TY  - JOUR
AU  - Nikolić-Kokić, Aleksandra
AU  - Marinković, Dragan
AU  - Perić, Stojan
AU  - Stević, Zorica
AU  - Spasić, Mihajlo B.
AU  - Blagojević, Duško
AU  - Rakočević-Stojanović, Vidosava
PY  - 2016
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/985
AB  - Objectives: The aim of our study was to determine if redox imbalance caused by the activities of antioxidant enzymes existed in erythrocytes of type 1 myotonic dystrophy ( DM1) patients. Methods: The activities of erythrocyte superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were measured in 30 DM1 patients and 15 healthy controls ( HCs). The obtained values were correlated with the Muscular Impairment Rating Scale ( MIRS) score and creatine kinase ( CK). Results: Superoxide dismutase and catalase activities were lower in DM1 patients compared to HCs. A positive correlation was found between disease duration and MIRS score as well as with glutathione reductase activity. In DM1 patients, there were positive correlations between catalase, glutathione peroxidase, and glutathione reductase activities. After sub-dividing DM1 patients according to CK levels, superoxide dismutase activity was still statistically different from HCs. However, catalase activity was significantly lower only in DM1 patients with increased CK. Discussion: Undesirable alterations in antioxidant enzyme activities during DM1 disease progression may result in conditions favoring oxidative stress and changes in metabolism which together could contribute to muscle wasting.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Redox Report
T1  - Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients
EP  - 237
IS  - 5
SP  - 232
VL  - 21
DO  - 10.1080/13510002.2015.1107311
ER  - 

@article{
author = "Nikolić-Kokić, Aleksandra and Marinković, Dragan and Perić, Stojan and Stević, Zorica and Spasić, Mihajlo B. and Blagojević, Duško and Rakočević-Stojanović, Vidosava",
year = "2016",
abstract = "Objectives: The aim of our study was to determine if redox imbalance caused by the activities of antioxidant enzymes existed in erythrocytes of type 1 myotonic dystrophy ( DM1) patients. Methods: The activities of erythrocyte superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were measured in 30 DM1 patients and 15 healthy controls ( HCs). The obtained values were correlated with the Muscular Impairment Rating Scale ( MIRS) score and creatine kinase ( CK). Results: Superoxide dismutase and catalase activities were lower in DM1 patients compared to HCs. A positive correlation was found between disease duration and MIRS score as well as with glutathione reductase activity. In DM1 patients, there were positive correlations between catalase, glutathione peroxidase, and glutathione reductase activities. After sub-dividing DM1 patients according to CK levels, superoxide dismutase activity was still statistically different from HCs. However, catalase activity was significantly lower only in DM1 patients with increased CK. Discussion: Undesirable alterations in antioxidant enzyme activities during DM1 disease progression may result in conditions favoring oxidative stress and changes in metabolism which together could contribute to muscle wasting.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Redox Report",
title = "Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients",
pages = "237-232",
number = "5",
volume = "21",
doi = "10.1080/13510002.2015.1107311"
}

Nikolić-Kokić, A., Marinković, D., Perić, S., Stević, Z., Spasić, M. B., Blagojević, D.,& Rakočević-Stojanović, V.. (2016). Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients. in Redox Report
Taylor & Francis Ltd, Abingdon., 21(5), 232-237.
https://doi.org/10.1080/13510002.2015.1107311

Nikolić-Kokić A, Marinković D, Perić S, Stević Z, Spasić MB, Blagojević D, Rakočević-Stojanović V. Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients. in Redox Report. 2016;21(5):232-237.
doi:10.1080/13510002.2015.1107311 .

Nikolić-Kokić, Aleksandra, Marinković, Dragan, Perić, Stojan, Stević, Zorica, Spasić, Mihajlo B., Blagojević, Duško, Rakočević-Stojanović, Vidosava, "Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients" in Redox Report, 21, no. 5 (2016):232-237,
https://doi.org/10.1080/13510002.2015.1107311 . .