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dc.creatorTamaš, Olivera
dc.creatorKostić, Milutin
dc.creatorKačar, Aleksandra
dc.creatorStefanova, Elka
dc.creatorÐokić, Biljana Salak
dc.creatorStanisavljević, Dejana
dc.creatorMilovanović, Andona
dc.creatorÐorđević, Mirjana
dc.creatorGlumbić, Nenad
dc.creatorDragašević-Mišković, Nataša
dc.date.accessioned2021-09-20T09:33:23Z
dc.date.available2021-09-20T09:33:23Z
dc.date.issued2021
dc.identifier.issn1662-5137
dc.identifier.urihttps://www.frontiersin.org/article/10.3389/fnsys.2021.664223
dc.identifier.urihttp://rfasper.fasper.bg.ac.rs/handle/123456789/3434
dc.description.abstractObjectiveCerebellar neurodegenerative disorders (CDs) are a heterogeneous group of disorders. It is known that the cerebellum plays a role not only in motor, but also in cognitive and social cognitive functions. The aim of this study was to investigate social cognition in patients with different CDs.Materials and MethodsSocial cognition was examined in 34 patients, 12 with spinocerebellar ataxia type 1 (SCA1), 6 with spinocerebellar ataxia type 2 (SCA2), and 16 with idiopathic late onset cerebellar ataxia (ILOCA). All patients were clinically evaluated using the Scale for the Rating and Assessment of Ataxia. In addition, 34 age, sex, and education-matched healthy control (HC) subjects were similarly analyzed. Social cognition was studied using two tests: the Faux Pas Recognition Test and the Reading the Mind in the Eyes Test (RMET). An appropriate array of neuropsychological tests was used to assess the global cognitive status as well as the frontal functions and mood.ResultsCD patients achieved significantly worse results on both tests of social cognition compared to the HCs. The SCA1 + 2 group achieved the poorest results on the Faux Pas Recognition Test and exhibited poor performance on all cognitive tests, but was only significantly worse compared to the ILOCA group on the Free and Cued Selective Reminding Test (FCSRT) – recognition. The patients in the SCA1 + 2 and ILOCA groups obtained similar scores on RMET. In the SCA1 + 2 group the findings significantly correlated with clinical parameters of disease severity and duration and executive functions (EFs), and with mood and executive functions in the ILOCA group. In the SCA group EFs appeared as the only significant predictor of RMET achievement. The Boston Naming Test (BTN) was a significant predictor of the CD patients’ achievement on RMET, while the BTN, the Trail Making Test Part A and FCSRT – Delayed free recall predicted their performance on the Faux Pas Recognition Test.ConclusionPatients with CD have social cognitive impairments as demonstrated by the Faux Pas Test and the RMET test results. The SCA1 and 2 patients exhibited a more pronounced impairment compared with the ILOCA patients. The independent cognitive predictors of social cognition impairment were EFs and language.
dc.publisherFrontiers Media [Commercial Publisher]
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Systems Neuroscience
dc.subjectcerebellum
dc.subjectneurodegenerative disorder
dc.subjectspinocerebellar ataxia
dc.subjecttheory of mind
dc.subjectsocial cognition
dc.titleSocial Cognition in Patients With Cerebellar Neurodegenerative Disorders
dc.typearticleen
dc.rights.licenseBY
dc.citation.rankM22
dc.citation.spage664223
dc.citation.volume15
dc.identifier.doi10.3389/fnsys.2021.664223
dc.identifier.fulltexthttp://rfasper.fasper.bg.ac.rs/bitstream/id/2944/fnsys-15-664223.pdf
dc.identifier.scopus2-s2.0-85114371776
dc.identifier.wos000698804600001
dc.type.versionpublishedVersion


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