence of motor skill disorders
(Pergamon-Elsevier Science Ltd, Oxford, 2009)
The main goal of this research was to establish the prevalence, form of manifestation, level and kind of motor skill disorders in three area of motor development functioning: neuromaturation, coordination and balance. The ...
Foxo3 is required for the regulation of oxidative stress in erythropoiesis
(Amer Soc Clinical Investigation Inc, Ann Arbor, 2007)
Erythroid cells accumulate hemoglobin as they mature and as a result are highly prone to oxidative damage. However, mechanisms of transcriptional control of antioxidant defense in erythroid cells have thus far been poorly ...