Приказ основних података о документу

dc.creatorMilovanović, Olivera
dc.creatorMilovanović, Jasmina R.
dc.creatorĐukić, Aleksandar
dc.creatorMatović, Milovan
dc.creatorTomić-Lučić, Aleksandra
dc.creatorGlumbić, Nenad
dc.creatorRadovanović, Ana M.
dc.creatorJanković, Slobodan M.
dc.date.accessioned2021-06-09T14:09:18Z
dc.date.available2021-06-09T14:09:18Z
dc.date.issued2015
dc.identifier.issn0946-1965
dc.identifier.urihttp://rfasper.fasper.bg.ac.rs/handle/123456789/916
dc.description.abstractObjectives: The aim of our study was to develop a population pharmacokinetic (PPK) model for 25-hydroxyvitamin D clearance in a healthy young adult population in Serbia. Methods: Study sample consisted of 70 healthy young students of the Faculty of Medical Science, University of Kragujevac, Serbia, with a mean age and body mass index of 22.39 +/- 1.82 years and 21.31 +/- 2.69 kgm(-2), respectively. Non-linear mixed-effect modeling (NONMEM) software was used for data analysis. A validation set of 16 participants was used to estimate the predictive performance of the pharmacokinetic model. Results: In the base model (without covariates), we had parameter estimates of 0.01 L/h for apparent clearance, 0.25 L for apparent volume of distribution, while value of minimum objective function (MOF) was 383.468. The full regression model was established by estimating the effects of 12 covariates. Mean intake of vitamin D from foods (DD) and value of phosphate in serum (PHO) were covariates included in the final model, while others were excluded in this process. The estimated value in the final MOF model was 274.555. The final regression model formula was: clearance (CL) (L/h) = 0.0711 + 0.738 x DD + 0.618 x PHO. Conclusions: The PPK model obtained determined clearance of 25-hydroxyvitamin D in a healthy young adult population in Serbia. Mean intake of vitamin D from foods and serum phosphate level are the most important covariates that influence value of 25-hydroxyvitamin D clearance in healthy young adults.en
dc.publisherDustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175007/RS//
dc.relationMinistry of Science, Montenegro
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Clinical Pharmacology and Therapeutics
dc.subjectVitamin Den
dc.subject25-hydroxyvitamin Den
dc.subjectpopulation pharmacokineticsen
dc.subjectclearanceen
dc.titlePopulation pharmacokinetics of 25-hydroxyvitamin D in healthy young adultsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage8
dc.citation.issue1
dc.citation.other53(1): 1-8
dc.citation.rankM23
dc.citation.spage1
dc.citation.volume53
dc.identifier.doi10.5414/CP202185
dc.identifier.pmid25407256
dc.identifier.scopus2-s2.0-84964310789
dc.identifier.wos000350392200001
dc.type.versionpublishedVersion


Документи

ДатотекеВеличинаФорматПреглед

Уз овај запис нема датотека.

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу