Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease
Само за регистроване кориснике
2014
Аутори
Veselinović, NikolaPavlović, Aleksandra M.
Petrović, Boris
Ristić, Aleksandar
Novaković, Ivana
Svabic-Medjedović, Tamara
Pavlović, Dragan
Šternić, Nadežda
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration... early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis.
Кључне речи:
transcranial B-mode sonography / prion / basal ganglia / sporadic Creutzfeldt-Jakob diseaseИзвор:
Cognitive and Behavioral Neurology, 2014, 27, 1, 48-50Издавач:
- Lippincott Williams & Wilkins, Philadelphia
Финансирање / пројекти:
- Депресија изазвана васкуларним болестима мозга: примена неуровизуализационих метода у превенцији, раном откривању и лечењу (RS-MESTD-Basic Research (BR or ON)-175022)
- Неуроендокрина контрола секреције хормона раста код човека - нови изазови. Контрола енергетске хомеостазе код човека у различитим патолошким стањима. Клиничко-патолошка корелација и генетска основа тумора хипофизе и неуроендокриних тумора (RS-MESTD-Basic Research (BR or ON)-175033)
- Анализа генетичких маркера мишићне дистоније (RS-MESTD-Basic Research (BR or ON)-175091)
DOI: 10.1097/WNN.0000000000000015
ISSN: 1543-3633
PubMed: 24674965
WoS: 000334996500006
Scopus: 2-s2.0-84897523256
Институција/група
rFASPERTY - JOUR AU - Veselinović, Nikola AU - Pavlović, Aleksandra M. AU - Petrović, Boris AU - Ristić, Aleksandar AU - Novaković, Ivana AU - Svabic-Medjedović, Tamara AU - Pavlović, Dragan AU - Šternić, Nadežda PY - 2014 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/863 AB - Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis. PB - Lippincott Williams & Wilkins, Philadelphia T2 - Cognitive and Behavioral Neurology T1 - Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease EP - 50 IS - 1 SP - 48 VL - 27 DO - 10.1097/WNN.0000000000000015 ER -
@article{ author = "Veselinović, Nikola and Pavlović, Aleksandra M. and Petrović, Boris and Ristić, Aleksandar and Novaković, Ivana and Svabic-Medjedović, Tamara and Pavlović, Dragan and Šternić, Nadežda", year = "2014", abstract = "Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "Cognitive and Behavioral Neurology", title = "Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease", pages = "50-48", number = "1", volume = "27", doi = "10.1097/WNN.0000000000000015" }
Veselinović, N., Pavlović, A. M., Petrović, B., Ristić, A., Novaković, I., Svabic-Medjedović, T., Pavlović, D.,& Šternić, N.. (2014). Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease. in Cognitive and Behavioral Neurology Lippincott Williams & Wilkins, Philadelphia., 27(1), 48-50. https://doi.org/10.1097/WNN.0000000000000015
Veselinović N, Pavlović AM, Petrović B, Ristić A, Novaković I, Svabic-Medjedović T, Pavlović D, Šternić N. Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease. in Cognitive and Behavioral Neurology. 2014;27(1):48-50. doi:10.1097/WNN.0000000000000015 .
Veselinović, Nikola, Pavlović, Aleksandra M., Petrović, Boris, Ristić, Aleksandar, Novaković, Ivana, Svabic-Medjedović, Tamara, Pavlović, Dragan, Šternić, Nadežda, "Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease" in Cognitive and Behavioral Neurology, 27, no. 1 (2014):48-50, https://doi.org/10.1097/WNN.0000000000000015 . .