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B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice
dc.creator | Samanta, DN | |
dc.creator | Palmetshofer, A | |
dc.creator | Marinković, Dragan | |
dc.creator | Wirth, Thomas | |
dc.creator | Serfling, E | |
dc.creator | Nitschke, L. | |
dc.date.accessioned | 2021-06-09T13:12:23Z | |
dc.date.available | 2021-06-09T13:12:23Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0022-1767 | |
dc.identifier.uri | http://rfasper.fasper.bg.ac.rs/handle/123456789/37 | |
dc.description.abstract | Marginal zone (MZ) B cells and peritoneal B-I cells provide a first defense system of thymus-independent Ab responses against foreign pathogens and therefore share a number of functional properties. Recently, development of B-1a cells was shown to be controlled by the transcription factor NFATc1. We show here that mice deficient for NFATc2 and c3 display a distinct lower representation of MZ B cells, which is correlated with a reduced capturing of trinitrophenyl-Ficoll. In contrast, mature follicular B cells from NFATc2/c3(-/-) mice are strongly increased in number. NFATc2/c3-/- B cells exhibit a marked increase in BCR-induced intracellular Ca(2+) mobilization and proliferation. However, trinitrophenyl-Ficoll-specific IgM and IgG3 responses of NFATc2/c3-deficient mice are intact, and chimeric mice reconstituted with NFATc2/3-deficient B cells show a normal number of MZ B cells and normal BCR responses. These observations suggest that the strongly elevated Th2 cytokine milieu in NFATc2/c3-deficient mice leads to a hyperactivation of mature, follicular B cells, whereas MZ B cells are less responsive to these signals. | en |
dc.publisher | Amer Assoc Immunologists, Bethesda | |
dc.rights | openAccess | |
dc.source | Journal of Immunology | |
dc.title | B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 4802 | |
dc.citation.issue | 8 | |
dc.citation.other | 174(8): 4797-4802 | |
dc.citation.rank | M21 | |
dc.citation.spage | 4797 | |
dc.citation.volume | 174 | |
dc.identifier.doi | 10.4049/jimmunol.174.8.4797 | |
dc.identifier.fulltext | http://rfasper.fasper.bg.ac.rs/bitstream/id/401/34.pdf | |
dc.identifier.pmid | 15814705 | |
dc.identifier.scopus | 2-s2.0-17044439536 | |
dc.identifier.wos | 000228234600045 | |
dc.type.version | publishedVersion |