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Foxo3 is required for the regulation of oxidative stress in erythropoiesis
(Amer Soc Clinical Investigation Inc, Ann Arbor, 2007)
Erythroid cells accumulate hemoglobin as they mature and as a result are highly prone to oxidative damage. However, mechanisms of transcriptional control of antioxidant defense in erythroid cells have thus far been poorly ...
ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice
(Wiley, Hoboken, 2010)
Reactive oxygen species (ROS) participate in normal intracellular signalling and in many diseases including cancer and aging, although the associated mechanisms are not fully understood. Forkhead Box O (FoxO) 3 transcription ...
BOB.1OBF.1 deficiency affects marginal-zone B-cell compartment
(Amer Soc Microbiology, Washington, 2002)
Marginal-zone (MZ) B cells represent a first line of defense against particulate blood-borne antigens. Together with the B1 cells, they are responsible for the early response against type It T-independent antigens. The ...
AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation
(Amer Soc Hematology, Washington, 2006)
AKT serine threonine kinase of the protein kinase B (PKB) family plays essential roles in cell survival, growth, metabolism, and differentiation. In the erythroid system, AKT is known to be rapidly phosphorylated and ...
B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice
(Rockefeller Univ Press, New York, 2003)
Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. ...
Foxo3 transcription factor regulates oxidative stress in in vivo erythropoiesis.
(Amer Soc Hematology, Washington, 2006)
The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells
(Amer Assoc Immunologists, Bethesda, 2003)
The accelerated development of systemic lupus erythematosus (SLE) in BXSB male mice is associated with the presence of an as yet unidentified mutant gene, Yaa (Y-linked autoimmune acceleration). In view of a possible role ...
The influence of manifest strabismus and stereoscopic vision on non-verbal abilities of visually impaired children
(Pergamon-Elsevier Science Ltd, Oxford, 2011)
This research was conducted in order to examine the influence of manifest strabismus and stereoscopic vision on non-verbal abilities. of visually impaired children aged between 7 and 15. The sample included 55 visually ...
Students' and teachers' perceptions of aggressive behaviour in adolescents with intellectual disability and typically developing adolescents
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
This study investigated aggressive behaviour in Serbian adolescents with intellectual disability (ID) compared to typically developing peers. The sample consisted of both male and female adolescents aged 12-18 years. One ...
Recovery after severe brain injury
(Lippincott Williams & Wilkins, Philadelphia, 2008)