Reduction of marginal zone B cells in CD22-deficient mice
Abstract
CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed a detailed analysis of the splenic B cell population and found that the subset of marginal zone (MZ) B cells was selectively reduced in CD22-deficient mice. CD22-deficient mice showed a lack of TNP-ficoll capturing cells in the MZ and a reduced response to TNP-ficoll, particularly when the antigen was applied intravenously. CD22-deficient B cells showed both enhanced motility as well as enhanced chemotaxis to certain chemokines. The altered chemokine responsiveness or the higher signaling capacity of CD22-deficient B cells may lead to the compromised MZ B cell compartment, as both processes have previously been shown to affect MZ composition.
Keywords:
marginal zone B cell / CD22 / chemokine / B cell differentiationSource:
European Journal of Immunology, 2002, 32, 2, 561-567Publisher:
- Wiley-V C H Verlag Gmbh, Weinheim
DOI: 10.1002/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H
ISSN: 0014-2980
PubMed: 11828373
WoS: 000173996100029
Scopus: 2-s2.0-0036180761
Collections
Institution/Community
rFASPERTY - JOUR AU - Samardžić, T. AU - Marinković, Dragan AU - Danzer, CP AU - Gerlach, J AU - Nitschke, L. AU - Wirth, Thomas PY - 2002 UR - http://rfasper.fasper.bg.ac.rs/handle/123456789/30 AB - CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed a detailed analysis of the splenic B cell population and found that the subset of marginal zone (MZ) B cells was selectively reduced in CD22-deficient mice. CD22-deficient mice showed a lack of TNP-ficoll capturing cells in the MZ and a reduced response to TNP-ficoll, particularly when the antigen was applied intravenously. CD22-deficient B cells showed both enhanced motility as well as enhanced chemotaxis to certain chemokines. The altered chemokine responsiveness or the higher signaling capacity of CD22-deficient B cells may lead to the compromised MZ B cell compartment, as both processes have previously been shown to affect MZ composition. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - European Journal of Immunology T1 - Reduction of marginal zone B cells in CD22-deficient mice EP - 567 IS - 2 SP - 561 VL - 32 DO - 10.1002/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H ER -
@article{ author = "Samardžić, T. and Marinković, Dragan and Danzer, CP and Gerlach, J and Nitschke, L. and Wirth, Thomas", year = "2002", abstract = "CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed a detailed analysis of the splenic B cell population and found that the subset of marginal zone (MZ) B cells was selectively reduced in CD22-deficient mice. CD22-deficient mice showed a lack of TNP-ficoll capturing cells in the MZ and a reduced response to TNP-ficoll, particularly when the antigen was applied intravenously. CD22-deficient B cells showed both enhanced motility as well as enhanced chemotaxis to certain chemokines. The altered chemokine responsiveness or the higher signaling capacity of CD22-deficient B cells may lead to the compromised MZ B cell compartment, as both processes have previously been shown to affect MZ composition.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "European Journal of Immunology", title = "Reduction of marginal zone B cells in CD22-deficient mice", pages = "567-561", number = "2", volume = "32", doi = "10.1002/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H" }
Samardžić, T., Marinković, D., Danzer, C., Gerlach, J., Nitschke, L.,& Wirth, T.. (2002). Reduction of marginal zone B cells in CD22-deficient mice. in European Journal of Immunology Wiley-V C H Verlag Gmbh, Weinheim., 32(2), 561-567. https://doi.org/10.1002/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H
Samardžić T, Marinković D, Danzer C, Gerlach J, Nitschke L, Wirth T. Reduction of marginal zone B cells in CD22-deficient mice. in European Journal of Immunology. 2002;32(2):561-567. doi:10.1002/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H .
Samardžić, T., Marinković, Dragan, Danzer, CP, Gerlach, J, Nitschke, L., Wirth, Thomas, "Reduction of marginal zone B cells in CD22-deficient mice" in European Journal of Immunology, 32, no. 2 (2002):561-567, https://doi.org/10.1002/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H . .