TY  - JOUR
AU  - Zidverc-Trajkovic, Jasna J
AU  - Pekmezovic, Tatjana
AU  - Jovanovic, Zagorka
AU  - Pavlović, Aleksandra
AU  - Mijajlovic, Milija
AU  - Radojicic, Aleksandra
AU  - Sternic, Nadezda
PY  - 2018
UR  - https://doi.org/10.1177/0333102416683918
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5030
AB  - ObjectiveTo evaluate long-term predictors of remission in patients with medication-overuse headache (MOH) by prospective cohort study.BackgroundKnowledge regarding long-term predictors of MOH outcome is limited.MethodsTwo hundred and forty MOH patients recruited from 2000 to 2005 were included in a one-year follow-up study and then subsequently followed until 31 December 2013. The median follow-up was three years (interquartile range, three years). Predictive values of selected variables were assessed by the Cox proportional hazard regression model.ResultsAt the end of follow-up, 102 (42.5%) patients were in remission. The most important predictors of remission were lower number of headache days per month before the one-year follow-up (HR-hazard ratio?=?0.936, 95% confidence interval (CI) 0.884?0.990, p?=?0.021) and efficient initial drug withdrawal (HR?=?0.136, 95% CI 0.042?0.444, p?=?0.001). Refractory MOH was observed in seven (2.9%) and MOH relapse in 131 patients (54.6%).ConclusionsOutcome at the one-year follow-up is a reliable predictor of MOH long-term remission.
PB  - Sage
T2  - Cephalalgia
T1  - Long-term predictors of remission in patients treated for medication-overuse headache at a specialized headache center: A prospective cohort study
EP  - 273
IS  - 2
SP  - 265
VL  - 38
DO  - 10.1177/0333102416683918
ER  - 

@article{
author = "Zidverc-Trajkovic, Jasna J and Pekmezovic, Tatjana and Jovanovic, Zagorka and Pavlović, Aleksandra and Mijajlovic, Milija and Radojicic, Aleksandra and Sternic, Nadezda",
year = "2018",
abstract = "ObjectiveTo evaluate long-term predictors of remission in patients with medication-overuse headache (MOH) by prospective cohort study.BackgroundKnowledge regarding long-term predictors of MOH outcome is limited.MethodsTwo hundred and forty MOH patients recruited from 2000 to 2005 were included in a one-year follow-up study and then subsequently followed until 31 December 2013. The median follow-up was three years (interquartile range, three years). Predictive values of selected variables were assessed by the Cox proportional hazard regression model.ResultsAt the end of follow-up, 102 (42.5%) patients were in remission. The most important predictors of remission were lower number of headache days per month before the one-year follow-up (HR-hazard ratio?=?0.936, 95% confidence interval (CI) 0.884?0.990, p?=?0.021) and efficient initial drug withdrawal (HR?=?0.136, 95% CI 0.042?0.444, p?=?0.001). Refractory MOH was observed in seven (2.9%) and MOH relapse in 131 patients (54.6%).ConclusionsOutcome at the one-year follow-up is a reliable predictor of MOH long-term remission.",
publisher = "Sage",
journal = "Cephalalgia",
title = "Long-term predictors of remission in patients treated for medication-overuse headache at a specialized headache center: A prospective cohort study",
pages = "273-265",
number = "2",
volume = "38",
doi = "10.1177/0333102416683918"
}

Zidverc-Trajkovic, J. J., Pekmezovic, T., Jovanovic, Z., Pavlović, A., Mijajlovic, M., Radojicic, A.,& Sternic, N.. (2018). Long-term predictors of remission in patients treated for medication-overuse headache at a specialized headache center: A prospective cohort study. in Cephalalgia
Sage., 38(2), 265-273.
https://doi.org/10.1177/0333102416683918

Zidverc-Trajkovic JJ, Pekmezovic T, Jovanovic Z, Pavlović A, Mijajlovic M, Radojicic A, Sternic N. Long-term predictors of remission in patients treated for medication-overuse headache at a specialized headache center: A prospective cohort study. in Cephalalgia. 2018;38(2):265-273.
doi:10.1177/0333102416683918 .

Zidverc-Trajkovic, Jasna J, Pekmezovic, Tatjana, Jovanovic, Zagorka, Pavlović, Aleksandra, Mijajlovic, Milija, Radojicic, Aleksandra, Sternic, Nadezda, "Long-term predictors of remission in patients treated for medication-overuse headache at a specialized headache center: A prospective cohort study" in Cephalalgia, 38, no. 2 (2018):265-273,
https://doi.org/10.1177/0333102416683918 . .

TY  - JOUR
AU  - Pavlovic, Aleksandra M.
AU  - Pekmezovic, Tatjana
AU  - Trajkovic, Jasna Zidverc
AU  - Tomic, Gordana
AU  - Cvitan, Edita
AU  - Sternic, Nada
PY  - 2018
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1111/jch.13357
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5029
AB  - Although cerebral small vessel disease (SVD) is traditionally associated with aging and hypertension (HT), there are patients exhibiting sporadic SVD, free of HT. We aimed to investigate the differences in clinical and neuroradiological presentation in SVD patients in reference to the presence of HT as a risk factor (RF). Vascular RF, cognitive and functional status were evaluated in a cohort of 424 patients. Patients were classified in two groups based on the presence of HT. Severity of vascular lesions was assessed using 1.5 T magnetic resonance imaging with Age-Related White Matter Changes scale total score (tARWMC) and Fazekas scale periventricular (PV) and deep subcortical (DS) scores. No difference between groups in age and sex distribution was noted. In univariate analysis, HT was associated with vascular cognitive impairment (vCI) (OR 2.30, 1.53-3.45, P < 0.0001), functional status (OR 1.47, 1.11-1.95, P = 0.007), depression (OR 2.13, 1.23-3.70, P = 0.007), tARWMC (OR 1.10, 1.05-1.16 95% CI, P < 0.0001), Fazekas PV score (OR 1.34, 1.08-1.67 95% CI, P = 0.008), Fazekas DS score (OR 1.95, 1.44-2.63 95% CI, P < 0.0001) and total number of lacunes (OR 1.10, 1.02-1.18 95% CI, P = 0.009). Multivariate logistic regression analysis indicated that HT was an independent RF for vCI (OR 1.74, 1.09-2.76 95% CI, P = 0.020) and higher Fazekas DS score (OR 1.57, 1.11-2.22 95% CI, P = 0.011). The Kaplan-Meier curve of estimates of survival of SVD patients without vCI revealed a higher proportion of patients with HT progressing to vCI over time when compared to HT-free cases. In patients with sporadic SVD, HT is a contributing factor to worse clinical outcomes and neuroradiological presentation.
PB  - Wiley
T2  - The Journal of Clinical Hypertension
T1  - Increased risk of cognitive impairment and more severe brain lesions in hypertensive compared to non-hypertensive patients with cerebral small vessel disease
EP  - 1265
IS  - 9
SP  - 1260
VL  - 20
DO  - 10.1111/jch.13357
ER  - 

@article{
author = "Pavlovic, Aleksandra M. and Pekmezovic, Tatjana and Trajkovic, Jasna Zidverc and Tomic, Gordana and Cvitan, Edita and Sternic, Nada",
year = "2018",
abstract = "Although cerebral small vessel disease (SVD) is traditionally associated with aging and hypertension (HT), there are patients exhibiting sporadic SVD, free of HT. We aimed to investigate the differences in clinical and neuroradiological presentation in SVD patients in reference to the presence of HT as a risk factor (RF). Vascular RF, cognitive and functional status were evaluated in a cohort of 424 patients. Patients were classified in two groups based on the presence of HT. Severity of vascular lesions was assessed using 1.5 T magnetic resonance imaging with Age-Related White Matter Changes scale total score (tARWMC) and Fazekas scale periventricular (PV) and deep subcortical (DS) scores. No difference between groups in age and sex distribution was noted. In univariate analysis, HT was associated with vascular cognitive impairment (vCI) (OR 2.30, 1.53-3.45, P < 0.0001), functional status (OR 1.47, 1.11-1.95, P = 0.007), depression (OR 2.13, 1.23-3.70, P = 0.007), tARWMC (OR 1.10, 1.05-1.16 95% CI, P < 0.0001), Fazekas PV score (OR 1.34, 1.08-1.67 95% CI, P = 0.008), Fazekas DS score (OR 1.95, 1.44-2.63 95% CI, P < 0.0001) and total number of lacunes (OR 1.10, 1.02-1.18 95% CI, P = 0.009). Multivariate logistic regression analysis indicated that HT was an independent RF for vCI (OR 1.74, 1.09-2.76 95% CI, P = 0.020) and higher Fazekas DS score (OR 1.57, 1.11-2.22 95% CI, P = 0.011). The Kaplan-Meier curve of estimates of survival of SVD patients without vCI revealed a higher proportion of patients with HT progressing to vCI over time when compared to HT-free cases. In patients with sporadic SVD, HT is a contributing factor to worse clinical outcomes and neuroradiological presentation.",
publisher = "Wiley",
journal = "The Journal of Clinical Hypertension",
title = "Increased risk of cognitive impairment and more severe brain lesions in hypertensive compared to non-hypertensive patients with cerebral small vessel disease",
pages = "1265-1260",
number = "9",
volume = "20",
doi = "10.1111/jch.13357"
}

Pavlovic, A. M., Pekmezovic, T., Trajkovic, J. Z., Tomic, G., Cvitan, E.,& Sternic, N.. (2018). Increased risk of cognitive impairment and more severe brain lesions in hypertensive compared to non-hypertensive patients with cerebral small vessel disease. in The Journal of Clinical Hypertension
Wiley., 20(9), 1260-1265.
https://doi.org/10.1111/jch.13357

Pavlovic AM, Pekmezovic T, Trajkovic JZ, Tomic G, Cvitan E, Sternic N. Increased risk of cognitive impairment and more severe brain lesions in hypertensive compared to non-hypertensive patients with cerebral small vessel disease. in The Journal of Clinical Hypertension. 2018;20(9):1260-1265.
doi:10.1111/jch.13357 .

Pavlovic, Aleksandra M., Pekmezovic, Tatjana, Trajkovic, Jasna Zidverc, Tomic, Gordana, Cvitan, Edita, Sternic, Nada, "Increased risk of cognitive impairment and more severe brain lesions in hypertensive compared to non-hypertensive patients with cerebral small vessel disease" in The Journal of Clinical Hypertension, 20, no. 9 (2018):1260-1265,
https://doi.org/10.1111/jch.13357 . .

TY  - JOUR
AU  - Jovanovic, Zagorka B.
AU  - Pavlović, Aleksandra M.
AU  - Vujisic Tesic, Bosiljka P.
AU  - Pekmezovic, Tatjana P.
AU  - Kostic Boricic, Marija V.
AU  - Cvitan, Edita Z.
AU  - Covickovic Sternic, Nadezda M.
PY  - 2018
PY  - 2017
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/jum.14355
UR  - C:\Users\FASPER\Zotero\storage\E5J8QD4U\Jovanovic et al. - 2018 - Comprehensive Ultrasound Assessment of the Cranioc.pdf
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5028
AB  - Objectives Structural changes and metabolic stress have been reported on diffusion-weighted magnetic resonance imaging in the cornu ammonis 1 area of the hippocampus in patients with transient global amnesia (TGA), but a consensus on pathogenesis is still lacking. The aim of our study was to perform a comprehensive ultrasound analysis of the cerebrovascular circulation in our population of patients with TGA. Methods One hundred patients with TGA and 50 age- and sex-matched control participants underwent ultrasound examinations of the cervicocranial circulation. Results The most significant risk factor for TGA was arterial hypertension (P < .01). There were no significant atherosclerotic lesions on the large arteries of the neck (mean internal carotid artery stenosis ± SD, 28.7% ± 11.7%) or on the large intracerebral arteries (good structural and hemodynamic status; P > .05). Rarely detected microembolic signals or a right-left cardiopulmonary shunt excluded an emboligenic mechanism of TGA (P > .05). The internal jugular vein valves were incompetent in 54% of patients with TGA, and this condition was associated with an increased risk of TGA (odds ratio, 4.16; 95% confidence interval, 1.91–9.04). The mean values of the breath holding index and pulsatility index, as parameters of small-vessel function, were within normal ranges and without differences between the TGA and control groups (P > .05). Conclusions Our ultrasound examination did not detect significant structural atherosclerotic changes of cervicocranial arteries, and an emboligenic mechanism was excluded. Only a significant rise of blood pressure in TGA and significant valvular insufficiency of the internal jugular vein were established. New research should clarify whether these simultaneous functional circulatory changes have relevance for metabolic stress in the cornu ammonis of the hippocampus.
PB  - Wiley
T2  - Journal of Ultrasound in Medicine
T1  - Comprehensive Ultrasound Assessment of the Craniocervical Circulation in Transient Global Amnesia
EP  - 486
IS  - 2
SP  - 479
VL  - 37
DO  - 10.1002/jum.14355
ER  - 

@article{
author = "Jovanovic, Zagorka B. and Pavlović, Aleksandra M. and Vujisic Tesic, Bosiljka P. and Pekmezovic, Tatjana P. and Kostic Boricic, Marija V. and Cvitan, Edita Z. and Covickovic Sternic, Nadezda M.",
year = "2018, 2017",
abstract = "Objectives Structural changes and metabolic stress have been reported on diffusion-weighted magnetic resonance imaging in the cornu ammonis 1 area of the hippocampus in patients with transient global amnesia (TGA), but a consensus on pathogenesis is still lacking. The aim of our study was to perform a comprehensive ultrasound analysis of the cerebrovascular circulation in our population of patients with TGA. Methods One hundred patients with TGA and 50 age- and sex-matched control participants underwent ultrasound examinations of the cervicocranial circulation. Results The most significant risk factor for TGA was arterial hypertension (P < .01). There were no significant atherosclerotic lesions on the large arteries of the neck (mean internal carotid artery stenosis ± SD, 28.7% ± 11.7%) or on the large intracerebral arteries (good structural and hemodynamic status; P > .05). Rarely detected microembolic signals or a right-left cardiopulmonary shunt excluded an emboligenic mechanism of TGA (P > .05). The internal jugular vein valves were incompetent in 54% of patients with TGA, and this condition was associated with an increased risk of TGA (odds ratio, 4.16; 95% confidence interval, 1.91–9.04). The mean values of the breath holding index and pulsatility index, as parameters of small-vessel function, were within normal ranges and without differences between the TGA and control groups (P > .05). Conclusions Our ultrasound examination did not detect significant structural atherosclerotic changes of cervicocranial arteries, and an emboligenic mechanism was excluded. Only a significant rise of blood pressure in TGA and significant valvular insufficiency of the internal jugular vein were established. New research should clarify whether these simultaneous functional circulatory changes have relevance for metabolic stress in the cornu ammonis of the hippocampus.",
publisher = "Wiley",
journal = "Journal of Ultrasound in Medicine",
title = "Comprehensive Ultrasound Assessment of the Craniocervical Circulation in Transient Global Amnesia",
pages = "486-479",
number = "2",
volume = "37",
doi = "10.1002/jum.14355"
}

Jovanovic, Z. B., Pavlović, A. M., Vujisic Tesic, B. P., Pekmezovic, T. P., Kostic Boricic, M. V., Cvitan, E. Z.,& Covickovic Sternic, N. M.. (2018). Comprehensive Ultrasound Assessment of the Craniocervical Circulation in Transient Global Amnesia. in Journal of Ultrasound in Medicine
Wiley., 37(2), 479-486.
https://doi.org/10.1002/jum.14355

Jovanovic ZB, Pavlović AM, Vujisic Tesic BP, Pekmezovic TP, Kostic Boricic MV, Cvitan EZ, Covickovic Sternic NM. Comprehensive Ultrasound Assessment of the Craniocervical Circulation in Transient Global Amnesia. in Journal of Ultrasound in Medicine. 2018;37(2):479-486.
doi:10.1002/jum.14355 .

Jovanovic, Zagorka B., Pavlović, Aleksandra M., Vujisic Tesic, Bosiljka P., Pekmezovic, Tatjana P., Kostic Boricic, Marija V., Cvitan, Edita Z., Covickovic Sternic, Nadezda M., "Comprehensive Ultrasound Assessment of the Craniocervical Circulation in Transient Global Amnesia" in Journal of Ultrasound in Medicine, 37, no. 2 (2018):479-486,
https://doi.org/10.1002/jum.14355 . .