TY  - JOUR
AU  - Šobot, Vesna
AU  - Stamenković, Miroslav
AU  - Simić, Tatjana
AU  - Jerotić, Đurđa
AU  - Đokic, Milica
AU  - Jakšić, Vesna
AU  - Božić, Marija
AU  - Milić, Jovan
AU  - Savić-Radojević, Ana
AU  - Đukić, Tatjana
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/3947
AB  - It is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression
of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms
in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase
(SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single
nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as
GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102
POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both
GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and
SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni
multiple test correction (OR = 6.66, p = 0.005). The present study supports the hypothesis that in combination,
GSTO1/GSTO2, modulate the risk of primary open angle glaucoma.
PB  - Elsevier
PB  - Academic Press
PB  - International Society for Eye Research
T2  - Experimental Eye Research
T1  - Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma
SP  - 108863
VL  - 2014
DO  - 10.1016/j.exer.2021.108863
ER  - 

@article{
author = "Šobot, Vesna and Stamenković, Miroslav and Simić, Tatjana and Jerotić, Đurđa and Đokic, Milica and Jakšić, Vesna and Božić, Marija and Milić, Jovan and Savić-Radojević, Ana and Đukić, Tatjana",
year = "2022",
abstract = "It is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression
of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms
in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase
(SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single
nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as
GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102
POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both
GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and
SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni
multiple test correction (OR = 6.66, p = 0.005). The present study supports the hypothesis that in combination,
GSTO1/GSTO2, modulate the risk of primary open angle glaucoma.",
publisher = "Elsevier, Academic Press, International Society for Eye Research",
journal = "Experimental Eye Research",
title = "Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma",
pages = "108863",
volume = "2014",
doi = "10.1016/j.exer.2021.108863"
}

Šobot, V., Stamenković, M., Simić, T., Jerotić, Đ., Đokic, M., Jakšić, V., Božić, M., Milić, J., Savić-Radojević, A.,& Đukić, T.. (2022). Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. in Experimental Eye Research
Elsevier., 2014, 108863.
https://doi.org/10.1016/j.exer.2021.108863

Šobot V, Stamenković M, Simić T, Jerotić Đ, Đokic M, Jakšić V, Božić M, Milić J, Savić-Radojević A, Đukić T. Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. in Experimental Eye Research. 2022;2014:108863.
doi:10.1016/j.exer.2021.108863 .

Šobot, Vesna, Stamenković, Miroslav, Simić, Tatjana, Jerotić, Đurđa, Đokic, Milica, Jakšić, Vesna, Božić, Marija, Milić, Jovan, Savić-Radojević, Ana, Đukić, Tatjana, "Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma" in Experimental Eye Research, 2014 (2022):108863,
https://doi.org/10.1016/j.exer.2021.108863 . .