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GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers
dc.creator | Stamenković, Miroslav | |
dc.creator | Lukić, Vesna | |
dc.creator | Šuvakov, Sonja | |
dc.creator | Simić, Tatjana | |
dc.creator | Senćanić, Ivan | |
dc.creator | Plješa-Ercegovac, Marija | |
dc.creator | Jakšić, Vesna | |
dc.creator | Babović, Siniša | |
dc.creator | Matić, Marija | |
dc.creator | Radosavljević, Aleksandra | |
dc.creator | Savić-Radojević, Ana | |
dc.creator | Đukić, Tatjana | |
dc.date.accessioned | 2021-06-09T14:24:53Z | |
dc.date.available | 2021-06-09T14:24:53Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2222-3959 | |
dc.identifier.uri | http://rfasper.fasper.bg.ac.rs/handle/123456789/1157 | |
dc.description.abstract | AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development. | en |
dc.publisher | IJO Press, Xi An | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175052/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45009/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | International Journal of Ophthalmology | |
dc.subject | GSTM1 | en |
dc.subject | GSTT1 | en |
dc.subject | primary open angle glaucoma risk | en |
dc.subject | smoking | en |
dc.subject | hypertension | en |
dc.subject | diabetes mellitus | en |
dc.title | GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 1520 | |
dc.citation.issue | 9 | |
dc.citation.other | 11(9): 1514-1520 | |
dc.citation.rank | M23 | |
dc.citation.spage | 1514 | |
dc.citation.volume | 11 | |
dc.identifier.doi | 10.18240/ijo.2018.09.14 | |
dc.identifier.fulltext | http://rfasper.fasper.bg.ac.rs/bitstream/id/134/1154.pdf | |
dc.identifier.pmid | 30225227 | |
dc.identifier.scopus | 2-s2.0-85053377610 | |
dc.identifier.wos | 000444411700014 | |
dc.type.version | publishedVersion |