TY  - JOUR
AU  - Milovanović, Olivera
AU  - Milovanović, Jasmina R.
AU  - Đukić, Aleksandar
AU  - Matović, Milovan
AU  - Tomić-Lučić, Aleksandra
AU  - Glumbić, Nenad
AU  - Radovanović, Ana M.
AU  - Janković, Slobodan M.
PY  - 2015
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/916
AB  - Objectives: The aim of our study was to develop a population pharmacokinetic (PPK) model for 25-hydroxyvitamin D clearance in a healthy young adult population in Serbia. Methods: Study sample consisted of 70 healthy young students of the Faculty of Medical Science, University of Kragujevac, Serbia, with a mean age and body mass index of 22.39 +/- 1.82 years and 21.31 +/- 2.69 kgm(-2), respectively. Non-linear mixed-effect modeling (NONMEM) software was used for data analysis. A validation set of 16 participants was used to estimate the predictive performance of the pharmacokinetic model. Results: In the base model (without covariates), we had parameter estimates of 0.01 L/h for apparent clearance, 0.25 L for apparent volume of distribution, while value of minimum objective function (MOF) was 383.468. The full regression model was established by estimating the effects of 12 covariates. Mean intake of vitamin D from foods (DD) and value of phosphate in serum (PHO) were covariates included in the final model, while others were excluded in this process. The estimated value in the final MOF model was 274.555. The final regression model formula was: clearance (CL) (L/h) = 0.0711 + 0.738 x DD + 0.618 x PHO. Conclusions: The PPK model obtained determined clearance of 25-hydroxyvitamin D in a healthy young adult population in Serbia. Mean intake of vitamin D from foods and serum phosphate level are the most important covariates that influence value of 25-hydroxyvitamin D clearance in healthy young adults.
PB  - Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
T2  - International Journal of Clinical Pharmacology and Therapeutics
T1  - Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults
EP  - 8
IS  - 1
SP  - 1
VL  - 53
DO  - 10.5414/CP202185
ER  - 

@article{
author = "Milovanović, Olivera and Milovanović, Jasmina R. and Đukić, Aleksandar and Matović, Milovan and Tomić-Lučić, Aleksandra and Glumbić, Nenad and Radovanović, Ana M. and Janković, Slobodan M.",
year = "2015",
abstract = "Objectives: The aim of our study was to develop a population pharmacokinetic (PPK) model for 25-hydroxyvitamin D clearance in a healthy young adult population in Serbia. Methods: Study sample consisted of 70 healthy young students of the Faculty of Medical Science, University of Kragujevac, Serbia, with a mean age and body mass index of 22.39 +/- 1.82 years and 21.31 +/- 2.69 kgm(-2), respectively. Non-linear mixed-effect modeling (NONMEM) software was used for data analysis. A validation set of 16 participants was used to estimate the predictive performance of the pharmacokinetic model. Results: In the base model (without covariates), we had parameter estimates of 0.01 L/h for apparent clearance, 0.25 L for apparent volume of distribution, while value of minimum objective function (MOF) was 383.468. The full regression model was established by estimating the effects of 12 covariates. Mean intake of vitamin D from foods (DD) and value of phosphate in serum (PHO) were covariates included in the final model, while others were excluded in this process. The estimated value in the final MOF model was 274.555. The final regression model formula was: clearance (CL) (L/h) = 0.0711 + 0.738 x DD + 0.618 x PHO. Conclusions: The PPK model obtained determined clearance of 25-hydroxyvitamin D in a healthy young adult population in Serbia. Mean intake of vitamin D from foods and serum phosphate level are the most important covariates that influence value of 25-hydroxyvitamin D clearance in healthy young adults.",
publisher = "Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen",
journal = "International Journal of Clinical Pharmacology and Therapeutics",
title = "Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults",
pages = "8-1",
number = "1",
volume = "53",
doi = "10.5414/CP202185"
}

Milovanović, O., Milovanović, J. R., Đukić, A., Matović, M., Tomić-Lučić, A., Glumbić, N., Radovanović, A. M.,& Janković, S. M.. (2015). Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults. in International Journal of Clinical Pharmacology and Therapeutics
Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen., 53(1), 1-8.
https://doi.org/10.5414/CP202185

Milovanović O, Milovanović JR, Đukić A, Matović M, Tomić-Lučić A, Glumbić N, Radovanović AM, Janković SM. Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults. in International Journal of Clinical Pharmacology and Therapeutics. 2015;53(1):1-8.
doi:10.5414/CP202185 .

Milovanović, Olivera, Milovanović, Jasmina R., Đukić, Aleksandar, Matović, Milovan, Tomić-Lučić, Aleksandra, Glumbić, Nenad, Radovanović, Ana M., Janković, Slobodan M., "Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults" in International Journal of Clinical Pharmacology and Therapeutics, 53, no. 1 (2015):1-8,
https://doi.org/10.5414/CP202185 . .

TY  - JOUR
AU  - Milovanović, Olivera
AU  - Milovanović, Jasmina R.
AU  - Đukić, Aleksandar
AU  - Matović, Milovan
AU  - Tomić-Lučić, Aleksandra
AU  - Glumbić, Nenad
AU  - Radovanović, Ana M.
AU  - Janković, Slobodan M.
PY  - 2015
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/915
PB  - Polskie Towarzystwo Farmaceutyczne, Warsaw
T2  - Acta Poloniae Pharmaceutica
T1  - Variation in vitamin d plasma levels according to study load of biomedical students
EP  - 215
IS  - 1
SP  - 213
VL  - 72
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_915
ER  - 

@article{
author = "Milovanović, Olivera and Milovanović, Jasmina R. and Đukić, Aleksandar and Matović, Milovan and Tomić-Lučić, Aleksandra and Glumbić, Nenad and Radovanović, Ana M. and Janković, Slobodan M.",
year = "2015",
publisher = "Polskie Towarzystwo Farmaceutyczne, Warsaw",
journal = "Acta Poloniae Pharmaceutica",
title = "Variation in vitamin d plasma levels according to study load of biomedical students",
pages = "215-213",
number = "1",
volume = "72",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_915"
}

Milovanović, O., Milovanović, J. R., Đukić, A., Matović, M., Tomić-Lučić, A., Glumbić, N., Radovanović, A. M.,& Janković, S. M.. (2015). Variation in vitamin d plasma levels according to study load of biomedical students. in Acta Poloniae Pharmaceutica
Polskie Towarzystwo Farmaceutyczne, Warsaw., 72(1), 213-215.
https://hdl.handle.net/21.15107/rcub_rfasper_915

Milovanović O, Milovanović JR, Đukić A, Matović M, Tomić-Lučić A, Glumbić N, Radovanović AM, Janković SM. Variation in vitamin d plasma levels according to study load of biomedical students. in Acta Poloniae Pharmaceutica. 2015;72(1):213-215.
https://hdl.handle.net/21.15107/rcub_rfasper_915 .

Milovanović, Olivera, Milovanović, Jasmina R., Đukić, Aleksandar, Matović, Milovan, Tomić-Lučić, Aleksandra, Glumbić, Nenad, Radovanović, Ana M., Janković, Slobodan M., "Variation in vitamin d plasma levels according to study load of biomedical students" in Acta Poloniae Pharmaceutica, 72, no. 1 (2015):213-215,
https://hdl.handle.net/21.15107/rcub_rfasper_915 .