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dc.creatorNikolić-Kokić, Aleksandra
dc.creatorMarinković, Dragan
dc.creatorPerić, Stojan
dc.creatorStević, Zorica
dc.creatorSpasić, Mihajlo B.
dc.creatorBlagojević, Duško
dc.creatorRakočević-Stojanović, Vidosava
dc.date.accessioned2021-06-09T14:13:46Z
dc.date.available2021-06-09T14:13:46Z
dc.date.issued2016
dc.identifier.issn1351-0002
dc.identifier.urihttp://rfasper.fasper.bg.ac.rs/handle/123456789/985
dc.description.abstractObjectives: The aim of our study was to determine if redox imbalance caused by the activities of antioxidant enzymes existed in erythrocytes of type 1 myotonic dystrophy ( DM1) patients. Methods: The activities of erythrocyte superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were measured in 30 DM1 patients and 15 healthy controls ( HCs). The obtained values were correlated with the Muscular Impairment Rating Scale ( MIRS) score and creatine kinase ( CK). Results: Superoxide dismutase and catalase activities were lower in DM1 patients compared to HCs. A positive correlation was found between disease duration and MIRS score as well as with glutathione reductase activity. In DM1 patients, there were positive correlations between catalase, glutathione peroxidase, and glutathione reductase activities. After sub-dividing DM1 patients according to CK levels, superoxide dismutase activity was still statistically different from HCs. However, catalase activity was significantly lower only in DM1 patients with increased CK. Discussion: Undesirable alterations in antioxidant enzyme activities during DM1 disease progression may result in conditions favoring oxidative stress and changes in metabolism which together could contribute to muscle wasting.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175083/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceRedox Report
dc.subjectCatalaseen
dc.subjectErythrocytesen
dc.subjectGlutathione reductaseen
dc.subjectGlutatione peroxidaseen
dc.subjectType 1 myotonic dystrophyen
dc.subjectSuperoxide dismutaseen
dc.titleRedox imbalance in peripheral blood of type 1 myotonic dystrophy patientsen
dc.typearticle
dc.rights.licenseBY-NC
dc.citation.epage237
dc.citation.issue5
dc.citation.other21(5): 232-237
dc.citation.rankM23
dc.citation.spage232
dc.citation.volume21
dc.identifier.doi10.1080/13510002.2015.1107311
dc.identifier.fulltexthttp://rfasper.fasper.bg.ac.rs/bitstream/id/844/982.pdf
dc.identifier.pmid26817806
dc.identifier.scopus2-s2.0-84978540179
dc.identifier.wos000380753800006
dc.type.versionpublishedVersion


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Приказ основних података о документу