Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults
No Thumbnail
Authors
Milovanović, Olivera
Milovanović, Jasmina R.

Đukić, Aleksandar

Matović, Milovan

Tomić-Lučić, Aleksandra

Glumbić, Nenad

Radovanović, Ana M.

Janković, Slobodan M.

Article (Published version)

Metadata
Show full item recordAbstract
Objectives: The aim of our study was to develop a population pharmacokinetic (PPK) model for 25-hydroxyvitamin D clearance in a healthy young adult population in Serbia. Methods: Study sample consisted of 70 healthy young students of the Faculty of Medical Science, University of Kragujevac, Serbia, with a mean age and body mass index of 22.39 +/- 1.82 years and 21.31 +/- 2.69 kgm(-2), respectively. Non-linear mixed-effect modeling (NONMEM) software was used for data analysis. A validation set of 16 participants was used to estimate the predictive performance of the pharmacokinetic model. Results: In the base model (without covariates), we had parameter estimates of 0.01 L/h for apparent clearance, 0.25 L for apparent volume of distribution, while value of minimum objective function (MOF) was 383.468. The full regression model was established by estimating the effects of 12 covariates. Mean intake of vitamin D from foods (DD) and value of phosphate in serum (PHO) were covariates include...d in the final model, while others were excluded in this process. The estimated value in the final MOF model was 274.555. The final regression model formula was: clearance (CL) (L/h) = 0.0711 + 0.738 x DD + 0.618 x PHO. Conclusions: The PPK model obtained determined clearance of 25-hydroxyvitamin D in a healthy young adult population in Serbia. Mean intake of vitamin D from foods and serum phosphate level are the most important covariates that influence value of 25-hydroxyvitamin D clearance in healthy young adults.
Keywords:
Vitamin D / 25-hydroxyvitamin D / population pharmacokinetics / clearanceSource:
International Journal of Clinical Pharmacology and Therapeutics, 2015, 53, 1, 1-8Publisher:
- Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
Funding / projects:
- Pharmacological analysis of effects of biologically active substances on isolated smooth muscles from human gastrointestinal and urogenital tract (RS-175007)
- Ministry of Science, Montenegro
DOI: 10.5414/CP202185
ISSN: 0946-1965
PubMed: 25407256
WoS: 000350392200001
Scopus: 2-s2.0-84964310789
Collections
Institution/Community
rFASPERTY - JOUR AU - Milovanović, Olivera AU - Milovanović, Jasmina R. AU - Đukić, Aleksandar AU - Matović, Milovan AU - Tomić-Lučić, Aleksandra AU - Glumbić, Nenad AU - Radovanović, Ana M. AU - Janković, Slobodan M. PY - 2015 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/916 AB - Objectives: The aim of our study was to develop a population pharmacokinetic (PPK) model for 25-hydroxyvitamin D clearance in a healthy young adult population in Serbia. Methods: Study sample consisted of 70 healthy young students of the Faculty of Medical Science, University of Kragujevac, Serbia, with a mean age and body mass index of 22.39 +/- 1.82 years and 21.31 +/- 2.69 kgm(-2), respectively. Non-linear mixed-effect modeling (NONMEM) software was used for data analysis. A validation set of 16 participants was used to estimate the predictive performance of the pharmacokinetic model. Results: In the base model (without covariates), we had parameter estimates of 0.01 L/h for apparent clearance, 0.25 L for apparent volume of distribution, while value of minimum objective function (MOF) was 383.468. The full regression model was established by estimating the effects of 12 covariates. Mean intake of vitamin D from foods (DD) and value of phosphate in serum (PHO) were covariates included in the final model, while others were excluded in this process. The estimated value in the final MOF model was 274.555. The final regression model formula was: clearance (CL) (L/h) = 0.0711 + 0.738 x DD + 0.618 x PHO. Conclusions: The PPK model obtained determined clearance of 25-hydroxyvitamin D in a healthy young adult population in Serbia. Mean intake of vitamin D from foods and serum phosphate level are the most important covariates that influence value of 25-hydroxyvitamin D clearance in healthy young adults. PB - Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen T2 - International Journal of Clinical Pharmacology and Therapeutics T1 - Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults EP - 8 IS - 1 SP - 1 VL - 53 DO - 10.5414/CP202185 ER -
@article{ author = "Milovanović, Olivera and Milovanović, Jasmina R. and Đukić, Aleksandar and Matović, Milovan and Tomić-Lučić, Aleksandra and Glumbić, Nenad and Radovanović, Ana M. and Janković, Slobodan M.", year = "2015", abstract = "Objectives: The aim of our study was to develop a population pharmacokinetic (PPK) model for 25-hydroxyvitamin D clearance in a healthy young adult population in Serbia. Methods: Study sample consisted of 70 healthy young students of the Faculty of Medical Science, University of Kragujevac, Serbia, with a mean age and body mass index of 22.39 +/- 1.82 years and 21.31 +/- 2.69 kgm(-2), respectively. Non-linear mixed-effect modeling (NONMEM) software was used for data analysis. A validation set of 16 participants was used to estimate the predictive performance of the pharmacokinetic model. Results: In the base model (without covariates), we had parameter estimates of 0.01 L/h for apparent clearance, 0.25 L for apparent volume of distribution, while value of minimum objective function (MOF) was 383.468. The full regression model was established by estimating the effects of 12 covariates. Mean intake of vitamin D from foods (DD) and value of phosphate in serum (PHO) were covariates included in the final model, while others were excluded in this process. The estimated value in the final MOF model was 274.555. The final regression model formula was: clearance (CL) (L/h) = 0.0711 + 0.738 x DD + 0.618 x PHO. Conclusions: The PPK model obtained determined clearance of 25-hydroxyvitamin D in a healthy young adult population in Serbia. Mean intake of vitamin D from foods and serum phosphate level are the most important covariates that influence value of 25-hydroxyvitamin D clearance in healthy young adults.", publisher = "Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen", journal = "International Journal of Clinical Pharmacology and Therapeutics", title = "Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults", pages = "8-1", number = "1", volume = "53", doi = "10.5414/CP202185" }
Milovanović, O., Milovanović, J. R., Đukić, A., Matović, M., Tomić-Lučić, A., Glumbić, N., Radovanović, A. M.,& Janković, S. M.. (2015). Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults. in International Journal of Clinical Pharmacology and Therapeutics Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen., 53(1), 1-8. https://doi.org/10.5414/CP202185
Milovanović O, Milovanović JR, Đukić A, Matović M, Tomić-Lučić A, Glumbić N, Radovanović AM, Janković SM. Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults. in International Journal of Clinical Pharmacology and Therapeutics. 2015;53(1):1-8. doi:10.5414/CP202185 .
Milovanović, Olivera, Milovanović, Jasmina R., Đukić, Aleksandar, Matović, Milovan, Tomić-Lučić, Aleksandra, Glumbić, Nenad, Radovanović, Ana M., Janković, Slobodan M., "Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults" in International Journal of Clinical Pharmacology and Therapeutics, 53, no. 1 (2015):1-8, https://doi.org/10.5414/CP202185 . .