GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers

2018
Authors
Stamenković, Miroslav
Lukić, Vesna
Šuvakov, Sonja
Simić, Tatjana

Senćanić, Ivan
Plješa-Ercegovac, Marija
Jakšić, Vesna

Babović, Siniša
Matić, Marija
Radosavljević, Aleksandra

Savić-Radojević, Ana
Đukić, Tatjana

Article (Published version)
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AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigar...ette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.
Keywords:
GSTM1 / GSTT1 / primary open angle glaucoma risk / smoking / hypertension / diabetes mellitusSource:
International Journal of Ophthalmology, 2018, 11, 9, 1514-1520Publisher:
- IJO Press, Xi An
Funding / projects:
- The role of glutathione transferase polymorphism in susceptibility to disease (RS-175052)
- Functionalization of Nanomaterials for obtaining new contact lenses, and early diagnostics of diabetes (RS-45009)
DOI: 10.18240/ijo.2018.09.14
ISSN: 2222-3959
PubMed: 30225227
WoS: 000444411700014
Scopus: 2-s2.0-85053377610
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rFASPERTY - JOUR AU - Stamenković, Miroslav AU - Lukić, Vesna AU - Šuvakov, Sonja AU - Simić, Tatjana AU - Senćanić, Ivan AU - Plješa-Ercegovac, Marija AU - Jakšić, Vesna AU - Babović, Siniša AU - Matić, Marija AU - Radosavljević, Aleksandra AU - Savić-Radojević, Ana AU - Đukić, Tatjana PY - 2018 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/1157 AB - AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development. PB - IJO Press, Xi An T2 - International Journal of Ophthalmology T1 - GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers EP - 1520 IS - 9 SP - 1514 VL - 11 DO - 10.18240/ijo.2018.09.14 ER -
@article{ author = "Stamenković, Miroslav and Lukić, Vesna and Šuvakov, Sonja and Simić, Tatjana and Senćanić, Ivan and Plješa-Ercegovac, Marija and Jakšić, Vesna and Babović, Siniša and Matić, Marija and Radosavljević, Aleksandra and Savić-Radojević, Ana and Đukić, Tatjana", year = "2018", abstract = "AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.", publisher = "IJO Press, Xi An", journal = "International Journal of Ophthalmology", title = "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers", pages = "1520-1514", number = "9", volume = "11", doi = "10.18240/ijo.2018.09.14" }
Stamenković, M., Lukić, V., Šuvakov, S., Simić, T., Senćanić, I., Plješa-Ercegovac, M., Jakšić, V., Babović, S., Matić, M., Radosavljević, A., Savić-Radojević, A.,& Đukić, T.. (2018). GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology IJO Press, Xi An., 11(9), 1514-1520. https://doi.org/10.18240/ijo.2018.09.14
Stamenković M, Lukić V, Šuvakov S, Simić T, Senćanić I, Plješa-Ercegovac M, Jakšić V, Babović S, Matić M, Radosavljević A, Savić-Radojević A, Đukić T. GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology. 2018;11(9):1514-1520. doi:10.18240/ijo.2018.09.14 .
Stamenković, Miroslav, Lukić, Vesna, Šuvakov, Sonja, Simić, Tatjana, Senćanić, Ivan, Plješa-Ercegovac, Marija, Jakšić, Vesna, Babović, Siniša, Matić, Marija, Radosavljević, Aleksandra, Savić-Radojević, Ana, Đukić, Tatjana, "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers" in International Journal of Ophthalmology, 11, no. 9 (2018):1514-1520, https://doi.org/10.18240/ijo.2018.09.14 . .