TY  - JOUR
AU  - Brunner, C
AU  - Marinković, Dragan
AU  - Klein, J
AU  - Samardžić, T.
AU  - Nitschke, L.
AU  - Wirth, Thomas
PY  - 2003
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/31
AB  - Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymphocytes are markedly reduced. Increased levels of B cell apoptosis in these mice prompted us to analyze expression and function of antiapoptotic proteins. Bcl2 expression is strongly reduced in BOB.1/OBF.1-deficient pre-B cells. When BOB.1/OBF.1-deficient mice were crossed with Bcl2-transgenic mice, B cell development in the bone marrow and numbers of B cells in peripheral lymphoid organs were normalized. However, neither germinal center B cells nor MZ B cells were rescued. Additionally, Bcl2 did not rescue the defects in signaling and affinity maturation found in BOB.1/OBF.1-deficient mice. Interestingly, Bcl2-transgenic mice by themselves show an MZ B cell defect. Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment.
PB  - Rockefeller Univ Press, New York
T2  - Journal of Experimental Medicine
T1  - B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice
EP  - 1211
IS  - 9
SP  - 1205
VL  - 197
DO  - 10.1084/jem.20022014
ER  - 

@article{
author = "Brunner, C and Marinković, Dragan and Klein, J and Samardžić, T. and Nitschke, L. and Wirth, Thomas",
year = "2003",
abstract = "Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymphocytes are markedly reduced. Increased levels of B cell apoptosis in these mice prompted us to analyze expression and function of antiapoptotic proteins. Bcl2 expression is strongly reduced in BOB.1/OBF.1-deficient pre-B cells. When BOB.1/OBF.1-deficient mice were crossed with Bcl2-transgenic mice, B cell development in the bone marrow and numbers of B cells in peripheral lymphoid organs were normalized. However, neither germinal center B cells nor MZ B cells were rescued. Additionally, Bcl2 did not rescue the defects in signaling and affinity maturation found in BOB.1/OBF.1-deficient mice. Interestingly, Bcl2-transgenic mice by themselves show an MZ B cell defect. Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment.",
publisher = "Rockefeller Univ Press, New York",
journal = "Journal of Experimental Medicine",
title = "B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice",
pages = "1211-1205",
number = "9",
volume = "197",
doi = "10.1084/jem.20022014"
}

Brunner, C., Marinković, D., Klein, J., Samardžić, T., Nitschke, L.,& Wirth, T.. (2003). B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice. in Journal of Experimental Medicine
Rockefeller Univ Press, New York., 197(9), 1205-1211.
https://doi.org/10.1084/jem.20022014

Brunner C, Marinković D, Klein J, Samardžić T, Nitschke L, Wirth T. B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice. in Journal of Experimental Medicine. 2003;197(9):1205-1211.
doi:10.1084/jem.20022014 .

Brunner, C, Marinković, Dragan, Klein, J, Samardžić, T., Nitschke, L., Wirth, Thomas, "B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice" in Journal of Experimental Medicine, 197, no. 9 (2003):1205-1211,
https://doi.org/10.1084/jem.20022014 . .