Brain plasticity: developmental and clinical aspects of importance for early intervention
Authors
Pavlović, DraganPavlović, Aleksandra

Komazec, Zoran
Marinković, Dragan

Rapaić, Dragan

Nedović, Goran

Kulić, Milan
Aleksić, Vuk
Sretenović, Ivana

Maksić, Jasmina

Contributors
Snežana NikolićRadmila Nikić
Vera Ilanković
Metadata
Show full item recordAbstract
Brain plasticity is not only accommodation of young brain tissue that can change
own characteristics, but process that occurs during whole life period, even during old
age. Mechanisms of plasticity incorporate: formation of new axon terminals and new
synapses, change in neuronal membrane excitability, change in the balance of excitation
and inhibition, a long-term potentiation (LTP) or long-term depression (LTD). Molecular
mechanisms of brain plasticity encompass neurotrophins, NMDA receptors, the role of
calcium ions and calcium channels, free radicals and lipid peroxides. Neuroplasticity
also may lead to destabilization of neuronal connections therefore without control of
this process plasticity becomes excessive and as a result pathological destabilization
and disease may occur. Compensation, which is reorganisation of behavior aimed at
minimizing or circumventing a particular disability, is also possible due to process of
neuroplasticity. Although, without any doubt, you...nger and growing brain has greater
potential for compensation of damage and higher ability for correction of dysfunctions.
Here we discussed biological potential of brain plasticity and importance of this
process for early intervention is special education and rehabilitation. Early intervention
will have full effect only if it is applied well-timed, otherwise the effects will be reduced.
Accurate early intervention should consider: definition of optimal time period for
beginning of early intervention; composition of proper protocols for methods of
stimulation and systemic exercise; and application of these measures in connection with
prospective biological potentials.
Keywords:
motor impairment / cognition / neural plasticity, brain / rehabilitationSource:
Thematic Collection of International Importance- Early Intervention in Special Education and Rehabilitation“, Beograd, Srbija, 2016., 2016, 43-62Publisher:
- University of Belgrade, Faculty of Special Education and Rehabilitation, Serbia / Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju
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Institution/Community
rFASPERPavlović, D., Pavlović, A., Komazec, Z., Marinković, D., Rapaić, D., Nedović, G., Kulić, M., Aleksić, V., Sretenović, I.,& Maksić, J.. (2016). Brain plasticity: developmental and clinical aspects of importance for early intervention. in Thematic Collection of International Importance- Early Intervention in Special Education and Rehabilitation“, Beograd, Srbija, 2016. University of Belgrade, Faculty of Special Education and Rehabilitation, Serbia / Univerzitet u Beogradu – Fakultet za specijalnu edukaciju i rehabilitaciju., 43-62. https://hdl.handle.net/21.15107/rcub_rfasper_2524
Pavlović D, Pavlović A, Komazec Z, Marinković D, Rapaić D, Nedović G, Kulić M, Aleksić V, Sretenović I, Maksić J. Brain plasticity: developmental and clinical aspects of importance for early intervention. in Thematic Collection of International Importance- Early Intervention in Special Education and Rehabilitation“, Beograd, Srbija, 2016.. 2016;:43-62. https://hdl.handle.net/21.15107/rcub_rfasper_2524 .
Pavlović, Dragan, Pavlović, Aleksandra, Komazec, Zoran, Marinković, Dragan, Rapaić, Dragan, Nedović, Goran, Kulić, Milan, Aleksić, Vuk, Sretenović, Ivana, Maksić, Jasmina, "Brain plasticity: developmental and clinical aspects of importance for early intervention" in Thematic Collection of International Importance- Early Intervention in Special Education and Rehabilitation“, Beograd, Srbija, 2016. (2016):43-62, https://hdl.handle.net/21.15107/rcub_rfasper_2524 .