Diabetic neuropathy (DN), the most common chronic and progressive complication of diabetes mellitus (DM), strongly affects patients’ quality of life. DN could be present as peripheral, autonomous or, clinically also relevant, uremic neuropathy. The etiopathogenesis of DN is multifactorial, and genetic components play a role both in its occurrence and clinical course. A number of gene polymorphisms in candidate genes have been assessed as susceptibility factors for DN, and most of them are linked to mechanisms such as reactive oxygen species production, neurovascular impairments and modified protein glycosylation, as well as immunomodulation and inflammation. Different epigenomic mechanisms such as DNA methylation, histone modifications and non-coding RNA action have been studied in DN, which also underline the importance of “metabolic memory” in DN appearance and progression. In this review, we summarize most of the relevant data in the field of genetics and epigenomics of DN, hoping t...hey will become significant for diagnosis, therapy and prevention of DN.
TY - JOUR
AU - Janković, M.
AU - Novaković, Ivana
AU - Nikolić, D.
AU - Maksić, Jasmina
AU - Branković, S.
AU - Petronić, I.
AU - Cirović, D.
AU - Ducić, S.
AU - Grajić, M.
AU - Bogićević, D.
PY - 2021
UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/1317
AB - Diabetic neuropathy (DN), the most common chronic and progressive complication of diabetes mellitus (DM), strongly affects patients’ quality of life. DN could be present as peripheral, autonomous or, clinically also relevant, uremic neuropathy. The etiopathogenesis of DN is multifactorial, and genetic components play a role both in its occurrence and clinical course. A number of gene polymorphisms in candidate genes have been assessed as susceptibility factors for DN, and most of them are linked to mechanisms such as reactive oxygen species production, neurovascular impairments and modified protein glycosylation, as well as immunomodulation and inflammation. Different epigenomic mechanisms such as DNA methylation, histone modifications and non-coding RNA action have been studied in DN, which also underline the importance of “metabolic memory” in DN appearance and progression. In this review, we summarize most of the relevant data in the field of genetics and epigenomics of DN, hoping they will become significant for diagnosis, therapy and prevention of DN.
PB - MDPI Ag
T2 - International Journal of Molecular Sciences
T1 - Genetic and epigenomic modifiers of diabetic neuropathy
IS - 9
SP - 4887
VL - 22
DO - 10.3390/ijms22094887
ER -
@article{
author = "Janković, M. and Novaković, Ivana and Nikolić, D. and Maksić, Jasmina and Branković, S. and Petronić, I. and Cirović, D. and Ducić, S. and Grajić, M. and Bogićević, D.",
year = "2021",
abstract = "Diabetic neuropathy (DN), the most common chronic and progressive complication of diabetes mellitus (DM), strongly affects patients’ quality of life. DN could be present as peripheral, autonomous or, clinically also relevant, uremic neuropathy. The etiopathogenesis of DN is multifactorial, and genetic components play a role both in its occurrence and clinical course. A number of gene polymorphisms in candidate genes have been assessed as susceptibility factors for DN, and most of them are linked to mechanisms such as reactive oxygen species production, neurovascular impairments and modified protein glycosylation, as well as immunomodulation and inflammation. Different epigenomic mechanisms such as DNA methylation, histone modifications and non-coding RNA action have been studied in DN, which also underline the importance of “metabolic memory” in DN appearance and progression. In this review, we summarize most of the relevant data in the field of genetics and epigenomics of DN, hoping they will become significant for diagnosis, therapy and prevention of DN.",
publisher = "MDPI Ag",
journal = "International Journal of Molecular Sciences",
title = "Genetic and epigenomic modifiers of diabetic neuropathy",
number = "9",
pages = "4887",
volume = "22",
doi = "10.3390/ijms22094887"
}
Janković, M., Novaković, I., Nikolić, D., Maksić, J., Branković, S., Petronić, I., Cirović, D., Ducić, S., Grajić, M.,& Bogićević, D.. (2021). Genetic and epigenomic modifiers of diabetic neuropathy. in International Journal of Molecular Sciences
MDPI Ag., 22(9), 4887.
https://doi.org/10.3390/ijms22094887
Janković M, Novaković I, Nikolić D, Maksić J, Branković S, Petronić I, Cirović D, Ducić S, Grajić M, Bogićević D. Genetic and epigenomic modifiers of diabetic neuropathy. in International Journal of Molecular Sciences. 2021;22(9):4887.
doi:10.3390/ijms22094887 .
Janković, M., Novaković, Ivana, Nikolić, D., Maksić, Jasmina, Branković, S., Petronić, I., Cirović, D., Ducić, S., Grajić, M., Bogićević, D., "Genetic and epigenomic modifiers of diabetic neuropathy" in International Journal of Molecular Sciences, 22, no. 9 (2021):4887,
https://doi.org/10.3390/ijms22094887 . .
