Приказ основних података о документу

dc.creatorBrunner, C
dc.creatorMarinković, Dragan
dc.creatorKlein, J
dc.creatorSamardžić, T.
dc.creatorNitschke, L.
dc.creatorWirth, Thomas
dc.date.accessioned2021-06-09T13:12:00Z
dc.date.available2021-06-09T13:12:00Z
dc.date.issued2003
dc.identifier.issn0022-1007
dc.identifier.urihttp://rfasper.fasper.bg.ac.rs/handle/123456789/31
dc.description.abstractMice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymphocytes are markedly reduced. Increased levels of B cell apoptosis in these mice prompted us to analyze expression and function of antiapoptotic proteins. Bcl2 expression is strongly reduced in BOB.1/OBF.1-deficient pre-B cells. When BOB.1/OBF.1-deficient mice were crossed with Bcl2-transgenic mice, B cell development in the bone marrow and numbers of B cells in peripheral lymphoid organs were normalized. However, neither germinal center B cells nor MZ B cells were rescued. Additionally, Bcl2 did not rescue the defects in signaling and affinity maturation found in BOB.1/OBF.1-deficient mice. Interestingly, Bcl2-transgenic mice by themselves show an MZ B cell defect. Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment.en
dc.publisherRockefeller Univ Press, New York
dc.rightsopenAccess
dc.sourceJournal of Experimental Medicine
dc.subjectB cell differentiationen
dc.subjectgerminal center reactionen
dc.subjectaffinity maturationen
dc.subjectmarginal zoneen
dc.subjecttranscription factoren
dc.titleB cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient miceen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1211
dc.citation.issue9
dc.citation.other197(9): 1205-1211
dc.citation.rankaM21
dc.citation.spage1205
dc.citation.volume197
dc.identifier.doi10.1084/jem.20022014
dc.identifier.fulltexthttp://rfasper.fasper.bg.ac.rs/bitstream/id/376/28.pdf
dc.identifier.pmid12732662
dc.identifier.scopus2-s2.0-0038219633
dc.identifier.wos000182752000015
dc.type.versionpublishedVersion


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Приказ основних података о документу