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dc.creatorStojanović, D.
dc.creatorMilenković, S. M.
dc.creatorMitrović, N.
dc.creatorMarinković, Dragan
dc.creatorStevanović, D.
dc.creatorRadovanović, D.
dc.date.accessioned2021-06-09T13:54:14Z
dc.date.available2021-06-09T13:54:14Z
dc.date.issued2013
dc.identifier.issn1107-0625
dc.identifier.urihttp://rfasper.fasper.bg.ac.rs/handle/123456789/683
dc.description.abstractPurpose: The prediction of outcome for patients with gastric cancer is determined largely by the presence of lymph node metastases, which could be detected by sentinel lymph node (SLN) biopsy (SLNB). The purpose of this work was to determine the feasibility of SLNB in patients with gastric cancer for the assessment of regional lymph node status, including performing immunohistochemical (IHC) staining of SLN tissue. Methods: We reviewed 137 consecutive patients with operable gastric cancer over a 10-year period using a retrospective (to examine skip metastases) and prospective (to evaluate successful mapping) study design. SLNs were mapped, biopsied and subsequently explored by routine hematoxylin & eosin (H&E) staining and by IHC staining using a cytokeratin 8/18 antibody. Results: The retrospective study showed a low incidence of skip metastases (3.7%). Mapping of SLNs in the prospective study was highly successful (98.2%). During the prospective study, IHC examination of SLNs from 56 patients showed statistically significant change in disease stage. Conclusion: This study demonstrated highly successful mapping and biopsy of SLNs (98.2%), as well as highest specificity (100%), sensitivity (100%) and accuracy (100%) to predict metastasis in the surrounding lymph nodes of gastric carcinoma. In addition, we believe that IHC study might enable "ultra staging" and additional selection of patients for further cancer treatment.en
dc.publisherBalkan Union of Oncology (B.U.ON.)
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175083/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of BUON
dc.subjectbiopsyen
dc.subjectgastric canceren
dc.subjectimmunohistochemistryen
dc.subjectsentinel lymph nodesen
dc.titleThe feasibility of sentinel lymph node biopsy for gastric cancer: the experience from Serbiaen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage168
dc.citation.issue1
dc.citation.other18(1): 162-168
dc.citation.rankM23
dc.citation.spage162
dc.citation.volume18
dc.identifier.pmid23613402
dc.identifier.rcubconv_1263
dc.identifier.scopus2-s2.0-84879010496
dc.identifier.wos000322750600020
dc.type.versionpublishedVersion


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