dc.creator | Brunner, C | |
dc.creator | Marinković, Dragan | |
dc.creator | Klein, J | |
dc.creator | Samardžić, T. | |
dc.creator | Nitschke, L. | |
dc.creator | Wirth, Thomas | |
dc.date.accessioned | 2021-06-09T13:12:00Z | |
dc.date.available | 2021-06-09T13:12:00Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0022-1007 | |
dc.identifier.uri | http://rfasper.fasper.bg.ac.rs/handle/123456789/31 | |
dc.description.abstract | Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymphocytes are markedly reduced. Increased levels of B cell apoptosis in these mice prompted us to analyze expression and function of antiapoptotic proteins. Bcl2 expression is strongly reduced in BOB.1/OBF.1-deficient pre-B cells. When BOB.1/OBF.1-deficient mice were crossed with Bcl2-transgenic mice, B cell development in the bone marrow and numbers of B cells in peripheral lymphoid organs were normalized. However, neither germinal center B cells nor MZ B cells were rescued. Additionally, Bcl2 did not rescue the defects in signaling and affinity maturation found in BOB.1/OBF.1-deficient mice. Interestingly, Bcl2-transgenic mice by themselves show an MZ B cell defect. Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment. | en |
dc.publisher | Rockefeller Univ Press, New York | |
dc.rights | openAccess | |
dc.source | Journal of Experimental Medicine | |
dc.subject | B cell differentiation | en |
dc.subject | germinal center reaction | en |
dc.subject | affinity maturation | en |
dc.subject | marginal zone | en |
dc.subject | transcription factor | en |
dc.title | B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 1211 | |
dc.citation.issue | 9 | |
dc.citation.other | 197(9): 1205-1211 | |
dc.citation.rank | aM21 | |
dc.citation.spage | 1205 | |
dc.citation.volume | 197 | |
dc.identifier.doi | 10.1084/jem.20022014 | |
dc.identifier.fulltext | http://rfasper.fasper.bg.ac.rs/bitstream/id/376/28.pdf | |
dc.identifier.pmid | 12732662 | |
dc.identifier.scopus | 2-s2.0-0038219633 | |
dc.identifier.wos | 000182752000015 | |
dc.type.version | publishedVersion | |