Приказ основних података о документу
Reduction of marginal zone B cells in CD22-deficient mice
dc.creator | Samardžić, T. | |
dc.creator | Marinković, Dragan | |
dc.creator | Danzer, CP | |
dc.creator | Gerlach, J | |
dc.creator | Nitschke, L. | |
dc.creator | Wirth, Thomas | |
dc.date.accessioned | 2021-06-09T13:11:55Z | |
dc.date.available | 2021-06-09T13:11:55Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0014-2980 | |
dc.identifier.uri | http://rfasper.fasper.bg.ac.rs/handle/123456789/30 | |
dc.description.abstract | CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed a detailed analysis of the splenic B cell population and found that the subset of marginal zone (MZ) B cells was selectively reduced in CD22-deficient mice. CD22-deficient mice showed a lack of TNP-ficoll capturing cells in the MZ and a reduced response to TNP-ficoll, particularly when the antigen was applied intravenously. CD22-deficient B cells showed both enhanced motility as well as enhanced chemotaxis to certain chemokines. The altered chemokine responsiveness or the higher signaling capacity of CD22-deficient B cells may lead to the compromised MZ B cell compartment, as both processes have previously been shown to affect MZ composition. | en |
dc.publisher | Wiley-V C H Verlag Gmbh, Weinheim | |
dc.rights | openAccess | |
dc.source | European Journal of Immunology | |
dc.subject | marginal zone B cell | en |
dc.subject | CD22 | en |
dc.subject | chemokine | en |
dc.subject | B cell differentiation | en |
dc.title | Reduction of marginal zone B cells in CD22-deficient mice | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 567 | |
dc.citation.issue | 2 | |
dc.citation.other | 32(2): 561-567 | |
dc.citation.rank | M21 | |
dc.citation.spage | 561 | |
dc.citation.volume | 32 | |
dc.identifier.doi | 10.1002/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H | |
dc.identifier.fulltext | http://rfasper.fasper.bg.ac.rs/bitstream/id/367/27.pdf | |
dc.identifier.pmid | 11828373 | |
dc.identifier.scopus | 2-s2.0-0036180761 | |
dc.identifier.wos | 000173996100029 | |
dc.type.version | publishedVersion |