Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation
Samo za registrovane korisnike
2014
Autori
Stamenković, MiroslavRadić, Tanja
Stefanović, Ivan
Corić, Vesna
Senćanić, Ivan
Plješa-Ercegovac, Marija
Matić, Marija
Jakšić, Vesna
Simić, Tatjana
Savić-Radojević, Ana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional ex...posure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.
Ključne reči:
disease risk / GSTO gene / associationIzvor:
Clinical and Experimental Ophthalmology, 2014, 42, 3, 277-283Izdavač:
- Wiley-Blackwell, Hoboken
Finansiranje / projekti:
- Značaj polimorfizma glutation transferaza u podložnosti za nastanak oboljenja (RS-175052)
- Funkcionalizacija nanomaterijala za dobijanje nove vrste kontaktnih sočiva i ranu detekciju dijabetesa (RS-45009)
DOI: 10.1111/ceo.12180
ISSN: 1442-6404
PubMed: 23927022
WoS: 000334428100012
Scopus: 2-s2.0-84899095688
Institucija/grupa
rFASPERTY - JOUR AU - Stamenković, Miroslav AU - Radić, Tanja AU - Stefanović, Ivan AU - Corić, Vesna AU - Senćanić, Ivan AU - Plješa-Ercegovac, Marija AU - Matić, Marija AU - Jakšić, Vesna AU - Simić, Tatjana AU - Savić-Radojević, Ana PY - 2014 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/868 AB - Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development. PB - Wiley-Blackwell, Hoboken T2 - Clinical and Experimental Ophthalmology T1 - Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation EP - 283 IS - 3 SP - 277 VL - 42 DO - 10.1111/ceo.12180 ER -
@article{ author = "Stamenković, Miroslav and Radić, Tanja and Stefanović, Ivan and Corić, Vesna and Senćanić, Ivan and Plješa-Ercegovac, Marija and Matić, Marija and Jakšić, Vesna and Simić, Tatjana and Savić-Radojević, Ana", year = "2014", abstract = "Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.", publisher = "Wiley-Blackwell, Hoboken", journal = "Clinical and Experimental Ophthalmology", title = "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation", pages = "283-277", number = "3", volume = "42", doi = "10.1111/ceo.12180" }
Stamenković, M., Radić, T., Stefanović, I., Corić, V., Senćanić, I., Plješa-Ercegovac, M., Matić, M., Jakšić, V., Simić, T.,& Savić-Radojević, A.. (2014). Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology Wiley-Blackwell, Hoboken., 42(3), 277-283. https://doi.org/10.1111/ceo.12180
Stamenković M, Radić T, Stefanović I, Corić V, Senćanić I, Plješa-Ercegovac M, Matić M, Jakšić V, Simić T, Savić-Radojević A. Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology. 2014;42(3):277-283. doi:10.1111/ceo.12180 .
Stamenković, Miroslav, Radić, Tanja, Stefanović, Ivan, Corić, Vesna, Senćanić, Ivan, Plješa-Ercegovac, Marija, Matić, Marija, Jakšić, Vesna, Simić, Tatjana, Savić-Radojević, Ana, "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation" in Clinical and Experimental Ophthalmology, 42, no. 3 (2014):277-283, https://doi.org/10.1111/ceo.12180 . .