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The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells
dc.creator | Amano, H. | |
dc.creator | Amano, E. | |
dc.creator | Moll, T. | |
dc.creator | Marinković, Dragan | |
dc.creator | Ibnou-Zekri, N | |
dc.creator | Martinez-Soria, E. | |
dc.creator | Semac, I | |
dc.creator | Wirth, Thomas | |
dc.creator | Nitschke, L. | |
dc.creator | Izui, S | |
dc.date.accessioned | 2021-06-09T13:12:04Z | |
dc.date.available | 2021-06-09T13:12:04Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0022-1767 | |
dc.identifier.uri | http://rfasper.fasper.bg.ac.rs/handle/123456789/32 | |
dc.description.abstract | The accelerated development of systemic lupus erythematosus (SLE) in BXSB male mice is associated with the presence of an as yet unidentified mutant gene, Yaa (Y-linked autoimmune acceleration). In view of a possible role of marginal zone (MZ) B cells in murine SLE, we have explored whether the expression of the Yaa mutation affects the differentiation of MZ and follicular B cells, thereby implicating the acceleration of the disease. In this study, we show that both BXSB and C57BL/6 Yaa mice, including two different substrains of BXSB Yaa males that are protected from SLE, displayed an impaired development of MZ B cells early in life. Studies in bone marrow chimeras revealed that the loss of MZ B cells resulted from a defect intrinsic to B cells expressing the Yaa mutation. The lack of selective expansion of MZ B cells in diseased BXSB Yaa males strongly argues against a major role of MZ B cells in the generation of pathogenic autoantibodies in the BXSB model of SLE. Furthermore, a comparative analysis with mice deficient in CD22 or expressing an IgM anti-trinitrophenyl/DNA transgene suggests that the hyperreactive phenotype of Yaa B cells, as judged by a markedly increased spontaneous IgM secretion, is likely to contribute to the enhanced maturation toward follicular B cells and the block in the MZ B cell generation. | en |
dc.publisher | Amer Assoc Immunologists, Bethesda | |
dc.rights | openAccess | |
dc.source | Journal of Immunology | |
dc.title | The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 2301 | |
dc.citation.issue | 5 | |
dc.citation.other | 170(5): 2293-2301 | |
dc.citation.rank | aM21 | |
dc.citation.spage | 2293 | |
dc.citation.volume | 170 | |
dc.identifier.doi | 10.4049/jimmunol.170.5.2293 | |
dc.identifier.fulltext | http://rfasper.fasper.bg.ac.rs/bitstream/id/385/29.pdf | |
dc.identifier.pmid | 12594250 | |
dc.identifier.scopus | 2-s2.0-0037371122 | |
dc.identifier.wos | 000181146800007 | |
dc.type.version | publishedVersion |