The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke
Апстракт
We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p lt 0.05), B12 level (r = -0.410, p lt 0.01), and vitamin D levels (r = -0.465, p lt 0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 mo...nths. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.
Извор:
Biomed Research International, 2017, 2017Издавач:
- Hindawi Ltd, London
Финансирање / пројекти:
- Неуроендокрина контрола секреције хормона раста код човека - нови изазови. Контрола енергетске хомеостазе код човека у различитим патолошким стањима. Клиничко-патолошка корелација и генетска основа тумора хипофизе и неуроендокриних тумора (RS-175033)
- Депресија изазвана васкуларним болестима мозга: примена неуровизуализационих метода у превенцији, раном откривању и лечењу (RS-175022)
DOI: 10.1155/2017/5489057
ISSN: 2314-6133
PubMed: 28424785
WoS: 000399106700001
Scopus: 2-s2.0-85017113058
Институција/група
rFASPERTY - JOUR AU - Markišić, Merdin Š. AU - Pavlović, Aleksandra M. AU - Pavlović, Dragan PY - 2017 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/1070 AB - We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p lt 0.05), B12 level (r = -0.410, p lt 0.01), and vitamin D levels (r = -0.465, p lt 0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up. PB - Hindawi Ltd, London T2 - Biomed Research International T1 - The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke VL - 2017 DO - 10.1155/2017/5489057 ER -
@article{ author = "Markišić, Merdin Š. and Pavlović, Aleksandra M. and Pavlović, Dragan", year = "2017", abstract = "We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p lt 0.05), B12 level (r = -0.410, p lt 0.01), and vitamin D levels (r = -0.465, p lt 0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.", publisher = "Hindawi Ltd, London", journal = "Biomed Research International", title = "The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke", volume = "2017", doi = "10.1155/2017/5489057" }
Markišić, M. Š., Pavlović, A. M.,& Pavlović, D.. (2017). The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. in Biomed Research International Hindawi Ltd, London., 2017. https://doi.org/10.1155/2017/5489057
Markišić MŠ, Pavlović AM, Pavlović D. The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. in Biomed Research International. 2017;2017. doi:10.1155/2017/5489057 .
Markišić, Merdin Š., Pavlović, Aleksandra M., Pavlović, Dragan, "The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke" in Biomed Research International, 2017 (2017), https://doi.org/10.1155/2017/5489057 . .