Приказ основних података о документу

dc.creatorKokai, Enikoe
dc.creatorVoss, Florian
dc.creatorFleischer, Frank
dc.creatorKempe, Sybille
dc.creatorMarinković, Dragan
dc.creatorWolburg, Hartwig
dc.creatorLeithaeuser, Frank
dc.creatorSchmidt, Volker
dc.creatorDeutsch, Urban
dc.creatorWirth, Thomas
dc.date.accessioned2021-06-09T13:26:23Z
dc.date.available2021-06-09T13:26:23Z
dc.date.issued2009
dc.identifier.issn0009-7330
dc.identifier.urihttp://rfasper.fasper.bg.ac.rs/handle/123456789/252
dc.description.abstractPrevious work has shown that c-Myc is required for adequate vasculogenesis and angiogenesis. To further investigate the contribution of Myc to these processes, we conditionally expressed c-Myc in embryonic endothelial cells using a tetracycline-regulated system. Endothelial Myc overexpression resulted in severe defects in the embryonic vascular system. Myc-expressing embryos undergo widespread edema formation and multiple hemorrhagic lesions. They die between embryonic days 14.5 and 17.5. The changes in vascular permeability are not caused by deficiencies in vascular basement membrane composition or pericyte coverage. However, the overall turnover of endothelial cells is elevated as is revealed by increased levels of both proliferation and apoptosis. Whole-mount immunohistochemical analysis revealed alterations in the architecture of capillary networks. The dermal vasculature of Myc-expressing embryos is characterized by a reduction in vessel branching, which occurs despite upregulation of the proangiogenic factors vascular endothelial growth factor-A and angiopoietin-2. Thus, the net outcome of an excess of vascular endothelial growth factor-A and angiopoietin-2 in the face of an elevated cellular turnover appears to be a defect in vascular integrity. (Circ Res. 2009;104:1151-1159.)en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.relationGerman Science FoundationGerman Research Foundation (DFG) [DFG-SFB451]
dc.rightsopenAccess
dc.sourceCirculation Research
dc.subjectMycen
dc.subjectVEGF-Aen
dc.subjectvascular permeabilityen
dc.subjectangiogenesisen
dc.titleMyc Regulates Embryonic Vascular Permeability and Remodelingen
dc.typearticle
dc.rights.licenseARR
dc.citation.epageU59
dc.citation.issue10
dc.citation.other104(10): 1151-U59
dc.citation.rankaM21
dc.citation.spage1151
dc.citation.volume104
dc.identifier.doi10.1161/CIRCRESAHA.108.191460
dc.identifier.fulltexthttp://rfasper.fasper.bg.ac.rs/bitstream/id/352/249.pdf
dc.identifier.pmid19407242
dc.identifier.scopus2-s2.0-66949134996
dc.identifier.wos000266300600006
dc.type.versionpublishedVersion


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Приказ основних података о документу