TY  - JOUR
AU  - Stojanović, D.
AU  - Milenković, S. M.
AU  - Mitrović, N.
AU  - Marinković, Dragan
AU  - Stevanović, D.
AU  - Radovanović, D.
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/683
AB  - Purpose: The prediction of outcome for patients with gastric cancer is determined largely by the presence of lymph node metastases, which could be detected by sentinel lymph node (SLN) biopsy (SLNB). The purpose of this work was to determine the feasibility of SLNB in patients with gastric cancer for the assessment of regional lymph node status, including performing immunohistochemical (IHC) staining of SLN tissue. Methods: We reviewed 137 consecutive patients with operable gastric cancer over a 10-year period using a retrospective (to examine skip metastases) and prospective (to evaluate successful mapping) study design. SLNs were mapped, biopsied and subsequently explored by routine hematoxylin & eosin (H&E) staining and by IHC staining using a cytokeratin 8/18 antibody. Results: The retrospective study showed a low incidence of skip metastases (3.7%). Mapping of SLNs in the prospective study was highly successful (98.2%). During the prospective study, IHC examination of SLNs from 56 patients showed statistically significant change in disease stage. Conclusion: This study demonstrated highly successful mapping and biopsy of SLNs (98.2%), as well as highest specificity (100%), sensitivity (100%) and accuracy (100%) to predict metastasis in the surrounding lymph nodes of gastric carcinoma. In addition, we believe that IHC study might enable "ultra staging" and additional selection of patients for further cancer treatment.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - The feasibility of sentinel lymph node biopsy for gastric cancer: the experience from Serbia
EP  - 168
IS  - 1
SP  - 162
VL  - 18
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_683
ER  - 

@article{
author = "Stojanović, D. and Milenković, S. M. and Mitrović, N. and Marinković, Dragan and Stevanović, D. and Radovanović, D.",
year = "2013",
abstract = "Purpose: The prediction of outcome for patients with gastric cancer is determined largely by the presence of lymph node metastases, which could be detected by sentinel lymph node (SLN) biopsy (SLNB). The purpose of this work was to determine the feasibility of SLNB in patients with gastric cancer for the assessment of regional lymph node status, including performing immunohistochemical (IHC) staining of SLN tissue. Methods: We reviewed 137 consecutive patients with operable gastric cancer over a 10-year period using a retrospective (to examine skip metastases) and prospective (to evaluate successful mapping) study design. SLNs were mapped, biopsied and subsequently explored by routine hematoxylin & eosin (H&E) staining and by IHC staining using a cytokeratin 8/18 antibody. Results: The retrospective study showed a low incidence of skip metastases (3.7%). Mapping of SLNs in the prospective study was highly successful (98.2%). During the prospective study, IHC examination of SLNs from 56 patients showed statistically significant change in disease stage. Conclusion: This study demonstrated highly successful mapping and biopsy of SLNs (98.2%), as well as highest specificity (100%), sensitivity (100%) and accuracy (100%) to predict metastasis in the surrounding lymph nodes of gastric carcinoma. In addition, we believe that IHC study might enable "ultra staging" and additional selection of patients for further cancer treatment.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "The feasibility of sentinel lymph node biopsy for gastric cancer: the experience from Serbia",
pages = "168-162",
number = "1",
volume = "18",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_683"
}

Stojanović, D., Milenković, S. M., Mitrović, N., Marinković, D., Stevanović, D.,& Radovanović, D.. (2013). The feasibility of sentinel lymph node biopsy for gastric cancer: the experience from Serbia. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 18(1), 162-168.
https://hdl.handle.net/21.15107/rcub_rfasper_683

Stojanović D, Milenković SM, Mitrović N, Marinković D, Stevanović D, Radovanović D. The feasibility of sentinel lymph node biopsy for gastric cancer: the experience from Serbia. in Journal of BUON. 2013;18(1):162-168.
https://hdl.handle.net/21.15107/rcub_rfasper_683 .

Stojanović, D., Milenković, S. M., Mitrović, N., Marinković, Dragan, Stevanović, D., Radovanović, D., "The feasibility of sentinel lymph node biopsy for gastric cancer: the experience from Serbia" in Journal of BUON, 18, no. 1 (2013):162-168,
https://hdl.handle.net/21.15107/rcub_rfasper_683 .