TY  - JOUR
AU  - Lačković, Maja
AU  - Ivković, Maja
AU  - Vićentić, Sreten
AU  - Jerotić, Stefan
AU  - Nestorović, Milica
AU  - Stojković, Tihomir
AU  - Pavlović, Aleksandra
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/4844
AB  - The blood-brain barrier (BBB) is formed by continuous, closely connected endothelial cells, enveloped in the basal lamina, pericytes, and foot extensions of astrocytes. BBB has a vital role in brain metabolism and protects the brain parenchyma from harmful agents present in the systemic circulation. Damage to the BBB and an increase in its permeability have an important role in many neurodegenerative diseases.
This paper aims to review the literature on the impact of the BBB damage on psychiatric illness, a largely neglected and under researched area. Links between BBB impairment and specific neuropsychiatric disorders are described including schizophrenia, affective disorders, dementias with behavioral disorders, and alcohol use disorder, with comparison to typical hereditary small vessel diseases affecting the BBB such as cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL) and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). The authors critically summarize possible pathogenic mechanisms linking BBB damage and these common disorders.
AB  - Крвно-мождана баријера (КМБ) се састоји од континураних, тесно спојених ендотелних ћелија омотаних базалном ламином, перицитима и сто-паластим продужецима астроцита. КМБ има виталну функцију и можданом метаболизму и штити мождани паренхим од штетних фактора присутних у системској циркулацији. Показано је да оштећење КМБ и повећање њене пропустљи-вости има значајну улогу у многим неуродегене-ративним обољењима.
Циљ овога рада је преглед литературе о значају оштећења КМБ код психијатријских обољења, до сада занемареној и недовољно истраженој облас-ти. Повезаност измедју поремећаја КМБ и неуро-психијатријских поремећаја је посебно анализи-рана за схизофренију, афективне поремећаје, де-менције са бихевиоралним изменама, поремећај употребе алкохола, са посебним освртом на на-следне болести малих крвних судова мозга са оштећењем КМБ као што су церебрална аутозо-мално доминантна артериопатија са супкортика-ним инфарктима и леукоенцефалопатијом (CADASIL) и митохондријска енцефаломиопатија са лактатном ацидозом и епизодама налик можда-ном удару (MELAS). Аутори критички сумирају могуће патогенетске механизме који повезују оштећења КМБ са овим честим обољењима.
PB  - Srpsko lekarsko društvo
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The role of the blood-brain barrier in psychiatric disorders
T1  - Uloga krvno-moždane barijere u psihijatrijskim oboljenjima
DO  - 10.2298/SARH220417081L
ER  - 

@article{
author = "Lačković, Maja and Ivković, Maja and Vićentić, Sreten and Jerotić, Stefan and Nestorović, Milica and Stojković, Tihomir and Pavlović, Aleksandra",
year = "2022",
abstract = "The blood-brain barrier (BBB) is formed by continuous, closely connected endothelial cells, enveloped in the basal lamina, pericytes, and foot extensions of astrocytes. BBB has a vital role in brain metabolism and protects the brain parenchyma from harmful agents present in the systemic circulation. Damage to the BBB and an increase in its permeability have an important role in many neurodegenerative diseases.
This paper aims to review the literature on the impact of the BBB damage on psychiatric illness, a largely neglected and under researched area. Links between BBB impairment and specific neuropsychiatric disorders are described including schizophrenia, affective disorders, dementias with behavioral disorders, and alcohol use disorder, with comparison to typical hereditary small vessel diseases affecting the BBB such as cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL) and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). The authors critically summarize possible pathogenic mechanisms linking BBB damage and these common disorders., Крвно-мождана баријера (КМБ) се састоји од континураних, тесно спојених ендотелних ћелија омотаних базалном ламином, перицитима и сто-паластим продужецима астроцита. КМБ има виталну функцију и можданом метаболизму и штити мождани паренхим од штетних фактора присутних у системској циркулацији. Показано је да оштећење КМБ и повећање њене пропустљи-вости има значајну улогу у многим неуродегене-ративним обољењима.
Циљ овога рада је преглед литературе о значају оштећења КМБ код психијатријских обољења, до сада занемареној и недовољно истраженој облас-ти. Повезаност измедју поремећаја КМБ и неуро-психијатријских поремећаја је посебно анализи-рана за схизофренију, афективне поремећаје, де-менције са бихевиоралним изменама, поремећај употребе алкохола, са посебним освртом на на-следне болести малих крвних судова мозга са оштећењем КМБ као што су церебрална аутозо-мално доминантна артериопатија са супкортика-ним инфарктима и леукоенцефалопатијом (CADASIL) и митохондријска енцефаломиопатија са лактатном ацидозом и епизодама налик можда-ном удару (MELAS). Аутори критички сумирају могуће патогенетске механизме који повезују оштећења КМБ са овим честим обољењима.",
publisher = "Srpsko lekarsko društvo",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The role of the blood-brain barrier in psychiatric disorders, Uloga krvno-moždane barijere u psihijatrijskim oboljenjima",
doi = "10.2298/SARH220417081L"
}

Lačković, M., Ivković, M., Vićentić, S., Jerotić, S., Nestorović, M., Stojković, T.,& Pavlović, A.. (2022). The role of the blood-brain barrier in psychiatric disorders. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo..
https://doi.org/10.2298/SARH220417081L

Lačković M, Ivković M, Vićentić S, Jerotić S, Nestorović M, Stojković T, Pavlović A. The role of the blood-brain barrier in psychiatric disorders. in Srpski arhiv za celokupno lekarstvo. 2022;.
doi:10.2298/SARH220417081L .

Lačković, Maja, Ivković, Maja, Vićentić, Sreten, Jerotić, Stefan, Nestorović, Milica, Stojković, Tihomir, Pavlović, Aleksandra, "The role of the blood-brain barrier in psychiatric disorders" in Srpski arhiv za celokupno lekarstvo (2022),
https://doi.org/10.2298/SARH220417081L . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Markišić, Merdin Š.
AU  - Pavlović, Aleksandra M.
AU  - Lačković, Maja
AU  - Božić, Marija M.
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/802
AB  - Vitamin A is essential for the early development and normal functioning of the brain throughout life. A deficiency of vitamin A is one of the leading causes of morbidity and mortality in developing countries, and subclinical deficiency is probably present worldwide. The main active molecule in vitamin A is retinoic acid, which is involved in vision, the immune system, skin health, olfaction and cognition (learning, memory, spatial functions, olfaction, etc.) through processes of neuroplasticity and neurogenesis. Vitamin A is involved in the regulation of about one-sixth of the human genome. It has non-genomic actions in protein translation and paracrine actions. Retinal vitamin A aldehyde is crucial for day and night vision. The best-known manifestation of hypovitaminosis A is night blindness but in more severe cases, it causes blindness. In the hypothalamus, vitamin A, with information from the retina, acts in circadian and seasonal regulation. Increased retinoic acid levels in the blood are associated with increased risk of depression, and lower levels have been connected with Alzheimer's disease, Parkinson's disease, cerebral ischemia, autistic spectrum disorders and schizophrenia. Higher doses and longer periods of treatment pose the threat of hypervitaminosis A. Vitamin A and its analogs are a promising new class of therapeutic agents in a wide spectrum of disorders, albeit with a narrow therapeutic window.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Vitamin a and the nervous system
EP  - 1590
IS  - 4
SP  - 1585
VL  - 66
DO  - 10.2298/ABS1404585P
ER  - 

@article{
author = "Pavlović, Dragan and Markišić, Merdin Š. and Pavlović, Aleksandra M. and Lačković, Maja and Božić, Marija M.",
year = "2014",
abstract = "Vitamin A is essential for the early development and normal functioning of the brain throughout life. A deficiency of vitamin A is one of the leading causes of morbidity and mortality in developing countries, and subclinical deficiency is probably present worldwide. The main active molecule in vitamin A is retinoic acid, which is involved in vision, the immune system, skin health, olfaction and cognition (learning, memory, spatial functions, olfaction, etc.) through processes of neuroplasticity and neurogenesis. Vitamin A is involved in the regulation of about one-sixth of the human genome. It has non-genomic actions in protein translation and paracrine actions. Retinal vitamin A aldehyde is crucial for day and night vision. The best-known manifestation of hypovitaminosis A is night blindness but in more severe cases, it causes blindness. In the hypothalamus, vitamin A, with information from the retina, acts in circadian and seasonal regulation. Increased retinoic acid levels in the blood are associated with increased risk of depression, and lower levels have been connected with Alzheimer's disease, Parkinson's disease, cerebral ischemia, autistic spectrum disorders and schizophrenia. Higher doses and longer periods of treatment pose the threat of hypervitaminosis A. Vitamin A and its analogs are a promising new class of therapeutic agents in a wide spectrum of disorders, albeit with a narrow therapeutic window.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Vitamin a and the nervous system",
pages = "1590-1585",
number = "4",
volume = "66",
doi = "10.2298/ABS1404585P"
}

Pavlović, D., Markišić, M. Š., Pavlović, A. M., Lačković, M.,& Božić, M. M.. (2014). Vitamin a and the nervous system. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 66(4), 1585-1590.
https://doi.org/10.2298/ABS1404585P

Pavlović D, Markišić MŠ, Pavlović AM, Lačković M, Božić MM. Vitamin a and the nervous system. in Archives of Biological Sciences. 2014;66(4):1585-1590.
doi:10.2298/ABS1404585P .

Pavlović, Dragan, Markišić, Merdin Š., Pavlović, Aleksandra M., Lačković, Maja, Božić, Marija M., "Vitamin a and the nervous system" in Archives of Biological Sciences, 66, no. 4 (2014):1585-1590,
https://doi.org/10.2298/ABS1404585P . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
AU  - Lačković, Maja
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/695
AB  - Omega-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs) are thought to be important for normal dopaminergic, glutamatergic and serotonergic neurotransmission. Depression is less prevalent in societies with high fish consumption, and depressed patients have significantly lower red blood cell ω-3 levels. Studies with ω-3 supplementation have led to controversial results. A significantly longer remission of bipolar symptomatology has been confirmed from a high-dose DHA and EPA mixture. Greater seafood consumption per capita has been connected with a lower prevalence of bipolar spectrum disorders. Reduced levels of ω-6 and ω-3 PUFAs were found in patients with schizophrenia.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Omega 3 fatty acids in psychiatry
EP  - 46
IS  - 1
SP  - 43
VL  - 65
DO  - 10.2298/ABS1301043P
ER  - 

@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M. and Lačković, Maja",
year = "2013",
abstract = "Omega-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs) are thought to be important for normal dopaminergic, glutamatergic and serotonergic neurotransmission. Depression is less prevalent in societies with high fish consumption, and depressed patients have significantly lower red blood cell ω-3 levels. Studies with ω-3 supplementation have led to controversial results. A significantly longer remission of bipolar symptomatology has been confirmed from a high-dose DHA and EPA mixture. Greater seafood consumption per capita has been connected with a lower prevalence of bipolar spectrum disorders. Reduced levels of ω-6 and ω-3 PUFAs were found in patients with schizophrenia.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Omega 3 fatty acids in psychiatry",
pages = "46-43",
number = "1",
volume = "65",
doi = "10.2298/ABS1301043P"
}

Pavlović, D., Pavlović, A. M.,& Lačković, M.. (2013). Omega 3 fatty acids in psychiatry. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 65(1), 43-46.
https://doi.org/10.2298/ABS1301043P

Pavlović D, Pavlović AM, Lačković M. Omega 3 fatty acids in psychiatry. in Archives of Biological Sciences. 2013;65(1):43-46.
doi:10.2298/ABS1301043P .

Pavlović, Dragan, Pavlović, Aleksandra M., Lačković, Maja, "Omega 3 fatty acids in psychiatry" in Archives of Biological Sciences, 65, no. 1 (2013):43-46,
https://doi.org/10.2298/ABS1301043P . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Pavlović, Aleksandra M.
AU  - Lačković, Maja
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/692
AB  - Alzheimer's disease (AD), the most prevalent dementia, is characterized not only by cognitive but also behavior- al changes that pose the heaviest burden to caregivers. Differences in the clinical picture depending on the time of disease onset have been observed. We correlated cognitive and behavioral deficits in patients with presenile- and senile-onset AD to explore the differences. We tested 60 AD patients, 19 male and 41 female, mean age 65.2 years with the Dementia Behavior Disturbance Scale (DBD) and a standard neuropsychological battery. The patients were divided according to their DBD score into two groups: group I - score 0-2 (n=24; 40%), group II - score 3≥ (n=36; 60%), comparable in disease duration and neurological findings. The cognitive scores were significantly higher in the group with less behavioral changes than in the group with more behavioral changes: Mini Mental State Examination score (p=0.0015), serial subtraction (p=0.0009), block design (p=0.0049), copy of complex figure (p=0.0125), complex visual organization (p=0.0099), divided attention, visual memory and speech comprehension. A significantly higher frequency of behavioral disturbances was registered in patients with senile onset than in the presenile-onset group (p lt 0.005). There were no sex differences. Our data show a correlation between cognitive decline and behavioral changes in late onset AD patients, indicating that more behavioral disturbances were associated with a more severe degree of cognitive decline, especially in non-verbal functions and attention deficits, compared to early onset patients.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease
EP  - 1147
IS  - 3
SP  - 1141
VL  - 65
DO  - 10.2298/ABS1303141P
ER  - 

@article{
author = "Pavlović, Dragan and Pavlović, Aleksandra M. and Lačković, Maja",
year = "2013",
abstract = "Alzheimer's disease (AD), the most prevalent dementia, is characterized not only by cognitive but also behavior- al changes that pose the heaviest burden to caregivers. Differences in the clinical picture depending on the time of disease onset have been observed. We correlated cognitive and behavioral deficits in patients with presenile- and senile-onset AD to explore the differences. We tested 60 AD patients, 19 male and 41 female, mean age 65.2 years with the Dementia Behavior Disturbance Scale (DBD) and a standard neuropsychological battery. The patients were divided according to their DBD score into two groups: group I - score 0-2 (n=24; 40%), group II - score 3≥ (n=36; 60%), comparable in disease duration and neurological findings. The cognitive scores were significantly higher in the group with less behavioral changes than in the group with more behavioral changes: Mini Mental State Examination score (p=0.0015), serial subtraction (p=0.0009), block design (p=0.0049), copy of complex figure (p=0.0125), complex visual organization (p=0.0099), divided attention, visual memory and speech comprehension. A significantly higher frequency of behavioral disturbances was registered in patients with senile onset than in the presenile-onset group (p lt 0.005). There were no sex differences. Our data show a correlation between cognitive decline and behavioral changes in late onset AD patients, indicating that more behavioral disturbances were associated with a more severe degree of cognitive decline, especially in non-verbal functions and attention deficits, compared to early onset patients.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease",
pages = "1147-1141",
number = "3",
volume = "65",
doi = "10.2298/ABS1303141P"
}

Pavlović, D., Pavlović, A. M.,& Lačković, M.. (2013). Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 65(3), 1141-1147.
https://doi.org/10.2298/ABS1303141P

Pavlović D, Pavlović AM, Lačković M. Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease. in Archives of Biological Sciences. 2013;65(3):1141-1147.
doi:10.2298/ABS1303141P .

Pavlović, Dragan, Pavlović, Aleksandra M., Lačković, Maja, "Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer's disease" in Archives of Biological Sciences, 65, no. 3 (2013):1141-1147,
https://doi.org/10.2298/ABS1303141P . .