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Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation
dc.creator | Stamenković, Miroslav | |
dc.creator | Radić, Tanja | |
dc.creator | Stefanović, Ivan | |
dc.creator | Corić, Vesna | |
dc.creator | Senćanić, Ivan | |
dc.creator | Plješa-Ercegovac, Marija | |
dc.creator | Matić, Marija | |
dc.creator | Jakšić, Vesna | |
dc.creator | Simić, Tatjana | |
dc.creator | Savić-Radojević, Ana | |
dc.date.accessioned | 2021-06-09T14:06:11Z | |
dc.date.available | 2021-06-09T14:06:11Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1442-6404 | |
dc.identifier.uri | http://rfasper.fasper.bg.ac.rs/handle/123456789/868 | |
dc.description.abstract | Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development. | en |
dc.publisher | Wiley-Blackwell, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175052/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45009/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical and Experimental Ophthalmology | |
dc.subject | disease risk | en |
dc.subject | GSTO gene | en |
dc.subject | association | en |
dc.title | Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 283 | |
dc.citation.issue | 3 | |
dc.citation.other | 42(3): 277-283 | |
dc.citation.rank | M21 | |
dc.citation.spage | 277 | |
dc.citation.volume | 42 | |
dc.identifier.doi | 10.1111/ceo.12180 | |
dc.identifier.pmid | 23927022 | |
dc.identifier.scopus | 2-s2.0-84899095688 | |
dc.identifier.wos | 000334428100012 | |
dc.type.version | publishedVersion |