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dc.creatorMoll, T.
dc.creatorMartinez-Soria, E.
dc.creatorSantiago-Raber, ML
dc.creatorAmano, H.
dc.creatorPihlgren-Bosch, M
dc.creatorMarinković, Dragan
dc.creatorIzui, S
dc.date.accessioned2021-06-09T13:12:19Z
dc.date.available2021-06-09T13:12:19Z
dc.date.issued2005
dc.identifier.issn0022-1767
dc.identifier.urihttp://rfasper.fasper.bg.ac.rs/handle/123456789/36
dc.description.abstractAn as-yet-unidentified mutation, Y-linked autoimmune acceleration (Yaa), is responsible for the accelerated development of lupus-like autoimmune syndrome in mice. In view of a possible role for Yaa as a positive regulator of BCR signaling, we have explored whether the expression of the Yaa mutation affects the development and activation of transgenic autoreactive B cells expressing either 4C8 IgM anti-RBC or Sp6 IgM anti-DNA. In this study, we show that the expression of the Yaa mutation induced a lethal form of autoimmune hemolytic anemia in 4C8 transgenic C57BL/6 mice, likely as a result of activation of 4C8 anti-RBC autoreactive B cells early in life. This was further supported, although indirectly, by increased T cell-independent IgM production in spleens of nontransgenic C57BL/6 mice bearing the Yaa mutation. In contrast, Yaa failed to induce activation of Sp6 anti-DNA autoreactive B cells, consistent with a lack of increased IgM anti-DNA production in nontransgenic C57BL/6 Yaa mice. Our results suggest that Yaa can activate autoreactive B cells in a BCR-dependent manner, related to differences in the form and nature of autoantigens.en
dc.publisherAmer Assoc Immunologists, Bethesda
dc.rightsopenAccess
dc.sourceJournal of Immunology
dc.titleDifferential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutationen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage709
dc.citation.issue2
dc.citation.other174(2): 702-709
dc.citation.rankM21
dc.citation.spage702
dc.citation.volume174
dc.identifier.doi10.4049/jimmunol.174.2.702
dc.identifier.fulltexthttp://rfasper.fasper.bg.ac.rs/bitstream/id/398/33.pdf
dc.identifier.pmid15634889
dc.identifier.scopus2-s2.0-11844281589
dc.identifier.wos000226360500017
dc.type.versionpublishedVersion


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