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BOB.1OBF.1 deficiency affects marginal-zone B-cell compartment
dc.creator | Samardžić, T. | |
dc.creator | Marinković, Dragan | |
dc.creator | Nielsen, P.J. | |
dc.creator | Nitschke, L. | |
dc.creator | Wirth, Thomas | |
dc.date.accessioned | 2021-06-09T13:11:48Z | |
dc.date.available | 2021-06-09T13:11:48Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0270-7306 | |
dc.identifier.uri | http://rfasper.fasper.bg.ac.rs/handle/123456789/28 | |
dc.description.abstract | Marginal-zone (MZ) B cells represent a first line of defense against particulate blood-borne antigens. Together with the B1 cells, they are responsible for the early response against type It T-independent antigens. The molecular pathways controlling the development of MZ B cells are only poorly understood. We found that these cells are virtually absent in mice deficient in the BOB.1/OBF.1 coactivator. Loss of these B cells was demonstrated by the lack. of cells showing the appropriate cell surface phenotype but also by histological analyses and tri-nitro-phenol-Ficoll capturing. The lack of these cells is a B-cell-intrinsic defect, as shown by bone marrow complementation experiments. We also show that the expression of BOB.1/OBF.1 in peripheral B cells is required for the development of MZ B lymphocytes. Our analysis of BOB.1/OBF.1-deficient splenic B cells reveals alterations in cell motility, tumor necrosis factor receptor expression, and B-cell receptor (BCR) signaling. These changes could contribute to the loss of MZ B lymphocytes by altering the maturation of the cells. Interestingly, development of and BCR signaling in B1 B cells are completely normal in BOB.1/OBF.1 mutant mice. | en |
dc.publisher | Amer Soc Microbiology, Washington | |
dc.rights | openAccess | |
dc.source | Molecular and Cellular Biology | |
dc.title | BOB.1OBF.1 deficiency affects marginal-zone B-cell compartment | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 8331 | |
dc.citation.issue | 23 | |
dc.citation.other | 22(23): 8320-8331 | |
dc.citation.rank | aM21 | |
dc.citation.spage | 8320 | |
dc.citation.volume | 22 | |
dc.identifier.doi | 10.1128/MCB.22.23.8320-8331.2002 | |
dc.identifier.fulltext | http://rfasper.fasper.bg.ac.rs/bitstream/id/357/25.pdf | |
dc.identifier.pmid | 12417733 | |
dc.identifier.scopus | 2-s2.0-0036889190 | |
dc.identifier.wos | 000179190600020 | |
dc.type.version | publishedVersion |