Putative role of marginal zone B cells in pathophysiological processes
Samo za registrovane korisnike
2020
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The maintenance of inner integrity of an organism is founded on the proper performance of two immunity branches, innate and adaptive immune responses. Recently, it became apparent that subset of splenic B cells named marginal zone B cells (MZB cells) exhibits unique developmental and functional features that bridge these two immunity branches. Strategically positioned at the site where blood and lymph are filtered, MZB cells represent a population of sentinels that rapidly proliferate and differentiate into IgM plasmablast cells when encountered with blood-borne, thymus-independent (TI) Ags. Moreover, MZB cells have intrinsic capability to induce potent CD4(+)helper T cell response and cytokine production upon stimulation with soluble antigens. Due to their ability to overcome a time gap prior the establishment of the full adaptive response towards pathogens, MZB cells connect and direct innate and adaptive immunity. An additional interesting characteristic of MZB cells is capacity to ...function as regulatory cells in autoimmune processes. MZB cells may also contribute to the control of autoimmunity via the induction of tolerance by apoptotic cells. Importantly, in the clear association with inflammation and autoimmunity, MZB cells may transform into MALT lymphoma, representing a concurrence point for the infection, immunity and malignancy. This paper presents an insight into the complex biology of marginal zone B cells and their role in intertwining and directing innate and adaptive immune processes at the physiological and pathological level.
Ključne reči:
autoimmunity / infection / lymphoma / marginal zone B cellsIzvor:
Scandinavian Journal of Immunology, 2020, 92, 3Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Ispitivanje molekularno-genetskih, patohistoloških i biohemijskih karakteristika neuromišićnih bolesti (RS-175083)
DOI: 10.1111/sji.12920
ISSN: 0300-9475
PubMed: 32594535
WoS: 000548156800001
Scopus: 2-s2.0-85087770888
Institucija/grupa
rFASPERTY - JOUR AU - Marinković, Dragan AU - Marinković, Tatjana PY - 2020 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/1277 AB - The maintenance of inner integrity of an organism is founded on the proper performance of two immunity branches, innate and adaptive immune responses. Recently, it became apparent that subset of splenic B cells named marginal zone B cells (MZB cells) exhibits unique developmental and functional features that bridge these two immunity branches. Strategically positioned at the site where blood and lymph are filtered, MZB cells represent a population of sentinels that rapidly proliferate and differentiate into IgM plasmablast cells when encountered with blood-borne, thymus-independent (TI) Ags. Moreover, MZB cells have intrinsic capability to induce potent CD4(+)helper T cell response and cytokine production upon stimulation with soluble antigens. Due to their ability to overcome a time gap prior the establishment of the full adaptive response towards pathogens, MZB cells connect and direct innate and adaptive immunity. An additional interesting characteristic of MZB cells is capacity to function as regulatory cells in autoimmune processes. MZB cells may also contribute to the control of autoimmunity via the induction of tolerance by apoptotic cells. Importantly, in the clear association with inflammation and autoimmunity, MZB cells may transform into MALT lymphoma, representing a concurrence point for the infection, immunity and malignancy. This paper presents an insight into the complex biology of marginal zone B cells and their role in intertwining and directing innate and adaptive immune processes at the physiological and pathological level. PB - Wiley, Hoboken T2 - Scandinavian Journal of Immunology T1 - Putative role of marginal zone B cells in pathophysiological processes IS - 3 VL - 92 DO - 10.1111/sji.12920 ER -
@article{ author = "Marinković, Dragan and Marinković, Tatjana", year = "2020", abstract = "The maintenance of inner integrity of an organism is founded on the proper performance of two immunity branches, innate and adaptive immune responses. Recently, it became apparent that subset of splenic B cells named marginal zone B cells (MZB cells) exhibits unique developmental and functional features that bridge these two immunity branches. Strategically positioned at the site where blood and lymph are filtered, MZB cells represent a population of sentinels that rapidly proliferate and differentiate into IgM plasmablast cells when encountered with blood-borne, thymus-independent (TI) Ags. Moreover, MZB cells have intrinsic capability to induce potent CD4(+)helper T cell response and cytokine production upon stimulation with soluble antigens. Due to their ability to overcome a time gap prior the establishment of the full adaptive response towards pathogens, MZB cells connect and direct innate and adaptive immunity. An additional interesting characteristic of MZB cells is capacity to function as regulatory cells in autoimmune processes. MZB cells may also contribute to the control of autoimmunity via the induction of tolerance by apoptotic cells. Importantly, in the clear association with inflammation and autoimmunity, MZB cells may transform into MALT lymphoma, representing a concurrence point for the infection, immunity and malignancy. This paper presents an insight into the complex biology of marginal zone B cells and their role in intertwining and directing innate and adaptive immune processes at the physiological and pathological level.", publisher = "Wiley, Hoboken", journal = "Scandinavian Journal of Immunology", title = "Putative role of marginal zone B cells in pathophysiological processes", number = "3", volume = "92", doi = "10.1111/sji.12920" }
Marinković, D.,& Marinković, T.. (2020). Putative role of marginal zone B cells in pathophysiological processes. in Scandinavian Journal of Immunology Wiley, Hoboken., 92(3). https://doi.org/10.1111/sji.12920
Marinković D, Marinković T. Putative role of marginal zone B cells in pathophysiological processes. in Scandinavian Journal of Immunology. 2020;92(3). doi:10.1111/sji.12920 .
Marinković, Dragan, Marinković, Tatjana, "Putative role of marginal zone B cells in pathophysiological processes" in Scandinavian Journal of Immunology, 92, no. 3 (2020), https://doi.org/10.1111/sji.12920 . .