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Приказ резултата 11-20 од 42
CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice
(Wiley-V C H Verlag Gmbh, Weinheim, 2002)
BOB.1/OBF1 (also called OCA-B), a B lymphocyte-specific transcriptional coactivator, is recruited to octamer-containing promoters by interacting with the Oct-1 or Oct-2 proteins. BOB.1/OBF.1-deficient mice show impaired ...
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
(Amer Soc Biochemistry Molecular Biology Inc, Bethesda, 2008)
Unchecked accumulation of reactive oxygen species (ROS) compromises maintenance of hematopoietic stem cells. Regulation of ROS by the tumor suppressor protein ataxia telangiectasia mutated (ATM) is critical for preserving ...
Prevalence of antibodies to Rickettsiae in different regions of Serbia
(Mary Ann Liebert, Inc, New Rochelle, 2008)
We assayed the presence of antibodies specific for Rickettsia typhi, R. akari, and R. conorii in sera of persons from several localities in Serbia with different geographic, climatic, and lifestyle characteristics. Sera ...
Identification of novel Myc target genes with a potential role in lymphomagenesis
(Oxford Univ Press, Oxford, 2004)
The c-Myc transcription factor regulates a wide set of genes involved in processes such as proliferation, differentiation and apoptosis. Therefore, altered expression of Myc leads to deregulation of a large number of target ...
c-MYC activation impairs the NF-kappa B and the interferon response: Implications for the pathogenesis of Burkitt's lymphoma
(Wiley-Liss, Hoboken, 2007)
Deregulation of the proto-oncogene c-myc is a key event in the pathogenesis of many tumors. A paradigm is the activation of the c-myc gene by chromosomal translocations in Burkitt lymphoma (BL). Despite expression of a ...
Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation
(Amer Assoc Immunologists, Bethesda, 2005)
An as-yet-unidentified mutation, Y-linked autoimmune acceleration (Yaa), is responsible for the accelerated development of lupus-like autoimmune syndrome in mice. In view of a possible role for Yaa as a positive regulator ...
Reduction of marginal zone B cells in CD22-deficient mice
(Wiley-V C H Verlag Gmbh, Weinheim, 2002)
CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed ...
B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice
(Amer Assoc Immunologists, Bethesda, 2005)
Marginal zone (MZ) B cells and peritoneal B-I cells provide a first defense system of thymus-independent Ab responses against foreign pathogens and therefore share a number of functional properties. Recently, development ...
Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee
(Sage Publications Ltd, London, 2021)
Purpose Many daily-life clinical decisions in patients with cerebrovascular disease and cognitive impairment are complex. Evidence-based information sustaining these decisions is frequently lacking. The aim of this paper ...
The new role for an old guy: MYC as an immunoplayer
(Wiley, Hoboken, 2021)
As an oncogene, myelocytomatosis oncogene (MYC) is implicated in the concept of "oncogene addiction," where switching off the oncogene leads to the cell cycle arrest and cell differentiation. However, recent data suggest ...