The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells
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2003
Аутори
Amano, H.Amano, E.
Moll, T.
Marinković, Dragan
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Ibnou-Zekri, N
Martinez-Soria, E.
Semac, I
Wirth, Thomas
Nitschke, L.
Izui, S
Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
The accelerated development of systemic lupus erythematosus (SLE) in BXSB male mice is associated with the presence of an as yet unidentified mutant gene, Yaa (Y-linked autoimmune acceleration). In view of a possible role of marginal zone (MZ) B cells in murine SLE, we have explored whether the expression of the Yaa mutation affects the differentiation of MZ and follicular B cells, thereby implicating the acceleration of the disease. In this study, we show that both BXSB and C57BL/6 Yaa mice, including two different substrains of BXSB Yaa males that are protected from SLE, displayed an impaired development of MZ B cells early in life. Studies in bone marrow chimeras revealed that the loss of MZ B cells resulted from a defect intrinsic to B cells expressing the Yaa mutation. The lack of selective expansion of MZ B cells in diseased BXSB Yaa males strongly argues against a major role of MZ B cells in the generation of pathogenic autoantibodies in the BXSB model of SLE. Furthermore, a com...parative analysis with mice deficient in CD22 or expressing an IgM anti-trinitrophenyl/DNA transgene suggests that the hyperreactive phenotype of Yaa B cells, as judged by a markedly increased spontaneous IgM secretion, is likely to contribute to the enhanced maturation toward follicular B cells and the block in the MZ B cell generation.
Извор:
Journal of Immunology, 2003, 170, 5, 2293-2301Издавач:
- Amer Assoc Immunologists, Bethesda
DOI: 10.4049/jimmunol.170.5.2293
ISSN: 0022-1767
PubMed: 12594250
WoS: 000181146800007
Scopus: 2-s2.0-0037371122
Институција/група
rFASPERTY - JOUR AU - Amano, H. AU - Amano, E. AU - Moll, T. AU - Marinković, Dragan AU - Ibnou-Zekri, N AU - Martinez-Soria, E. AU - Semac, I AU - Wirth, Thomas AU - Nitschke, L. AU - Izui, S PY - 2003 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/32 AB - The accelerated development of systemic lupus erythematosus (SLE) in BXSB male mice is associated with the presence of an as yet unidentified mutant gene, Yaa (Y-linked autoimmune acceleration). In view of a possible role of marginal zone (MZ) B cells in murine SLE, we have explored whether the expression of the Yaa mutation affects the differentiation of MZ and follicular B cells, thereby implicating the acceleration of the disease. In this study, we show that both BXSB and C57BL/6 Yaa mice, including two different substrains of BXSB Yaa males that are protected from SLE, displayed an impaired development of MZ B cells early in life. Studies in bone marrow chimeras revealed that the loss of MZ B cells resulted from a defect intrinsic to B cells expressing the Yaa mutation. The lack of selective expansion of MZ B cells in diseased BXSB Yaa males strongly argues against a major role of MZ B cells in the generation of pathogenic autoantibodies in the BXSB model of SLE. Furthermore, a comparative analysis with mice deficient in CD22 or expressing an IgM anti-trinitrophenyl/DNA transgene suggests that the hyperreactive phenotype of Yaa B cells, as judged by a markedly increased spontaneous IgM secretion, is likely to contribute to the enhanced maturation toward follicular B cells and the block in the MZ B cell generation. PB - Amer Assoc Immunologists, Bethesda T2 - Journal of Immunology T1 - The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells EP - 2301 IS - 5 SP - 2293 VL - 170 DO - 10.4049/jimmunol.170.5.2293 ER -
@article{ author = "Amano, H. and Amano, E. and Moll, T. and Marinković, Dragan and Ibnou-Zekri, N and Martinez-Soria, E. and Semac, I and Wirth, Thomas and Nitschke, L. and Izui, S", year = "2003", abstract = "The accelerated development of systemic lupus erythematosus (SLE) in BXSB male mice is associated with the presence of an as yet unidentified mutant gene, Yaa (Y-linked autoimmune acceleration). In view of a possible role of marginal zone (MZ) B cells in murine SLE, we have explored whether the expression of the Yaa mutation affects the differentiation of MZ and follicular B cells, thereby implicating the acceleration of the disease. In this study, we show that both BXSB and C57BL/6 Yaa mice, including two different substrains of BXSB Yaa males that are protected from SLE, displayed an impaired development of MZ B cells early in life. Studies in bone marrow chimeras revealed that the loss of MZ B cells resulted from a defect intrinsic to B cells expressing the Yaa mutation. The lack of selective expansion of MZ B cells in diseased BXSB Yaa males strongly argues against a major role of MZ B cells in the generation of pathogenic autoantibodies in the BXSB model of SLE. Furthermore, a comparative analysis with mice deficient in CD22 or expressing an IgM anti-trinitrophenyl/DNA transgene suggests that the hyperreactive phenotype of Yaa B cells, as judged by a markedly increased spontaneous IgM secretion, is likely to contribute to the enhanced maturation toward follicular B cells and the block in the MZ B cell generation.", publisher = "Amer Assoc Immunologists, Bethesda", journal = "Journal of Immunology", title = "The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells", pages = "2301-2293", number = "5", volume = "170", doi = "10.4049/jimmunol.170.5.2293" }
Amano, H., Amano, E., Moll, T., Marinković, D., Ibnou-Zekri, N., Martinez-Soria, E., Semac, I., Wirth, T., Nitschke, L.,& Izui, S.. (2003). The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells. in Journal of Immunology Amer Assoc Immunologists, Bethesda., 170(5), 2293-2301. https://doi.org/10.4049/jimmunol.170.5.2293
Amano H, Amano E, Moll T, Marinković D, Ibnou-Zekri N, Martinez-Soria E, Semac I, Wirth T, Nitschke L, Izui S. The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells. in Journal of Immunology. 2003;170(5):2293-2301. doi:10.4049/jimmunol.170.5.2293 .
Amano, H., Amano, E., Moll, T., Marinković, Dragan, Ibnou-Zekri, N, Martinez-Soria, E., Semac, I, Wirth, Thomas, Nitschke, L., Izui, S, "The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells" in Journal of Immunology, 170, no. 5 (2003):2293-2301, https://doi.org/10.4049/jimmunol.170.5.2293 . .