Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma
Samo za registrovane korisnike
2022
Autori
Šobot, VesnaStamenković, Miroslav
Simić, Tatjana
Jerotić, Đurđa
Đokic, Milica
Jakšić, Vesna
Božić, Marija
Milić, Jovan
Savić-Radojević, Ana
Đukić, Tatjana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
It is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression
of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms
in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase
(SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single
nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as
GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102
POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both
GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and
SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni
multiple test correction (OR = 6.66, p = 0.0...05). The present study supports the hypothesis that in combination,
GSTO1/GSTO2, modulate the risk of primary open angle glaucoma.
Ključne reči:
Primary open angle glaucoma / Glutathione transferases omega 1 / Glutathione transferases omega 2 / Glutathione transferases pi 1 / Glutathione peroxidase 1 / Superoxide dismutase 2Izvor:
Experimental Eye Research, 2022, 2014, 108863-Izdavač:
- Elsevier
- Academic Press
- International Society for Eye Research
DOI: 10.1016/j.exer.2021.108863
ISSN: 0014-4835
WoS: 000723713800002
Scopus: 2-s2.0-85119902102
Institucija/grupa
rFASPERTY - JOUR AU - Šobot, Vesna AU - Stamenković, Miroslav AU - Simić, Tatjana AU - Jerotić, Đurđa AU - Đokic, Milica AU - Jakšić, Vesna AU - Božić, Marija AU - Milić, Jovan AU - Savić-Radojević, Ana AU - Đukić, Tatjana PY - 2022 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/3947 AB - It is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase (SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102 POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni multiple test correction (OR = 6.66, p = 0.005). The present study supports the hypothesis that in combination, GSTO1/GSTO2, modulate the risk of primary open angle glaucoma. PB - Elsevier PB - Academic Press PB - International Society for Eye Research T2 - Experimental Eye Research T1 - Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma SP - 108863 VL - 2014 DO - 10.1016/j.exer.2021.108863 ER -
@article{ author = "Šobot, Vesna and Stamenković, Miroslav and Simić, Tatjana and Jerotić, Đurđa and Đokic, Milica and Jakšić, Vesna and Božić, Marija and Milić, Jovan and Savić-Radojević, Ana and Đukić, Tatjana", year = "2022", abstract = "It is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase (SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102 POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni multiple test correction (OR = 6.66, p = 0.005). The present study supports the hypothesis that in combination, GSTO1/GSTO2, modulate the risk of primary open angle glaucoma.", publisher = "Elsevier, Academic Press, International Society for Eye Research", journal = "Experimental Eye Research", title = "Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma", pages = "108863", volume = "2014", doi = "10.1016/j.exer.2021.108863" }
Šobot, V., Stamenković, M., Simić, T., Jerotić, Đ., Đokic, M., Jakšić, V., Božić, M., Milić, J., Savić-Radojević, A.,& Đukić, T.. (2022). Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. in Experimental Eye Research Elsevier., 2014, 108863. https://doi.org/10.1016/j.exer.2021.108863
Šobot V, Stamenković M, Simić T, Jerotić Đ, Đokic M, Jakšić V, Božić M, Milić J, Savić-Radojević A, Đukić T. Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. in Experimental Eye Research. 2022;2014:108863. doi:10.1016/j.exer.2021.108863 .
Šobot, Vesna, Stamenković, Miroslav, Simić, Tatjana, Jerotić, Đurđa, Đokic, Milica, Jakšić, Vesna, Božić, Marija, Milić, Jovan, Savić-Radojević, Ana, Đukić, Tatjana, "Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma" in Experimental Eye Research, 2014 (2022):108863, https://doi.org/10.1016/j.exer.2021.108863 . .