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dc.creatorMarinković, Dragan
dc.creatorMarinković, Tatjana
dc.date.accessioned2021-06-09T14:32:32Z
dc.date.available2021-06-09T14:32:32Z
dc.date.issued2020
dc.identifier.issn0300-9475
dc.identifier.urihttp://rfasper.fasper.bg.ac.rs/handle/123456789/1277
dc.description.abstractThe maintenance of inner integrity of an organism is founded on the proper performance of two immunity branches, innate and adaptive immune responses. Recently, it became apparent that subset of splenic B cells named marginal zone B cells (MZB cells) exhibits unique developmental and functional features that bridge these two immunity branches. Strategically positioned at the site where blood and lymph are filtered, MZB cells represent a population of sentinels that rapidly proliferate and differentiate into IgM plasmablast cells when encountered with blood-borne, thymus-independent (TI) Ags. Moreover, MZB cells have intrinsic capability to induce potent CD4(+)helper T cell response and cytokine production upon stimulation with soluble antigens. Due to their ability to overcome a time gap prior the establishment of the full adaptive response towards pathogens, MZB cells connect and direct innate and adaptive immunity. An additional interesting characteristic of MZB cells is capacity to function as regulatory cells in autoimmune processes. MZB cells may also contribute to the control of autoimmunity via the induction of tolerance by apoptotic cells. Importantly, in the clear association with inflammation and autoimmunity, MZB cells may transform into MALT lymphoma, representing a concurrence point for the infection, immunity and malignancy. This paper presents an insight into the complex biology of marginal zone B cells and their role in intertwining and directing innate and adaptive immune processes at the physiological and pathological level.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175083/RS//
dc.rightsrestrictedAccess
dc.sourceScandinavian Journal of Immunology
dc.subjectautoimmunityen
dc.subjectinfectionen
dc.subjectlymphomaen
dc.subjectmarginal zone B cellsen
dc.titlePutative role of marginal zone B cells in pathophysiological processesen
dc.typearticle
dc.rights.licenseARR
dc.citation.issue3
dc.citation.other92(3): -
dc.citation.rankM23
dc.citation.volume92
dc.identifier.doi10.1111/sji.12920
dc.identifier.pmid32594535
dc.identifier.scopus2-s2.0-85087770888
dc.identifier.wos000548156800001
dc.type.versionpublishedVersion


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