The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke
Abstract
We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p lt 0.05), B12 level (r = -0.410, p lt 0.01), and vitamin D levels (r = -0.465, p lt 0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 mo...nths. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.
Source:
Biomed Research International, 2017, 2017Publisher:
- Hindawi Ltd, London
Funding / projects:
- Neuroendocrine control of growth hormone secretion in humans - new challenges. Control of energy homeostasis in humans in various pathological conditions. Genetics in familial pituitary tumorigenesis. Clinical-pathological correlations in atypical pituit (RS-175033)
- Depression caused by vascular brain diseases: the role of neuroimaging methods in prevention, early detection ant treatment (RS-175022)
DOI: 10.1155/2017/5489057
ISSN: 2314-6133
PubMed: 28424785
WoS: 000399106700001
Scopus: 2-s2.0-85017113058
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Institution/Community
rFASPERTY - JOUR AU - Markišić, Merdin Š. AU - Pavlović, Aleksandra M. AU - Pavlović, Dragan PY - 2017 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/1070 AB - We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p lt 0.05), B12 level (r = -0.410, p lt 0.01), and vitamin D levels (r = -0.465, p lt 0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up. PB - Hindawi Ltd, London T2 - Biomed Research International T1 - The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke VL - 2017 DO - 10.1155/2017/5489057 ER -
@article{ author = "Markišić, Merdin Š. and Pavlović, Aleksandra M. and Pavlović, Dragan", year = "2017", abstract = "We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p lt 0.05), B12 level (r = -0.410, p lt 0.01), and vitamin D levels (r = -0.465, p lt 0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.", publisher = "Hindawi Ltd, London", journal = "Biomed Research International", title = "The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke", volume = "2017", doi = "10.1155/2017/5489057" }
Markišić, M. Š., Pavlović, A. M.,& Pavlović, D.. (2017). The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. in Biomed Research International Hindawi Ltd, London., 2017. https://doi.org/10.1155/2017/5489057
Markišić MŠ, Pavlović AM, Pavlović D. The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. in Biomed Research International. 2017;2017. doi:10.1155/2017/5489057 .
Markišić, Merdin Š., Pavlović, Aleksandra M., Pavlović, Dragan, "The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke" in Biomed Research International, 2017 (2017), https://doi.org/10.1155/2017/5489057 . .