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Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation
dc.creator | Moll, T. | |
dc.creator | Martinez-Soria, E. | |
dc.creator | Santiago-Raber, ML | |
dc.creator | Amano, H. | |
dc.creator | Pihlgren-Bosch, M | |
dc.creator | Marinković, Dragan | |
dc.creator | Izui, S | |
dc.date.accessioned | 2021-06-09T13:12:19Z | |
dc.date.available | 2021-06-09T13:12:19Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0022-1767 | |
dc.identifier.uri | http://rfasper.fasper.bg.ac.rs/handle/123456789/36 | |
dc.description.abstract | An as-yet-unidentified mutation, Y-linked autoimmune acceleration (Yaa), is responsible for the accelerated development of lupus-like autoimmune syndrome in mice. In view of a possible role for Yaa as a positive regulator of BCR signaling, we have explored whether the expression of the Yaa mutation affects the development and activation of transgenic autoreactive B cells expressing either 4C8 IgM anti-RBC or Sp6 IgM anti-DNA. In this study, we show that the expression of the Yaa mutation induced a lethal form of autoimmune hemolytic anemia in 4C8 transgenic C57BL/6 mice, likely as a result of activation of 4C8 anti-RBC autoreactive B cells early in life. This was further supported, although indirectly, by increased T cell-independent IgM production in spleens of nontransgenic C57BL/6 mice bearing the Yaa mutation. In contrast, Yaa failed to induce activation of Sp6 anti-DNA autoreactive B cells, consistent with a lack of increased IgM anti-DNA production in nontransgenic C57BL/6 Yaa mice. Our results suggest that Yaa can activate autoreactive B cells in a BCR-dependent manner, related to differences in the form and nature of autoantigens. | en |
dc.publisher | Amer Assoc Immunologists, Bethesda | |
dc.rights | openAccess | |
dc.source | Journal of Immunology | |
dc.title | Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 709 | |
dc.citation.issue | 2 | |
dc.citation.other | 174(2): 702-709 | |
dc.citation.rank | M21 | |
dc.citation.spage | 702 | |
dc.citation.volume | 174 | |
dc.identifier.doi | 10.4049/jimmunol.174.2.702 | |
dc.identifier.fulltext | http://rfasper.fasper.bg.ac.rs/bitstream/id/398/33.pdf | |
dc.identifier.pmid | 15634889 | |
dc.identifier.scopus | 2-s2.0-11844281589 | |
dc.identifier.wos | 000226360500017 | |
dc.type.version | publishedVersion |